3g2s - Revision history

OCA at 15:35, 1 November 2023

OCA — Wed, 01 Nov 2023 15:35:27 GMT

←Older revision		Revision as of 15:35, 1 November 2023
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	<StructureSection load='3g2s' size='340' side='right'caption='[[3g2s]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3g2s' size='340' side='right'caption='[[3g2s]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3g2s]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G2S OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3G2S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3g2s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G2S FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=HEZ:HEXANE~~-1~~,6-DIOL'>HEZ</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[3g2t\|3g2t]]~~, ~~[[3g2u\|3g2u]], [[3g2v\|3g2v]], [[3g2w\|3g2w]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3g2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g2s OCA], [~~http~~://pdbe.org/3g2s PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3g2s RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3g2s PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3g2s ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g2s OCA], [https://pdbe.org/3g2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g2s RCSB], [https://www.ebi.ac.uk/pdbsum/3g2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g2s ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GGA1_HUMAN GGA1_HUMAN]] Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.<ref>PMID:11301005</ref> [[http://www.uniprot.org/uniprot/SORL_HUMAN SORL_HUMAN]] Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction.	+	[https://www.uniprot.org/uniprot/GGA1_HUMAN GGA1_HUMAN] Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.<ref>PMID:11301005</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Behrens~~, M A~~]]	+	[[Category: Behrens MA]]
-	[[Category: Cramer~~, J F~~]]	+	[[Category: Cramer JF]]
-	[[Category: Gustafsen, C]]	+	[[Category: Gustafsen C]]
-	[[Category: Madsen, P]]	+	[[Category: Madsen P]]
-	[[Category: Oliveira~~, C L.P~~]]	+	[[Category: Oliveira CLP]]
-	[[Category: Pedersen~~, J S~~]]	+	[[Category: Pedersen JS]]
-	[[Category: Petersen~~, C M~~]]	+	[[Category: Petersen CM]]
-	[[Category: Thirup~~, S S]]~~	+	[[Category: Thirup SS]]
-	~~[[Category: Acidic-cluster dileucine signal]]~~	+
-	~~[[Category: Adp-ribosylation factor binding protein gga1]]~~	+
-	~~[[Category: Protein transport]]~~	+
-	~~[[Category: Sorla]]~~	+
-	~~[[Category: Vh~~]]	+

OCA at 10:35, 9 September 2020

OCA — Wed, 09 Sep 2020 10:35:42 GMT

←Older revision		Revision as of 10:35, 9 September 2020
Line 1:		Line 1:

	==VHS Domain of human GGA1 complexed with SorLA C-terminal Peptide==		==VHS Domain of human GGA1 complexed with SorLA C-terminal Peptide==
-	<StructureSection load='3g2s' size='340' side='right' caption='[[3g2s]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='3g2s' size='340' side='right'caption='[[3g2s]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3g2s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G2S OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3G2S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3g2s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G2S OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3G2S FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g2t\|3g2t]], [[3g2u\|3g2u]], [[3g2v\|3g2v]], [[3g2w\|3g2w]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g2t\|3g2t]], [[3g2u\|3g2u]], [[3g2v\|3g2v]], [[3g2w\|3g2w]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3g2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g2s OCA], [http://pdbe.org/3g2s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g2s RCSB], [http://www.ebi.ac.uk/pdbsum/3g2s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3g2s ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3g2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g2s OCA], [http://pdbe.org/3g2s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g2s RCSB], [http://www.ebi.ac.uk/pdbsum/3g2s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3g2s ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Behrens, M A]]		[[Category: Behrens, M A]]
	[[Category: Cramer, J F]]		[[Category: Cramer, J F]]

OCA at 08:06, 5 December 2018

OCA — Wed, 05 Dec 2018 08:06:21 GMT

←Older revision		Revision as of 08:06, 5 December 2018
Line 1:		Line 1:
		+
	==VHS Domain of human GGA1 complexed with SorLA C-terminal Peptide==		==VHS Domain of human GGA1 complexed with SorLA C-terminal Peptide==
	<StructureSection load='3g2s' size='340' side='right' caption='[[3g2s]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3g2s' size='340' side='right' caption='[[3g2s]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g2t\|3g2t]], [[3g2u\|3g2u]], [[3g2v\|3g2v]], [[3g2w\|3g2w]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g2t\|3g2t]], [[3g2u\|3g2u]], [[3g2v\|3g2v]], [[3g2w\|3g2w]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g2s OCA], [http://pdbe.org/3g2s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g2s RCSB], [http://www.ebi.ac.uk/pdbsum/3g2s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g2s OCA], [http://pdbe.org/3g2s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g2s RCSB], [http://www.ebi.ac.uk/pdbsum/3g2s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3g2s ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g2/3g2s_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g2/3g2s_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 17:42, 7 February 2016

OCA — Sun, 07 Feb 2016 17:42:21 GMT

←Older revision		Revision as of 17:42, 7 February 2016
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g2t\|3g2t]], [[3g2u\|3g2u]], [[3g2v\|3g2v]], [[3g2w\|3g2w]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g2t\|3g2t]], [[3g2u\|3g2u]], [[3g2v\|3g2v]], [[3g2w\|3g2w]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g2s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g2s RCSB], [http://www.ebi.ac.uk/pdbsum/3g2s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g2s OCA], [http://pdbe.org/3g2s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g2s RCSB], [http://www.ebi.ac.uk/pdbsum/3g2s PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g2s ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3g2s" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:09, 24 December 2014

OCA — Wed, 24 Dec 2014 17:09:59 GMT

←Older revision		Revision as of 17:09, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g2s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g2s RCSB], [http://www.ebi.ac.uk/pdbsum/3g2s PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g2s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g2s RCSB], [http://www.ebi.ac.uk/pdbsum/3g2s PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GGA1_HUMAN GGA1_HUMAN]] Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.<ref>PMID:11301005</ref> [[http://www.uniprot.org/uniprot/SORL_HUMAN SORL_HUMAN]] Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 18:53, 21 December 2014

OCA — Sun, 21 Dec 2014 18:53:52 GMT

←Older revision		Revision as of 18:53, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3g2s\| PDB=3g2s \| SCENE= }}~~	+	==VHS Domain of human GGA1 complexed with SorLA C-terminal Peptide==
-	===VHS Domain of human GGA1 complexed with SorLA C-terminal Peptide===	+	<StructureSection load='3g2s' size='340' side='right' caption='[[3g2s]], [[Resolution\|resolution]] 1.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20015111}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3g2s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G2S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G2S FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g2t\|3g2t]], [[3g2u\|3g2u]], [[3g2v\|3g2v]], [[3g2w\|3g2w]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g2s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g2s RCSB], [http://www.ebi.ac.uk/pdbsum/3g2s PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g2/3g2s_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The cytosolic adaptors GGA1-3 mediate sorting of transmembrane proteins displaying a C-terminal acidic dileucine motif (DXXLL) in their cytosolic domain. GGA1 and GGA3 contain similar but intrinsic motifs that are believed to serve as autoinhibitory sites activated by the phosphorylation of a serine positioned three residues upstream of the DXXLL motif. In the present study, we have subjected the widely acknowledged concept of GGA1 autoinhibition to a thorough structural and functional examination. We find that (i) the intrinsic motif of GGA1 is inactive, (ii) only C-terminal DXXLL motifs constitute active GGA binding sites, (iii) while aspartates and phosphorylated serines one or two positions upstream of the DXXLL motif increase GGA1 binding, phosphoserines further upstream have little or no influence and (iv) phosphorylation of GGA1 does not affect its conformation or binding to Sortilin and SorLA. Taken together, our findings seem to refute the functional significance of GGA autoinhibition in particular and of intrinsic GGA binding motifs in general.

-	~~==Function==~~	+	GGA Autoinhibition Revisited.,Cramer JF, Gustafsen C, Behrens MA, Oliveira CL, Pedersen JS, Madsen P, Petersen CM, Thirup SS Traffic. 2010 Feb;11(2):259-73. Epub 2009 Nov 10. PMID:20015111<ref>PMID:20015111</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/GGA1_HUMAN GGA1_HUMAN]] Plays a role in protein sorting and trafficking between the trans-Golgi network~~ (~~TGN~~) ~~and endosomes. Mediates the ARF~~-~~dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif~~.<ref>PMID:~~11301005~~</ref> [[http://www.uniprot.org/uniprot/SORL_HUMAN SORL_HUMAN]] Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3g2s]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Human Human]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3G2S OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020015111</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Behrens, M A.]]	+	[[Category: Behrens, M A]]
-	[[Category: Cramer, J F.]]	+	[[Category: Cramer, J F]]
-	[[Category: Gustafsen, C.]]	+	[[Category: Gustafsen, C]]
-	[[Category: Madsen, P.]]	+	[[Category: Madsen, P]]
-	[[Category: Oliveira, C L.P.]]	+	[[Category: Oliveira, C L.P]]
-	[[Category: Pedersen, J S.]]	+	[[Category: Pedersen, J S]]
-	[[Category: Petersen, C M.]]	+	[[Category: Petersen, C M]]
-	[[Category: Thirup, S S.]]	+	[[Category: Thirup, S S]]
	[[Category: Acidic-cluster dileucine signal]]		[[Category: Acidic-cluster dileucine signal]]
	[[Category: Adp-ribosylation factor binding protein gga1]]		[[Category: Adp-ribosylation factor binding protein gga1]]

OCA at 09:17, 5 February 2014

OCA — Wed, 05 Feb 2014 09:17:27 GMT

←Older revision		Revision as of 09:17, 5 February 2014
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-	[[Image:3g2s.png\|left\|200px]]
-
	{{STRUCTURE_3g2s\| PDB=3g2s \| SCENE= }}		{{STRUCTURE_3g2s\| PDB=3g2s \| SCENE= }}
-
	===VHS Domain of human GGA1 complexed with SorLA C-terminal Peptide===		===VHS Domain of human GGA1 complexed with SorLA C-terminal Peptide===
		+	{{ABSTRACT_PUBMED_20015111}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/GGA1_HUMAN GGA1_HUMAN]] Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.<ref>PMID:11301005</ref> [[http://www.uniprot.org/uniprot/SORL_HUMAN SORL_HUMAN]] Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction.

	==About this Structure==		==About this Structure==
-	[[3g2s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G2S OCA].	+	[[3g2s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G2S OCA].
-	[[Category: ~~Homo sapiens~~]]	+
		+	==Reference==
		+	<ref group="xtra">PMID:020015111</ref><references group="xtra"/><references/>
		+	[[Category: Human]]
	[[Category: Behrens, M A.]]		[[Category: Behrens, M A.]]
	[[Category: Cramer, J F.]]		[[Category: Cramer, J F.]]

OCA: Protected "3g2s" [edit=sysop:move=sysop]

OCA — Wed, 20 Feb 2013 14:45:49 GMT

Protected "3g2s" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:45, 20 February 2013

OCA at 14:45, 20 February 2013

OCA — Wed, 20 Feb 2013 14:45:42 GMT

←Older revision		Revision as of 14:45, 20 February 2013
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-	~~{{Seed}}~~	+	[[Image:3g2s.png\|left\|200px]]
-	[[Image:3g2s.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3g2s", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3g2s\| PDB=3g2s \| SCENE= }}		{{STRUCTURE_3g2s\| PDB=3g2s \| SCENE= }}

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	==About this Structure==		==About this Structure==
-	~~3G2S~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G2S OCA].	+	[[3g2s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G2S OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Behrens, M A.]]		[[Category: Behrens, M A.]]
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	[[Category: Sorla]]		[[Category: Sorla]]
	[[Category: Vh]]		[[Category: Vh]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 16 13:43:52 2009''

OCA at 11:43, 16 December 2009

OCA — Wed, 16 Dec 2009 11:43:54 GMT

←Older revision		Revision as of 11:43, 16 December 2009
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3g2s.jpg\|left\|200px]]

-	The ~~entry 3g2s~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3g2s", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3g2s\| PDB=3g2s \| SCENE= }}

-	~~Authors: Cramer, J.F., Behrens, M.A., Gustafsen,~~ C~~., Oliveira, C.L., Pedersen, J.S., Madsen, P., Petersen, C.M., Thirup, S.~~	+	===VHS Domain of human GGA1 complexed with SorLA C-terminal Peptide===

-	Description: VHS Domain of human GGA1 complexed with SorLA C-terminal Peptide

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Mar 4 14~~:43:22 2009''	+	==About this Structure==
		+	3G2S is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G2S OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Behrens, M A.]]
		+	[[Category: Cramer, J F.]]
		+	[[Category: Gustafsen, C.]]
		+	[[Category: Madsen, P.]]
		+	[[Category: Oliveira, C L.P.]]
		+	[[Category: Pedersen, J S.]]
		+	[[Category: Petersen, C M.]]
		+	[[Category: Thirup, S S.]]
		+	[[Category: Acidic-cluster dileucine signal]]
		+	[[Category: Adp-ribosylation factor binding protein gga1]]
		+	[[Category: Protein transport]]
		+	[[Category: Sorla]]
		+	[[Category: Vh]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 16 13:43:52 2009''