3f9o - Revision history

OCA at 15:28, 1 November 2023

OCA — Wed, 01 Nov 2023 15:28:18 GMT

←Older revision		Revision as of 15:28, 1 November 2023
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	<StructureSection load='3f9o' size='340' side='right'caption='[[3f9o]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='3f9o' size='340' side='right'caption='[[3f9o]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3f9o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"aeromonas_liquefaciens"_kluyver_and_van_niel_1936 "aeromonas liquefaciens" kluyver and van niel 1936~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F9O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3f9o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aeromonas_hydrophila Aeromonas hydrophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F9O FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~, ~~<scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.03Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1x8g\|1x8g]], [[1x8h\|1x8h]], [[1x8i\|1x8i]], [[2gkl\|2gkl]], [[2qds\|2qds]], [[3fai\|3fai]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td><~~td class~~=~~"sblockDat">cphA ([https~~:~~//www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=644 "Aeromonas liquefaciens" Kluyver and van Niel 1936])</td~~></tr>	+
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f9o OCA], [https://pdbe.org/3f9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f9o RCSB], [https://www.ebi.ac.uk/pdbsum/3f9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f9o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f9o OCA], [https://pdbe.org/3f9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f9o RCSB], [https://www.ebi.ac.uk/pdbsum/3f9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f9o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BLAB_AERHY BLAB_AERHY]] Can hydrolyze carbapenem compounds.	+	[https://www.uniprot.org/uniprot/BLAB_AERHY BLAB_AERHY] Can hydrolyze carbapenem compounds.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Aeromonas ~~liquefaciens kluyver and van niel 1936]]~~	+	[[Category: Aeromonas hydrophila]]
-	~~[[Category: Beta-lactamase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Delbruck, H]]	+	[[Category: Delbruck H]]
-	[[Category: Hoffmann~~, K M.V]]~~	+	[[Category: Hoffmann KMV]]
-	~~[[Category: Antibiotic resistance]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Metal-binding~~]]	+

OCA at 09:27, 23 February 2022

OCA — Wed, 23 Feb 2022 09:27:05 GMT

←Older revision		Revision as of 09:27, 23 February 2022
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	==Crystal Structure of the Di-Zinc Carbapenemase CphA from Aeromonas Hydrophila==		==Crystal Structure of the Di-Zinc Carbapenemase CphA from Aeromonas Hydrophila==
-	<StructureSection load='3f9o' size='340' side='right' caption='[[3f9o]], [[Resolution\|resolution]] 2.03Å' scene=''>	+	<StructureSection load='3f9o' size='340' side='right'caption='[[3f9o]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3f9o]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"aeromonas_liquefaciens"_kluyver_and_van_niel_1936 "aeromonas liquefaciens" kluyver and van niel 1936]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F9O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3F9O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3f9o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"aeromonas_liquefaciens"_kluyver_and_van_niel_1936 "aeromonas liquefaciens" kluyver and van niel 1936]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F9O FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1x8g\|1x8g]], [[1x8h\|1x8h]], [[1x8i\|1x8i]], [[2gkl\|2gkl]], [[2qds\|2qds]], [[3fai\|3fai]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1x8g\|1x8g]], [[1x8h\|1x8h]], [[1x8i\|1x8i]], [[2gkl\|2gkl]], [[2qds\|2qds]], [[3fai\|3fai]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cphA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=644 "Aeromonas liquefaciens" Kluyver and van Niel 1936])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cphA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=644 "Aeromonas liquefaciens" Kluyver and van Niel 1936])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3f9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f9o OCA], [~~http~~://pdbe.org/3f9o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3f9o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3f9o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3f9o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f9o OCA], [https://pdbe.org/3f9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f9o RCSB], [https://www.ebi.ac.uk/pdbsum/3f9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f9o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BLAB_AERHY BLAB_AERHY]] Can hydrolyze carbapenem compounds.	+	[[https://www.uniprot.org/uniprot/BLAB_AERHY BLAB_AERHY]] Can hydrolyze carbapenem compounds.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:

	==See Also==		==See Also==
-	*[[Beta-lactamase\|Beta-lactamase]]	+	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 40:		Line 40:
	[[Category: Aeromonas liquefaciens kluyver and van niel 1936]]		[[Category: Aeromonas liquefaciens kluyver and van niel 1936]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
		+	[[Category: Large Structures]]
	[[Category: Delbruck, H]]		[[Category: Delbruck, H]]
	[[Category: Hoffmann, K M.V]]		[[Category: Hoffmann, K M.V]]

OCA at 08:03, 5 December 2018

OCA — Wed, 05 Dec 2018 08:03:22 GMT

←Older revision		Revision as of 08:03, 5 December 2018
Line 1:		Line 1:
		+
	==Crystal Structure of the Di-Zinc Carbapenemase CphA from Aeromonas Hydrophila==		==Crystal Structure of the Di-Zinc Carbapenemase CphA from Aeromonas Hydrophila==
	<StructureSection load='3f9o' size='340' side='right' caption='[[3f9o]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='3f9o' size='340' side='right' caption='[[3f9o]], [[Resolution\|resolution]] 2.03Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cphA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=644 "Aeromonas liquefaciens" Kluyver and van Niel 1936])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cphA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=644 "Aeromonas liquefaciens" Kluyver and van Niel 1936])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f9o OCA], [http://pdbe.org/3f9o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f9o RCSB], [http://www.ebi.ac.uk/pdbsum/3f9o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f9o OCA], [http://pdbe.org/3f9o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f9o RCSB], [http://www.ebi.ac.uk/pdbsum/3f9o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3f9o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f9/3f9o_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f9/3f9o_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 03:28, 9 February 2016

OCA — Tue, 09 Feb 2016 03:28:59 GMT

←Older revision		Revision as of 03:28, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3f9o' size='340' side='right' caption='[[3f9o]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='3f9o' size='340' side='right' caption='[[3f9o]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3f9o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Aeromonas_hydrophila Aeromonas hydrophila~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F9O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F9O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3f9o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"aeromonas_liquefaciens"_kluyver_and_van_niel_1936 "aeromonas liquefaciens" kluyver and van niel 1936]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F9O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F9O FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1x8g\|1x8g]], [[1x8h\|1x8h]], [[1x8i\|1x8i]], [[2gkl\|2gkl]], [[2qds\|2qds]], [[3fai\|3fai]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1x8g\|1x8g]], [[1x8h\|1x8h]], [[1x8i\|1x8i]], [[2gkl\|2gkl]], [[2qds\|2qds]], [[3fai\|3fai]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cphA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=644 Aeromonas ~~hydrophila~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cphA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=644 "Aeromonas liquefaciens" Kluyver and van Niel 1936])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f9o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f9o RCSB], [http://www.ebi.ac.uk/pdbsum/3f9o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f9o OCA], [http://pdbe.org/3f9o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3f9o RCSB], [http://www.ebi.ac.uk/pdbsum/3f9o PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3f9o ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3f9o" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Aeromonas ~~hydrophila~~]]	+	[[Category: Aeromonas liquefaciens kluyver and van niel 1936]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
	[[Category: Delbruck, H]]		[[Category: Delbruck, H]]

OCA at 04:06, 25 December 2014

OCA — Thu, 25 Dec 2014 04:06:05 GMT

←Older revision		Revision as of 04:06, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3f9o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aeromonas_hydrophila Aeromonas hydrophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F9O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F9O FirstGlance]. <br>		<table><tr><td colspan='2'>[[3f9o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aeromonas_hydrophila Aeromonas hydrophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F9O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F9O FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1x8g\|1x8g]], [[1x8h\|1x8h]], [[1x8i\|1x8i]], [[2gkl\|2gkl]], [[2qds\|2qds]], [[3fai\|3fai]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1x8g\|1x8g]], [[1x8h\|1x8h]], [[1x8i\|1x8i]], [[2gkl\|2gkl]], [[2qds\|2qds]], [[3fai\|3fai]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cphA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=644 Aeromonas hydrophila])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cphA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=644 Aeromonas hydrophila])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f9o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f9o RCSB], [http://www.ebi.ac.uk/pdbsum/3f9o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f9o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f9o RCSB], [http://www.ebi.ac.uk/pdbsum/3f9o PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BLAB_AERHY BLAB_AERHY]] Can hydrolyze carbapenem compounds.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Aeromonas hydrophila]]		[[Category: Aeromonas hydrophila]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
-	[[Category: Delbruck, H.]]	+	[[Category: Delbruck, H]]
-	[[Category: Hoffmann, K M.V.]]	+	[[Category: Hoffmann, K M.V]]
	[[Category: Antibiotic resistance]]		[[Category: Antibiotic resistance]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]

OCA at 12:38, 29 September 2014

OCA — Mon, 29 Sep 2014 12:38:34 GMT

←Older revision		Revision as of 12:38, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3f9o.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of the Di-Zinc Carbapenemase CphA from Aeromonas Hydrophila==
		+	<StructureSection load='3f9o' size='340' side='right' caption='[[3f9o]], [[Resolution\|resolution]] 2.03Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3f9o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aeromonas_hydrophila Aeromonas hydrophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F9O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F9O FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1x8g\|1x8g]], [[1x8h\|1x8h]], [[1x8i\|1x8i]], [[2gkl\|2gkl]], [[2qds\|2qds]], [[3fai\|3fai]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cphA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=644 Aeromonas hydrophila])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f9o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f9o RCSB], [http://www.ebi.ac.uk/pdbsum/3f9o PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f9/3f9o_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bacteria can defend themselves against beta-lactam antibiotics through the expression of class B beta-lactamases, which cleave the beta-lactam amide bond and render the molecule harmless. There are three subclasses of class B beta-lactamases (B1, B2, and B3), all of which require Zn2+ for activity and can bind either one or two zinc ions. Whereas the B1 and B3 metallo-beta-lactamases are most active as dizinc enzymes, subclass B2 enzymes, such as Aeromonas hydrophila CphA, are inhibited by the binding of a second zinc ion. We crystallized A. hydrophila CphA in order to determine the binding site of the inhibitory zinc ion. X-ray data from zinc-saturated crystals allowed us to solve the crystal structures of the dizinc forms of the wild-type enzyme and N220G mutant. The first zinc ion binds in the cysteine site, as previously determined for the monozinc form of the enzyme. The second zinc ion occupies a slightly modified histidine site, where the conserved His118 and His196 residues act as metal ligands. This atypical coordination sphere probably explains the rather high dissociation constant for the second zinc ion compared to those observed with enzymes of subclasses B1 and B3. Inhibition by the second zinc ion results from immobilization of the catalytically important His118 and His196 residues, as well as the folding of the Gly232-Asn233 loop into a position that covers the active site.

-	~~{{STRUCTURE_3f9o\| PDB=3f9o \| SCENE= }}~~	+	The structure of the dizinc subclass B2 metallo-beta-lactamase CphA reveals that the second inhibitory zinc ion binds in the histidine site.,Bebrone C, Delbruck H, Kupper MB, Schlomer P, Willmann C, Frere JM, Fischer R, Galleni M, Hoffmann KM Antimicrob Agents Chemother. 2009 Oct;53(10):4464-71. Epub 2009 Aug 3. PMID:19651913<ref>PMID:19651913</ref>

-	~~===Crystal Structure~~ of the ~~Di-Zinc Carbapenemase CphA from Aeromonas Hydrophila===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19651913}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3f9o]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Aeromonas_hydrophila Aeromonas hydrophila]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3F9O OCA].~~	+

	==See Also==		==See Also==
	*[[Beta-lactamase\|Beta-lactamase]]		*[[Beta-lactamase\|Beta-lactamase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019651913<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Aeromonas hydrophila]]		[[Category: Aeromonas hydrophila]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]

OCA at 12:29, 20 October 2012

OCA — Sat, 20 Oct 2012 12:29:10 GMT

←Older revision		Revision as of 12:29, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3f9o]] is a 1 chain structure ~~of [[Beta-lactamase]]~~ with sequence from [http://en.wikipedia.org/wiki/Aeromonas_hydrophila Aeromonas hydrophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F9O OCA].	+	[[3f9o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aeromonas_hydrophila Aeromonas hydrophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F9O OCA].

	==See Also==		==See Also==

OCA: Protected "3f9o" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 08:52:40 GMT

Protected "3f9o" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:52, 26 July 2012

OCA at 08:52, 26 July 2012

OCA — Thu, 26 Jul 2012 08:52:39 GMT

←Older revision		Revision as of 08:52, 26 July 2012
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-	{{Seed}}
	[[Image:3f9o.png\|left\|200px]]		[[Image:3f9o.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3f9o", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3f9o\| PDB=3f9o \| SCENE= }}		{{STRUCTURE_3f9o\| PDB=3f9o \| SCENE= }}

	===Crystal Structure of the Di-Zinc Carbapenemase CphA from Aeromonas Hydrophila===		===Crystal Structure of the Di-Zinc Carbapenemase CphA from Aeromonas Hydrophila===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19651913}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19651913 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_19651913}}		{{ABSTRACT_PUBMED_19651913}}

	==About this Structure==		==About this Structure==
-	~~3F9O~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Aeromonas_hydrophila Aeromonas hydrophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F9O OCA].	+	[[3f9o]] is a 1 chain structure of [[Beta-lactamase]] with sequence from [http://en.wikipedia.org/wiki/Aeromonas_hydrophila Aeromonas hydrophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F9O OCA].
		+
		+	==See Also==
		+	*[[Beta-lactamase\|Beta-lactamase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19651913~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019651913</ref><references group="xtra"/>
	[[Category: Aeromonas hydrophila]]		[[Category: Aeromonas hydrophila]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
Line 31:		Line 22:
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
-	[[Category: Periplasm]]
-	[[Category: Zinc]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 30 08:53:13 2009''

OCA at 06:53, 30 September 2009

OCA — Wed, 30 Sep 2009 06:53:13 GMT

←Older revision		Revision as of 06:53, 30 September 2009
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	{{Seed}}		{{Seed}}
-	[[Image:3f9o.~~jpg~~\|left\|200px]]	+	[[Image:3f9o.png\|left\|200px]]

	<!--		<!--
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	[[Category: Zinc]]		[[Category: Zinc]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu~~ Sep ~~3 15~~:50:18 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 30 08:53:13 2009''