3g66 - Revision history

OCA at 07:00, 6 September 2023

OCA — Wed, 06 Sep 2023 07:00:06 GMT

←Older revision		Revision as of 07:00, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3g66' size='340' side='right'caption='[[3g66]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3g66' size='340' side='right'caption='[[3g66]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3g66]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus~~ pneumoniae~~" (klein 1884) weichselbaum 1886~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G66 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3g66]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G66 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MES:2~~-~~(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[3g69\|3g69]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>SP_0467, srtC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1313~~ "~~Diplococcus pneumoniae~~" (~~Klein 1884) Weichselbaum 1886]~~)</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g66 OCA], [https://pdbe.org/3g66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g66 RCSB], [https://www.ebi.ac.uk/pdbsum/3g66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g66 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g66 OCA], [https://pdbe.org/3g66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g66 RCSB], [https://www.ebi.ac.uk/pdbsum/3g66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g66 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A7KT63_STREE A7KT63_STREE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Achour, A]]	+	[[Category: Streptococcus pneumoniae]]
-	[[Category: Dessen, A]]	+	[[Category: Achour A]]
-	[[Category: Falker, S]]	+	[[Category: Dessen A]]
-	[[Category: Henriques-Normark, B]]	+	[[Category: Falker S]]
-	[[Category: Madhurantakam, C]]	+	[[Category: Henriques-Normark B]]
-	[[Category: Manzano, C]]	+	[[Category: Madhurantakam C]]
-	[[Category: Neiers, F]]	+	[[Category: Manzano C]]
-	[[Category: Normark, S]]	+	[[Category: Neiers F]]
-	~~[[Category: Pilus]]~~	+	[[Category: Normark S]]
-	~~[[Category: S. pneumoniae]]~~	+
-	~~[[Category: Sortase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:56, 9 March 2022

OCA — Wed, 09 Mar 2022 07:56:35 GMT

←Older revision		Revision as of 07:56, 9 March 2022
Line 1:		Line 1:

	==The crystal structure of Streptococcus pneumoniae Sortase C provides novel insights into catalysis as well as pilin substrate specificity==		==The crystal structure of Streptococcus pneumoniae Sortase C provides novel insights into catalysis as well as pilin substrate specificity==
-	<StructureSection load='3g66' size='340' side='right' caption='[[3g66]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='3g66' size='340' side='right'caption='[[3g66]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3g66]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G66 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3G66 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3g66]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G66 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g69\|3g69]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3g69\|3g69]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SP_0467, srtC ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SP_0467, srtC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3g66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g66 OCA], [~~http~~://pdbe.org/3g66 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3g66 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3g66 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3g66 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g66 OCA], [https://pdbe.org/3g66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g66 RCSB], [https://www.ebi.ac.uk/pdbsum/3g66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g66 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Achour, A]]		[[Category: Achour, A]]
	[[Category: Dessen, A]]		[[Category: Dessen, A]]

OCA at 07:57, 5 December 2018

OCA — Wed, 05 Dec 2018 07:57:16 GMT

←Older revision		Revision as of 07:57, 5 December 2018
Line 1:		Line 1:
		+
	==The crystal structure of Streptococcus pneumoniae Sortase C provides novel insights into catalysis as well as pilin substrate specificity==		==The crystal structure of Streptococcus pneumoniae Sortase C provides novel insights into catalysis as well as pilin substrate specificity==
	<StructureSection load='3g66' size='340' side='right' caption='[[3g66]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3g66' size='340' side='right' caption='[[3g66]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g69\|3g69]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g69\|3g69]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SP_0467, srtC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SP_0467, srtC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g66 OCA], [http://pdbe.org/3g66 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g66 RCSB], [http://www.ebi.ac.uk/pdbsum/3g66 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g66 OCA], [http://pdbe.org/3g66 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g66 RCSB], [http://www.ebi.ac.uk/pdbsum/3g66 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3g66 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/3g66_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/3g66_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 11:59, 8 February 2016

OCA — Mon, 08 Feb 2016 11:59:19 GMT

←Older revision		Revision as of 11:59, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3g66' size='340' side='right' caption='[[3g66]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3g66' size='340' side='right' caption='[[3g66]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3g66]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptococcus_pneumoniae Streptococcus~~ pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G66 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3g66]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G66 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g69\|3g69]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g69\|3g69]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SP_0467, srtC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 ~~Streptococcus~~ pneumoniae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SP_0467, srtC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g66 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g66 RCSB], [http://www.ebi.ac.uk/pdbsum/3g66 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g66 OCA], [http://pdbe.org/3g66 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g66 RCSB], [http://www.ebi.ac.uk/pdbsum/3g66 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g66 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3g66" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Streptococcus pneumoniae]]
	[[Category: Achour, A]]		[[Category: Achour, A]]
	[[Category: Dessen, A]]		[[Category: Dessen, A]]

OCA at 10:16, 3 December 2014

OCA — Wed, 03 Dec 2014 10:16:10 GMT

←Older revision		Revision as of 10:16, 3 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3g66.~~png~~\|~~left~~\|200px]]	+	==The crystal structure of Streptococcus pneumoniae Sortase C provides novel insights into catalysis as well as pilin substrate specificity==
		+	<StructureSection load='3g66' size='340' side='right' caption='[[3g66]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3g66]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G66 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g69\|3g69]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SP_0467, srtC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 Streptococcus pneumoniae])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g66 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g66 RCSB], [http://www.ebi.ac.uk/pdbsum/3g66 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/3g66_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The respiratory tract pathogen Streptococcus pneumoniae is a primary cause of morbidity and mortality worldwide. Pili enhance initial adhesion as well as the capacity of pneumococci to cause pneumonia and bacteremia. Pilus-associated sortases (SrtB, SrtC, and SrtD) are involved in the biogenesis of pneumococcal pili, composed of repeating units of RrgB that create the stalk to which the RrgA adhesin and the preferential pilus tip subunit RrgC are covalently associated. Using single sortase-expressing strains, we demonstrate that both pilin-polymerizing sortases SrtB and SrtC can covalently link pili to the peptidoglycan cell wall, a property shared with the non-pilus-polymerizing enzyme SrtD and the housekeeping sortase SrtA. Comparative analysis of the crystal structures of S. pneumoniae SrtC and SrtB revealed structural differences explaining the incapacity of SrtC, but not of SrtB, to incorporate RrgC into the pilus. Accordingly, site-directed mutagenesis of Thr(160) in SrtB to an arginine as in SrtC (Arg(160)) partially converted its substrate specificity into that of SrtC. Solving two crystal structures for SrtC suggests that an opening of a flexible lid and a concomitant cysteine rotation are important for catalysis and the activation of the catalytic cysteine of pilus-associated sortases.

-	~~{{STRUCTURE_3g66\| PDB=3g66 \| SCENE= }}~~	+	Two crystal structures of pneumococcal pilus sortase C provide novel insights into catalysis and substrate specificity.,Neiers F, Madhurantakam C, Falker S, Manzano C, Dessen A, Normark S, Henriques-Normark B, Achour A J Mol Biol. 2009 Oct 30;393(3):704-16. Epub 2009 Aug 31. PMID:19729023<ref>PMID:19729023</ref>

-	~~===The crystal structure~~ of ~~Streptococcus pneumoniae Sortase C provides novel insights into catalysis as well as pilin substrate specificity===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19729023}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3g66]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3G66 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019729023<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Streptococcus pneumoniae]]		[[Category: Streptococcus pneumoniae]]
-	[[Category: Achour, A.]]	+	[[Category: Achour, A]]
-	[[Category: Dessen, A.]]	+	[[Category: Dessen, A]]
-	[[Category: Falker, S.]]	+	[[Category: Falker, S]]
-	[[Category: Henriques-Normark, B.]]	+	[[Category: Henriques-Normark, B]]
-	[[Category: Madhurantakam, C.]]	+	[[Category: Madhurantakam, C]]
-	[[Category: Manzano, C.]]	+	[[Category: Manzano, C]]
-	[[Category: Neiers, F.]]	+	[[Category: Neiers, F]]
-	[[Category: Normark, S.]]	+	[[Category: Normark, S]]
	[[Category: Pilus]]		[[Category: Pilus]]
	[[Category: S. pneumoniae]]		[[Category: S. pneumoniae]]
	[[Category: Sortase]]		[[Category: Sortase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA: Protected "3g66" [edit=sysop:move=sysop]

OCA — Wed, 20 Feb 2013 14:34:08 GMT

Protected "3g66" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:34, 20 February 2013

OCA at 14:34, 20 February 2013

OCA — Wed, 20 Feb 2013 14:34:05 GMT

←Older revision		Revision as of 14:34, 20 February 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3g66.png\|left\|200px]]		[[Image:3g66.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3g66", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3g66\| PDB=3g66 \| SCENE= }}		{{STRUCTURE_3g66\| PDB=3g66 \| SCENE= }}

	===The crystal structure of Streptococcus pneumoniae Sortase C provides novel insights into catalysis as well as pilin substrate specificity===		===The crystal structure of Streptococcus pneumoniae Sortase C provides novel insights into catalysis as well as pilin substrate specificity===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19729023}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19729023 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19729023}}		{{ABSTRACT_PUBMED_19729023}}

	==About this Structure==		==About this Structure==
-	~~3G66~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G66 OCA].	+	[[3g66]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G66 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19729023~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019729023</ref><references group="xtra"/>
	[[Category: Streptococcus pneumoniae]]		[[Category: Streptococcus pneumoniae]]
	[[Category: Achour, A.]]		[[Category: Achour, A.]]
Line 37:		Line 25:
	[[Category: Sortase]]		[[Category: Sortase]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 28 09:20:07 2009''

OCA at 07:20, 28 October 2009

OCA — Wed, 28 Oct 2009 07:20:08 GMT

←Older revision		Revision as of 07:20, 28 October 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3g66.~~jpg~~\|left\|200px]]	+	[[Image:3g66.png\|left\|200px]]

	<!--		<!--
Line 12:		Line 12:
	===The crystal structure of Streptococcus pneumoniae Sortase C provides novel insights into catalysis as well as pilin substrate specificity===		===The crystal structure of Streptococcus pneumoniae Sortase C provides novel insights into catalysis as well as pilin substrate specificity===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19729023}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19729023 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19729023}}

	==About this Structure==		==About this Structure==
	3G66 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G66 OCA].		3G66 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G66 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19729023</ref><references group="xtra"/>
	[[Category: Streptococcus pneumoniae]]		[[Category: Streptococcus pneumoniae]]
	[[Category: Achour, A.]]		[[Category: Achour, A.]]
Line 29:		Line 38:
	[[Category: Transferase]]		[[Category: Transferase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Sep 3 16~~:10:58 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 28 09:20:07 2009''

OCA at 13:10, 3 September 2009

OCA — Thu, 03 Sep 2009 13:10:59 GMT

←Older revision		Revision as of 13:10, 3 September 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3g66.jpg\|left\|200px]]

-	The ~~entry 3g66~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3g66", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3g66\| PDB=3g66 \| SCENE= }}

-	~~Authors: Neiers, F., Madhurantakam,~~ C~~., Falker, S., Manzano, C., Dessen, A., Normark, S., Henriques-Normark, B., Achour, A.~~	+	===The crystal structure of Streptococcus pneumoniae Sortase C provides novel insights into catalysis as well as pilin substrate specificity===

-	Description: The crystal structure of Streptococcus pneumoniae Sortase C provides novel insights into catalysis as well as pilin substrate specificity

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jun 10 17~~:56:39 2009''	+	==About this Structure==
		+	3G66 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G66 OCA].
		+	[[Category: Streptococcus pneumoniae]]
		+	[[Category: Achour, A.]]
		+	[[Category: Dessen, A.]]
		+	[[Category: Falker, S.]]
		+	[[Category: Henriques-Normark, B.]]
		+	[[Category: Madhurantakam, C.]]
		+	[[Category: Manzano, C.]]
		+	[[Category: Neiers, F.]]
		+	[[Category: Normark, S.]]
		+	[[Category: Pilus]]
		+	[[Category: S. pneumoniae]]
		+	[[Category: Sortase]]
		+	[[Category: Transferase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Sep 3 16:10:58 2009''

OCA at 14:56, 10 June 2009

OCA — Wed, 10 Jun 2009 14:56:39 GMT

←Older revision		Revision as of 14:56, 10 June 2009
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3g66 is ON HOLD	+	The entry 3g66 is ON HOLD until Paper Publication

	Authors: Neiers, F., Madhurantakam, C., Falker, S., Manzano, C., Dessen, A., Normark, S., Henriques-Normark, B., Achour, A.		Authors: Neiers, F., Madhurantakam, C., Falker, S., Manzano, C., Dessen, A., Normark, S., Henriques-Normark, B., Achour, A.
Line 7:		Line 7:
	Description: The crystal structure of Streptococcus pneumoniae Sortase C provides novel insights into catalysis as well as pilin substrate specificity		Description: The crystal structure of Streptococcus pneumoniae Sortase C provides novel insights into catalysis as well as pilin substrate specificity

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Feb 25 09:26~~:56 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 10 17:56:39 2009''