3fhz - Revision history

OCA at 06:46, 6 September 2023

OCA — Wed, 06 Sep 2023 06:46:31 GMT

←Older revision		Revision as of 06:46, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3fhz' size='340' side='right'caption='[[3fhz]], [[Resolution\|resolution]] 3.27Å' scene=''>		<StructureSection load='3fhz' size='340' side='right'caption='[[3fhz]], [[Resolution\|resolution]] 3.27Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3fhz]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FHZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3fhz]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FHZ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>~~, ~~<scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.27Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[3bue\|3bue]], [[2zfz\|2zfz]], [[3cag\|3cag]], [[3ere\|3ere]]~~</~~div~~><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">ahrC, argR, MT1695, MTCY06H11.22, Rv1657 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fhz OCA], [https://pdbe.org/3fhz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fhz RCSB], [https://www.ebi.ac.uk/pdbsum/3fhz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fhz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fhz OCA], [https://pdbe.org/3fhz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fhz RCSB], [https://www.ebi.ac.uk/pdbsum/3fhz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fhz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ARGR_MYCTU ARGR_MYCTU]] Regulates arginine biosynthesis genes (By similarity).	+	[https://www.uniprot.org/uniprot/ARGR_MYCTU ARGR_MYCTU] Regulates arginine biosynthesis genes (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Myctu~~]]	+	[[Category: Mycobacterium tuberculosis H37Rv]]
-	[[Category: Cherney~~, L T~~]]	+	[[Category: Cherney LT]]
-	[[Category: Cherney~~, M M~~]]	+	[[Category: Cherney MM]]
-	[[Category: Garen~~, C R~~]]	+	[[Category: Garen CR]]
-	[[Category: James~~, M N.G]]~~	+	[[Category: James MNG]]
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Amino-acid biosynthesis]]~~	+
-	~~[[Category: Arginine biosynthesis]]~~	+
-	~~[[Category: Arginine repressor protein]]~~	+
-	~~[[Category: Argr-operator ternary complex]]~~	+
-	~~[[Category: Dna binding]]~~	+
-	~~[[Category: Dna binding protein-dna complex]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Mycobacterium tuberculosis]]~~	+
-	~~[[Category: Repressor]]~~	+
-	~~[[Category: Tbsgc]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation~~]]	+

OCA at 08:02, 2 March 2022

OCA — Wed, 02 Mar 2022 08:02:03 GMT

←Older revision		Revision as of 08:02, 2 March 2022
Line 1:		Line 1:

	==Crystal structure of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator and co-repressor, L-arginine==		==Crystal structure of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator and co-repressor, L-arginine==
-	<StructureSection load='3fhz' size='340' side='right' caption='[[3fhz]], [[Resolution\|resolution]] 3.27Å' scene=''>	+	<StructureSection load='3fhz' size='340' side='right'caption='[[3fhz]], [[Resolution\|resolution]] 3.27Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3fhz]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FHZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3FHZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3fhz]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FHZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bue\|3bue]], [[2zfz\|2zfz]], [[3cag\|3cag]], [[3ere\|3ere]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3bue\|3bue]], [[2zfz\|2zfz]], [[3cag\|3cag]], [[3ere\|3ere]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ahrC, argR, MT1695, MTCY06H11.22, Rv1657 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ahrC, argR, MT1695, MTCY06H11.22, Rv1657 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3fhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fhz OCA], [~~http~~://pdbe.org/3fhz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3fhz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3fhz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3fhz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fhz OCA], [https://pdbe.org/3fhz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fhz RCSB], [https://www.ebi.ac.uk/pdbsum/3fhz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fhz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ARGR_MYCTU ARGR_MYCTU]] Regulates arginine biosynthesis genes (By similarity).	+	[[https://www.uniprot.org/uniprot/ARGR_MYCTU ARGR_MYCTU]] Regulates arginine biosynthesis genes (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fh/3fhz_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fh/3fhz_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 3fhz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3fhz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Arginine repressor 3D structures\|Arginine repressor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Myctu]]		[[Category: Myctu]]
	[[Category: Cherney, L T]]		[[Category: Cherney, L T]]

OCA at 06:42, 1 November 2017

OCA — Wed, 01 Nov 2017 06:42:53 GMT

←Older revision		Revision as of 06:42, 1 November 2017
Line 1:		Line 1:
		+
	==Crystal structure of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator and co-repressor, L-arginine==		==Crystal structure of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator and co-repressor, L-arginine==
	<StructureSection load='3fhz' size='340' side='right' caption='[[3fhz]], [[Resolution\|resolution]] 3.27Å' scene=''>		<StructureSection load='3fhz' size='340' side='right' caption='[[3fhz]], [[Resolution\|resolution]] 3.27Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bue\|3bue]], [[2zfz\|2zfz]], [[3cag\|3cag]], [[3ere\|3ere]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bue\|3bue]], [[2zfz\|2zfz]], [[3cag\|3cag]], [[3ere\|3ere]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ahrC, argR, MT1695, MTCY06H11.22, Rv1657 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ahrC, argR, MT1695, MTCY06H11.22, Rv1657 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fhz OCA], [http://pdbe.org/3fhz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fhz RCSB], [http://www.ebi.ac.uk/pdbsum/3fhz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fhz OCA], [http://pdbe.org/3fhz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fhz RCSB], [http://www.ebi.ac.uk/pdbsum/3fhz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fhz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 3fhz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3fhz" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Arginine repressor\|Arginine repressor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 01:52, 9 February 2016

OCA — Tue, 09 Feb 2016 01:52:52 GMT

←Older revision		Revision as of 01:52, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3fhz' size='340' side='right' caption='[[3fhz]], [[Resolution\|resolution]] 3.27Å' scene=''>		<StructureSection load='3fhz' size='340' side='right' caption='[[3fhz]], [[Resolution\|resolution]] 3.27Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3fhz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium tuberculosis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FHZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3fhz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FHZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bue\|3bue]], [[2zfz\|2zfz]], [[3cag\|3cag]], [[3ere\|3ere]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bue\|3bue]], [[2zfz\|2zfz]], [[3cag\|3cag]], [[3ere\|3ere]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ahrC, argR, MT1695, MTCY06H11.22, Rv1657 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~1773 Mycobacterium tuberculosis~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ahrC, argR, MT1695, MTCY06H11.22, Rv1657 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fhz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fhz RCSB], [http://www.ebi.ac.uk/pdbsum/3fhz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fhz OCA], [http://pdbe.org/3fhz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fhz RCSB], [http://www.ebi.ac.uk/pdbsum/3fhz PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fhz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3fhz" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mycobacterium tuberculosis~~]]	+	[[Category: Myctu]]
	[[Category: Cherney, L T]]		[[Category: Cherney, L T]]
	[[Category: Cherney, M M]]		[[Category: Cherney, M M]]
Line 48:		Line 49:
	[[Category: Dna binding protein-dna complex]]		[[Category: Dna binding protein-dna complex]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
		+	[[Category: Mycobacterium tuberculosis]]
	[[Category: Repressor]]		[[Category: Repressor]]
	[[Category: Tbsgc]]		[[Category: Tbsgc]]
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]

OCA at 03:36, 25 December 2014

OCA — Thu, 25 Dec 2014 03:36:33 GMT

←Older revision		Revision as of 03:36, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fhz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fhz RCSB], [http://www.ebi.ac.uk/pdbsum/3fhz PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fhz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fhz RCSB], [http://www.ebi.ac.uk/pdbsum/3fhz PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ARGR_MYCTU ARGR_MYCTU]] Regulates arginine biosynthesis genes (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:53, 26 November 2014

OCA — Wed, 26 Nov 2014 08:53:13 GMT

←Older revision		Revision as of 08:53, 26 November 2014
Line 1:		Line 1:
-	[[~~Image:~~3fhz.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator and co-repressor, L-arginine==
		+	<StructureSection load='3fhz' size='340' side='right' caption='[[3fhz]], [[Resolution\|resolution]] 3.27Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3fhz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FHZ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bue\|3bue]], [[2zfz\|2zfz]], [[3cag\|3cag]], [[3ere\|3ere]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ahrC, argR, MT1695, MTCY06H11.22, Rv1657 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fhz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fhz RCSB], [http://www.ebi.ac.uk/pdbsum/3fhz PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fh/3fhz_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The biosynthesis of arginine is an essential function for the metabolism of Mycobacterium tuberculosis (Mtb) and for the metabolism of many other microorganisms. The arginine repressor (ArgR) proteins control the transcription of genes encoding the arginine biosynthetic enzymes; they belong to repressors having one of the most intricate oligomerization patterns. Here, we present the crystal structure of the MtbArgR hexamer bound to three copies of the 20 base-pair DNA operator and to the co-repressor, L-arginine, determined to 3.3 A resolution. This is the first ternary structure of an intact hexameric ArgR in complex with its DNA operator. The structure reported here is very different from the suggested models of the ternary ArgR-DNA complexes; it has revealed the sophisticated symmetry of the complex and the presence of two remarkably different protomer conformations, folded and extended. Both features provide flexibility to DNA binding and are important for understanding the detailed function of ArgRs. Two of the 20 base-pair DNA operators align in a unified double-helical structure, suggesting the possible presence of a double ARG box in the promoter region of the Mtb arginine operon. Two pairs of protomers bind to the unified double ARG box so that the two folded protomers bind to the central half-sites of the double ARG box, whereas the two extended protomers bind to the remote half-sites. The protomers of the third pair bound to the single DNA operator also have a folded and an extended conformation. A probable mechanism for arginine repression is suggested on the basis of this structure.

-	~~{{STRUCTURE_3fhz\| PDB=3fhz \| SCENE= }}~~	+	The structure of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator and Co-repressor, L-arginine.,Cherney LT, Cherney MM, Garen CR, James MN J Mol Biol. 2009 Apr 24;388(1):85-97. Epub 2009 Mar 2. PMID:19265706<ref>PMID:19265706</ref>

-	~~===Crystal structure~~ of the ~~arginine repressor from Mycobacterium tuberculosis bound with its DNA operator and co-repressor, L-arginine===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_19265706}}~~	+	==See Also==
-		+	*[[Arginine repressor\|Arginine repressor]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~3fhz~~]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FHZ OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:019265706<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Cherney, L T.]]	+	[[Category: Cherney, L T]]
-	[[Category: Cherney, M M.]]	+	[[Category: Cherney, M M]]
-	[[Category: Garen, C R.]]	+	[[Category: Garen, C R]]
-	[[Category: James, M N.G.]]	+	[[Category: James, M N.G]]
-	[[Category: ~~TBSGC, TB~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
	[[Category: Amino-acid biosynthesis]]		[[Category: Amino-acid biosynthesis]]
	[[Category: Arginine biosynthesis]]		[[Category: Arginine biosynthesis]]
Line 25:		Line 46:
	[[Category: Dna binding protein-dna complex]]		[[Category: Dna binding protein-dna complex]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
-	[[Category: Mycobacterium tuberculosis]]
	[[Category: Repressor]]		[[Category: Repressor]]
-	[[Category: Structural genomic]]
-	[[Category: Tb structural genomic]]
-	[[Category: Tb structural genomics consortium]]
	[[Category: Tbsgc]]		[[Category: Tbsgc]]
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]

OCA: Protected "3fhz" [edit=sysop:move=sysop]

OCA — Wed, 13 Feb 2013 11:17:37 GMT

Protected "3fhz" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:17, 13 February 2013

OCA at 11:17, 13 February 2013

OCA — Wed, 13 Feb 2013 11:17:33 GMT

←Older revision		Revision as of 11:17, 13 February 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3fhz.png\|left\|200px]]		[[Image:3fhz.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3fhz", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3fhz\| PDB=3fhz \| SCENE= }}		{{STRUCTURE_3fhz\| PDB=3fhz \| SCENE= }}

	===Crystal structure of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator and co-repressor, L-arginine===		===Crystal structure of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator and co-repressor, L-arginine===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19265706}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19265706 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19265706}}		{{ABSTRACT_PUBMED_19265706}}

	==About this Structure==		==About this Structure==
-	~~3FHZ~~ is a 12 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FHZ OCA].	+	[[3fhz]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FHZ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19265706~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019265706</ref><references group="xtra"/>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Cherney, L T.]]		[[Category: Cherney, L T.]]
Line 34:		Line 22:
	[[Category: Arginine repressor protein]]		[[Category: Arginine repressor protein]]
	[[Category: Argr-operator ternary complex]]		[[Category: Argr-operator ternary complex]]
-	[[Category: Cytoplasm]]
	[[Category: Dna binding]]		[[Category: Dna binding]]
-	[[Category: Dna binding protein/dna complex]]	+	[[Category: Dna binding protein-dna complex]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
Line 46:		Line 33:
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
-	[[Category: X-ray crystallography]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 22 10:46:34 2009''

OCA at 07:46, 22 April 2009

OCA — Wed, 22 Apr 2009 07:46:35 GMT

←Older revision		Revision as of 07:46, 22 April 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3fhz.~~jpg~~\|left\|200px]]	+	[[Image:3fhz.png\|left\|200px]]

	<!--		<!--
Line 48:		Line 48:
	[[Category: X-ray crystallography]]		[[Category: X-ray crystallography]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Mar 25 12~~:30:08 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 22 10:46:34 2009''

OCA at 10:30, 25 March 2009

OCA — Wed, 25 Mar 2009 10:30:14 GMT

←Older revision		Revision as of 10:30, 25 March 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3fhz.jpg\|left\|200px]]

-	The ~~entry 3fhz~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3fhz", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3fhz\| PDB=3fhz \| SCENE= }}

-	~~Authors: Cherney~~, L~~.T., Cherney, M.M., Garen, C.R., James, M.N.G., TB Structural Genomics Consortium (TBSGC)~~	+	===Crystal structure of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator and co-repressor, L-arginine===

-	Description: Crystal structure of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator and co-repressor, L-arginine

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Dec 31 09~~:48:~~06 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19265706}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19265706 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19265706}}
		+
		+	==About this Structure==
		+	3FHZ is a 12 chains structure of sequences from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FHZ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19265706</ref><references group="xtra"/>
		+	[[Category: Mycobacterium tuberculosis]]
		+	[[Category: Cherney, L T.]]
		+	[[Category: Cherney, M M.]]
		+	[[Category: Garen, C R.]]
		+	[[Category: James, M N.G.]]
		+	[[Category: TBSGC, TB Structural Genomics Consortium.]]
		+	[[Category: Amino-acid biosynthesis]]
		+	[[Category: Arginine biosynthesis]]
		+	[[Category: Arginine repressor protein]]
		+	[[Category: Argr-operator ternary complex]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Dna binding]]
		+	[[Category: Dna binding protein/dna complex]]
		+	[[Category: Dna-binding]]
		+	[[Category: Mycobacterium tuberculosis]]
		+	[[Category: Repressor]]
		+	[[Category: Structural genomic]]
		+	[[Category: Tb structural genomic]]
		+	[[Category: Tb structural genomics consortium]]
		+	[[Category: Tbsgc]]
		+	[[Category: Transcription]]
		+	[[Category: Transcription regulation]]
		+	[[Category: X-ray crystallography]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 25 12:30:08 2009''