3fwn - Revision history

OCA at 15:32, 1 November 2023

OCA — Wed, 01 Nov 2023 15:32:40 GMT

←Older revision		Revision as of 15:32, 1 November 2023
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	<StructureSection load='3fwn' size='340' side='right'caption='[[3fwn]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3fwn' size='340' side='right'caption='[[3fwn]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3fwn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FWN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FWN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3fwn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FWN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FWN FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=6PG:6~~-~~PHOSPHOGLUCONIC+ACID'>6PG</scene>~~, ~~<scene name='pdbligand=ATR:2-MONOPHOSPHOADENOSINE-5-DIPHOSPHATE'>ATR</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[2zya\|2zya]], [[3fwd\|3fwd]], [[2zyg\|2zyg]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6PG:6-PHOSPHOGLUCONIC+ACID'>6PG</scene>, <scene name='pdbligand=ATR:2-MONOPHOSPHOADENOSINE-5-DIPHOSPHATE'>ATR</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>gnd ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~83333 ECOLI])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Phosphogluconate_dehydrogenase_(NADP(+)~~-~~dependent,_decarboxylating) Phosphogluconate dehydrogenase (NADP(+)~~-~~dependent, decarboxylating)], with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=1.1.1.44 1.1.1.44]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fwn OCA], [https://pdbe.org/3fwn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fwn RCSB], [https://www.ebi.ac.uk/pdbsum/3fwn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fwn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fwn OCA], [https://pdbe.org/3fwn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fwn RCSB], [https://www.ebi.ac.uk/pdbsum/3fwn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fwn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/6PGD_ECOLI 6PGD_ECOLI]] Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.	+	[https://www.uniprot.org/uniprot/6PGD_ECOLI 6PGD_ECOLI] Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ecoli~~]]	+	[[Category: Escherichia coli K-12]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, Y Y]]	+	[[Category: Chen Y-Y]]
-	[[Category: Ko, T P]]	+	[[Category: Ko T-P]]
-	[[Category: Lin, C H]]	+	[[Category: Lin C-H]]
-	[[Category: Lo, L P]]	+	[[Category: Lo L-P]]
-	[[Category: Wang~~, A H.~~J]]	+	[[Category: Wang AH-J]]
-	~~[[Category: 6-phosphogluconate]]~~	+
-	~~[[Category: 6-phosphogluconate dehydrogenase]]~~	+
-	~~[[Category: Gluconate utilization]]~~	+
-	~~[[Category: Nadp]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Pentose phosphate pathway]]~~	+
-	~~[[Category: Pentose shunt~~]]	+

OCA at 07:40, 10 November 2021

OCA — Wed, 10 Nov 2021 07:40:31 GMT

←Older revision		Revision as of 07:40, 10 November 2021
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	==Dimeric 6-phosphogluconate dehydrogenase complexed with 6-phosphogluconate and 2'-monophosphoadenosine-5'-diphosphate==		==Dimeric 6-phosphogluconate dehydrogenase complexed with 6-phosphogluconate and 2'-monophosphoadenosine-5'-diphosphate==
-	<StructureSection load='3fwn' size='340' side='right' caption='[[3fwn]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='3fwn' size='340' side='right'caption='[[3fwn]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3fwn]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FWN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3FWN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3fwn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FWN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FWN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6PG:6-PHOSPHOGLUCONIC+ACID'>6PG</scene>, <scene name='pdbligand=ATR:2-MONOPHOSPHOADENOSINE-5-DIPHOSPHATE'>ATR</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6PG:6-PHOSPHOGLUCONIC+ACID'>6PG</scene>, <scene name='pdbligand=ATR:2-MONOPHOSPHOADENOSINE-5-DIPHOSPHATE'>ATR</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zya\|2zya]], [[3fwd\|3fwd]], [[2zyg\|2zyg]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zya\|2zya]], [[3fwd\|3fwd]], [[2zyg\|2zyg]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gnd ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gnd ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Phosphogluconate_dehydrogenase_(NADP(+)-dependent,_decarboxylating) Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.44 1.1.1.44] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphogluconate_dehydrogenase_(NADP(+)-dependent,_decarboxylating) Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.44 1.1.1.44] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3fwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fwn OCA], [~~http~~://pdbe.org/3fwn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3fwn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3fwn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3fwn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fwn OCA], [https://pdbe.org/3fwn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fwn RCSB], [https://www.ebi.ac.uk/pdbsum/3fwn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fwn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/6PGD_ECOLI 6PGD_ECOLI]] Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.	+	[[https://www.uniprot.org/uniprot/6PGD_ECOLI 6PGD_ECOLI]] Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fw/3fwn_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fw/3fwn_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 3fwn" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3fwn" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[6-phosphogluconate dehydrogenase 3D structures\|6-phosphogluconate dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Ecoli]]		[[Category: Ecoli]]
		+	[[Category: Large Structures]]
	[[Category: Chen, Y Y]]		[[Category: Chen, Y Y]]
	[[Category: Ko, T P]]		[[Category: Ko, T P]]

OCA at 06:51, 1 November 2017

OCA — Wed, 01 Nov 2017 06:51:27 GMT

←Older revision		Revision as of 06:51, 1 November 2017
Line 1:		Line 1:
		+
	==Dimeric 6-phosphogluconate dehydrogenase complexed with 6-phosphogluconate and 2'-monophosphoadenosine-5'-diphosphate==		==Dimeric 6-phosphogluconate dehydrogenase complexed with 6-phosphogluconate and 2'-monophosphoadenosine-5'-diphosphate==
	<StructureSection load='3fwn' size='340' side='right' caption='[[3fwn]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3fwn' size='340' side='right' caption='[[3fwn]], [[Resolution\|resolution]] 1.50Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gnd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gnd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphogluconate_dehydrogenase_(NADP(+)-dependent,_decarboxylating) Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.44 1.1.1.44] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphogluconate_dehydrogenase_(NADP(+)-dependent,_decarboxylating) Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.44 1.1.1.44] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fwn OCA], [http://pdbe.org/3fwn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fwn RCSB], [http://www.ebi.ac.uk/pdbsum/3fwn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fwn OCA], [http://pdbe.org/3fwn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fwn RCSB], [http://www.ebi.ac.uk/pdbsum/3fwn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fwn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 3fwn" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3fwn" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[6-phosphogluconate dehydrogenase\|6-phosphogluconate dehydrogenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 00:22, 10 February 2016

OCA — Wed, 10 Feb 2016 00:22:15 GMT

←Older revision		Revision as of 00:22, 10 February 2016
Line 7:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gnd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gnd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphogluconate_dehydrogenase_(NADP(+)-dependent,_decarboxylating) Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.44 1.1.1.44] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphogluconate_dehydrogenase_(NADP(+)-dependent,_decarboxylating) Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.44 1.1.1.44] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fwn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fwn RCSB], [http://www.ebi.ac.uk/pdbsum/3fwn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fwn OCA], [http://pdbe.org/3fwn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fwn RCSB], [http://www.ebi.ac.uk/pdbsum/3fwn PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fwn ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3fwn" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 10:30, 25 December 2014

OCA — Thu, 25 Dec 2014 10:30:24 GMT

←Older revision		Revision as of 10:30, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fwn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fwn RCSB], [http://www.ebi.ac.uk/pdbsum/3fwn PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fwn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fwn RCSB], [http://www.ebi.ac.uk/pdbsum/3fwn PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/6PGD_ECOLI 6PGD_ECOLI]] Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 17:21, 21 December 2014

OCA — Sun, 21 Dec 2014 17:21:26 GMT

←Older revision		Revision as of 17:21, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3fwn\| PDB=3fwn \| SCENE= }}~~	+	==Dimeric 6-phosphogluconate dehydrogenase complexed with 6-phosphogluconate and 2'-monophosphoadenosine-5'-diphosphate==
-	===Dimeric 6-phosphogluconate dehydrogenase complexed with 6-phosphogluconate and 2'-monophosphoadenosine-5'-diphosphate===	+	<StructureSection load='3fwn' size='340' side='right' caption='[[3fwn]], [[Resolution\|resolution]] 1.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19686854}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3fwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FWN FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6PG:6-PHOSPHOGLUCONIC+ACID'>6PG</scene>, <scene name='pdbligand=ATR:2-MONOPHOSPHOADENOSINE-5-DIPHOSPHATE'>ATR</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zya\|2zya]], [[3fwd\|3fwd]], [[2zyg\|2zyg]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gnd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphogluconate_dehydrogenase_(NADP(+)-dependent,_decarboxylating) Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.44 1.1.1.44] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fwn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fwn RCSB], [http://www.ebi.ac.uk/pdbsum/3fwn PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fw/3fwn_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	6-Phosphogluconate dehydrogenase (6PGDH), the third enzyme of the pentose phosphate pathway, catalyzes the oxidative decarboxylation of 6-phosphogluconate, making ribulose 5-phosphate, along with the reduction of NADP(+) to NADPH and the release of CO(2). Here, we report the first apo-form crystal structure of the pathogenic Klebsiella pneumoniae 6PGDH (Kp6PGDH) and the structures of the highly homologous Escherichia coli K12 6PGDH (Ec6PGDH) complexed with substrate, substrate/NADPH and glucose at high resolution. The binding of NADPH to one subunit of the homodimeric structure triggered a 10 degrees rotation and resulting in a 7A movement of the coenzyme-binding domain. The coenzyme was thus trapped in a closed enzyme conformation, in contrast to the open conformation of the neighboring subunit. Comparison of our Ec/Kp6PGDH structures with those of other species illustrated how the domain conformation can be affected upon binding of the coenzyme, which in turn gives rise to concomitant movements of two important NADP(+)-interacting amino acids, M14 and N102. We propose that the catalysis follows an ordered binding mechanism with alternating conformational changes in the corresponding subunits, involving several related amino acid residues.

-	~~==Function==~~	+	Conformational changes associated with cofactor/substrate binding of 6-phosphogluconate dehydrogenase from Escherichia coli and Klebsiella pneumoniae: Implications for enzyme mechanism.,Chen YY, Ko TP, Chen WH, Lo LP, Lin CH, Wang AH J Struct Biol. 2010 Jan;169(1):25-35. Epub 2009 Aug 15. PMID:19686854<ref>PMID:19686854</ref>
-	~~[[http:/~~/~~www.uniprot.org/uniprot/6PGD_ECOLI 6PGD_ECOLI]] Catalyzes the oxidative decarboxylation~~ of 6-phosphogluconate ~~to ribulose 5-phosphate~~ and CO(2)~~, with concomitant reduction of NADP to NADPH~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3fwn]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Ecoli Ecoli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3FWN OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[6-phosphogluconate dehydrogenase\|6-phosphogluconate dehydrogenase]]		*[[6-phosphogluconate dehydrogenase\|6-phosphogluconate dehydrogenase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:019686854</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Ecoli]]		[[Category: Ecoli]]
-	[[Category: Chen, Y Y.]]	+	[[Category: Chen, Y Y]]
-	[[Category: Ko, T P.]]	+	[[Category: Ko, T P]]
-	[[Category: Lin, C H.]]	+	[[Category: Lin, C H]]
-	[[Category: Lo, L P.]]	+	[[Category: Lo, L P]]
-	[[Category: Wang, A H.J.]]	+	[[Category: Wang, A H.J]]
	[[Category: 6-phosphogluconate]]		[[Category: 6-phosphogluconate]]
	[[Category: 6-phosphogluconate dehydrogenase]]		[[Category: 6-phosphogluconate dehydrogenase]]

OCA at 06:09, 22 January 2014

OCA — Wed, 22 Jan 2014 06:09:11 GMT

←Older revision		Revision as of 06:09, 22 January 2014
Line 1:		Line 1:
-	[[Image:3fwn.png\|left\|200px]]
-
	{{STRUCTURE_3fwn\| PDB=3fwn \| SCENE= }}		{{STRUCTURE_3fwn\| PDB=3fwn \| SCENE= }}
-
	===Dimeric 6-phosphogluconate dehydrogenase complexed with 6-phosphogluconate and 2'-monophosphoadenosine-5'-diphosphate===		===Dimeric 6-phosphogluconate dehydrogenase complexed with 6-phosphogluconate and 2'-monophosphoadenosine-5'-diphosphate===
		+	{{ABSTRACT_PUBMED_19686854}}

-	~~{{ABSTRACT_PUBMED_19686854}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/6PGD_ECOLI 6PGD_ECOLI]] Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.

	==About this Structure==		==About this Structure==
-	[[3fwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli_k-12 Escherichia coli k-12~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FWN OCA].	+	[[3fwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FWN OCA].

	==See Also==		==See Also==
Line 14:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:019686854</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019686854</ref><references group="xtra"/><references/>
-	[[Category: ~~Escherichia coli k-12~~]]	+	[[Category: Ecoli]]
	[[Category: Chen, Y Y.]]		[[Category: Chen, Y Y.]]
	[[Category: Ko, T P.]]		[[Category: Ko, T P.]]

OCA at 15:39, 20 October 2012

OCA — Sat, 20 Oct 2012 15:39:26 GMT

←Older revision		Revision as of 15:39, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3fwn]] is a 2 chain structure ~~of [[6-phosphogluconate dehydrogenase]]~~ with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli~~ Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FWN OCA].	+	[[3fwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FWN OCA].

	==See Also==		==See Also==
Line 15:		Line 15:
	==Reference==		==Reference==
	<ref group="xtra">PMID:019686854</ref><references group="xtra"/>		<ref group="xtra">PMID:019686854</ref><references group="xtra"/>
-	[[Category: Escherichia coli]]	+	[[Category: Escherichia coli k-12]]
	[[Category: Chen, Y Y.]]		[[Category: Chen, Y Y.]]
	[[Category: Ko, T P.]]		[[Category: Ko, T P.]]

OCA: Protected "3fwn" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 19:04:06 GMT

Protected "3fwn" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:04, 26 July 2012

OCA at 19:04, 26 July 2012

OCA — Thu, 26 Jul 2012 19:04:04 GMT

←Older revision		Revision as of 19:04, 26 July 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3fwn.png\|left\|200px]]
-	[[Image:3fwn.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3fwn", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3fwn\| PDB=3fwn \| SCENE= }}		{{STRUCTURE_3fwn\| PDB=3fwn \| SCENE= }}

	===Dimeric 6-phosphogluconate dehydrogenase complexed with 6-phosphogluconate and 2'-monophosphoadenosine-5'-diphosphate===		===Dimeric 6-phosphogluconate dehydrogenase complexed with 6-phosphogluconate and 2'-monophosphoadenosine-5'-diphosphate===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19686854}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19686854 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19686854}}		{{ABSTRACT_PUBMED_19686854}}

	==About this Structure==		==About this Structure==
-	~~3FWN~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/~~Escherichia_coli_k-12~~ Escherichia coli ~~k-12~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FWN OCA].	+	[[3fwn]] is a 2 chain structure of [[6-phosphogluconate dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FWN OCA].
		+
		+	==See Also==
		+	*[[6-phosphogluconate dehydrogenase\|6-phosphogluconate dehydrogenase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19686854~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019686854</ref><references group="xtra"/>
-	[[Category: Escherichia coli ~~k-12~~]]	+	[[Category: Escherichia coli]]
	[[Category: Chen, Y Y.]]		[[Category: Chen, Y Y.]]
	[[Category: Ko, T P.]]		[[Category: Ko, T P.]]
Line 37:		Line 28:
	[[Category: Pentose phosphate pathway]]		[[Category: Pentose phosphate pathway]]
	[[Category: Pentose shunt]]		[[Category: Pentose shunt]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Sep 3 15:32:19 2009''