3fjb - Revision history

OCA at 06:46, 6 September 2023

OCA — Wed, 06 Sep 2023 06:46:54 GMT

←Older revision		Revision as of 06:46, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3fjb' size='340' side='right'caption='[[3fjb]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3fjb' size='340' side='right'caption='[[3fjb]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3fjb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FJB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FJB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3fjb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FJB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FJB FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[1jqz\|1jqz]], [[3fgm\|3fgm]], [[3fj8\|3fj8]], [[3fj9\|3fj9]], [[3fja\|3fja]], [[3fjc\|3fjc]], [[3fjd\|3fjd]], [[3fje\|3fje]], [[3fjf\|3fjf]], [[3fjh\|3fjh]], [[3fji\|3fji]], [[3fjj\|3fjj]], [[3fjk\|3fjk]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">FGF1, FGFA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fjb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fjb OCA], [https://pdbe.org/3fjb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fjb RCSB], [https://www.ebi.ac.uk/pdbsum/3fjb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fjb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fjb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fjb OCA], [https://pdbe.org/3fjb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fjb RCSB], [https://www.ebi.ac.uk/pdbsum/3fjb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fjb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>	+	[https://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Blaber, M]]	+	[[Category: Blaber M]]
-	[[Category: Lee, J]]	+	[[Category: Lee J]]
-	~~[[Category: Acetylation]]~~	+
-	~~[[Category: Angiogenesis]]~~	+
-	~~[[Category: Beta-trefoil]]~~	+
-	~~[[Category: Developmental protein]]~~	+
-	~~[[Category: Differentiation]]~~	+
-	~~[[Category: Growth factor]]~~	+
-	~~[[Category: Heparin-binding]]~~	+
-	~~[[Category: Hormone]]~~	+
-	~~[[Category: Mitogen]]~~	+
-	~~[[Category: Polymorphism~~]]	+

OCA at 19:55, 20 October 2021

OCA — Wed, 20 Oct 2021 19:55:13 GMT

←Older revision		Revision as of 19:55, 20 October 2021
Line 1:		Line 1:

	==Crystal structure of V31I mutant of Human acidic fibroblast growth factor==		==Crystal structure of V31I mutant of Human acidic fibroblast growth factor==
-	<StructureSection load='3fjb' size='340' side='right' caption='[[3fjb]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='3fjb' size='340' side='right'caption='[[3fjb]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3fjb]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FJB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3FJB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3fjb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FJB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FJB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jqz\|1jqz]], [[3fgm\|3fgm]], [[3fj8\|3fj8]], [[3fj9\|3fj9]], [[3fja\|3fja]], [[3fjc\|3fjc]], [[3fjd\|3fjd]], [[3fje\|3fje]], [[3fjf\|3fjf]], [[3fjh\|3fjh]], [[3fji\|3fji]], [[3fjj\|3fjj]], [[3fjk\|3fjk]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jqz\|1jqz]], [[3fgm\|3fgm]], [[3fj8\|3fj8]], [[3fj9\|3fj9]], [[3fja\|3fja]], [[3fjc\|3fjc]], [[3fjd\|3fjd]], [[3fje\|3fje]], [[3fjf\|3fjf]], [[3fjh\|3fjh]], [[3fji\|3fji]], [[3fjj\|3fjj]], [[3fjk\|3fjk]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3fjb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fjb OCA], [~~http~~://pdbe.org/3fjb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3fjb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3fjb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3fjb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fjb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fjb OCA], [https://pdbe.org/3fjb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fjb RCSB], [https://www.ebi.ac.uk/pdbsum/3fjb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fjb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>	+	[[https://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
-	*[[Fibroblast growth factor\|Fibroblast growth factor]]	+	*[[Fibroblast growth factor 3D structures\|Fibroblast growth factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Blaber, M]]		[[Category: Blaber, M]]
	[[Category: Lee, J]]		[[Category: Lee, J]]

OCA at 07:26, 5 December 2018

OCA — Wed, 05 Dec 2018 07:26:59 GMT

←Older revision		Revision as of 07:26, 5 December 2018
Line 1:		Line 1:
		+
	==Crystal structure of V31I mutant of Human acidic fibroblast growth factor==		==Crystal structure of V31I mutant of Human acidic fibroblast growth factor==
	<StructureSection load='3fjb' size='340' side='right' caption='[[3fjb]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3fjb' size='340' side='right' caption='[[3fjb]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jqz\|1jqz]], [[3fgm\|3fgm]], [[3fj8\|3fj8]], [[3fj9\|3fj9]], [[3fja\|3fja]], [[3fjc\|3fjc]], [[3fjd\|3fjd]], [[3fje\|3fje]], [[3fjf\|3fjf]], [[3fjh\|3fjh]], [[3fji\|3fji]], [[3fjj\|3fjj]], [[3fjk\|3fjk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jqz\|1jqz]], [[3fgm\|3fgm]], [[3fj8\|3fj8]], [[3fj9\|3fj9]], [[3fja\|3fja]], [[3fjc\|3fjc]], [[3fjd\|3fjd]], [[3fje\|3fje]], [[3fjf\|3fjf]], [[3fjh\|3fjh]], [[3fji\|3fji]], [[3fjj\|3fjj]], [[3fjk\|3fjk]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fjb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fjb OCA], [http://pdbe.org/3fjb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fjb RCSB], [http://www.ebi.ac.uk/pdbsum/3fjb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fjb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fjb OCA], [http://pdbe.org/3fjb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fjb RCSB], [http://www.ebi.ac.uk/pdbsum/3fjb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fjb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fj/3fjb_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fj/3fjb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 39:		Line 40:
	[[Category: Blaber, M]]		[[Category: Blaber, M]]
	[[Category: Lee, J]]		[[Category: Lee, J]]
		+	[[Category: Acetylation]]
	[[Category: Angiogenesis]]		[[Category: Angiogenesis]]
	[[Category: Beta-trefoil]]		[[Category: Beta-trefoil]]
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	[[Category: Hormone]]		[[Category: Hormone]]
	[[Category: Mitogen]]		[[Category: Mitogen]]
		+	[[Category: Polymorphism]]

OCA at 06:01, 10 February 2016

OCA — Wed, 10 Feb 2016 06:01:34 GMT

←Older revision		Revision as of 06:01, 10 February 2016
Line 2:		Line 2:
	<StructureSection load='3fjb' size='340' side='right' caption='[[3fjb]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3fjb' size='340' side='right' caption='[[3fjb]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3fjb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FJB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FJB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3fjb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FJB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FJB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jqz\|1jqz]], [[3fgm\|3fgm]], [[3fj8\|3fj8]], [[3fj9\|3fj9]], [[3fja\|3fja]], [[3fjc\|3fjc]], [[3fjd\|3fjd]], [[3fje\|3fje]], [[3fjf\|3fjf]], [[3fjh\|3fjh]], [[3fji\|3fji]], [[3fjj\|3fjj]], [[3fjk\|3fjk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jqz\|1jqz]], [[3fgm\|3fgm]], [[3fj8\|3fj8]], [[3fj9\|3fj9]], [[3fja\|3fja]], [[3fjc\|3fjc]], [[3fjd\|3fjd]], [[3fje\|3fje]], [[3fjf\|3fjf]], [[3fjh\|3fjh]], [[3fji\|3fji]], [[3fjj\|3fjj]], [[3fjk\|3fjk]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fjb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fjb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fjb RCSB], [http://www.ebi.ac.uk/pdbsum/3fjb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fjb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fjb OCA], [http://pdbe.org/3fjb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fjb RCSB], [http://www.ebi.ac.uk/pdbsum/3fjb PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fjb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3fjb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Blaber, M]]		[[Category: Blaber, M]]
	[[Category: Lee, J]]		[[Category: Lee, J]]

OCA at 12:18, 25 December 2014

OCA — Thu, 25 Dec 2014 12:18:27 GMT

←Older revision		Revision as of 12:18, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fjb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fjb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fjb RCSB], [http://www.ebi.ac.uk/pdbsum/3fjb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fjb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fjb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fjb RCSB], [http://www.ebi.ac.uk/pdbsum/3fjb PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:15, 3 December 2014

OCA — Wed, 03 Dec 2014 10:15:13 GMT

←Older revision		Revision as of 10:15, 3 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3fjb.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of V31I mutant of Human acidic fibroblast growth factor==
		+	<StructureSection load='3fjb' size='340' side='right' caption='[[3fjb]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3fjb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FJB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FJB FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jqz\|1jqz]], [[3fgm\|3fgm]], [[3fj8\|3fj8]], [[3fj9\|3fj9]], [[3fja\|3fja]], [[3fjc\|3fjc]], [[3fjd\|3fjd]], [[3fje\|3fje]], [[3fjf\|3fjf]], [[3fjh\|3fjh]], [[3fji\|3fji]], [[3fjj\|3fjj]], [[3fjk\|3fjk]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fjb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fjb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fjb RCSB], [http://www.ebi.ac.uk/pdbsum/3fjb PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fj/3fjb_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Protein biopharmaceuticals are an important and growing area of human therapeutics; however, the intrinsic property of proteins to adopt alternative conformations (such as during protein unfolding and aggregation) presents numerous challenges, limiting their effective application as biopharmaceuticals. Using fibroblast growth factor-1 as model system, we describe a cooperative interaction between the intrinsic property of thermostability and the reactivity of buried free-cysteine residues that can substantially modulate protein functional half-life. A mutational strategy that combines elimination of buried free cysteines and secondary mutations that enhance thermostability to achieve a substantial gain in functional half-life is described. Furthermore, the implementation of this design strategy utilizing stabilizing mutations within the core region resulted in a mutant protein that is essentially indistinguishable from wild type as regard protein surface and solvent structure, thus minimizing the immunogenic potential of the mutations. This design strategy should be generally applicable to soluble globular proteins containing buried free-cysteine residues.

-	~~{{STRUCTURE_3fjb\| PDB=3fjb \| SCENE= }}~~	+	The interaction between thermodynamic stability and buried free cysteines in regulating the functional half-life of fibroblast growth factor-1.,Lee J, Blaber M J Mol Biol. 2009 Oct 16;393(1):113-27. Epub 2009 Aug 18. PMID:19695265<ref>PMID:19695265</ref>

-	~~===Crystal structure~~ of ~~V31I mutant~~ of ~~Human acidic fibroblast growth factor===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_19695265}}~~	+	==See Also==
-		+	*[[Fibroblast growth factor\|Fibroblast growth factor]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~3fjb~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FJB OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:019695265<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Blaber, M.]]	+	[[Category: Blaber, M]]
-	[[Category: Lee, J.]]	+	[[Category: Lee, J]]
	[[Category: Angiogenesis]]		[[Category: Angiogenesis]]
	[[Category: Beta-trefoil]]		[[Category: Beta-trefoil]]

OCA: Protected "3fjb" [edit=sysop:move=sysop]

OCA — Wed, 13 Feb 2013 11:06:09 GMT

Protected "3fjb" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:06, 13 February 2013

OCA at 11:06, 13 February 2013

OCA — Wed, 13 Feb 2013 11:06:05 GMT

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	[[Image:3fjb.png\|left\|200px]]		[[Image:3fjb.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_3fjb\| PDB=3fjb \| SCENE= }}		{{STRUCTURE_3fjb\| PDB=3fjb \| SCENE= }}

	===Crystal structure of V31I mutant of Human acidic fibroblast growth factor===		===Crystal structure of V31I mutant of Human acidic fibroblast growth factor===

-
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	{{ABSTRACT_PUBMED_19695265}}		{{ABSTRACT_PUBMED_19695265}}

	==About this Structure==		==About this Structure==
-	~~3FJB~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FJB OCA].	+	[[3fjb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FJB OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19695265~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019695265</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Blaber, M.]]		[[Category: Blaber, M.]]
	[[Category: Lee, J.]]		[[Category: Lee, J.]]
-	[[Category: Acetylation]]
	[[Category: Angiogenesis]]		[[Category: Angiogenesis]]
	[[Category: Beta-trefoil]]		[[Category: Beta-trefoil]]
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	[[Category: Hormone]]		[[Category: Hormone]]
	[[Category: Mitogen]]		[[Category: Mitogen]]
-	[[Category: Polymorphism]]
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OCA at 12:46, 28 January 2010

OCA — Thu, 28 Jan 2010 12:46:44 GMT

←Older revision		Revision as of 12:46, 28 January 2010
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	==About this Structure==		==About this Structure==
-	3FJB is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FJB OCA].	+	3FJB is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FJB OCA].

	==Reference==		==Reference==
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	[[Category: Polymorphism]]		[[Category: Polymorphism]]

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OCA — Wed, 14 Oct 2009 07:57:07 GMT

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