3g4d - Revision history

OCA at 06:59, 6 September 2023

OCA — Wed, 06 Sep 2023 06:59:13 GMT

←Older revision		Revision as of 06:59, 6 September 2023
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	<StructureSection load='3g4d' size='340' side='right'caption='[[3g4d]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3g4d' size='340' side='right'caption='[[3g4d]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3g4d]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Gosar Gosar~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G4D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3G4D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3g4d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gossypium_arboreum Gossypium arboreum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G4D FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BME:BETA~~-~~MERCAPTOETHANOL'>BME</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.403Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[3g4f\|3g4f]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/(+)-delta-cadinene_synthase (+)-delta-cadinene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.13 4.2.3.13]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g4d OCA], [https://pdbe.org/3g4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g4d RCSB], [https://www.ebi.ac.uk/pdbsum/3g4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g4d ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3g4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g4d OCA], [~~http~~://pdbe.org/3g4d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3g4d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3g4d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3g4d ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DCS1_GOSAR DCS1_GOSAR]] Responsible for the cyclization of trans,trans-farnesyl diphosphate (FPP) to (+)-delta cadinene.<ref>PMID:19489610</ref>	+	[https://www.uniprot.org/uniprot/DCS1_GOSAR DCS1_GOSAR] Responsible for the cyclization of trans,trans-farnesyl diphosphate (FPP) to (+)-delta cadinene.<ref>PMID:19489610</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Gosar~~]]	+	[[Category: Gossypium arboreum]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Allemann~~, R K~~]]	+	[[Category: Allemann RK]]
-	[[Category: Christianson~~, D W~~]]	+	[[Category: Christianson DW]]
-	[[Category: Costanzo, L Di]]	+	[[Category: Di Costanzo L]]
-	[[Category: Gennadios~~, H A~~]]	+	[[Category: Gennadios HA]]
-	[[Category: Miller~~, D J]]~~	+	[[Category: Miller DJ]]
-	~~[[Category: Cyclase]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Magnesium]]~~	+
-	~~[[Category: Metal-binding~~]]	+

OCA at 10:36, 9 September 2020

OCA — Wed, 09 Sep 2020 10:36:15 GMT

←Older revision		Revision as of 10:36, 9 September 2020
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	==Crystal Structure of (+)-delta-Cadinene Synthase from Gossypium arboreum and Evolutionary Divergence of Metal Binding Motifs for Catalysis==		==Crystal Structure of (+)-delta-Cadinene Synthase from Gossypium arboreum and Evolutionary Divergence of Metal Binding Motifs for Catalysis==
-	<StructureSection load='3g4d' size='340' side='right' caption='[[3g4d]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='3g4d' size='340' side='right'caption='[[3g4d]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3g4d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gosar Gosar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G4D OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3G4D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3g4d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gosar Gosar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G4D OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3G4D FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g4f\|3g4f]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g4f\|3g4f]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(+)-delta-cadinene_synthase (+)-delta-cadinene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.13 4.2.3.13] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(+)-delta-cadinene_synthase (+)-delta-cadinene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.13 4.2.3.13] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3g4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g4d OCA], [http://pdbe.org/3g4d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g4d RCSB], [http://www.ebi.ac.uk/pdbsum/3g4d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3g4d ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3g4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g4d OCA], [http://pdbe.org/3g4d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g4d RCSB], [http://www.ebi.ac.uk/pdbsum/3g4d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3g4d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</StructureSection>		</StructureSection>
	[[Category: Gosar]]		[[Category: Gosar]]
		+	[[Category: Large Structures]]
	[[Category: Allemann, R K]]		[[Category: Allemann, R K]]
	[[Category: Christianson, D W]]		[[Category: Christianson, D W]]

OCA at 07:22, 5 December 2018

OCA — Wed, 05 Dec 2018 07:22:08 GMT

←Older revision		Revision as of 07:22, 5 December 2018
Line 1:		Line 1:
		+
	==Crystal Structure of (+)-delta-Cadinene Synthase from Gossypium arboreum and Evolutionary Divergence of Metal Binding Motifs for Catalysis==		==Crystal Structure of (+)-delta-Cadinene Synthase from Gossypium arboreum and Evolutionary Divergence of Metal Binding Motifs for Catalysis==
	<StructureSection load='3g4d' size='340' side='right' caption='[[3g4d]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3g4d' size='340' side='right' caption='[[3g4d]], [[Resolution\|resolution]] 2.40Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g4f\|3g4f]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g4f\|3g4f]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(+)-delta-cadinene_synthase (+)-delta-cadinene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.13 4.2.3.13] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(+)-delta-cadinene_synthase (+)-delta-cadinene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.13 4.2.3.13] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g4d OCA], [http://pdbe.org/3g4d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g4d RCSB], [http://www.ebi.ac.uk/pdbsum/3g4d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g4d OCA], [http://pdbe.org/3g4d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g4d RCSB], [http://www.ebi.ac.uk/pdbsum/3g4d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3g4d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g4/3g4d_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g4/3g4d_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 35:		Line 36:
	[[Category: Gosar]]		[[Category: Gosar]]
	[[Category: Allemann, R K]]		[[Category: Allemann, R K]]
-	[[Category: Christianson,D W]]	+	[[Category: Christianson, D W]]
	[[Category: Costanzo, L Di]]		[[Category: Costanzo, L Di]]
-	[[Category: Gennadios,H A]]	+	[[Category: Gennadios, H A]]
	[[Category: Miller, D J]]		[[Category: Miller, D J]]
	[[Category: Cyclase]]		[[Category: Cyclase]]

OCA at 10:18, 7 February 2016

OCA — Sun, 07 Feb 2016 10:18:14 GMT

←Older revision		Revision as of 10:18, 7 February 2016
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	<StructureSection load='3g4d' size='340' side='right' caption='[[3g4d]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3g4d' size='340' side='right' caption='[[3g4d]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3g4d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Gossypium_arboreum Gossypium arboreum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G4D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G4D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3g4d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gosar Gosar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G4D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G4D FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g4f\|3g4f]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g4f\|3g4f]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(+)-delta-cadinene_synthase (+)-delta-cadinene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.13 4.2.3.13] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(+)-delta-cadinene_synthase (+)-delta-cadinene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.13 4.2.3.13] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g4d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g4d RCSB], [http://www.ebi.ac.uk/pdbsum/3g4d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g4d OCA], [http://pdbe.org/3g4d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g4d RCSB], [http://www.ebi.ac.uk/pdbsum/3g4d PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g4d ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3g4d" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Gossypium arboreum~~]]	+	[[Category: Gosar]]
	[[Category: Allemann, R K]]		[[Category: Allemann, R K]]
	[[Category: Christianson,D W]]		[[Category: Christianson,D W]]

OCA at 14:21, 24 December 2014

OCA — Wed, 24 Dec 2014 14:21:32 GMT

←Older revision		Revision as of 14:21, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g4d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g4d RCSB], [http://www.ebi.ac.uk/pdbsum/3g4d PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g4d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g4d RCSB], [http://www.ebi.ac.uk/pdbsum/3g4d PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DCS1_GOSAR DCS1_GOSAR]] Responsible for the cyclization of trans,trans-farnesyl diphosphate (FPP) to (+)-delta cadinene.<ref>PMID:19489610</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:11, 3 December 2014

OCA — Wed, 03 Dec 2014 10:11:29 GMT

←Older revision		Revision as of 10:11, 3 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3g4d.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of (+)-delta-Cadinene Synthase from Gossypium arboreum and Evolutionary Divergence of Metal Binding Motifs for Catalysis==
		+	<StructureSection load='3g4d' size='340' side='right' caption='[[3g4d]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3g4d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gossypium_arboreum Gossypium arboreum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G4D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G4D FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g4f\|3g4f]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/(+)-delta-cadinene_synthase (+)-delta-cadinene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.13 4.2.3.13] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g4d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g4d RCSB], [http://www.ebi.ac.uk/pdbsum/3g4d PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g4/3g4d_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	(+)--Cadinene synthase (DCS) from Gossypium arboreum (tree cotton) is a sesquiterpene cyclase that catalyzes the cyclization of farnesyl diphosphate in the first committed step of the biosynthesis of gossypol, a phytoalexin that defends the plant from bacterial and fungal pathogens. Here, we report the X-ray crystal structure of unliganded DCS at 2.4 A resolution and the structure of its complex with three putative Mg2+ ions and the substrate analogue inhibitor 2-fluorofarnesyl diphosphate (2F-FPP) at 2.75 A resolution. These structures illuminate unusual features that accommodate the trinuclear metal cluster required for substrate binding and catalysis. Like other terpenoid cyclases, DCS contains a characteristic aspartate-rich motif D307DTYD311 on helix D that interacts with Mg2+A and Mg2+C. However, DCS appears to be unique among terpenoid cyclases in that it does not contain the "NSE/DTE" motif on helix H that specifically chelates Mg2+B, which is usually found as the signature sequence (N, D)D(L, I, V)X(S, T)XXXE (boldface indicates Mg2+B ligands). Instead, DCS contains a second aspartate-rich motif, D451DVAE455, that interacts with Mg2+B. In this regard, DCS is more similar to the isoprenoid chain elongation enzyme farnesyl diphosphate synthase, which also contains two aspartate-rich motifs, rather than the greater family of terpenoid cyclases. Nevertheless, the structure of the DCS-2F-FPP complex shows that the structure of the trinuclear magnesium cluster is generally similar to that of other terpenoid cyclases despite the alternative Mg2+B-binding motif. Analyses of DCS mutants with alanine substitutions in the D307DTYD311 and D451DVAE455 segments reveal the contributions of these segments to catalysis.

-	~~{{STRUCTURE_3g4d\| PDB=3g4d \| SCENE= }}~~	+	Crystal Structure of (+)--Cadinene Synthase from Gossypium arboreum and Evolutionary Divergence of Metal Binding Motifs for Catalysis.,Gennadios HA, Gonzalez V, Di Costanzo L, Li A, Yu F, Miller DJ, Allemann RK, Christianson DW Biochemistry. 2009 Jun 2. PMID:19489610<ref>PMID:19489610</ref>

-	~~===Crystal Structure~~ of ~~(+)-delta-Cadinene Synthase from Gossypium arboreum and Evolutionary Divergence of Metal Binding Motifs for Catalysis===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19489610}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3g4d]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Gossypium_arboreum Gossypium arboreum]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3G4D OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019489610<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Gossypium arboreum]]		[[Category: Gossypium arboreum]]
-	[[Category: Allemann, R K.]]	+	[[Category: Allemann, R K]]
-	[[Category: Christianson,D W.]]	+	[[Category: Christianson,D W]]
-	[[Category: Costanzo, L Di.]]	+	[[Category: Costanzo, L Di]]
-	[[Category: Gennadios,H A.]]	+	[[Category: Gennadios,H A]]
-	[[Category: Miller, D J.]]	+	[[Category: Miller, D J]]
	[[Category: Cyclase]]		[[Category: Cyclase]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Magnesium]]		[[Category: Magnesium]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]

OCA: Protected "3g4d" [edit=sysop:move=sysop]

OCA — Wed, 20 Feb 2013 14:26:27 GMT

Protected "3g4d" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:26, 20 February 2013

OCA at 14:26, 20 February 2013

OCA — Wed, 20 Feb 2013 14:26:24 GMT

←Older revision		Revision as of 14:26, 20 February 2013
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-	{{Seed}}
	[[Image:3g4d.png\|left\|200px]]		[[Image:3g4d.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3g4d", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3g4d\| PDB=3g4d \| SCENE= }}		{{STRUCTURE_3g4d\| PDB=3g4d \| SCENE= }}

	===Crystal Structure of (+)-delta-Cadinene Synthase from Gossypium arboreum and Evolutionary Divergence of Metal Binding Motifs for Catalysis===		===Crystal Structure of (+)-delta-Cadinene Synthase from Gossypium arboreum and Evolutionary Divergence of Metal Binding Motifs for Catalysis===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19489610}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19489610 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19489610}}		{{ABSTRACT_PUBMED_19489610}}

	==About this Structure==		==About this Structure==
-	~~3G4D~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Gossypium_arboreum Gossypium arboreum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G4D OCA].	+	[[3g4d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gossypium_arboreum Gossypium arboreum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G4D OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19489610~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019489610</ref><references group="xtra"/>
	[[Category: Gossypium arboreum]]		[[Category: Gossypium arboreum]]
	[[Category: Allemann, R K.]]		[[Category: Allemann, R K.]]
Line 34:		Line 22:
	[[Category: Magnesium]]		[[Category: Magnesium]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 25 08:25:57 2009''

OCA at 05:26, 25 June 2009

OCA — Thu, 25 Jun 2009 05:26:00 GMT

←Older revision		Revision as of 05:26, 25 June 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3g4d.~~jpg~~\|left\|200px]]	+	[[Image:3g4d.png\|left\|200px]]

	<!--		<!--
Line 35:		Line 35:
	[[Category: Metal-binding]]		[[Category: Metal-binding]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed~~ Jun ~~17 10~~:15:09 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 25 08:25:57 2009''

OCA at 07:15, 17 June 2009

OCA — Wed, 17 Jun 2009 07:15:11 GMT

←Older revision		Revision as of 07:15, 17 June 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3g4d.jpg\|left\|200px]]

-	The ~~entry 3g4d~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3g4d", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3g4d\| PDB=3g4d \| SCENE= }}

-	~~Authors: Gennadios,H.A., Costanzo,L.D., Miller, D.J., Allemann, R.K., Christianson,D.W.~~	+	===Crystal Structure of (+)-delta-Cadinene Synthase from Gossypium arboreum and Evolutionary Divergence of Metal Binding Motifs for Catalysis===

-	Description: Crystal Structure of (+)-delta-Cadinene Synthase from Gossypium arboreum and Evolutionary Divergence of Metal Binding Motifs for Catalysis

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 10 17:56:34 2009''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19489610}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19489610 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19489610}}
		+
		+	==About this Structure==
		+	3G4D is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Gossypium_arboreum Gossypium arboreum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G4D OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19489610</ref><references group="xtra"/>
		+	[[Category: Gossypium arboreum]]
		+	[[Category: Allemann, R K.]]
		+	[[Category: Christianson,D W.]]
		+	[[Category: Costanzo, L Di.]]
		+	[[Category: Gennadios,H A.]]
		+	[[Category: Miller, D J.]]
		+	[[Category: Cyclase]]
		+	[[Category: Lyase]]
		+	[[Category: Magnesium]]
		+	[[Category: Metal-binding]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 17 10:15:09 2009''