3g5b - Revision history

OCA at 19:20, 29 May 2024

OCA — Wed, 29 May 2024 19:20:52 GMT

←Older revision		Revision as of 19:20, 29 May 2024
Line 3:		Line 3:
	<StructureSection load='3g5b' size='340' side='right'caption='[[3g5b]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3g5b' size='340' side='right'caption='[[3g5b]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3g5b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G5B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3g5b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G5B FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Unc5b ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5b OCA], [https://pdbe.org/3g5b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g5b RCSB], [https://www.ebi.ac.uk/pdbsum/3g5b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g5b ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5b OCA], [https://pdbe.org/3g5b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g5b RCSB], [https://www.ebi.ac.uk/pdbsum/3g5b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g5b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/UNC5B_RAT UNC5B_RAT]] Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity).	+	[https://www.uniprot.org/uniprot/UNC5B_RAT UNC5B_RAT] Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Wang, R~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Wei, Z~~]]	+	[[Category: Wang R]]
-	[[Category: ~~Zhang, M~~]]	+	[[Category: Wei Z]]
-	[[Category: ~~Apoptosis]]~~	+	[[Category: Zhang M]]
-	~~[[Category: Death domain]]~~	+
-	~~[[Category: Developmental protein]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Immunoglobulin domain]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Transmembrane]]~~	+
-	~~[[Category: Upa]]~~	+
-	~~[[Category: Zu5~~]]	+

OCA at 07:41, 10 November 2021

OCA — Wed, 10 Nov 2021 07:41:06 GMT

←Older revision		Revision as of 07:41, 10 November 2021
Line 1:		Line 1:

	==The structure of UNC5b cytoplasmic domain==		==The structure of UNC5b cytoplasmic domain==
-	<StructureSection load='3g5b' size='340' side='right' caption='[[3g5b]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='3g5b' size='340' side='right'caption='[[3g5b]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3g5b]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5B OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3G5B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3g5b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G5B FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Unc5b ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Unc5b ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3g5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5b OCA], [~~http~~://pdbe.org/3g5b PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3g5b RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3g5b PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3g5b ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5b OCA], [https://pdbe.org/3g5b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g5b RCSB], [https://www.ebi.ac.uk/pdbsum/3g5b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g5b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/UNC5B_RAT UNC5B_RAT]] Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity).	+	[[https://www.uniprot.org/uniprot/UNC5B_RAT UNC5B_RAT]] Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Wang, R]]		[[Category: Wang, R]]
	[[Category: Wei, Z]]		[[Category: Wei, Z]]

OCA at 07:57, 5 December 2018

OCA — Wed, 05 Dec 2018 07:57:30 GMT

←Older revision		Revision as of 07:57, 5 December 2018
Line 1:		Line 1:
		+
	==The structure of UNC5b cytoplasmic domain==		==The structure of UNC5b cytoplasmic domain==
	<StructureSection load='3g5b' size='340' side='right' caption='[[3g5b]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3g5b' size='340' side='right' caption='[[3g5b]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Unc5b ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Unc5b ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5b OCA], [http://pdbe.org/3g5b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g5b RCSB], [http://www.ebi.ac.uk/pdbsum/3g5b PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5b OCA], [http://pdbe.org/3g5b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g5b RCSB], [http://www.ebi.ac.uk/pdbsum/3g5b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3g5b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g5/3g5b_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g5/3g5b_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 3g5b" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3g5b" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Netrin receptor\|Netrin receptor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 23:31, 7 February 2016

OCA — Sun, 07 Feb 2016 23:31:25 GMT

←Older revision		Revision as of 23:31, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3g5b' size='340' side='right' caption='[[3g5b]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3g5b' size='340' side='right' caption='[[3g5b]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3g5b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G5B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3g5b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G5B FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Unc5b ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Unc5b ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g5b RCSB], [http://www.ebi.ac.uk/pdbsum/3g5b PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5b OCA], [http://pdbe.org/3g5b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g5b RCSB], [http://www.ebi.ac.uk/pdbsum/3g5b PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g5b ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3g5b" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Wang, R]]		[[Category: Wang, R]]
	[[Category: Wei, Z]]		[[Category: Wei, Z]]

OCA at 18:58, 24 December 2014

OCA — Wed, 24 Dec 2014 18:58:18 GMT

←Older revision		Revision as of 18:58, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g5b RCSB], [http://www.ebi.ac.uk/pdbsum/3g5b PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g5b RCSB], [http://www.ebi.ac.uk/pdbsum/3g5b PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/UNC5B_RAT UNC5B_RAT]] Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:16, 3 December 2014

OCA — Wed, 03 Dec 2014 10:16:17 GMT

←Older revision		Revision as of 10:16, 3 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3g5b.~~png~~\|~~left~~\|200px]]	+	==The structure of UNC5b cytoplasmic domain==
		+	<StructureSection load='3g5b' size='340' side='right' caption='[[3g5b]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3g5b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G5B FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Unc5b ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g5b RCSB], [http://www.ebi.ac.uk/pdbsum/3g5b PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g5/3g5b_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The cytoplasmic domains of UNC5 are responsible for its netrin-mediated signaling events in axonal migrations, blood vessel patterning, and apoptosis, although the molecular mechanisms governing these processes are unknown. To provide a foundation for the elucidation of the UNC5-mediated signaling mechanism, we determined the crystal structure of the cytoplasmic portion of UNC5b. We found that it contains three distinctly folded domains, namely ZU5, UPA, and death domain (DD). These three domains form a structural supramodule, with ZU5 binding to both UPA and DD, thereby locking the ZU5-UPA-DD supramodule in a closed conformation and suppressing its biological activities. Release of the closed conformation of the ZU5-UPA-DD supramodule leads to the activation of the receptor in the promotion of apoptosis and blood vessel patterning. Finally, we provide evidence showing that the supramodular nature of UNC5 ZU5-UPA-DD is likely to be shared by the ankyrin and PIDD families of scaffold proteins.

-	~~{{STRUCTURE_3g5b\| PDB=3g5b \| SCENE= }}~~	+	Autoinhibition of UNC5b revealed by the cytoplasmic domain structure of the receptor.,Wang R, Wei Z, Jin H, Wu H, Yu C, Wen W, Chan LN, Wen Z, Zhang M Mol Cell. 2009 Mar 27;33(6):692-703. PMID:19328064<ref>PMID:19328064</ref>

-	~~===The structure~~ of ~~UNC5b cytoplasmic domain===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19328064}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3g5b]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3G5B OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019328064<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Wang, R.]]	+	[[Category: Wang, R]]
-	[[Category: Wei, Z.]]	+	[[Category: Wei, Z]]
-	[[Category: Zhang, M.]]	+	[[Category: Zhang, M]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Death domain]]		[[Category: Death domain]]

OCA: Protected "3g5b" [edit=sysop:move=sysop]

OCA — Wed, 20 Feb 2013 14:34:21 GMT

Protected "3g5b" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:34, 20 February 2013

OCA at 14:34, 20 February 2013

OCA — Wed, 20 Feb 2013 14:34:17 GMT

←Older revision		Revision as of 14:34, 20 February 2013
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-	{{Seed}}
	[[Image:3g5b.png\|left\|200px]]		[[Image:3g5b.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3g5b", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3g5b\| PDB=3g5b \| SCENE= }}		{{STRUCTURE_3g5b\| PDB=3g5b \| SCENE= }}

	===The structure of UNC5b cytoplasmic domain===		===The structure of UNC5b cytoplasmic domain===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19328064}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19328064 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19328064}}		{{ABSTRACT_PUBMED_19328064}}

	==About this Structure==		==About this Structure==
-	~~3G5B~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5B OCA].	+	[[3g5b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5B OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19328064~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019328064</ref><references group="xtra"/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Wang, R.]]		[[Category: Wang, R.]]
Line 39:		Line 27:
	[[Category: Upa]]		[[Category: Upa]]
	[[Category: Zu5]]		[[Category: Zu5]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 6 10:44:08 2009''

OCA at 07:44, 6 May 2009

OCA — Wed, 06 May 2009 07:44:09 GMT

←Older revision		Revision as of 07:44, 6 May 2009
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	{{Seed}}		{{Seed}}
-	[[Image:3g5b.~~jpg~~\|left\|200px]]	+	[[Image:3g5b.png\|left\|200px]]

	<!--		<!--
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	[[Category: Zu5]]		[[Category: Zu5]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Apr~~ ~~9 12~~:21:52 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 6 10:44:08 2009''

OCA at 09:21, 9 April 2009

OCA — Thu, 09 Apr 2009 09:21:53 GMT

←Older revision		Revision as of 09:21, 9 April 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3g5b.jpg\|left\|200px]]

-	The ~~entry 3g5b~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3g5b", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3g5b\| PDB=3g5b \| SCENE= }}

-	~~Authors: Wang, R., Wei, Z., Jin, H., Wu, H., Wen, W., -N Chan, L., Yu, C., Wen, Z., Zhang, M.~~	+	===The structure of UNC5b cytoplasmic domain===

-	Description: The structure of UNC5b cytoplasmic domain

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Feb 25 09~~:26:38 2009''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19328064}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19328064 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19328064}}
		+
		+	==About this Structure==
		+	3G5B is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5B OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19328064</ref><references group="xtra"/>
		+	[[Category: Rattus norvegicus]]
		+	[[Category: Wang, R.]]
		+	[[Category: Wei, Z.]]
		+	[[Category: Zhang, M.]]
		+	[[Category: Apoptosis]]
		+	[[Category: Death domain]]
		+	[[Category: Developmental protein]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Immunoglobulin domain]]
		+	[[Category: Membrane]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Receptor]]
		+	[[Category: Transmembrane]]
		+	[[Category: Upa]]
		+	[[Category: Zu5]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 9 12:21:52 2009''