3fpo - Revision history

OCA at 09:50, 21 February 2024

OCA — Wed, 21 Feb 2024 09:50:15 GMT

←Older revision		Revision as of 09:50, 21 February 2024
Line 9:		Line 9:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/IAPP_HUMAN IAPP_HUMAN] Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.		[https://www.uniprot.org/uniprot/IAPP_HUMAN IAPP_HUMAN] Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	In prion inheritance and transmission, strains are phenotypic variants encoded by protein 'conformations'. However, it is unclear how a protein conformation can be stable enough to endure transmission between cells or organisms. Here we describe new polymorphic crystal structures of segments of prion and other amyloid proteins, which offer two structural mechanisms for the encoding of prion strains. In packing polymorphism, prion strains are encoded by alternative packing arrangements (polymorphs) of beta-sheets formed by the same segment of a protein; in segmental polymorphism, prion strains are encoded by distinct beta-sheets built from different segments of a protein. Both forms of polymorphism can produce enduring conformations capable of encoding strains. These molecular mechanisms for transfer of protein-encoded information into prion strains share features with the familiar mechanism for transfer of nucleic acid-encoded information into microbial strains, including sequence specificity and recognition by noncovalent bonds.
-
-	Molecular mechanisms for protein-encoded inheritance.,Wiltzius JJ, Landau M, Nelson R, Sawaya MR, Apostol MI, Goldschmidt L, Soriaga AB, Cascio D, Rajashankar K, Eisenberg D Nat Struct Mol Biol. 2009 Sep;16(9):973-8. Epub 2009 Aug 16. PMID:19684598<ref>PMID:19684598</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3fpo" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 09:33, 6 December 2023

OCA — Wed, 06 Dec 2023 09:33:29 GMT

←Older revision		Revision as of 09:33, 6 December 2023
Line 3:		Line 3:
	<StructureSection load='3fpo' size='340' side='right'caption='[[3fpo]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3fpo' size='340' side='right'caption='[[3fpo]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3fpo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FPO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3fpo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FPO FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[3dgj\|3dgj]]~~, [[~~3dg1~~\|~~3dg1~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fpo OCA], [https://pdbe.org/3fpo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fpo RCSB], [https://www.ebi.ac.uk/pdbsum/3fpo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fpo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fpo OCA], [https://pdbe.org/3fpo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fpo RCSB], [https://www.ebi.ac.uk/pdbsum/3fpo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fpo ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IAPP_HUMAN IAPP_HUMAN] Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Eisenberg, D]]	+	[[Category: Eisenberg D]]
-	[[Category: Sawaya~~, M R~~]]	+	[[Category: Sawaya MR]]
-	[[Category: Wiltzius~~, J J.W]]~~	+	[[Category: Wiltzius JJW]]
-	~~[[Category: Amyloid-like protofibril]]~~	+
-	~~[[Category: Protein fibril~~]]	+

OCA at 08:07, 2 March 2022

OCA — Wed, 02 Mar 2022 08:07:36 GMT

←Older revision		Revision as of 08:07, 2 March 2022
Line 3:		Line 3:
	<StructureSection load='3fpo' size='340' side='right'caption='[[3fpo]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3fpo' size='340' side='right'caption='[[3fpo]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3fpo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FPO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3FPO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3fpo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FPO FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dgj\|3dgj]], [[3dg1\|3dg1]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3dgj\|3dgj]], [[3dg1\|3dg1]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3fpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fpo OCA], [~~http~~://pdbe.org/3fpo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3fpo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3fpo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3fpo ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fpo OCA], [https://pdbe.org/3fpo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fpo RCSB], [https://www.ebi.ac.uk/pdbsum/3fpo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fpo ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:41, 7 August 2019

OCA — Wed, 07 Aug 2019 06:41:49 GMT

←Older revision		Revision as of 06:41, 7 August 2019
Line 1:		Line 1:

	==HSSNNF segment from Islet Amyloid Polypeptide (IAPP or Amylin)==		==HSSNNF segment from Islet Amyloid Polypeptide (IAPP or Amylin)==
-	<StructureSection load='3fpo' size='340' side='right' caption='[[3fpo]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='3fpo' size='340' side='right'caption='[[3fpo]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3fpo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FPO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FPO FirstGlance]. <br>		<table><tr><td colspan='2'>[[3fpo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FPO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FPO FirstGlance]. <br>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Eisenberg, D]]		[[Category: Eisenberg, D]]
	[[Category: Sawaya, M R]]		[[Category: Sawaya, M R]]

OCA at 20:23, 9 December 2016

OCA — Fri, 09 Dec 2016 20:23:36 GMT

←Older revision		Revision as of 20:23, 9 December 2016
Line 1:		Line 1:
		+
	==HSSNNF segment from Islet Amyloid Polypeptide (IAPP or Amylin)==		==HSSNNF segment from Islet Amyloid Polypeptide (IAPP or Amylin)==
	<StructureSection load='3fpo' size='340' side='right' caption='[[3fpo]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3fpo' size='340' side='right' caption='[[3fpo]], [[Resolution\|resolution]] 1.50Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[3fpo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FPO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FPO FirstGlance]. <br>		<table><tr><td colspan='2'>[[3fpo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FPO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FPO FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dgj\|3dgj]], [[3dg1\|3dg1]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dgj\|3dgj]], [[3dg1\|3dg1]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fpo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fpo RCSB], [http://www.ebi.ac.uk/pdbsum/3fpo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fpo OCA], [http://pdbe.org/3fpo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fpo RCSB], [http://www.ebi.ac.uk/pdbsum/3fpo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fpo ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3fpo" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:12, 3 December 2014

OCA — Wed, 03 Dec 2014 10:12:54 GMT

←Older revision		Revision as of 10:12, 3 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3fpo.~~png~~\|~~left~~\|~~200px~~]]	+	==HSSNNF segment from Islet Amyloid Polypeptide (IAPP or Amylin)==
		+	<StructureSection load='3fpo' size='340' side='right' caption='[[3fpo]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3fpo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FPO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FPO FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3dgj\|3dgj]], [[3dg1\|3dg1]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fpo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fpo RCSB], [http://www.ebi.ac.uk/pdbsum/3fpo PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In prion inheritance and transmission, strains are phenotypic variants encoded by protein 'conformations'. However, it is unclear how a protein conformation can be stable enough to endure transmission between cells or organisms. Here we describe new polymorphic crystal structures of segments of prion and other amyloid proteins, which offer two structural mechanisms for the encoding of prion strains. In packing polymorphism, prion strains are encoded by alternative packing arrangements (polymorphs) of beta-sheets formed by the same segment of a protein; in segmental polymorphism, prion strains are encoded by distinct beta-sheets built from different segments of a protein. Both forms of polymorphism can produce enduring conformations capable of encoding strains. These molecular mechanisms for transfer of protein-encoded information into prion strains share features with the familiar mechanism for transfer of nucleic acid-encoded information into microbial strains, including sequence specificity and recognition by noncovalent bonds.

-	~~{{STRUCTURE_3fpo\| PDB=3fpo \| SCENE= }}~~	+	Molecular mechanisms for protein-encoded inheritance.,Wiltzius JJ, Landau M, Nelson R, Sawaya MR, Apostol MI, Goldschmidt L, Soriaga AB, Cascio D, Rajashankar K, Eisenberg D Nat Struct Mol Biol. 2009 Sep;16(9):973-8. Epub 2009 Aug 16. PMID:19684598<ref>PMID:19684598</ref>

-	~~===HSSNNF segment from Islet Amyloid Polypeptide (IAPP or Amylin)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19684598}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3fpo]] is~~ a ~~1 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3FPO OCA].~~	+	</StructureSection>
-		+	[[Category: Eisenberg, D]]
-	==~~Reference~~==	+	[[Category: Sawaya, M R]]
-	<~~ref group="xtra">PMID:019684598<~~/~~ref~~><~~ref group="xtra">PMID:019319932</ref><references group="xtra"~~/>	+	[[Category: Wiltzius, J J.W]]
-	[[Category: Eisenberg, D.]]	+
-	[[Category: Sawaya, M R.]]	+
-	[[Category: Wiltzius, J J.W.]]	+
	[[Category: Amyloid-like protofibril]]		[[Category: Amyloid-like protofibril]]
	[[Category: Protein fibril]]		[[Category: Protein fibril]]

OCA: Protected "3fpo" [edit=sysop:move=sysop]

OCA — Wed, 20 Feb 2013 14:28:24 GMT

Protected "3fpo" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:28, 20 February 2013

OCA at 14:28, 20 February 2013

OCA — Wed, 20 Feb 2013 14:28:21 GMT

←Older revision		Revision as of 14:28, 20 February 2013
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-	{{Seed}}
	[[Image:3fpo.png\|left\|200px]]		[[Image:3fpo.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3fpo", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3fpo\| PDB=3fpo \| SCENE= }}		{{STRUCTURE_3fpo\| PDB=3fpo \| SCENE= }}

	===HSSNNF segment from Islet Amyloid Polypeptide (IAPP or Amylin)===		===HSSNNF segment from Islet Amyloid Polypeptide (IAPP or Amylin)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19684598}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19684598 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19684598}}		{{ABSTRACT_PUBMED_19684598}}

	==About this Structure==		==About this Structure==
-	~~3FPO~~ is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FPO OCA].	+	[[3fpo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FPO OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19684598~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019684598</ref><ref group="xtra">PMID:019319932</ref><references group="xtra"/>
	[[Category: Eisenberg, D.]]		[[Category: Eisenberg, D.]]
	[[Category: Sawaya, M R.]]		[[Category: Sawaya, M R.]]
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	[[Category: Amyloid-like protofibril]]		[[Category: Amyloid-like protofibril]]
	[[Category: Protein fibril]]		[[Category: Protein fibril]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:32:53 2009''

OCA at 05:32, 16 September 2009

OCA — Wed, 16 Sep 2009 05:32:53 GMT

←Older revision		Revision as of 05:32, 16 September 2009
Line 12:		Line 12:
	===HSSNNF segment from Islet Amyloid Polypeptide (IAPP or Amylin)===		===HSSNNF segment from Islet Amyloid Polypeptide (IAPP or Amylin)===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19684598}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19684598 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19684598}}

	==About this Structure==		==About this Structure==
	3FPO is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FPO OCA].		3FPO is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FPO OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19684598</ref><references group="xtra"/>
	[[Category: Eisenberg, D.]]		[[Category: Eisenberg, D.]]
	[[Category: Sawaya, M R.]]		[[Category: Sawaya, M R.]]
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	[[Category: Protein fibril]]		[[Category: Protein fibril]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug 19 13~~:56:35 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:32:53 2009''

OCA at 10:56, 19 August 2009

OCA — Wed, 19 Aug 2009 10:56:37 GMT

←Older revision		Revision as of 10:56, 19 August 2009
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	{{Seed}}		{{Seed}}
-	[[Image:3fpo.~~jpg~~\|left\|200px]]	+	[[Image:3fpo.png\|left\|200px]]

	<!--		<!--
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	[[Category: Protein fibril]]		[[Category: Protein fibril]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jul 1 09:37~~:56 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 19 13:56:35 2009''