3g3q - Revision history

OCA at 06:58, 6 September 2023

OCA — Wed, 06 Sep 2023 06:58:54 GMT

←Older revision		Revision as of 06:58, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3g3q' size='340' side='right'caption='[[3g3q]], [[Resolution\|resolution]] 2.64Å' scene=''>		<StructureSection load='3g3q' size='340' side='right'caption='[[3g3q]], [[Resolution\|resolution]] 2.64Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3g3q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G3Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G3Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3g3q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G3Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G3Q FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.64Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[3g3o\|3g3o]], [[3g3r\|3g3r]], [[3g3t\|3g3t]], [[3g3u\|3g3u]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">J1345, PHM3, VTC4, YJL012C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g3q OCA], [https://pdbe.org/3g3q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g3q RCSB], [https://www.ebi.ac.uk/pdbsum/3g3q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g3q ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g3q OCA], [https://pdbe.org/3g3q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g3q RCSB], [https://www.ebi.ac.uk/pdbsum/3g3q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g3q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/VTC4_YEAST VTC4_YEAST]] Component of the vacuolar transporter chaperone (VTC) complex, which plays a role in vacuolar membrane fusion. Required for SEC18/NSF activity in SNARE priming, membrane binding of LMA1 and V(0) trans-complex formation.<ref>PMID:11102525</ref> <ref>PMID:11823419</ref> <ref>PMID:12584253</ref>	+	[https://www.uniprot.org/uniprot/VTC4_YEAST VTC4_YEAST] Component of the vacuolar transporter chaperone (VTC) complex, which plays a role in vacuolar membrane fusion. Required for SEC18/NSF activity in SNARE priming, membrane binding of LMA1 and V(0) trans-complex formation.<ref>PMID:11102525</ref> <ref>PMID:11823419</ref> <ref>PMID:12584253</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Hothorn, M~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Scheffzek, K~~]]	+	[[Category: Hothorn M]]
-	[[Category: ~~Biosynthetic protein]]~~	+	[[Category: Scheffzek K]]
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Polyphosphate kinase]]~~	+
-	~~[[Category: Polyphosphate polymerase]]~~	+
-	~~[[Category: Transmembrane]]~~	+
-	~~[[Category: Tunnel enzyme]]~~	+
-	~~[[Category: Vacuolar transporter chaperone]]~~	+
-	~~[[Category: Vacuole]]~~	+
-	~~[[Category: Vtc complex~~]]	+

OCA at 07:55, 9 March 2022

OCA — Wed, 09 Mar 2022 07:55:03 GMT

←Older revision		Revision as of 07:55, 9 March 2022
Line 1:		Line 1:

	==Crystal structure of a eukaryotic polyphosphate polymerase in complex with a phosphate polymer==		==Crystal structure of a eukaryotic polyphosphate polymerase in complex with a phosphate polymer==
-	<StructureSection load='3g3q' size='340' side='right' caption='[[3g3q]], [[Resolution\|resolution]] 2.64Å' scene=''>	+	<StructureSection load='3g3q' size='340' side='right'caption='[[3g3q]], [[Resolution\|resolution]] 2.64Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3g3q]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G3Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3G3Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3g3q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G3Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G3Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g3o\|3g3o]], [[3g3r\|3g3r]], [[3g3t\|3g3t]], [[3g3u\|3g3u]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3g3o\|3g3o]], [[3g3r\|3g3r]], [[3g3t\|3g3t]], [[3g3u\|3g3u]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">J1345, PHM3, VTC4, YJL012C ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">J1345, PHM3, VTC4, YJL012C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3g3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g3q OCA], [~~http~~://pdbe.org/3g3q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3g3q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3g3q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3g3q ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g3q OCA], [https://pdbe.org/3g3q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g3q RCSB], [https://www.ebi.ac.uk/pdbsum/3g3q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g3q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/VTC4_YEAST VTC4_YEAST]] Component of the vacuolar transporter chaperone (VTC) complex, which plays a role in vacuolar membrane fusion. Required for SEC18/NSF activity in SNARE priming, membrane binding of LMA1 and V(0) trans-complex formation.<ref>PMID:11102525</ref> <ref>PMID:11823419</ref> <ref>PMID:12584253</ref>	+	[[https://www.uniprot.org/uniprot/VTC4_YEAST VTC4_YEAST]] Component of the vacuolar transporter chaperone (VTC) complex, which plays a role in vacuolar membrane fusion. Required for SEC18/NSF activity in SNARE priming, membrane binding of LMA1 and V(0) trans-complex formation.<ref>PMID:11102525</ref> <ref>PMID:11823419</ref> <ref>PMID:12584253</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Hothorn, M]]		[[Category: Hothorn, M]]
	[[Category: Scheffzek, K]]		[[Category: Scheffzek, K]]

OCA at 07:48, 5 December 2018

OCA — Wed, 05 Dec 2018 07:48:16 GMT

←Older revision		Revision as of 07:48, 5 December 2018
Line 1:		Line 1:
		+
	==Crystal structure of a eukaryotic polyphosphate polymerase in complex with a phosphate polymer==		==Crystal structure of a eukaryotic polyphosphate polymerase in complex with a phosphate polymer==
	<StructureSection load='3g3q' size='340' side='right' caption='[[3g3q]], [[Resolution\|resolution]] 2.64Å' scene=''>		<StructureSection load='3g3q' size='340' side='right' caption='[[3g3q]], [[Resolution\|resolution]] 2.64Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g3o\|3g3o]], [[3g3r\|3g3r]], [[3g3t\|3g3t]], [[3g3u\|3g3u]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g3o\|3g3o]], [[3g3r\|3g3r]], [[3g3t\|3g3t]], [[3g3u\|3g3u]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">J1345, PHM3, VTC4, YJL012C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">J1345, PHM3, VTC4, YJL012C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g3q OCA], [http://pdbe.org/3g3q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g3q RCSB], [http://www.ebi.ac.uk/pdbsum/3g3q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g3q OCA], [http://pdbe.org/3g3q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g3q RCSB], [http://www.ebi.ac.uk/pdbsum/3g3q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3g3q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g3/3g3q_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g3/3g3q_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 04:33, 8 February 2016

OCA — Mon, 08 Feb 2016 04:33:02 GMT

←Older revision		Revision as of 04:33, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3g3q' size='340' side='right' caption='[[3g3q]], [[Resolution\|resolution]] 2.64Å' scene=''>		<StructureSection load='3g3q' size='340' side='right' caption='[[3g3q]], [[Resolution\|resolution]] 2.64Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3g3q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G3Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G3Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3g3q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G3Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G3Q FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g3o\|3g3o]], [[3g3r\|3g3r]], [[3g3t\|3g3t]], [[3g3u\|3g3u]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g3o\|3g3o]], [[3g3r\|3g3r]], [[3g3t\|3g3t]], [[3g3u\|3g3u]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">J1345, PHM3, VTC4, YJL012C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">J1345, PHM3, VTC4, YJL012C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g3q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g3q RCSB], [http://www.ebi.ac.uk/pdbsum/3g3q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g3q OCA], [http://pdbe.org/3g3q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g3q RCSB], [http://www.ebi.ac.uk/pdbsum/3g3q PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g3q ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3g3q" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Hothorn, M]]		[[Category: Hothorn, M]]
	[[Category: Scheffzek, K]]		[[Category: Scheffzek, K]]

OCA at 20:38, 24 December 2014

OCA — Wed, 24 Dec 2014 20:38:49 GMT

←Older revision		Revision as of 20:38, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g3q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g3q RCSB], [http://www.ebi.ac.uk/pdbsum/3g3q PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g3q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g3q RCSB], [http://www.ebi.ac.uk/pdbsum/3g3q PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/VTC4_YEAST VTC4_YEAST]] Component of the vacuolar transporter chaperone (VTC) complex, which plays a role in vacuolar membrane fusion. Required for SEC18/NSF activity in SNARE priming, membrane binding of LMA1 and V(0) trans-complex formation.<ref>PMID:11102525</ref> <ref>PMID:11823419</ref> <ref>PMID:12584253</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:09, 3 December 2014

OCA — Wed, 03 Dec 2014 10:09:10 GMT

←Older revision		Revision as of 10:09, 3 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3g3q.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of a eukaryotic polyphosphate polymerase in complex with a phosphate polymer==
		+	<StructureSection load='3g3q' size='340' side='right' caption='[[3g3q]], [[Resolution\|resolution]] 2.64Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3g3q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G3Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G3Q FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g3o\|3g3o]], [[3g3r\|3g3r]], [[3g3t\|3g3t]], [[3g3u\|3g3u]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">J1345, PHM3, VTC4, YJL012C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g3q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g3q RCSB], [http://www.ebi.ac.uk/pdbsum/3g3q PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g3/3g3q_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Polyphosphate (polyP) occurs ubiquitously in cells, but its functions are poorly understood and its synthesis has only been characterized in bacteria. Using x-ray crystallography, we identified a eukaryotic polyphosphate polymerase within the membrane-integral vacuolar transporter chaperone (VTC) complex. A 2.6 angstrom crystal structure of the catalytic domain grown in the presence of adenosine triphosphate (ATP) reveals polyP winding through a tunnel-shaped pocket. Nucleotide- and phosphate-bound structures suggest that the enzyme functions by metal-assisted cleavage of the ATP gamma-phosphate, which is then in-line transferred to an acceptor phosphate to form polyP chains. Mutational analysis of the transmembrane domain indicates that VTC may integrate cytoplasmic polymer synthesis with polyP membrane translocation. Identification of the polyP-synthesizing enzyme opens the way to determine the functions of polyP in lower eukaryotes.

-	~~{{STRUCTURE_3g3q\| PDB=3g3q \| SCENE= }}~~	+	Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase.,Hothorn M, Neumann H, Lenherr ED, Wehner M, Rybin V, Hassa PO, Uttenweiler A, Reinhardt M, Schmidt A, Seiler J, Ladurner AG, Herrmann C, Scheffzek K, Mayer A Science. 2009 Apr 24;324(5926):513-6. PMID:19390046<ref>PMID:19390046</ref>

-	~~===Crystal structure~~ of ~~a eukaryotic polyphosphate polymerase in complex with a phosphate polymer===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19390046}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3g3q]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3G3Q OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019390046<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Hothorn, M.]]	+	[[Category: Hothorn, M]]
-	[[Category: Scheffzek, K.]]	+	[[Category: Scheffzek, K]]
	[[Category: Biosynthetic protein]]		[[Category: Biosynthetic protein]]
	[[Category: Membrane]]		[[Category: Membrane]]

OCA: Protected "3g3q" [edit=sysop:move=sysop]

OCA — Wed, 20 Feb 2013 14:23:59 GMT

Protected "3g3q" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:23, 20 February 2013

OCA at 14:23, 20 February 2013

OCA — Wed, 20 Feb 2013 14:23:55 GMT

←Older revision		Revision as of 14:23, 20 February 2013
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3g3q.png\|left\|200px]]
-	[[Image:3g3q.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3g3q", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3g3q\| PDB=3g3q \| SCENE= }}		{{STRUCTURE_3g3q\| PDB=3g3q \| SCENE= }}

	===Crystal structure of a eukaryotic polyphosphate polymerase in complex with a phosphate polymer===		===Crystal structure of a eukaryotic polyphosphate polymerase in complex with a phosphate polymer===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19390046}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19390046 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19390046}}		{{ABSTRACT_PUBMED_19390046}}

	==About this Structure==		==About this Structure==
-	~~3G3Q~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G3Q OCA].	+	[[3g3q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G3Q OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19390046~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019390046</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Hothorn, M.]]		[[Category: Hothorn, M.]]
Line 37:		Line 25:
	[[Category: Vacuole]]		[[Category: Vacuole]]
	[[Category: Vtc complex]]		[[Category: Vtc complex]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 6 10:32:59 2009''

OCA at 07:33, 6 May 2009

OCA — Wed, 06 May 2009 07:33:00 GMT

←Older revision		Revision as of 07:33, 6 May 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3g3q.jpg\|left\|200px]]

-	The ~~entry 3g3q~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3g3q", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3g3q\| PDB=3g3q \| SCENE= }}

-	~~Authors: Hothorn, M., Scheffzek, K.~~	+	===Crystal structure of a eukaryotic polyphosphate polymerase in complex with a phosphate polymer===

-	Description: Crystal structure of a eukaryotic polyphosphate polymerase in complex with a phosphate polymer

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Apr 15 09~~:51:48 2009''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19390046}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19390046 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19390046}}
		+
		+	==About this Structure==
		+	3G3Q is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G3Q OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19390046</ref><references group="xtra"/>
		+	[[Category: Saccharomyces cerevisiae]]
		+	[[Category: Hothorn, M.]]
		+	[[Category: Scheffzek, K.]]
		+	[[Category: Biosynthetic protein]]
		+	[[Category: Membrane]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Polyphosphate kinase]]
		+	[[Category: Polyphosphate polymerase]]
		+	[[Category: Transmembrane]]
		+	[[Category: Tunnel enzyme]]
		+	[[Category: Vacuolar transporter chaperone]]
		+	[[Category: Vacuole]]
		+	[[Category: Vtc complex]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 6 10:32:59 2009''

OCA at 06:51, 15 April 2009

OCA — Wed, 15 Apr 2009 06:51:49 GMT

←Older revision		Revision as of 06:51, 15 April 2009
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3g3q is ON HOLD	+	The entry 3g3q is ON HOLD until Paper Publication

	Authors: Hothorn, M., Scheffzek, K.		Authors: Hothorn, M., Scheffzek, K.
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	Description: Crystal structure of a eukaryotic polyphosphate polymerase in complex with a phosphate polymer		Description: Crystal structure of a eukaryotic polyphosphate polymerase in complex with a phosphate polymer

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Feb 18 08~~:54:40 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 15 09:51:48 2009''