3fqa - Revision history

OCA at 06:50, 6 September 2023

OCA — Wed, 06 Sep 2023 06:50:14 GMT

←Older revision		Revision as of 06:50, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3fqa' size='340' side='right'caption='[[3fqa]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='3fqa' size='340' side='right'caption='[[3fqa]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3fqa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Anacystis_nidulans Anacystis nidulans~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FQA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3fqa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synechococcus_elongatus_PCC_6301 Synechococcus elongatus PCC 6301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FQA FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GAB:3~~-~~AMINOBENZOIC+ACID'>GAB</scene>~~, ~~<scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.35Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[3fq7\|3fq7]], [[3fq8\|3fq8]], [[2hp1\|2hp1]], [[2hp2\|2hp2]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAB:3-AMINOBENZOIC+ACID'>GAB</scene>, <scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>hemL, gsa, syc0881_c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~269084 Anacystis nidulans])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Glutamate~~-1-~~semialdehyde_2,1~~-~~aminomutase Glutamate~~-1-~~semialdehyde 2,1-aminomutase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.8 5.4.3.8]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fqa OCA], [https://pdbe.org/3fqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fqa RCSB], [https://www.ebi.ac.uk/pdbsum/3fqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fqa ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fqa OCA], [https://pdbe.org/3fqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fqa RCSB], [https://www.ebi.ac.uk/pdbsum/3fqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fqa ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GSA_SYNP6 GSA_SYNP6]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Anacystis nidulans]]
-	[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Stetefeld, J~~]]	+	[[Category: Synechococcus elongatus PCC 6301]]
-	[[Category: ~~Chlorophyll biosynthesis]]~~	+	[[Category: Stetefeld J]]
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Drug resistance]]~~	+
-	~~[[Category: Integrated approach]]~~	+
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Microevilution]]~~	+
-	~~[[Category: Porphyrin biosynthesis]]~~	+
-	~~[[Category: Pyridoxal phosphate~~]]	+

OCA at 19:57, 20 October 2021

OCA — Wed, 20 Oct 2021 19:57:38 GMT

←Older revision		Revision as of 19:57, 20 October 2021
Line 1:		Line 1:

	==Gabaculien complex of gabaculine resistant GSAM version==		==Gabaculien complex of gabaculine resistant GSAM version==
-	<StructureSection load='3fqa' size='340' side='right' caption='[[3fqa]], [[Resolution\|resolution]] 2.35Å' scene=''>	+	<StructureSection load='3fqa' size='340' side='right'caption='[[3fqa]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3fqa]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Anacystis_nidulans Anacystis nidulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FQA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3FQA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3fqa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Anacystis_nidulans Anacystis nidulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FQA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAB:3-AMINOBENZOIC+ACID'>GAB</scene>, <scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAB:3-AMINOBENZOIC+ACID'>GAB</scene>, <scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fq7\|3fq7]], [[3fq8\|3fq8]], [[2hp1\|2hp1]], [[2hp2\|2hp2]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3fq7\|3fq7]], [[3fq8\|3fq8]], [[2hp1\|2hp1]], [[2hp2\|2hp2]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hemL, gsa, syc0881_c ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=269084 Anacystis nidulans])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hemL, gsa, syc0881_c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=269084 Anacystis nidulans])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glutamate-1-semialdehyde_2,1-aminomutase Glutamate-1-semialdehyde 2,1-aminomutase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.8 5.4.3.8] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutamate-1-semialdehyde_2,1-aminomutase Glutamate-1-semialdehyde 2,1-aminomutase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.8 5.4.3.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3fqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fqa OCA], [~~http~~://pdbe.org/3fqa PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3fqa RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3fqa PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3fqa ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fqa OCA], [https://pdbe.org/3fqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fqa RCSB], [https://www.ebi.ac.uk/pdbsum/3fqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fqa ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Aminomutase\|Aminomutase]]	+	*[[Aminomutase 3D structures\|Aminomutase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 38:
	[[Category: Anacystis nidulans]]		[[Category: Anacystis nidulans]]
	[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]		[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]
		+	[[Category: Large Structures]]
	[[Category: Stetefeld, J]]		[[Category: Stetefeld, J]]
	[[Category: Chlorophyll biosynthesis]]		[[Category: Chlorophyll biosynthesis]]

OCA at 07:30, 5 December 2018

OCA — Wed, 05 Dec 2018 07:30:12 GMT

←Older revision		Revision as of 07:30, 5 December 2018
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fq/3fqa_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fq/3fqa_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 40:		Line 40:
	[[Category: Stetefeld, J]]		[[Category: Stetefeld, J]]
	[[Category: Chlorophyll biosynthesis]]		[[Category: Chlorophyll biosynthesis]]
		+	[[Category: Cytoplasm]]
	[[Category: Drug resistance]]		[[Category: Drug resistance]]
	[[Category: Integrated approach]]		[[Category: Integrated approach]]

OCA at 20:28, 9 December 2016

OCA — Fri, 09 Dec 2016 20:28:15 GMT

←Older revision		Revision as of 20:28, 9 December 2016
Line 1:		Line 1:
		+
	==Gabaculien complex of gabaculine resistant GSAM version==		==Gabaculien complex of gabaculine resistant GSAM version==
	<StructureSection load='3fqa' size='340' side='right' caption='[[3fqa]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='3fqa' size='340' side='right' caption='[[3fqa]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3fqa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Synechococcus_elongatus_pcc_6301 Synechococcus elongatus pcc 6301~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FQA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3fqa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anacystis_nidulans Anacystis nidulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FQA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAB:3-AMINOBENZOIC+ACID'>GAB</scene>, <scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAB:3-AMINOBENZOIC+ACID'>GAB</scene>, <scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fq7\|3fq7]], [[3fq8\|3fq8]], [[2hp1\|2hp1]], [[2hp2\|2hp2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fq7\|3fq7]], [[3fq8\|3fq8]], [[2hp1\|2hp1]], [[2hp2\|2hp2]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hemL, gsa, syc0881_c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=269084 ~~Synechococcus elongatus PCC 6301~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hemL, gsa, syc0881_c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=269084 Anacystis nidulans])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate-1-semialdehyde_2,1-aminomutase Glutamate-1-semialdehyde 2,1-aminomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.8 5.4.3.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate-1-semialdehyde_2,1-aminomutase Glutamate-1-semialdehyde 2,1-aminomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.8 5.4.3.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fqa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fqa RCSB], [http://www.ebi.ac.uk/pdbsum/3fqa PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fqa OCA], [http://pdbe.org/3fqa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fqa RCSB], [http://www.ebi.ac.uk/pdbsum/3fqa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fqa ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fqa ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3fqa" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aminomutase\|Aminomutase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Anacystis nidulans]]
	[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]		[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]
-	[[Category: Synechococcus elongatus pcc 6301]]
	[[Category: Stetefeld, J]]		[[Category: Stetefeld, J]]
	[[Category: Chlorophyll biosynthesis]]		[[Category: Chlorophyll biosynthesis]]

OCA at 10:17, 3 December 2014

OCA — Wed, 03 Dec 2014 10:17:13 GMT

←Older revision		Revision as of 10:17, 3 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3fqa.~~png~~\|~~left~~\|200px]]	+	==Gabaculien complex of gabaculine resistant GSAM version==
		+	<StructureSection load='3fqa' size='340' side='right' caption='[[3fqa]], [[Resolution\|resolution]] 2.35Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3fqa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechococcus_elongatus_pcc_6301 Synechococcus elongatus pcc 6301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FQA FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAB:3-AMINOBENZOIC+ACID'>GAB</scene>, <scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fq7\|3fq7]], [[3fq8\|3fq8]], [[2hp1\|2hp1]], [[2hp2\|2hp2]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hemL, gsa, syc0881_c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=269084 Synechococcus elongatus PCC 6301])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate-1-semialdehyde_2,1-aminomutase Glutamate-1-semialdehyde 2,1-aminomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.8 5.4.3.8] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fqa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fqa RCSB], [http://www.ebi.ac.uk/pdbsum/3fqa PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fq/3fqa_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Gabaculine is a potent inhibitor of the vitamin B6-dependent key enzyme in chlorophyll biosynthesis, glutamate-1-semialdehyde aminomutase (GSAM). The inhibition effect is caused by an enzymatic deprotonation of the neurotoxin and requires the aldimine (PLP) form of the cofactor at the active site. In this study, we show that a single-point mutation confers resistance to gabaculine. A combined functional and structural analysis of wild-type GSAM in complex with gabaculine and the GSAM(M248I) form allowed us to decipher in atomic detail the molecular basis of this unique resistance. Interestingly, the gabaculine tolerance is caused by the absence of an essential water molecule that has a dual functional role. It serves as a nucleophilic shuttle for the hydroxyl anion along the reaction pathway and holds active-site Lys273 in a catalytically competent conformation. The single-point mutant is not able to fix this catalytic water between the beta-branched side chain of Ile248 and Lys273. As a consequence, the mutant enzyme is trapped in a gabaculine-insensitive but still enzymatically active amine (PMP) form.

-	~~{{STRUCTURE_3fqa\| PDB=3fqa \| SCENE= }}~~	+	Absence of a catalytic water confers resistance to the neurotoxin gabaculine.,Orriss GL, Patel TR, Sorensen J, Stetefeld J FASEB J. 2010 Feb;24(2):404-14. Epub 2009 Sep 28. PMID:19786580<ref>PMID:19786580</ref>

-	~~===Gabaculien complex~~ of ~~gabaculine resistant GSAM version===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19786580}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3fqa]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Synechococcus_elongatus_pcc_6301 Synechococcus elongatus pcc 6301]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3FQA OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019786580<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]		[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]
	[[Category: Synechococcus elongatus pcc 6301]]		[[Category: Synechococcus elongatus pcc 6301]]
-	[[Category: Stetefeld, J.]]	+	[[Category: Stetefeld, J]]
	[[Category: Chlorophyll biosynthesis]]		[[Category: Chlorophyll biosynthesis]]
	[[Category: Drug resistance]]		[[Category: Drug resistance]]

OCA: Protected "3fqa" [edit=sysop:move=sysop]

OCA — Wed, 20 Feb 2013 14:35:47 GMT

Protected "3fqa" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:35, 20 February 2013

OCA at 14:35, 20 February 2013

OCA — Wed, 20 Feb 2013 14:35:43 GMT

←Older revision		Revision as of 14:35, 20 February 2013
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-	{{Seed}}
	[[Image:3fqa.png\|left\|200px]]		[[Image:3fqa.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3fqa", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3fqa\| PDB=3fqa \| SCENE= }}		{{STRUCTURE_3fqa\| PDB=3fqa \| SCENE= }}

	===Gabaculien complex of gabaculine resistant GSAM version===		===Gabaculien complex of gabaculine resistant GSAM version===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19786580}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19786580 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19786580}}		{{ABSTRACT_PUBMED_19786580}}

	==About this Structure==		==About this Structure==
-	~~3FQA~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Synechococcus_elongatus_pcc_6301 Synechococcus elongatus pcc 6301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FQA OCA].	+	[[3fqa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechococcus_elongatus_pcc_6301 Synechococcus elongatus pcc 6301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FQA OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19786580~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019786580</ref><references group="xtra"/>
	[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]		[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]
	[[Category: Synechococcus elongatus pcc 6301]]		[[Category: Synechococcus elongatus pcc 6301]]
	[[Category: Stetefeld, J.]]		[[Category: Stetefeld, J.]]
	[[Category: Chlorophyll biosynthesis]]		[[Category: Chlorophyll biosynthesis]]
-	[[Category: Cytoplasm]]
	[[Category: Drug resistance]]		[[Category: Drug resistance]]
	[[Category: Integrated approach]]		[[Category: Integrated approach]]
Line 35:		Line 22:
	[[Category: Porphyrin biosynthesis]]		[[Category: Porphyrin biosynthesis]]
	[[Category: Pyridoxal phosphate]]		[[Category: Pyridoxal phosphate]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 28 14:52:55 2010''

OCA at 12:52, 28 January 2010

OCA — Thu, 28 Jan 2010 12:52:56 GMT

←Older revision		Revision as of 12:52, 28 January 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3fqa.~~jpg~~\|left\|200px]]	+	[[Image:3fqa.png\|left\|200px]]

	<!--		<!--
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	3FQA is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Synechococcus_elongatus_pcc_6301 Synechococcus elongatus pcc 6301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FQA OCA].	+	3FQA is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Synechococcus_elongatus_pcc_6301 Synechococcus elongatus pcc 6301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FQA OCA].

	==Reference==		==Reference==
Line 36:		Line 36:
	[[Category: Pyridoxal phosphate]]		[[Category: Pyridoxal phosphate]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Nov 25 09~~:31:~~58 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 28 14:52:55 2010''

OCA at 07:31, 25 November 2009

OCA — Wed, 25 Nov 2009 07:31:58 GMT

←Older revision		Revision as of 07:31, 25 November 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3fqa.jpg\|left\|200px]]

-	The ~~entry 3fqa~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3fqa", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3fqa\| PDB=3fqa \| SCENE= }}

-	~~Authors: Stetefeld, J.~~	+	===Gabaculien complex of gabaculine resistant GSAM version===

-	Description: Gabaculien complex of gabaculine resistant GSAM version

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jun 10 17~~:56:07 2009''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19786580}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19786580 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19786580}}
		+
		+	==About this Structure==
		+	3FQA is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Synechococcus_elongatus_pcc_6301 Synechococcus elongatus pcc 6301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FQA OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19786580</ref><references group="xtra"/>
		+	[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]
		+	[[Category: Synechococcus elongatus pcc 6301]]
		+	[[Category: Stetefeld, J.]]
		+	[[Category: Chlorophyll biosynthesis]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Drug resistance]]
		+	[[Category: Integrated approach]]
		+	[[Category: Isomerase]]
		+	[[Category: Microevilution]]
		+	[[Category: Porphyrin biosynthesis]]
		+	[[Category: Pyridoxal phosphate]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 25 09:31:58 2009''

OCA at 14:56, 10 June 2009

OCA — Wed, 10 Jun 2009 14:56:07 GMT

←Older revision		Revision as of 14:56, 10 June 2009
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3fqa is ON HOLD	+	The entry 3fqa is ON HOLD until Paper Publication

	Authors: Stetefeld, J.		Authors: Stetefeld, J.
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	Description: Gabaculien complex of gabaculine resistant GSAM version		Description: Gabaculien complex of gabaculine resistant GSAM version

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jan 21~~ 10:39:10 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 10 17:56:07 2009''