3fje - Revision history

OCA at 06:46, 6 September 2023

OCA — Wed, 06 Sep 2023 06:46:59 GMT

←Older revision		Revision as of 06:46, 6 September 2023
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	<StructureSection load='3fje' size='340' side='right'caption='[[3fje]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3fje' size='340' side='right'caption='[[3fje]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3fje]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FJE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FJE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3fje]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FJE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FJE FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>[[1jqz\|1jqz]], [[3fgm\|3fgm]], [[3fj8\|3fj8]], [[3fj9\|3fj9]], [[3fja\|3fja]], [[3fjb\|3fjb]], [[3fjc\|3fjc]], [[3fjd\|3fjd]], [[3fjf\|3fjf]], [[3fjh\|3fjh]], [[3fji\|3fji]], [[3fjj\|3fjj]], [[3fjk\|3fjk]], [[3hom\|3hom]]</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">FGF1, FGFA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fje OCA], [https://pdbe.org/3fje PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fje RCSB], [https://www.ebi.ac.uk/pdbsum/3fje PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fje ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fje OCA], [https://pdbe.org/3fje PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fje RCSB], [https://www.ebi.ac.uk/pdbsum/3fje PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fje ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>	+	[https://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Blaber, M]]	+	[[Category: Blaber M]]
-	[[Category: Lee, J]]	+	[[Category: Lee J]]
-	~~[[Category: Acetylation]]~~	+
-	~~[[Category: Angiogenesis]]~~	+
-	~~[[Category: Beta-trefoil]]~~	+
-	~~[[Category: Developmental protein]]~~	+
-	~~[[Category: Differentiation]]~~	+
-	~~[[Category: Growth factor]]~~	+
-	~~[[Category: Heparin-binding]]~~	+
-	~~[[Category: Hormone]]~~	+
-	~~[[Category: Mitogen]]~~	+
-	~~[[Category: Polymorphism~~]]	+

OCA at 19:55, 20 October 2021

OCA — Wed, 20 Oct 2021 19:55:21 GMT

←Older revision		Revision as of 19:55, 20 October 2021
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	==Crystal structure of C83S mutant of Human acidic fibroblast growth factor==		==Crystal structure of C83S mutant of Human acidic fibroblast growth factor==
-	<StructureSection load='3fje' size='340' side='right' caption='[[3fje]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='3fje' size='340' side='right'caption='[[3fje]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3fje]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FJE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3FJE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3fje]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FJE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FJE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jqz\|1jqz]], [[3fgm\|3fgm]], [[3fj8\|3fj8]], [[3fj9\|3fj9]], [[3fja\|3fja]], [[3fjb\|3fjb]], [[3fjc\|3fjc]], [[3fjd\|3fjd]], [[3fjf\|3fjf]], [[3fjh\|3fjh]], [[3fji\|3fji]], [[3fjj\|3fjj]], [[3fjk\|3fjk]], [[3hom\|3hom]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jqz\|1jqz]], [[3fgm\|3fgm]], [[3fj8\|3fj8]], [[3fj9\|3fj9]], [[3fja\|3fja]], [[3fjb\|3fjb]], [[3fjc\|3fjc]], [[3fjd\|3fjd]], [[3fjf\|3fjf]], [[3fjh\|3fjh]], [[3fji\|3fji]], [[3fjj\|3fjj]], [[3fjk\|3fjk]], [[3hom\|3hom]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3fje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fje OCA], [~~http~~://pdbe.org/3fje PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3fje RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3fje PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3fje ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fje OCA], [https://pdbe.org/3fje PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fje RCSB], [https://www.ebi.ac.uk/pdbsum/3fje PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fje ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>	+	[[https://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
-	*[[Fibroblast growth factor\|Fibroblast growth factor]]	+	*[[Fibroblast growth factor 3D structures\|Fibroblast growth factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Blaber, M]]		[[Category: Blaber, M]]
	[[Category: Lee, J]]		[[Category: Lee, J]]

OCA at 07:36, 5 December 2018

OCA — Wed, 05 Dec 2018 07:36:32 GMT

←Older revision		Revision as of 07:36, 5 December 2018
Line 1:		Line 1:
		+
	==Crystal structure of C83S mutant of Human acidic fibroblast growth factor==		==Crystal structure of C83S mutant of Human acidic fibroblast growth factor==
	<StructureSection load='3fje' size='340' side='right' caption='[[3fje]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3fje' size='340' side='right' caption='[[3fje]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jqz\|1jqz]], [[3fgm\|3fgm]], [[3fj8\|3fj8]], [[3fj9\|3fj9]], [[3fja\|3fja]], [[3fjb\|3fjb]], [[3fjc\|3fjc]], [[3fjd\|3fjd]], [[3fjf\|3fjf]], [[3fjh\|3fjh]], [[3fji\|3fji]], [[3fjj\|3fjj]], [[3fjk\|3fjk]], [[3hom\|3hom]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jqz\|1jqz]], [[3fgm\|3fgm]], [[3fj8\|3fj8]], [[3fj9\|3fj9]], [[3fja\|3fja]], [[3fjb\|3fjb]], [[3fjc\|3fjc]], [[3fjd\|3fjd]], [[3fjf\|3fjf]], [[3fjh\|3fjh]], [[3fji\|3fji]], [[3fjj\|3fjj]], [[3fjk\|3fjk]], [[3hom\|3hom]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fje OCA], [http://pdbe.org/3fje PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fje RCSB], [http://www.ebi.ac.uk/pdbsum/3fje PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fje OCA], [http://pdbe.org/3fje PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fje RCSB], [http://www.ebi.ac.uk/pdbsum/3fje PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fje ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fj/3fje_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fj/3fje_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	[[Category: Blaber, M]]		[[Category: Blaber, M]]
	[[Category: Lee, J]]		[[Category: Lee, J]]
		+	[[Category: Acetylation]]
	[[Category: Angiogenesis]]		[[Category: Angiogenesis]]
	[[Category: Beta-trefoil]]		[[Category: Beta-trefoil]]
Line 47:		Line 49:
	[[Category: Hormone]]		[[Category: Hormone]]
	[[Category: Mitogen]]		[[Category: Mitogen]]
		+	[[Category: Polymorphism]]

OCA at 04:38, 10 February 2016

OCA — Wed, 10 Feb 2016 04:38:56 GMT

←Older revision		Revision as of 04:38, 10 February 2016
Line 2:		Line 2:
	<StructureSection load='3fje' size='340' side='right' caption='[[3fje]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3fje' size='340' side='right' caption='[[3fje]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3fje]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FJE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FJE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3fje]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FJE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FJE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jqz\|1jqz]], [[3fgm\|3fgm]], [[3fj8\|3fj8]], [[3fj9\|3fj9]], [[3fja\|3fja]], [[3fjb\|3fjb]], [[3fjc\|3fjc]], [[3fjd\|3fjd]], [[3fjf\|3fjf]], [[3fjh\|3fjh]], [[3fji\|3fji]], [[3fjj\|3fjj]], [[3fjk\|3fjk]], [[3hom\|3hom]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jqz\|1jqz]], [[3fgm\|3fgm]], [[3fj8\|3fj8]], [[3fj9\|3fj9]], [[3fja\|3fja]], [[3fjb\|3fjb]], [[3fjc\|3fjc]], [[3fjd\|3fjd]], [[3fjf\|3fjf]], [[3fjh\|3fjh]], [[3fji\|3fji]], [[3fjj\|3fjj]], [[3fjk\|3fjk]], [[3hom\|3hom]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fje OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fje RCSB], [http://www.ebi.ac.uk/pdbsum/3fje PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fje OCA], [http://pdbe.org/3fje PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fje RCSB], [http://www.ebi.ac.uk/pdbsum/3fje PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fje ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3fje" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Blaber, M]]		[[Category: Blaber, M]]
	[[Category: Lee, J]]		[[Category: Lee, J]]

OCA at 11:50, 25 December 2014

OCA — Thu, 25 Dec 2014 11:50:48 GMT

←Older revision		Revision as of 11:50, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fje OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fje RCSB], [http://www.ebi.ac.uk/pdbsum/3fje PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fje OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fje RCSB], [http://www.ebi.ac.uk/pdbsum/3fje PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN]] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:25, 3 December 2014

OCA — Wed, 03 Dec 2014 10:25:05 GMT

←Older revision		Revision as of 10:25, 3 December 2014
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-	[[~~Image:~~3fje.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of C83S mutant of Human acidic fibroblast growth factor==
		+	<StructureSection load='3fje' size='340' side='right' caption='[[3fje]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3fje]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FJE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FJE FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jqz\|1jqz]], [[3fgm\|3fgm]], [[3fj8\|3fj8]], [[3fj9\|3fj9]], [[3fja\|3fja]], [[3fjb\|3fjb]], [[3fjc\|3fjc]], [[3fjd\|3fjd]], [[3fjf\|3fjf]], [[3fjh\|3fjh]], [[3fji\|3fji]], [[3fjj\|3fjj]], [[3fjk\|3fjk]], [[3hom\|3hom]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FGF1, FGFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fje OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fje RCSB], [http://www.ebi.ac.uk/pdbsum/3fje PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fj/3fje_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The 22 members of the mouse/human fibroblast growth factor (FGF) family of proteins contain a conserved cysteine residue at position 83 (numbering scheme of the 140-residue form of FGF-1). Sequence and structure information suggests that this position is a free cysteine in 16 members and participates as a half-cystine in at least 3 (and perhaps as many as 6) other members. While a structural role as a half-cystine provides a stability basis for possible selective pressure, it is less clear why this residue is conserved as a free cysteine (although free buried thiols can limit protein functional half-life). To probe the structural role of the free cysteine at position 83 in FGF-1, we constructed Ala, Ser, Thr, Val, and Ile mutations and determined their effects on structure and stability. These results show that position 83 in FGF-1 is thermodynamically optimized to accept a free cysteine. A second cysteine mutation was introduced into wild-type FGF-1 at adjacent position Ala66, which is known to participate as a half-cystine with position 83 in FGF-8, FGF-19, and FGF-23. Results show that, unlike position 83, a free cysteine at position 66 destabilizes FGF-1; however, upon oxidation, a near-optimal disulfide bond is formed between Cys66 and Cys83, resulting in approximately 14 kJ/mol of increased thermostability. Thus, while the conserved free cysteine at position 83 in the majority of the FGF proteins may have a principal role in limiting functional half-life, evidence suggests that it is a vestigial half-cystine.

-	~~{{STRUCTURE_3fje\| PDB=3fje \| SCENE= }}~~	+	Structural basis of conserved cysteine in the fibroblast growth factor family: evidence for a vestigial half-cystine.,Lee J, Blaber M J Mol Biol. 2009 Oct 16;393(1):128-39. Epub 2009 Aug 13. PMID:19683004<ref>PMID:19683004</ref>

-	~~===Crystal structure~~ of ~~C83S mutant~~ of ~~Human acidic fibroblast growth factor===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_19683004}}~~	+	==See Also==
-		+	*[[Fibroblast growth factor\|Fibroblast growth factor]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~3fje~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FJE OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:019683004<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Blaber, M.]]	+	[[Category: Blaber, M]]
-	[[Category: Lee, J.]]	+	[[Category: Lee, J]]
	[[Category: Angiogenesis]]		[[Category: Angiogenesis]]
	[[Category: Beta-trefoil]]		[[Category: Beta-trefoil]]

OCA: Protected "3fje" [edit=sysop:move=sysop]

OCA — Wed, 13 Feb 2013 11:16:46 GMT

Protected "3fje" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:16, 13 February 2013

OCA at 11:16, 13 February 2013

OCA — Wed, 13 Feb 2013 11:16:42 GMT

←Older revision		Revision as of 11:16, 13 February 2013
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-	{{Seed}}
	[[Image:3fje.png\|left\|200px]]		[[Image:3fje.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3fje", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3fje\| PDB=3fje \| SCENE= }}		{{STRUCTURE_3fje\| PDB=3fje \| SCENE= }}

	===Crystal structure of C83S mutant of Human acidic fibroblast growth factor===		===Crystal structure of C83S mutant of Human acidic fibroblast growth factor===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19683004}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19683004 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_19683004}}		{{ABSTRACT_PUBMED_19683004}}

	==About this Structure==		==About this Structure==
-	~~3FJE~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FJE OCA].	+	[[3fje]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FJE OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19683004~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019683004</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Blaber, M.]]		[[Category: Blaber, M.]]
	[[Category: Lee, J.]]		[[Category: Lee, J.]]
-	[[Category: Acetylation]]
	[[Category: Angiogenesis]]		[[Category: Angiogenesis]]
	[[Category: Beta-trefoil]]		[[Category: Beta-trefoil]]
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	[[Category: Hormone]]		[[Category: Hormone]]
	[[Category: Mitogen]]		[[Category: Mitogen]]
-	[[Category: Polymorphism]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 21 09:45:47 2009''

OCA at 07:45, 21 October 2009

OCA — Wed, 21 Oct 2009 07:45:47 GMT

←Older revision		Revision as of 07:45, 21 October 2009
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	{{Seed}}		{{Seed}}
-	[[Image:3fje.~~jpg~~\|left\|200px]]	+	[[Image:3fje.png\|left\|200px]]

	<!--		<!--
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	[[Category: Polymorphism]]		[[Category: Polymorphism]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct ~~7 14~~:00:20 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 21 09:45:47 2009''

OCA at 12:00, 7 October 2009

OCA — Wed, 07 Oct 2009 12:00:22 GMT

←Older revision		Revision as of 12:00, 7 October 2009
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3fje.jpg\|left\|200px]]

-	The ~~entry 3fje~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3fje", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3fje\| PDB=3fje \| SCENE= }}

-	~~Authors: Blaber, M., Lee, J.~~	+	===Crystal structure of C83S mutant of Human acidic fibroblast growth factor===

-	Description: Crystal structure of C83S mutant of Human acidic fibroblast growth factor

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jan 21 10~~:38:25 2009''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19683004}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19683004 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19683004}}
		+
		+	==About this Structure==
		+	3FJE is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FJE OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19683004</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Blaber, M.]]
		+	[[Category: Lee, J.]]
		+	[[Category: Acetylation]]
		+	[[Category: Angiogenesis]]
		+	[[Category: Beta-trefoil]]
		+	[[Category: Developmental protein]]
		+	[[Category: Differentiation]]
		+	[[Category: Growth factor]]
		+	[[Category: Heparin-binding]]
		+	[[Category: Hormone]]
		+	[[Category: Mitogen]]
		+	[[Category: Polymorphism]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 7 14:00:20 2009''