3g6u - Revision history

OCA at 07:00, 6 September 2023

OCA — Wed, 06 Sep 2023 07:00:35 GMT

←Older revision		Revision as of 07:00, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3g6u' size='340' side='right'caption='[[3g6u]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3g6u' size='340' side='right'caption='[[3g6u]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3g6u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G6U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3g6u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G6U FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[3fyl\|3fyl]], [[3g6p\|3g6p]], [[3g6q\|3g6q]], [[3g6r\|3g6r]], [[3g6t\|3g6t]], [[3g8x\|3g8x]], [[3g97\|3g97]], [[3g99\|3g99]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">Grl, Nr3c1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g6u OCA], [https://pdbe.org/3g6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g6u RCSB], [https://www.ebi.ac.uk/pdbsum/3g6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g6u ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g6u OCA], [https://pdbe.org/3g6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g6u RCSB], [https://www.ebi.ac.uk/pdbsum/3g6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g6u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GCR_RAT GCR_RAT]] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation (By similarity).<ref>PMID:12917342</ref>	+	[https://www.uniprot.org/uniprot/GCR_RAT GCR_RAT] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation (By similarity).<ref>PMID:12917342</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Meijsing, S H~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Pufall, M A~~]]	+	[[Category: Meijsing SH]]
-	[[Category: ~~Yamamoto, K R~~]]	+	[[Category: Pufall MA]]
-	[[Category: ~~Allostery]]~~	+	[[Category: Yamamoto KR]]
-	~~[[Category: Alternative initiation]]~~	+
-	~~[[Category: Chromatin regulator]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Glucocorticoid]]~~	+
-	~~[[Category: Hormone]]~~	+
-	~~[[Category: Lever arm]]~~	+
-	~~[[Category: Lipid-binding]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Steroid-binding]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation]]~~	+
-	~~[[Category: Transcription-dna complex]]~~	+
-	~~[[Category: Ubl conjugation]]~~	+
-	~~[[Category: Zinc]]~~	+
-	~~[[Category: Zinc-finger~~]]	+

OCA at 07:57, 9 March 2022

OCA — Wed, 09 Mar 2022 07:57:11 GMT

←Older revision		Revision as of 07:57, 9 March 2022
Line 1:		Line 1:

	==GR DNA-binding domain:FKBP5 16bp complex-49==		==GR DNA-binding domain:FKBP5 16bp complex-49==
-	<StructureSection load='3g6u' size='340' side='right' caption='[[3g6u]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='3g6u' size='340' side='right'caption='[[3g6u]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3g6u]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G6U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3G6U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3g6u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G6U FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fyl\|3fyl]], [[3g6p\|3g6p]], [[3g6q\|3g6q]], [[3g6r\|3g6r]], [[3g6t\|3g6t]], [[3g8x\|3g8x]], [[3g97\|3g97]], [[3g99\|3g99]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3fyl\|3fyl]], [[3g6p\|3g6p]], [[3g6q\|3g6q]], [[3g6r\|3g6r]], [[3g6t\|3g6t]], [[3g8x\|3g8x]], [[3g97\|3g97]], [[3g99\|3g99]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Grl, Nr3c1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Grl, Nr3c1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3g6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g6u OCA], [~~http~~://pdbe.org/3g6u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3g6u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3g6u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3g6u ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g6u OCA], [https://pdbe.org/3g6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g6u RCSB], [https://www.ebi.ac.uk/pdbsum/3g6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g6u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GCR_RAT GCR_RAT]] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation (By similarity).<ref>PMID:12917342</ref>	+	[[https://www.uniprot.org/uniprot/GCR_RAT GCR_RAT]] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation (By similarity).<ref>PMID:12917342</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/3g6u_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/3g6u_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 3g6u" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3g6u" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Glucocorticoid receptor 3D structures\|Glucocorticoid receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Meijsing, S H]]		[[Category: Meijsing, S H]]
	[[Category: Pufall, M A]]		[[Category: Pufall, M A]]

OCA at 06:58, 1 November 2017

OCA — Wed, 01 Nov 2017 06:58:09 GMT

←Older revision		Revision as of 06:58, 1 November 2017
Line 1:		Line 1:
		+
	==GR DNA-binding domain:FKBP5 16bp complex-49==		==GR DNA-binding domain:FKBP5 16bp complex-49==
	<StructureSection load='3g6u' size='340' side='right' caption='[[3g6u]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3g6u' size='340' side='right' caption='[[3g6u]], [[Resolution\|resolution]] 1.90Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fyl\|3fyl]], [[3g6p\|3g6p]], [[3g6q\|3g6q]], [[3g6r\|3g6r]], [[3g6t\|3g6t]], [[3g8x\|3g8x]], [[3g97\|3g97]], [[3g99\|3g99]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fyl\|3fyl]], [[3g6p\|3g6p]], [[3g6q\|3g6q]], [[3g6r\|3g6r]], [[3g6t\|3g6t]], [[3g8x\|3g8x]], [[3g97\|3g97]], [[3g99\|3g99]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Grl, Nr3c1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Grl, Nr3c1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g6u OCA], [http://pdbe.org/3g6u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g6u RCSB], [http://www.ebi.ac.uk/pdbsum/3g6u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g6u OCA], [http://pdbe.org/3g6u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g6u RCSB], [http://www.ebi.ac.uk/pdbsum/3g6u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3g6u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 3g6u" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3g6u" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Glucocorticoid receptor\|Glucocorticoid receptor]]
	== References ==		== References ==
	<references/>		<references/>
Line 43:		Line 41:
	[[Category: Alternative initiation]]		[[Category: Alternative initiation]]
	[[Category: Chromatin regulator]]		[[Category: Chromatin regulator]]
		+	[[Category: Cytoplasm]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
	[[Category: Glucocorticoid]]		[[Category: Glucocorticoid]]
Line 51:		Line 50:
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
		+	[[Category: Polymorphism]]
	[[Category: Receptor]]		[[Category: Receptor]]
	[[Category: Steroid-binding]]		[[Category: Steroid-binding]]
Line 56:		Line 56:
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
	[[Category: Transcription-dna complex]]		[[Category: Transcription-dna complex]]
		+	[[Category: Ubl conjugation]]
		+	[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

OCA at 12:01, 8 February 2016

OCA — Mon, 08 Feb 2016 12:01:56 GMT

←Older revision		Revision as of 12:01, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3g6u' size='340' side='right' caption='[[3g6u]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3g6u' size='340' side='right' caption='[[3g6u]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3g6u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G6U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G6U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3g6u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G6U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G6U FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fyl\|3fyl]], [[3g6p\|3g6p]], [[3g6q\|3g6q]], [[3g6r\|3g6r]], [[3g6t\|3g6t]], [[3g8x\|3g8x]], [[3g97\|3g97]], [[3g99\|3g99]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fyl\|3fyl]], [[3g6p\|3g6p]], [[3g6q\|3g6q]], [[3g6r\|3g6r]], [[3g6t\|3g6t]], [[3g8x\|3g8x]], [[3g97\|3g97]], [[3g99\|3g99]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Grl, Nr3c1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Grl, Nr3c1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g6u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g6u RCSB], [http://www.ebi.ac.uk/pdbsum/3g6u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g6u OCA], [http://pdbe.org/3g6u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g6u RCSB], [http://www.ebi.ac.uk/pdbsum/3g6u PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g6u ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3g6u" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Meijsing, S H]]		[[Category: Meijsing, S H]]
	[[Category: Pufall, M A]]		[[Category: Pufall, M A]]

OCA at 23:10, 24 December 2014

OCA — Wed, 24 Dec 2014 23:10:00 GMT

←Older revision		Revision as of 23:10, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3g6u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G6U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G6U FirstGlance]. <br>		<table><tr><td colspan='2'>[[3g6u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G6U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G6U FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fyl\|3fyl]], [[3g6p\|3g6p]], [[3g6q\|3g6q]], [[3g6r\|3g6r]], [[3g6t\|3g6t]], [[3g8x\|3g8x]], [[3g97\|3g97]], [[3g99\|3g99]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fyl\|3fyl]], [[3g6p\|3g6p]], [[3g6q\|3g6q]], [[3g6r\|3g6r]], [[3g6t\|3g6t]], [[3g8x\|3g8x]], [[3g97\|3g97]], [[3g99\|3g99]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Grl, Nr3c1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Grl, Nr3c1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g6u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g6u RCSB], [http://www.ebi.ac.uk/pdbsum/3g6u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g6u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g6u RCSB], [http://www.ebi.ac.uk/pdbsum/3g6u PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GCR_RAT GCR_RAT]] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation (By similarity).<ref>PMID:12917342</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Meijsing, S H.]]	+	[[Category: Meijsing, S H]]
-	[[Category: Pufall, M A.]]	+	[[Category: Pufall, M A]]
-	[[Category: Yamamoto, K R.]]	+	[[Category: Yamamoto, K R]]
	[[Category: Allostery]]		[[Category: Allostery]]
	[[Category: Alternative initiation]]		[[Category: Alternative initiation]]

OCA at 13:27, 29 September 2014

OCA — Mon, 29 Sep 2014 13:27:54 GMT

←Older revision		Revision as of 13:27, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3g6u.~~png~~\|~~left~~\|200px]]	+	==GR DNA-binding domain:FKBP5 16bp complex-49==
		+	<StructureSection load='3g6u' size='340' side='right' caption='[[3g6u]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3g6u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G6U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G6U FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3fyl\|3fyl]], [[3g6p\|3g6p]], [[3g6q\|3g6q]], [[3g6r\|3g6r]], [[3g6t\|3g6t]], [[3g8x\|3g8x]], [[3g97\|3g97]], [[3g99\|3g99]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Grl, Nr3c1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g6u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g6u RCSB], [http://www.ebi.ac.uk/pdbsum/3g6u PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/3g6u_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Genes are not simply turned on or off, but instead their expression is fine-tuned to meet the needs of a cell. How genes are modulated so precisely is not well understood. The glucocorticoid receptor (GR) regulates target genes by associating with specific DNA binding sites, the sequences of which differ between genes. Traditionally, these binding sites have been viewed only as docking sites. Using structural, biochemical, and cell-based assays, we show that GR binding sequences, differing by as little as a single base pair, differentially affect GR conformation and regulatory activity. We therefore propose that DNA is a sequence-specific allosteric ligand of GR that tailors the activity of the receptor toward specific target genes.

-	~~{{STRUCTURE_3g6u\| PDB=3g6u \| SCENE= }}~~	+	DNA binding site sequence directs glucocorticoid receptor structure and activity.,Meijsing SH, Pufall MA, So AY, Bates DL, Chen L, Yamamoto KR Science. 2009 Apr 17;324(5925):407-10. PMID:19372434<ref>PMID:19372434</ref>

-	~~===GR DNA-binding domain:FKBP5 16bp complex-49===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19372434}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3g6u]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3G6U OCA].~~	+

	==See Also==		==See Also==
	*[[Glucocorticoid receptor\|Glucocorticoid receptor]]		*[[Glucocorticoid receptor\|Glucocorticoid receptor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019372434<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Meijsing, S H.]]		[[Category: Meijsing, S H.]]

OCA at 10:04, 20 October 2012

OCA — Sat, 20 Oct 2012 10:04:05 GMT

←Older revision		Revision as of 10:04, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3g6u]] is a 4 chain structure ~~of [[Glucocorticoid receptor]]~~ with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G6U OCA].	+	[[3g6u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G6U OCA].

	==See Also==		==See Also==

OCA: Protected "3g6u" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 00:52:21 GMT

Protected "3g6u" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:52, 26 July 2012

OCA at 00:52, 26 July 2012

OCA — Thu, 26 Jul 2012 00:52:19 GMT

←Older revision		Revision as of 00:52, 26 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3g6u.png\|left\|200px]]		[[Image:3g6u.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3g6u", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3g6u\| PDB=3g6u \| SCENE= }}		{{STRUCTURE_3g6u\| PDB=3g6u \| SCENE= }}

	===GR DNA-binding domain:FKBP5 16bp complex-49===		===GR DNA-binding domain:FKBP5 16bp complex-49===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19372434}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19372434 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19372434}}		{{ABSTRACT_PUBMED_19372434}}

	==About this Structure==		==About this Structure==
-	~~3G6U~~ is a 4 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G6U OCA].	+	[[3g6u]] is a 4 chain structure of [[Glucocorticoid receptor]] with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G6U OCA].
		+
		+	==See Also==
		+	*[[Glucocorticoid receptor\|Glucocorticoid receptor]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19372434~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019372434</ref><references group="xtra"/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Meijsing, S H.]]		[[Category: Meijsing, S H.]]
Line 31:		Line 22:
	[[Category: Alternative initiation]]		[[Category: Alternative initiation]]
	[[Category: Chromatin regulator]]		[[Category: Chromatin regulator]]
-	[[Category: Cytoplasm]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
	[[Category: Glucocorticoid]]		[[Category: Glucocorticoid]]
Line 40:		Line 30:
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
-	[[Category: Polymorphism]]
	[[Category: Receptor]]		[[Category: Receptor]]
	[[Category: Steroid-binding]]		[[Category: Steroid-binding]]
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
-	[[Category: Transcription/dna complex]]	+	[[Category: Transcription-dna complex]]
-	~~[[Category: Ubl conjugation]]~~	+
-	~~[[Category: Zinc~~]]	+
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 3 09:37:51 2009''

OCA at 06:37, 3 June 2009

OCA — Wed, 03 Jun 2009 06:37:51 GMT

←Older revision		Revision as of 06:37, 3 June 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3g6u.~~jpg~~\|left\|200px]]	+	[[Image:3g6u.png\|left\|200px]]

	<!--		<!--
Line 12:		Line 12:
	===GR DNA-binding domain:FKBP5 16bp complex-49===		===GR DNA-binding domain:FKBP5 16bp complex-49===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19372434}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19372434 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19372434}}

	==About this Structure==		==About this Structure==
	3G6U is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G6U OCA].		3G6U is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G6U OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19372434</ref><references group="xtra"/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Meijsing, S H.]]		[[Category: Meijsing, S H.]]
Line 41:		Line 50:
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Apr 22 11~~:37:09 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 3 09:37:51 2009''