3f75 - Revision history

OCA at 06:42, 6 September 2023

OCA — Wed, 06 Sep 2023 06:42:40 GMT

←Older revision		Revision as of 06:42, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3f75' size='340' side='right'caption='[[3f75]], [[Resolution\|resolution]] 1.99Å' scene=''>		<StructureSection load='3f75' size='340' side='right'caption='[[3f75]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3f75]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Toxoplasma_gondii_rh~~ Toxoplasma gondii rh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F75 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F75 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3f75]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii_RH Toxoplasma gondii RH]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F75 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F75 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>~~, ~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:~~1~~,2-ETHANEDIOL'>EDO</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.99Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~CPL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=383379 Toxoplasma gondii RH])</td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Cathepsin_L Cathepsin L]~~, ~~with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f75 OCA], [https://pdbe.org/3f75 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f75 RCSB], [https://www.ebi.ac.uk/pdbsum/3f75 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f75 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f75 OCA], [https://pdbe.org/3f75 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f75 RCSB], [https://www.ebi.ac.uk/pdbsum/3f75 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f75 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q6DMN0_TOXGO Q6DMN0_TOXGO]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Cathepsin L]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Toxoplasma gondii rh]]	+	[[Category: Toxoplasma gondii RH]]
-	[[Category: Larson~~, E T]]~~	+	[[Category: Larson ET]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Merritt EA]]
-	[[Category: Merritt~~, E A]]~~	+
-	~~[[Category: Cysteine protease]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Msgpp]]~~	+
-	~~[[Category: Parasite]]~~	+
-	~~[[Category: Protozoa]]~~	+
-	~~[[Category: Thiol protease~~]]	+

OCA at 09:25, 23 February 2022

OCA — Wed, 23 Feb 2022 09:25:35 GMT

←Older revision		Revision as of 09:25, 23 February 2022
Line 1:		Line 1:

	==Activated Toxoplasma gondii cathepsin L (TgCPL) in complex with its propeptide==		==Activated Toxoplasma gondii cathepsin L (TgCPL) in complex with its propeptide==
-	<StructureSection load='3f75' size='340' side='right' caption='[[3f75]], [[Resolution\|resolution]] 1.99Å' scene=''>	+	<StructureSection load='3f75' size='340' side='right'caption='[[3f75]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3f75]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Toxoplasma_gondii_rh Toxoplasma gondii rh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F75 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3F75 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3f75]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii_rh Toxoplasma gondii rh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F75 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F75 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CPL ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=383379 Toxoplasma gondii RH])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CPL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=383379 Toxoplasma gondii RH])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3f75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f75 OCA], [~~http~~://pdbe.org/3f75 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3f75 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3f75 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3f75 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f75 OCA], [https://pdbe.org/3f75 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f75 RCSB], [https://www.ebi.ac.uk/pdbsum/3f75 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f75 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f7/3f75_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f7/3f75_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 3f75" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3f75" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cathepsin 3D structures\|Cathepsin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Cathepsin L]]		[[Category: Cathepsin L]]
		+	[[Category: Large Structures]]
	[[Category: Toxoplasma gondii rh]]		[[Category: Toxoplasma gondii rh]]
	[[Category: Larson, E T]]		[[Category: Larson, E T]]

OCA at 09:27, 25 October 2017

OCA — Wed, 25 Oct 2017 09:27:34 GMT

←Older revision		Revision as of 09:27, 25 October 2017
Line 1:		Line 1:
		+
	==Activated Toxoplasma gondii cathepsin L (TgCPL) in complex with its propeptide==		==Activated Toxoplasma gondii cathepsin L (TgCPL) in complex with its propeptide==
	<StructureSection load='3f75' size='340' side='right' caption='[[3f75]], [[Resolution\|resolution]] 1.99Å' scene=''>		<StructureSection load='3f75' size='340' side='right' caption='[[3f75]], [[Resolution\|resolution]] 1.99Å' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CPL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=383379 Toxoplasma gondii RH])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CPL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=383379 Toxoplasma gondii RH])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f75 OCA], [http://pdbe.org/3f75 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f75 RCSB], [http://www.ebi.ac.uk/pdbsum/3f75 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f75 OCA], [http://pdbe.org/3f75 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f75 RCSB], [http://www.ebi.ac.uk/pdbsum/3f75 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3f75 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 3f75" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3f75" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Cathepsin\|Cathepsin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:55, 9 February 2016

OCA — Tue, 09 Feb 2016 12:55:56 GMT

←Older revision		Revision as of 12:55, 9 February 2016
Line 6:		Line 6:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CPL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=383379 Toxoplasma gondii RH])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CPL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=383379 Toxoplasma gondii RH])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f75 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f75 RCSB], [http://www.ebi.ac.uk/pdbsum/3f75 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f75 OCA], [http://pdbe.org/3f75 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f75 RCSB], [http://www.ebi.ac.uk/pdbsum/3f75 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3f75 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3f75" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 13:33, 18 December 2014

OCA — Thu, 18 Dec 2014 13:33:16 GMT

←Older revision		Revision as of 13:33, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3f75~~\| ~~PDB~~=3f75 \| ~~SCENE~~= }}	+	==Activated Toxoplasma gondii cathepsin L (TgCPL) in complex with its propeptide==
-	===~~Activated~~ Toxoplasma gondii cathepsin L (TgCPL) in complex with its propeptide~~===~~	+	<StructureSection load='3f75' size='340' side='right' caption='[[3f75]], [[Resolution\|resolution]] 1.99Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19596863}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3f75]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii_rh Toxoplasma gondii rh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F75 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F75 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CPL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=383379 Toxoplasma gondii RH])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f75 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f75 RCSB], [http://www.ebi.ac.uk/pdbsum/3f75 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f7/3f75_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The protozoan parasite Toxoplasma gondii relies on post-translational modification, including proteolysis, of proteins required for recognition and invasion of host cells. We have characterized the T. gondii cysteine protease cathepsin L (TgCPL), one of five cathepsins found in the T. gondii genome. We show that TgCPL is the primary target of the compound morpholinurea-leucyl-homophenyl-vinyl sulfone phenyl (LHVS), which was previously shown to inhibit parasite invasion by blocking the release of invasion proteins from microneme secretory organelles. As shown by fluorescently labeled LHVS and TgCPL-specific antibodies, TgCPL is associated with a discrete vesicular structure in the apical region of extracellular parasites but is found in multiple puncta throughout the cytoplasm of intracellular replicating parasites. LHVS fails to label cells lacking TgCPL due to targeted disruption of the TgCPL gene in two different parasite strains. We present a structural model for the inhibition of TgCPL by LHVS based on a 2.0 A resolution crystal structure of TgCPL in complex with its propeptide. We discuss possible roles for TgCPL as a protease involved in the degradation or limited proteolysis of parasite proteins involved in invasion.

-	~~==About this Structure==~~	+	Toxoplasma gondii cathepsin L is the primary target of the invasion-inhibitory compound morpholinurea-leucyl-homophenyl-vinyl sulfone phenyl.,Larson ET, Parussini F, Huynh MH, Giebel JD, Kelley AM, Zhang L, Bogyo M, Merritt EA, Carruthers VB J Biol Chem. 2009 Sep 25;284(39):26839-50. Epub 2009 Jul 13. PMID:19596863<ref>PMID:19596863</ref>
-	~~[[3f75]]~~ is ~~a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Toxoplasma_gondii_rh Toxoplasma gondii rh]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=3F75 OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Cathepsin\|Cathepsin]]		*[[Cathepsin\|Cathepsin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:019596863</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Cathepsin L]]		[[Category: Cathepsin L]]
	[[Category: Toxoplasma gondii rh]]		[[Category: Toxoplasma gondii rh]]
-	[[Category: Larson, E T.]]	+	[[Category: Larson, E T]]
-	[[Category: ~~MSGPP, Medical~~ Structural ~~Genomics of Pathogenic Protozoa.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Merritt, E A.]]	+	[[Category: Merritt, E A]]
	[[Category: Cysteine protease]]		[[Category: Cysteine protease]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
-	[[Category: Medical structural genomics of pathogenic protozoa]]
	[[Category: Msgpp]]		[[Category: Msgpp]]
	[[Category: Parasite]]		[[Category: Parasite]]
	[[Category: Protozoa]]		[[Category: Protozoa]]
	[[Category: Thiol protease]]		[[Category: Thiol protease]]

OCA at 03:26, 1 August 2013

OCA — Thu, 01 Aug 2013 03:26:04 GMT

←Older revision		Revision as of 03:26, 1 August 2013
Line 1:		Line 1:
-	[[Image:3f75.png\|left\|200px]]
-
	{{STRUCTURE_3f75\| PDB=3f75 \| SCENE= }}		{{STRUCTURE_3f75\| PDB=3f75 \| SCENE= }}
-
	===Activated Toxoplasma gondii cathepsin L (TgCPL) in complex with its propeptide===		===Activated Toxoplasma gondii cathepsin L (TgCPL) in complex with its propeptide===
-
	{{ABSTRACT_PUBMED_19596863}}		{{ABSTRACT_PUBMED_19596863}}

	==About this Structure==		==About this Structure==
-	[[3f75]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Toxoplasma_gondii~~ Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F75 OCA].	+	[[3f75]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii_rh Toxoplasma gondii rh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F75 OCA].

	==See Also==		==See Also==
Line 14:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:019596863</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019596863</ref><references group="xtra"/><references/>
	[[Category: Cathepsin L]]		[[Category: Cathepsin L]]
-	[[Category: Toxoplasma gondii]]	+	[[Category: Toxoplasma gondii rh]]
	[[Category: Larson, E T.]]		[[Category: Larson, E T.]]
	[[Category: MSGPP, Medical Structural Genomics of Pathogenic Protozoa.]]		[[Category: MSGPP, Medical Structural Genomics of Pathogenic Protozoa.]]

OCA at 13:55, 20 October 2012

OCA — Sat, 20 Oct 2012 13:55:22 GMT

←Older revision		Revision as of 13:55, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3f75]] is a 2 chain structure ~~of [[Cathepsin]]~~ with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F75 OCA].	+	[[3f75]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F75 OCA].

	==See Also==		==See Also==

OCA at 13:30, 26 July 2012

OCA — Thu, 26 Jul 2012 13:30:55 GMT

←Older revision		Revision as of 13:30, 26 July 2012
Line 1:		Line 1:
	[[Image:3f75.png\|left\|200px]]		[[Image:3f75.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3f75", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3f75\| PDB=3f75 \| SCENE= }}		{{STRUCTURE_3f75\| PDB=3f75 \| SCENE= }}

	===Activated Toxoplasma gondii cathepsin L (TgCPL) in complex with its propeptide===		===Activated Toxoplasma gondii cathepsin L (TgCPL) in complex with its propeptide===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19596863}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19596863 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19596863}}		{{ABSTRACT_PUBMED_19596863}}

	==About this Structure==		==About this Structure==
-	[[3f75]] is a 2 chain structure of [[Cathepsin]] with sequence from [http://en.wikipedia.org/wiki/~~Toxoplasma_gondii_rh~~ Toxoplasma gondii rh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F75 OCA].	+	[[3f75]] is a 2 chain structure of [[Cathepsin]] with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F75 OCA].

	==See Also==		==See Also==
-	*[[Cathepsin]]	+	*[[Cathepsin\|Cathepsin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19596863~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019596863</ref><references group="xtra"/>
	[[Category: Cathepsin L]]		[[Category: Cathepsin L]]
-	[[Category: Toxoplasma gondii rh]]	+	[[Category: Toxoplasma gondii]]
	[[Category: Larson, E T.]]		[[Category: Larson, E T.]]
	[[Category: MSGPP, Medical Structural Genomics of Pathogenic Protozoa.]]		[[Category: MSGPP, Medical Structural Genomics of Pathogenic Protozoa.]]

OCA: Protected "3f75" [edit=sysop:move=sysop]

OCA — Sun, 26 Dec 2010 08:30:26 GMT

Protected "3f75" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:30, 26 December 2010

OCA at 08:30, 26 December 2010

OCA — Sun, 26 Dec 2010 08:30:25 GMT

←Older revision		Revision as of 08:30, 26 December 2010
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3f75.png\|left\|200px]]		[[Image:3f75.png\|left\|200px]]

Line 12:		Line 11:
	===Activated Toxoplasma gondii cathepsin L (TgCPL) in complex with its propeptide===		===Activated Toxoplasma gondii cathepsin L (TgCPL) in complex with its propeptide===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19596863}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19596863 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19596863}}

	==About this Structure==		==About this Structure==
-	~~3F75~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Toxoplasma_gondii_rh Toxoplasma gondii rh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F75 OCA].	+	[[3f75]] is a 2 chain structure of [[Cathepsin]] with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii_rh Toxoplasma gondii rh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F75 OCA].
		+
		+	==See Also==
		+	*[[Cathepsin]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19596863</ref><references group="xtra"/>
	[[Category: Cathepsin L]]		[[Category: Cathepsin L]]
	[[Category: Toxoplasma gondii rh]]		[[Category: Toxoplasma gondii rh]]
Line 27:		Line 38:
	[[Category: Protozoa]]		[[Category: Protozoa]]
	[[Category: Thiol protease]]		[[Category: Thiol protease]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 30 20:06:31 2009''