3g5z - Revision history

OCA at 10:37, 9 September 2020

OCA — Wed, 09 Sep 2020 10:37:08 GMT

←Older revision		Revision as of 10:37, 9 September 2020
Line 1:		Line 1:

	==Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR==		==Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR==
-	<StructureSection load='3g5z' size='340' side='right' caption='[[3g5z]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='3g5z' size='340' side='right'caption='[[3g5z]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3g5z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5Z OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3G5Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3g5z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5Z OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3G5Z FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3g5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5z OCA], [http://pdbe.org/3g5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g5z RCSB], [http://www.ebi.ac.uk/pdbsum/3g5z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3g5z ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3g5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5z OCA], [http://pdbe.org/3g5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g5z RCSB], [http://www.ebi.ac.uk/pdbsum/3g5z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3g5z ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 27:

	==See Also==		==See Also==
-	*[[Epidermal ~~Growth Factor Receptor~~\|Epidermal ~~Growth Factor Receptor~~]]	+	*[[Epidermal growth factor receptor 3D structures\|Epidermal growth factor receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Burgess, A W]]		[[Category: Burgess, A W]]

OCA at 07:59, 5 December 2018

OCA — Wed, 05 Dec 2018 07:59:15 GMT

←Older revision		Revision as of 07:59, 5 December 2018
Line 1:		Line 1:
		+
	==Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR==		==Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR==
	<StructureSection load='3g5z' size='340' side='right' caption='[[3g5z]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3g5z' size='340' side='right' caption='[[3g5z]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3g5z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G5Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[3g5z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G5Z FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5z OCA], [http://pdbe.org/3g5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g5z RCSB], [http://www.ebi.ac.uk/pdbsum/3g5z PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5z OCA], [http://pdbe.org/3g5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g5z RCSB], [http://www.ebi.ac.uk/pdbsum/3g5z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3g5z ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 9:		Line 10:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g5/3g5z_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g5/3g5z_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 17:32, 7 February 2016

OCA — Sun, 07 Feb 2016 17:32:40 GMT

←Older revision		Revision as of 17:32, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3g5z' size='340' side='right' caption='[[3g5z]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3g5z' size='340' side='right' caption='[[3g5z]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3g5z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G5Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3g5z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G5Z FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g5z RCSB], [http://www.ebi.ac.uk/pdbsum/3g5z PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5z OCA], [http://pdbe.org/3g5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g5z RCSB], [http://www.ebi.ac.uk/pdbsum/3g5z PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 13:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g5z ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 23:		Line 23:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3g5z" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 30:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Burgess, A W]]		[[Category: Burgess, A W]]
	[[Category: Garrett, T P.J]]		[[Category: Garrett, T P.J]]
	[[Category: Antibody]]		[[Category: Antibody]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 11:43, 20 January 2015

OCA — Tue, 20 Jan 2015 11:43:44 GMT

←Older revision		Revision as of 11:43, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3g5z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G5Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[3g5z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G5Z FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g5z RCSB], [http://www.ebi.ac.uk/pdbsum/3g5z PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g5z RCSB], [http://www.ebi.ac.uk/pdbsum/3g5z PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Burgess, A W.]]	+	[[Category: Burgess, A W]]
-	[[Category: Garrett, T P.J.]]	+	[[Category: Garrett, T P.J]]
	[[Category: Antibody]]		[[Category: Antibody]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 13:28, 29 September 2014

OCA — Mon, 29 Sep 2014 13:28:44 GMT

←Older revision		Revision as of 13:28, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:3g5z.~~png\|left~~\|200px]]	+	==Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR==
		+	<StructureSection load='3g5z' size='340' side='right' caption='[[3g5z]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3g5z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G5Z FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g5z RCSB], [http://www.ebi.ac.uk/pdbsum/3g5z PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g5/3g5z_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Epidermal Growth Factor Receptor (EGFR) is involved in stimulating the growth of many human tumors, but the success of therapeutic agents has been limited in part by interference from the EGFR on normal tissues. Previously, we reported an antibody (mab806) against a truncated form of EGFR found commonly in gliomas. Remarkably, it also recognizes full-length EGFR on tumor cells but not on normal cells. However, the mechanism for this activity was unclear. Crystallographic structures for Fab:EGFR(287-302) complexes of mAb806 (and a second, related antibody, mAb175) show that this peptide epitope adopts conformations similar to those found in the wtEGFR. However, in both conformations observed for wtEGFR, tethered and untethered, antibody binding would be prohibited by significant steric clashes with the CR1 domain. Thus, these antibodies must recognize a cryptic epitope in EGFR. Structurally, it appeared that breaking the disulfide bond preceding the epitope might allow the CR1 domain to open up sufficiently for antibody binding. The EGFR(C271A/C283A) mutant not only binds mAb806, but binds with 1:1 stoichiometry, which is significantly greater than wtEGFR binding. Although mAb806 and mAb175 decrease tumor growth in xenografts displaying mutant, overexpressed, or autocrine stimulated EGFR, neither antibody inhibits the in vitro growth of cells expressing wtEGFR. In contrast, mAb806 completely inhibits the ligand-associated stimulation of cells expressing EGFR(C271A/C283A). Clearly, the binding of mAb806 and mAb175 to the wtEGFR requires the epitope to be exposed either during receptor activation, mutation, or overexpression. This mechanism suggests the possibility of generating antibodies to target other wild-type receptors on tumor cells.

-	~~{{STRUCTURE_3g5z\| PDB=3g5z \| SCENE= }}~~	+	Antibodies specifically targeting a locally misfolded region of tumor associated EGFR.,Garrett TP, Burgess AW, Gan HK, Luwor RB, Cartwright G, Walker F, Orchard SG, Clayton AH, Nice EC, Rothacker J, Catimel B, Cavenee WK, Old LJ, Stockert E, Ritter G, Adams TE, Hoyne PA, Wittrup D, Chao G, Cochran JR, Luo C, Lou M, Huyton T, Xu Y, Fairlie WD, Yao S, Scott AM, Johns TG Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5082-7. Epub 2009 Mar 16. PMID:19289842<ref>PMID:19289842</ref>

-	~~===Antibodies Specifically Targeting~~ a ~~Locally Misfolded Region~~ of ~~Tumor Associated EGFR===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19289842}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3g5z]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3G5Z OCA].~~	+

	==See Also==		==See Also==
	*[[Epidermal Growth Factor Receptor\|Epidermal Growth Factor Receptor]]		*[[Epidermal Growth Factor Receptor\|Epidermal Growth Factor Receptor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019289842<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Burgess, A W.]]		[[Category: Burgess, A W.]]

OCA at 07:23, 20 October 2012

OCA — Sat, 20 Oct 2012 07:23:12 GMT

←Older revision		Revision as of 07:23, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3g5z]] is a 2 chain structure ~~of [[Epidermal Growth Factor Receptor]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5Z OCA].	+	[[3g5z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5Z OCA].

	==See Also==		==See Also==

OCA at 16:09, 25 July 2012

OCA — Wed, 25 Jul 2012 16:09:00 GMT

←Older revision		Revision as of 16:09, 25 July 2012
Line 1:		Line 1:
	[[Image:3g5z.png\|left\|200px]]		[[Image:3g5z.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3g5z", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3g5z\| PDB=3g5z \| SCENE= }}		{{STRUCTURE_3g5z\| PDB=3g5z \| SCENE= }}

	===Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR===		===Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19289842}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19289842 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19289842}}		{{ABSTRACT_PUBMED_19289842}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Epidermal Growth Factor Receptor]]	+	*[[Epidermal Growth Factor Receptor\|Epidermal Growth Factor Receptor]]

	==Reference==		==Reference==

OCA: Protected "3g5z" [edit=sysop:move=sysop]

OCA — Sun, 30 Oct 2011 07:55:14 GMT

Protected "3g5z" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:55, 30 October 2011

OCA at 07:55, 30 October 2011

OCA — Sun, 30 Oct 2011 07:55:12 GMT

←Older revision		Revision as of 07:55, 30 October 2011
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3g5z.png\|left\|200px]]
-	[[Image:3g5z.~~jpg~~\|left\|200px]]	+

	<!--		<!--
Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	~~3G5Z~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5Z OCA].	+	[[3g5z]] is a 2 chain structure of [[Epidermal Growth Factor Receptor]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5Z OCA].
		+
		+	==See Also==
		+	*[[Epidermal Growth Factor Receptor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19289842~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019289842</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Burgess, A W.]]		[[Category: Burgess, A W.]]
Line 29:		Line 31:
	[[Category: Antibody]]		[[Category: Antibody]]
	[[Category: Immune system]]		[[Category: Immune system]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 10 17:13:36 2010''

OCA at 15:13, 10 February 2010

OCA — Wed, 10 Feb 2010 15:13:37 GMT

←Older revision		Revision as of 15:13, 10 February 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3g5z.jpg\|left\|200px]]

-	The ~~entry 3g5z~~ is ~~ON HOLD until sometime in~~ the ~~future~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3g5z", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3g5z\| PDB=3g5z \| SCENE= }}

-	~~Authors: Garrett, T.P.J., Burgess, A.W.~~	+	===Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR===

-	Description: Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Mar 11 11:~~10:~~51 2009~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19289842}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19289842 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19289842}}
		+
		+	==About this Structure==
		+	3G5Z is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5Z OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19289842</ref><references group="xtra"/>
		+	[[Category: Mus musculus]]
		+	[[Category: Burgess, A W.]]
		+	[[Category: Garrett, T P.J.]]
		+	[[Category: Antibody]]
		+	[[Category: Immune system]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 10 17:13:36 2010''