3f7u - Revision history

OCA at 06:37, 3 April 2024

OCA — Wed, 03 Apr 2024 06:37:26 GMT

←Older revision		Revision as of 06:37, 3 April 2024
Line 22:		Line 22:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3f7u ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3f7u ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	A novel series of potent thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV was discovered using structure-based drug design. Synthesis, structure-activity relationship, and optimization of physicochemical properties are described. Low nanomolar potency was achieved, and selected compounds with improved thermodynamic solubility showed promising in vitro inhibition of carbonic anhydrase activity in rabbit iris ciliary body homogenate.
-
-	Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: structure-based drug design, synthesis, and biological evaluation.,Vernier W, Chong W, Rewolinski D, Greasley S, Pauly T, Shaw M, Dinh D, Ferre RA, Nukui S, Ornelas M, Reyner E Bioorg Med Chem. 2010 May 1;18(9):3307-19. Epub 2010 Mar 11. PMID:20363633<ref>PMID:20363633</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3f7u" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 00:29, 28 December 2023

OCA — Thu, 28 Dec 2023 00:29:25 GMT

←Older revision		Revision as of 00:29, 28 December 2023
Line 3:		Line 3:
	<StructureSection load='3f7u' size='340' side='right'caption='[[3f7u]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3f7u' size='340' side='right'caption='[[3f7u]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3f7u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F7U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F7U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3f7u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F7U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F7U FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=AG4:N~~-~~(3-METHOXYPROPYL)-2-(PHENYLSULFANYL)-5-SULFAMOYLPYRIDINE-3-CARBOXAMIDE'>AG4</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[3f7b\|3f7b]], [[3fw3\|3fw3]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AG4:N-(3-METHOXYPROPYL)-2-(PHENYLSULFANYL)-5-SULFAMOYLPYRIDINE-3-CARBOXAMIDE'>AG4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>CA4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f7u OCA], [https://pdbe.org/3f7u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f7u RCSB], [https://www.ebi.ac.uk/pdbsum/3f7u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f7u ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f7u OCA], [https://pdbe.org/3f7u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f7u RCSB], [https://www.ebi.ac.uk/pdbsum/3f7u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f7u ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/CAH4_HUMAN CAH4_HUMAN]] Defects in CA4 are the cause of retinitis pigmentosa type 17 (RP17) [MIM:[https://omim.org/entry/600852 600852]]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP17 inheritance is autosomal dominant. Note=Defective acid overload removal from retina and retinal epithelium, due to mutant CA4, is responsible for photoreceptor degeneration, indicating that impaired pH homeostasis is the most likely cause underlying the RP17 phenotype.<ref>PMID:15563508</ref>	+	[https://www.uniprot.org/uniprot/CAH4_HUMAN CAH4_HUMAN] Defects in CA4 are the cause of retinitis pigmentosa type 17 (RP17) [MIM:[https://omim.org/entry/600852 600852]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP17 inheritance is autosomal dominant. Note=Defective acid overload removal from retina and retinal epithelium, due to mutant CA4, is responsible for photoreceptor degeneration, indicating that impaired pH homeostasis is the most likely cause underlying the RP17 phenotype.<ref>PMID:15563508</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CAH4_HUMAN CAH4_HUMAN]] Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.<ref>PMID:15563508</ref>	+	[https://www.uniprot.org/uniprot/CAH4_HUMAN CAH4_HUMAN] Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.<ref>PMID:15563508</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 40:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Carbonate dehydratase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ferre~~, R A.A~~]]	+	[[Category: Ferre RAA]]
-	[[Category: Greasley~~, S E~~]]	+	[[Category: Greasley SE]]
-	[[Category: Pauly~~, T A~~]]	+	[[Category: Pauly TA]]
-	[[Category: Paz, R]]	+	[[Category: Paz R]]
-	~~[[Category: Cell membrane]]~~	+
-	~~[[Category: Disease mutation]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Gpi-anchor]]~~	+
-	~~[[Category: Lipoprotein]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Retinitis pigmentosa]]~~	+
-	~~[[Category: Sensory transduction]]~~	+
-	~~[[Category: Structure-based drug design. small molecule complex. co-crystal]]~~	+
-	~~[[Category: Vision]]~~	+
-	~~[[Category: Zinc~~]]	+

OCA at 09:25, 23 February 2022

OCA — Wed, 23 Feb 2022 09:25:59 GMT

←Older revision		Revision as of 09:25, 23 February 2022
Line 1:		Line 1:

	==Crystal Structure of soluble domain of CA4 in complex with small molecule.==		==Crystal Structure of soluble domain of CA4 in complex with small molecule.==
-	<StructureSection load='3f7u' size='340' side='right' caption='[[3f7u]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='3f7u' size='340' side='right'caption='[[3f7u]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3f7u]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F7U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3F7U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3f7u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F7U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F7U FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AG4:N-(3-METHOXYPROPYL)-2-(PHENYLSULFANYL)-5-SULFAMOYLPYRIDINE-3-CARBOXAMIDE'>AG4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AG4:N-(3-METHOXYPROPYL)-2-(PHENYLSULFANYL)-5-SULFAMOYLPYRIDINE-3-CARBOXAMIDE'>AG4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3f7b\|3f7b]], [[3fw3\|3fw3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3f7b\|3f7b]], [[3fw3\|3fw3]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA4 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3f7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f7u OCA], [~~http~~://pdbe.org/3f7u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3f7u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3f7u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3f7u ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f7u OCA], [https://pdbe.org/3f7u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f7u RCSB], [https://www.ebi.ac.uk/pdbsum/3f7u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f7u ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/CAH4_HUMAN CAH4_HUMAN]] Defects in CA4 are the cause of retinitis pigmentosa type 17 (RP17) [MIM:[~~http~~://omim.org/entry/600852 600852]]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP17 inheritance is autosomal dominant. Note=Defective acid overload removal from retina and retinal epithelium, due to mutant CA4, is responsible for photoreceptor degeneration, indicating that impaired pH homeostasis is the most likely cause underlying the RP17 phenotype.<ref>PMID:15563508</ref>	+	[[https://www.uniprot.org/uniprot/CAH4_HUMAN CAH4_HUMAN]] Defects in CA4 are the cause of retinitis pigmentosa type 17 (RP17) [MIM:[https://omim.org/entry/600852 600852]]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP17 inheritance is autosomal dominant. Note=Defective acid overload removal from retina and retinal epithelium, due to mutant CA4, is responsible for photoreceptor degeneration, indicating that impaired pH homeostasis is the most likely cause underlying the RP17 phenotype.<ref>PMID:15563508</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CAH4_HUMAN CAH4_HUMAN]] Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.<ref>PMID:15563508</ref>	+	[[https://www.uniprot.org/uniprot/CAH4_HUMAN CAH4_HUMAN]] Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.<ref>PMID:15563508</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:

	==See Also==		==See Also==
-	*[[Carbonic anhydrase\|Carbonic anhydrase]]	+	*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 42:		Line 42:
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ferre, R A.A]]		[[Category: Ferre, R A.A]]
	[[Category: Greasley, S E]]		[[Category: Greasley, S E]]

OCA at 07:25, 5 December 2018

OCA — Wed, 05 Dec 2018 07:25:27 GMT

←Older revision		Revision as of 07:25, 5 December 2018
Line 1:		Line 1:
		+
	==Crystal Structure of soluble domain of CA4 in complex with small molecule.==		==Crystal Structure of soluble domain of CA4 in complex with small molecule.==
	<StructureSection load='3f7u' size='340' side='right' caption='[[3f7u]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3f7u' size='340' side='right' caption='[[3f7u]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f7u OCA], [http://pdbe.org/3f7u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f7u RCSB], [http://www.ebi.ac.uk/pdbsum/3f7u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f7u OCA], [http://pdbe.org/3f7u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f7u RCSB], [http://www.ebi.ac.uk/pdbsum/3f7u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3f7u ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 17:		Line 18:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f7/3f7u_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f7/3f7u_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 57:		Line 58:
	[[Category: Structure-based drug design. small molecule complex. co-crystal]]		[[Category: Structure-based drug design. small molecule complex. co-crystal]]
	[[Category: Vision]]		[[Category: Vision]]
		+	[[Category: Zinc]]

OCA at 22:25, 7 February 2016

OCA — Sun, 07 Feb 2016 22:25:21 GMT

←Older revision		Revision as of 22:25, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3f7u' size='340' side='right' caption='[[3f7u]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3f7u' size='340' side='right' caption='[[3f7u]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3f7u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F7U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F7U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3f7u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F7U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F7U FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AG4:N-(3-METHOXYPROPYL)-2-(PHENYLSULFANYL)-5-SULFAMOYLPYRIDINE-3-CARBOXAMIDE'>AG4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AG4:N-(3-METHOXYPROPYL)-2-(PHENYLSULFANYL)-5-SULFAMOYLPYRIDINE-3-CARBOXAMIDE'>AG4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3f7b\|3f7b]], [[3fw3\|3fw3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3f7b\|3f7b]], [[3fw3\|3fw3]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f7u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f7u RCSB], [http://www.ebi.ac.uk/pdbsum/3f7u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f7u OCA], [http://pdbe.org/3f7u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f7u RCSB], [http://www.ebi.ac.uk/pdbsum/3f7u PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 21:		Line 21:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3f7u ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 31:		Line 31:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3f7u" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 39:		Line 40:
	</StructureSection>		</StructureSection>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Ferre, R A.A]]		[[Category: Ferre, R A.A]]
	[[Category: Greasley, S E]]		[[Category: Greasley, S E]]

OCA at 13:27, 18 December 2014

OCA — Thu, 18 Dec 2014 13:27:13 GMT

←Older revision		Revision as of 13:27, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3f7u\| PDB=3f7u \| SCENE= }}~~	+	==Crystal Structure of soluble domain of CA4 in complex with small molecule.==
-	===Crystal Structure of soluble domain of CA4 in complex with small molecule.===	+	<StructureSection load='3f7u' size='340' side='right' caption='[[3f7u]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20363633}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3f7u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F7U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F7U FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AG4:N-(3-METHOXYPROPYL)-2-(PHENYLSULFANYL)-5-SULFAMOYLPYRIDINE-3-CARBOXAMIDE'>AG4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3f7b\|3f7b]], [[3fw3\|3fw3]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f7u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f7u RCSB], [http://www.ebi.ac.uk/pdbsum/3f7u PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CAH4_HUMAN CAH4_HUMAN]] Defects in CA4 are the cause of retinitis pigmentosa type 17 (RP17) [MIM:[http://omim.org/entry/600852 600852]]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP17 inheritance is autosomal dominant. Note=Defective acid overload removal from retina and retinal epithelium, due to mutant CA4, is responsible for photoreceptor degeneration, indicating that impaired pH homeostasis is the most likely cause underlying the RP17 phenotype.<ref>PMID:15563508</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CAH4_HUMAN CAH4_HUMAN]] Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.<ref>PMID:15563508</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f7/3f7u_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A novel series of potent thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV was discovered using structure-based drug design. Synthesis, structure-activity relationship, and optimization of physicochemical properties are described. Low nanomolar potency was achieved, and selected compounds with improved thermodynamic solubility showed promising in vitro inhibition of carbonic anhydrase activity in rabbit iris ciliary body homogenate.

-	~~==Disease==~~	+	Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: structure-based drug design, synthesis, and biological evaluation.,Vernier W, Chong W, Rewolinski D, Greasley S, Pauly T, Shaw M, Dinh D, Ferre RA, Nukui S, Ornelas M, Reyner E Bioorg Med Chem. 2010 May 1;18(9):3307-19. Epub 2010 Mar 11. PMID:20363633<ref>PMID:20363633</ref>
-	~~[[http://www.uniprot.org/uniprot/CAH4_HUMAN CAH4_HUMAN]] Defects in CA4 are the cause~~ of ~~retinitis pigmentosa type 17 (RP17) [MIM:[http://omim.org/entry/600852 600852]]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness~~ and ~~loss of midperipheral visual field. As their condition progresses~~, ~~they lose their far peripheral visual field~~ and ~~eventually central vision as well~~. ~~RP17 inheritance is autosomal dominant. Note=Defective acid overload removal from retina and retinal epithelium~~, ~~due to mutant CA4~~, ~~is responsible for photoreceptor degeneration~~, ~~indicating that impaired pH homeostasis is the most likely cause underlying the RP17 phenotype~~.<ref>PMID:~~15563508~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www~~.~~uniprot~~.~~org/uniprot/CAH4_HUMAN CAH4_HUMAN]] Reversible hydration~~ of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.<~~ref~~>~~PMID:15563508~~</~~ref~~>	+	</div>
-		+
-	~~==About this Structure==~~	+
-	[[3f7u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F7U OCA].	+

	==See Also==		==See Also==
	*[[Carbonic anhydrase\|Carbonic anhydrase]]		*[[Carbonic anhydrase\|Carbonic anhydrase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020363633</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Ferre, R A.A.]]	+	[[Category: Ferre, R A.A]]
-	[[Category: Greasley, S E.]]	+	[[Category: Greasley, S E]]
-	[[Category: Pauly, T A.]]	+	[[Category: Pauly, T A]]
-	[[Category: Paz, R.]]	+	[[Category: Paz, R]]
	[[Category: Cell membrane]]		[[Category: Cell membrane]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]
Line 33:		Line 54:
	[[Category: Retinitis pigmentosa]]		[[Category: Retinitis pigmentosa]]
	[[Category: Sensory transduction]]		[[Category: Sensory transduction]]
-	[[Category: Structure-based drug design. small molecule complex. co-crystal.]]	+	[[Category: Structure-based drug design. small molecule complex. co-crystal]]
	[[Category: Vision]]		[[Category: Vision]]

OCA at 01:09, 25 March 2013

OCA — Mon, 25 Mar 2013 01:09:25 GMT

←Older revision		Revision as of 01:09, 25 March 2013
Line 1:		Line 1:
-	[[Image:3f7u.png\|left\|200px]]
-
	{{STRUCTURE_3f7u\| PDB=3f7u \| SCENE= }}		{{STRUCTURE_3f7u\| PDB=3f7u \| SCENE= }}
-
	===Crystal Structure of soluble domain of CA4 in complex with small molecule.===		===Crystal Structure of soluble domain of CA4 in complex with small molecule.===
		+	{{ABSTRACT_PUBMED_20363633}}

-	~~{{ABSTRACT_PUBMED_20363633}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/CAH4_HUMAN CAH4_HUMAN]] Defects in CA4 are the cause of retinitis pigmentosa type 17 (RP17) [MIM:[http://omim.org/entry/600852 600852]]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP17 inheritance is autosomal dominant. Note=Defective acid overload removal from retina and retinal epithelium, due to mutant CA4, is responsible for photoreceptor degeneration, indicating that impaired pH homeostasis is the most likely cause underlying the RP17 phenotype.<ref>PMID:15563508</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/CAH4_HUMAN CAH4_HUMAN]] Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.<ref>PMID:15563508</ref>

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020363633</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020363633</ref><references group="xtra"/><references/>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 08:01, 20 October 2012

OCA — Sat, 20 Oct 2012 08:01:41 GMT

←Older revision		Revision as of 08:01, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3f7u]] is a 4 chain structure ~~of [[Carbonic anhydrase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F7U OCA].	+	[[3f7u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F7U OCA].

	==See Also==		==See Also==

OCA: Protected "3f7u" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 18:12:47 GMT

Protected "3f7u" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:12, 25 July 2012

OCA at 18:12, 25 July 2012

OCA — Wed, 25 Jul 2012 18:12:46 GMT

←Older revision		Revision as of 18:12, 25 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3f7u.png\|left\|200px]]		[[Image:3f7u.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3f7u", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3f7u\| PDB=3f7u \| SCENE= }}		{{STRUCTURE_3f7u\| PDB=3f7u \| SCENE= }}

	===Crystal Structure of soluble domain of CA4 in complex with small molecule.===		===Crystal Structure of soluble domain of CA4 in complex with small molecule.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20363633}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20363633 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20363633}}		{{ABSTRACT_PUBMED_20363633}}
-
-	==Disease==
-	Known disease associated with this structure: Retinitis pigmentosa-17 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=114760 114760]]

	==About this Structure==		==About this Structure==
-	~~3F7U~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F7U OCA].	+	[[3f7u]] is a 4 chain structure of [[Carbonic anhydrase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F7U OCA].
		+
		+	==See Also==
		+	*[[Carbonic anhydrase\|Carbonic anhydrase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20363633~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020363633</ref><references group="xtra"/>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
Line 45:		Line 33:
	[[Category: Structure-based drug design. small molecule complex. co-crystal.]]		[[Category: Structure-based drug design. small molecule complex. co-crystal.]]
	[[Category: Vision]]		[[Category: Vision]]
-	[[Category: Zinc]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 12 10:33:46 2010''