3f9a - Revision history

OCA at 06:43, 6 September 2023

OCA — Wed, 06 Sep 2023 06:43:25 GMT

←Older revision		Revision as of 06:43, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3f9a' size='340' side='right'caption='[[3f9a]], [[Resolution\|resolution]] 1.69Å' scene=''>		<StructureSection load='3f9a' size='340' side='right'caption='[[3f9a]], [[Resolution\|resolution]] 1.69Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3f9a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_enterocolitica_(~~type_0~~:9) Yersinia enterocolitica (type 0:9)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F9A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3f9a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_enterocolitica_(type_O:9) Yersinia enterocolitica (type O:9)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F9A FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=WO4:TUNGSTATE(VI)ION'>WO4</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.69Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;'>[[3f99\|3f99]]~~, [[~~3f9b~~\|~~3f9b~~]]~~</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WO4:TUNGSTATE(VI)ION'>WO4</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>yopH, yop51 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~34055 Yersinia enterocolitica (type 0:9)])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f9a OCA], [https://pdbe.org/3f9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f9a RCSB], [https://www.ebi.ac.uk/pdbsum/3f9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f9a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f9a OCA], [https://pdbe.org/3f9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f9a RCSB], [https://www.ebi.ac.uk/pdbsum/3f9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f9a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/YOPH_YEREN YOPH_YEREN]] Essential virulence determinant. This protein is a protein tyrosine phosphatase. The essential function of YopH in Yersinia pathogenesis is host-protein dephosphorylation. It contributes to the ability of the bacteria to resist phagocytosis by peritoneal macrophages.	+	[https://www.uniprot.org/uniprot/YOPH_YEREN YOPH_YEREN] Essential virulence determinant. This protein is a protein tyrosine phosphatase. The essential function of YopH in Yersinia pathogenesis is host-protein dephosphorylation. It contributes to the ability of the bacteria to resist phagocytosis by peritoneal macrophages.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Protein-tyrosine-phosphatase]]~~	+	[[Category: Brandao TAS]]
-	[[Category: Brandao~~, T A.S~~]]	+	[[Category: Hengge AC]]
-	[[Category: Hengge~~, A C~~]]	+	[[Category: Johnson SJ]]
-	[[Category: Johnson~~, S J~~]]	+	[[Category: Robinson H]]
-	[[Category: Robinson, H]]	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Outer membrane]]~~	+
-	~~[[Category: P-loop]]~~	+
-	~~[[Category: Protein phosphatase]]~~	+
-	~~[[Category: Secreted]]~~	+
-	~~[[Category: Tungstate]]~~	+
-	~~[[Category: Virulence]]~~	+
-	~~[[Category: Wpd-loop~~]]	+

OCA at 19:51, 20 October 2021

OCA — Wed, 20 Oct 2021 19:51:23 GMT

←Older revision		Revision as of 19:51, 20 October 2021
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	==W354F Yersinia enterocolitica PTPase complexed with tungstate==		==W354F Yersinia enterocolitica PTPase complexed with tungstate==
-	<StructureSection load='3f9a' size='340' side='right' caption='[[3f9a]], [[Resolution\|resolution]] 1.69Å' scene=''>	+	<StructureSection load='3f9a' size='340' side='right'caption='[[3f9a]], [[Resolution\|resolution]] 1.69Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3f9a]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Yersinia_enterocolitica_(type_0:9) Yersinia enterocolitica (type 0:9)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F9A OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3F9A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3f9a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_enterocolitica_(type_0:9) Yersinia enterocolitica (type 0:9)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F9A FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=WO4:TUNGSTATE(VI)ION'>WO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WO4:TUNGSTATE(VI)ION'>WO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3f99\|3f99]], [[3f9b\|3f9b]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3f99\|3f99]], [[3f9b\|3f9b]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">yopH, yop51 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=34055 Yersinia enterocolitica (type 0:9)])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">yopH, yop51 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=34055 Yersinia enterocolitica (type 0:9)])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3f9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f9a OCA], [~~http~~://pdbe.org/3f9a PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3f9a RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3f9a PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3f9a ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f9a OCA], [https://pdbe.org/3f9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f9a RCSB], [https://www.ebi.ac.uk/pdbsum/3f9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f9a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/YOPH_YEREN YOPH_YEREN]] Essential virulence determinant. This protein is a protein tyrosine phosphatase. The essential function of YopH in Yersinia pathogenesis is host-protein dephosphorylation. It contributes to the ability of the bacteria to resist phagocytosis by peritoneal macrophages.	+	[[https://www.uniprot.org/uniprot/YOPH_YEREN YOPH_YEREN]] Essential virulence determinant. This protein is a protein tyrosine phosphatase. The essential function of YopH in Yersinia pathogenesis is host-protein dephosphorylation. It contributes to the ability of the bacteria to resist phagocytosis by peritoneal macrophages.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
	[[Category: Brandao, T A.S]]		[[Category: Brandao, T A.S]]

OCA at 07:38, 5 December 2018

OCA — Wed, 05 Dec 2018 07:38:31 GMT

←Older revision		Revision as of 07:38, 5 December 2018
Line 1:		Line 1:
		+
	==W354F Yersinia enterocolitica PTPase complexed with tungstate==		==W354F Yersinia enterocolitica PTPase complexed with tungstate==
	<StructureSection load='3f9a' size='340' side='right' caption='[[3f9a]], [[Resolution\|resolution]] 1.69Å' scene=''>		<StructureSection load='3f9a' size='340' side='right' caption='[[3f9a]], [[Resolution\|resolution]] 1.69Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">yopH, yop51 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=34055 Yersinia enterocolitica (type 0:9)])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">yopH, yop51 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=34055 Yersinia enterocolitica (type 0:9)])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f9a OCA], [http://pdbe.org/3f9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f9a RCSB], [http://www.ebi.ac.uk/pdbsum/3f9a PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f9a OCA], [http://pdbe.org/3f9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f9a RCSB], [http://www.ebi.ac.uk/pdbsum/3f9a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3f9a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f9/3f9a_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f9/3f9a_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 3f9a" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3f9a" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 23:27, 8 February 2016

OCA — Mon, 08 Feb 2016 23:27:58 GMT

←Older revision		Revision as of 23:27, 8 February 2016
Line 7:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">yopH, yop51 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=34055 Yersinia enterocolitica (type 0:9)])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">yopH, yop51 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=34055 Yersinia enterocolitica (type 0:9)])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f9a RCSB], [http://www.ebi.ac.uk/pdbsum/3f9a PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f9a OCA], [http://pdbe.org/3f9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f9a RCSB], [http://www.ebi.ac.uk/pdbsum/3f9a PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3f9a ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3f9a" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 02:52, 25 December 2014

OCA — Thu, 25 Dec 2014 02:52:51 GMT

←Older revision		Revision as of 02:52, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3f9a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_enterocolitica_(type_0:9) Yersinia enterocolitica (type 0:9)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F9A FirstGlance]. <br>		<table><tr><td colspan='2'>[[3f9a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_enterocolitica_(type_0:9) Yersinia enterocolitica (type 0:9)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F9A FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=WO4:TUNGSTATE(VI)ION'>WO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=WO4:TUNGSTATE(VI)ION'>WO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3f99\|3f99]], [[3f9b\|3f9b]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3f99\|3f99]], [[3f9b\|3f9b]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">yopH, yop51 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=34055 Yersinia enterocolitica (type 0:9)])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">yopH, yop51 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=34055 Yersinia enterocolitica (type 0:9)])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f9a RCSB], [http://www.ebi.ac.uk/pdbsum/3f9a PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f9a RCSB], [http://www.ebi.ac.uk/pdbsum/3f9a PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/YOPH_YEREN YOPH_YEREN]] Essential virulence determinant. This protein is a protein tyrosine phosphatase. The essential function of YopH in Yersinia pathogenesis is host-protein dephosphorylation. It contributes to the ability of the bacteria to resist phagocytosis by peritoneal macrophages.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 27:
	Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures.,Brandao TA, Robinson H, Johnson SJ, Hengge AC J Am Chem Soc. 2009 Jan 21;131(2):778-86. PMID:19140798<ref>PMID:19140798</ref>		Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures.,Brandao TA, Robinson H, Johnson SJ, Hengge AC J Am Chem Soc. 2009 Jan 21;131(2):778-86. PMID:19140798<ref>PMID:19140798</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]
	== References ==		== References ==
	<references/>		<references/>
Line 32:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
-	[[Category: Brandao, T A.S.]]	+	[[Category: Brandao, T A.S]]
-	[[Category: Hengge, A C.]]	+	[[Category: Hengge, A C]]
-	[[Category: Johnson, S J.]]	+	[[Category: Johnson, S J]]
-	[[Category: Robinson, H.]]	+	[[Category: Robinson, H]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Membrane]]		[[Category: Membrane]]

OCA at 09:51, 21 May 2014

OCA — Wed, 21 May 2014 09:51:08 GMT

←Older revision		Revision as of 09:51, 21 May 2014
Line 1:		Line 1:
-	[[~~Image:~~3f9a.~~png~~\|~~left~~\|200px]]	+	==W354F Yersinia enterocolitica PTPase complexed with tungstate==
		+	<StructureSection load='3f9a' size='340' side='right' caption='[[3f9a]], [[Resolution\|resolution]] 1.69Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3f9a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_enterocolitica_(type_0:9) Yersinia enterocolitica (type 0:9)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F9A FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=WO4:TUNGSTATE(VI)ION'>WO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3f99\|3f99]], [[3f9b\|3f9b]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">yopH, yop51 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=34055 Yersinia enterocolitica (type 0:9)])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f9a RCSB], [http://www.ebi.ac.uk/pdbsum/3f9a PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f9/3f9a_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Catalysis by the Yersinia protein-tyrosine phosphatase YopH is significantly impaired by the mutation of the conserved Trp354 residue to Phe. Though not a catalytic residue, this Trp is a hinge residue in a conserved flexible loop (the WPD-loop) that must close during catalysis. To learn why this seemingly conservative mutation reduces catalysis by 2 orders of magnitude, we have solved high-resolution crystal structures for the W354F YopH in the absence and in the presence of tungstate and vanadate. Oxyanion binding to the P-loop in W354F is analogous to that observed in the native enzyme. However, the WPD-loop in the presence of oxyanions assumes a half-closed conformation, in contrast to the fully closed state observed in structures of the native enzyme. This observation provides an explanation for the impaired general acid catalysis observed in kinetic experiments with Trp mutants. A 1.4 A structure of the W354F mutant obtained in the presence of vanadate reveals an unusual divanadate species with a cyclic [VO](2) core, which has precedent in small molecules but has not been previously reported in a protein crystal structure.

-	~~<!--~~	+	Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures.,Brandao TA, Robinson H, Johnson SJ, Hengge AC J Am Chem Soc. 2009 Jan 21;131(2):778-86. PMID:19140798<ref>PMID:19140798</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3f9a"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3f9a\| PDB=3f9a \| SCENE= }}~~	+

-	~~===W354F Yersinia enterocolitica PTPase complexed with tungstate===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_19140798}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 19140798 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_19140798}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3f9a]] is a 1 chain structure with sequence from [http:~~//en.wikipedia.org/wiki/Yersinia_enterocolitica_(type_o:9) Yersinia enterocolitica (type o:9)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F9A OCA].	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019140798<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
	[[Category: Brandao, T A.S.]]		[[Category: Brandao, T A.S.]]

OCA: Protected "3f9a" [edit=sysop:move=sysop]

OCA — Wed, 21 Mar 2012 06:46:21 GMT

Protected "3f9a" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:46, 21 March 2012

OCA at 06:46, 21 March 2012

OCA — Wed, 21 Mar 2012 06:46:18 GMT

←Older revision		Revision as of 06:46, 21 March 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3f9a.png\|left\|200px]]
-	[[Image:3f9a.~~jpg~~\|left\|200px]]	+

	<!--		<!--
Line 12:		Line 11:
	===W354F Yersinia enterocolitica PTPase complexed with tungstate===		===W354F Yersinia enterocolitica PTPase complexed with tungstate===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19140798}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19140798 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19140798}}

	==About this Structure==		==About this Structure==
-	~~3F9A~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/~~Bacteria Bacteria~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F9A OCA].	+	[[3f9a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_enterocolitica_(type_o:9) Yersinia enterocolitica (type o:9)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F9A OCA].
-	~~[[Category~~: ~~Bacteria]]~~	+
		+	==Reference==
		+	<ref group="xtra">PMID:019140798</ref><references group="xtra"/>
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
	[[Category: Brandao, T A.S.]]		[[Category: Brandao, T A.S.]]
Line 25:		Line 32:
	[[Category: Outer membrane]]		[[Category: Outer membrane]]
	[[Category: P-loop]]		[[Category: P-loop]]
-	[[Category: Plasmid]]
	[[Category: Protein phosphatase]]		[[Category: Protein phosphatase]]
	[[Category: Secreted]]		[[Category: Secreted]]
Line 31:		Line 37:
	[[Category: Virulence]]		[[Category: Virulence]]
	[[Category: Wpd-loop]]		[[Category: Wpd-loop]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 21 10:48:58 2009''

OCA at 08:49, 21 January 2009

OCA — Wed, 21 Jan 2009 08:49:01 GMT

←Older revision		Revision as of 08:49, 21 January 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3f9a.jpg\|left\|200px]]

-	The ~~entry 3f9a~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3f9a", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3f9a\| PDB=3f9a \| SCENE= }}

-	~~Authors: Brandao, T.A.S., Robinson, H., Johnson, S.J., Hengge, A.C.~~	+	===W354F Yersinia enterocolitica PTPase complexed with tungstate===

-	Description: W354F Yersinia enterocolitica PTPase complexed with tungstate

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Dec 24 11~~:29:~~20 2008~~''	+	==About this Structure==
		+	3F9A is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bacteria Bacteria]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F9A OCA].
		+	[[Category: Bacteria]]
		+	[[Category: Protein-tyrosine-phosphatase]]
		+	[[Category: Brandao, T A.S.]]
		+	[[Category: Hengge, A C.]]
		+	[[Category: Johnson, S J.]]
		+	[[Category: Robinson, H.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Membrane]]
		+	[[Category: Outer membrane]]
		+	[[Category: P-loop]]
		+	[[Category: Plasmid]]
		+	[[Category: Protein phosphatase]]
		+	[[Category: Secreted]]
		+	[[Category: Tungstate]]
		+	[[Category: Virulence]]
		+	[[Category: Wpd-loop]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 21 10:48:58 2009''

OCA at 09:29, 24 December 2008

OCA — Wed, 24 Dec 2008 09:29:20 GMT

←Older revision		Revision as of 09:29, 24 December 2008
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3f9a is ON HOLD	+	The entry 3f9a is ON HOLD until Paper Publication

	Authors: Brandao, T.A.S., Robinson, H., Johnson, S.J., Hengge, A.C.		Authors: Brandao, T.A.S., Robinson, H., Johnson, S.J., Hengge, A.C.
Line 7:		Line 7:
	Description: W354F Yersinia enterocolitica PTPase complexed with tungstate		Description: W354F Yersinia enterocolitica PTPase complexed with tungstate

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec ~~3 23~~:15:41 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 24 11:29:20 2008''