3g83 - Revision history

OCA at 07:01, 6 September 2023

OCA — Wed, 06 Sep 2023 07:01:44 GMT

←Older revision		Revision as of 07:01, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3g83' size='340' side='right'caption='[[3g83]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3g83' size='340' side='right'caption='[[3g83]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3g83]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G83 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G83 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3g83]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G83 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G83 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~, ~~<scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2ork\|2ork]], [[2os9\|2os9]], [[2orj\|2orj]], [[2ggx\|2ggx]], [[2ggu\|2ggu]], [[2ria\|2ria]], [[3g84\|3g84]], [[3g81\|3g81]]~~</~~div~~><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=PRD_900111:2alpha-alpha-mannobiose'>PRD_900111</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">SFTPD, PSPD, SFTP4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g83 OCA], [https://pdbe.org/3g83 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g83 RCSB], [https://www.ebi.ac.uk/pdbsum/3g83 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g83 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g83 OCA], [https://pdbe.org/3g83 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g83 RCSB], [https://www.ebi.ac.uk/pdbsum/3g83 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g83 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SFTPD_HUMAN SFTPD_HUMAN]] Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.	+	[https://www.uniprot.org/uniprot/SFTPD_HUMAN SFTPD_HUMAN] Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Head~~, J F]]~~	+	[[Category: Head JF]]
-	~~[[Category: Carbohydrate recognition domain]]~~	+
-	~~[[Category: Collagen]]~~	+
-	~~[[Category: Extracellular matrix]]~~	+
-	~~[[Category: Gaseous exchange]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Hydroxylation]]~~	+
-	~~[[Category: Lectin]]~~	+
-	~~[[Category: Secreted]]~~	+
-	~~[[Category: Sugar binding protein]]~~	+
-	~~[[Category: Surface film]]~~	+
-	~~[[Category: Surfactant protein]]~~	+
-	~~[[Category: Trimeric~~]]	+

OCA at 07:58, 9 March 2022

OCA — Wed, 09 Mar 2022 07:58:08 GMT

←Older revision		Revision as of 07:58, 9 March 2022
Line 1:		Line 1:

	==Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with alpha 1,2 dimannose.==		==Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with alpha 1,2 dimannose.==
-	<StructureSection load='3g83' size='340' side='right' caption='[[3g83]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='3g83' size='340' side='right'caption='[[3g83]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3g83]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G83 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3G83 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3g83]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G83 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G83 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ork\|2ork]], [[2os9\|2os9]], [[2orj\|2orj]], [[2ggx\|2ggx]], [[2ggu\|2ggu]], [[2ria\|2ria]], [[3g84\|3g84]], [[3g81\|3g81]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ork\|2ork]], [[2os9\|2os9]], [[2orj\|2orj]], [[2ggx\|2ggx]], [[2ggu\|2ggu]], [[2ria\|2ria]], [[3g84\|3g84]], [[3g81\|3g81]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SFTPD, PSPD, SFTP4 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SFTPD, PSPD, SFTP4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3g83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g83 OCA], [~~http~~://pdbe.org/3g83 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3g83 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3g83 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3g83 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g83 OCA], [https://pdbe.org/3g83 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g83 RCSB], [https://www.ebi.ac.uk/pdbsum/3g83 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g83 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SFTPD_HUMAN SFTPD_HUMAN]] Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.	+	[[https://www.uniprot.org/uniprot/SFTPD_HUMAN SFTPD_HUMAN]] Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g8/3g83_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g8/3g83_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Head, J F]]		[[Category: Head, J F]]
	[[Category: Carbohydrate recognition domain]]		[[Category: Carbohydrate recognition domain]]

OCA at 06:07, 5 August 2016

OCA — Fri, 05 Aug 2016 06:07:33 GMT

←Older revision		Revision as of 06:07, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with alpha 1,2 dimannose.==		==Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with alpha 1,2 dimannose.==
	<StructureSection load='3g83' size='340' side='right' caption='[[3g83]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3g83' size='340' side='right' caption='[[3g83]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3g83]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G83 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G83 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3g83]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G83 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G83 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ork\|2ork]], [[2os9\|2os9]], [[2orj\|2orj]], [[2ggx\|2ggx]], [[2ggu\|2ggu]], [[2ria\|2ria]], [[3g84\|3g84]], [[3g81\|3g81]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ork\|2ork]], [[2os9\|2os9]], [[2orj\|2orj]], [[2ggx\|2ggx]], [[2ggu\|2ggu]], [[2ria\|2ria]], [[3g84\|3g84]], [[3g81\|3g81]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SFTPD, PSPD, SFTP4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SFTPD, PSPD, SFTP4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g83 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g83 RCSB], [http://www.ebi.ac.uk/pdbsum/3g83 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g83 OCA], [http://pdbe.org/3g83 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g83 RCSB], [http://www.ebi.ac.uk/pdbsum/3g83 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3g83 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g83 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3g83" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Head, J F]]		[[Category: Head, J F]]
	[[Category: Carbohydrate recognition domain]]		[[Category: Carbohydrate recognition domain]]

OCA at 16:24, 25 December 2014

OCA — Thu, 25 Dec 2014 16:24:04 GMT

←Older revision		Revision as of 16:24, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g83 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g83 RCSB], [http://www.ebi.ac.uk/pdbsum/3g83 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g83 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g83 RCSB], [http://www.ebi.ac.uk/pdbsum/3g83 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SFTPD_HUMAN SFTPD_HUMAN]] Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:14, 3 December 2014

OCA — Wed, 03 Dec 2014 10:14:29 GMT

←Older revision		Revision as of 10:14, 3 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3g83.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with alpha 1,2 dimannose.==
		+	<StructureSection load='3g83' size='340' side='right' caption='[[3g83]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3g83]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G83 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G83 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ork\|2ork]], [[2os9\|2os9]], [[2orj\|2orj]], [[2ggx\|2ggx]], [[2ggu\|2ggu]], [[2ria\|2ria]], [[3g84\|3g84]], [[3g81\|3g81]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SFTPD, PSPD, SFTP4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g83 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g83 RCSB], [http://www.ebi.ac.uk/pdbsum/3g83 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g8/3g83_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Surfactant protein D (SP-D) plays important roles in antiviral host defense. Although SP-D shows a preference for glucose/maltose, the protein also recognizes D-mannose and a variety of mannose-rich microbial ligands. This latter preference prompted an examination of the mechanisms of mannose recognition, particularly as they relate to high-mannose viral glycans. Trimeric neck+carbohydrate recognition domains from human SP-D (hNCRD) preferred alpha1-2 linked dimannose (DM) over the branched trimannose (TM) core, alpha1-3 or alpha1-6 DM, or D-mannose. Previous studies have shown residues flanking the carbohydrate binding site can fine-tune ligand recognition. A mutant with valine at 343 (R343V) showed enhanced binding to mannan relative to wild-type and R343A. No alteration in affinity was observed for D-mannose or for alpha1-3 or alpha1-6 linked DM; however, substantially increased affinity was observed for alpha1-2DM. Both proteins showed efficient recognition of linear and branched sub-domains of high-mannose glycans on carbohydrate microarrays, and R343V showed increased binding to a subset of the oligosaccharides. Crystallographic analysis of an R343V complex with 1,2-DM showed a novel mode of binding. The disaccharide is bound to calcium by the reducing sugar ring, and a stabilizing H-bond is formed between the 2-OH of the non-reducing sugar ring and Arg349. Although hNCRDs show negligible binding to influenza A virus (IAV), R343V showed markedly enhanced viral neutralizing activity. Hydrophobic substitutions for Arg343 selectively blocked binding of a monoclonal antibody (Hyb 246-05) that inhibits IAV binding activity. Our findings demonstrate an extended ligand binding site for mannosylated ligands and the significant contribution of the 343 side chain to specific recognition of multivalent microbial ligands, including high-mannose viral glycans.

-	~~{{STRUCTURE_3g83\| PDB=3g83 \| SCENE= }}~~	+	Recognition of Mannosylated Ligands and Influenza A Virus by Human SP-D: Contributions of an Extended Site and Residue 343.,Crouch E, Hartshorn K, Horlacher T, McDonald B, Smith K, Cafarella T, Seaton B, Seeberger P, Head J Biochemistry. 2009 Feb 27. PMID:19249874<ref>PMID:19249874</ref>

-	~~===Crystal structure~~ of the ~~trimeric neck and carbohydrate recognition domain~~ of ~~human surfactant protein D in complex with alpha 1,2 dimannose~~.~~===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19249874}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3g83]] is a 3 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G83 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019249874<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Head, J F.]]	+	[[Category: Head, J F]]
	[[Category: Carbohydrate recognition domain]]		[[Category: Carbohydrate recognition domain]]
	[[Category: Collagen]]		[[Category: Collagen]]

OCA at 14:30, 20 February 2013

OCA — Wed, 20 Feb 2013 14:30:03 GMT

←Older revision		Revision as of 14:30, 20 February 2013
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	[[Image:3g83.png\|left\|200px]]		[[Image:3g83.png\|left\|200px]]

-	<!--
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-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3g83\| PDB=3g83 \| SCENE= }}		{{STRUCTURE_3g83\| PDB=3g83 \| SCENE= }}

	===Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with alpha 1,2 dimannose.===		===Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with alpha 1,2 dimannose.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19249874}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19249874 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_19249874}}		{{ABSTRACT_PUBMED_19249874}}

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19249874~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019249874</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Head, J F.]]		[[Category: Head, J F.]]
		+	[[Category: Carbohydrate recognition domain]]
		+	[[Category: Collagen]]
		+	[[Category: Extracellular matrix]]
		+	[[Category: Gaseous exchange]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Hydroxylation]]
		+	[[Category: Lectin]]
		+	[[Category: Secreted]]
		+	[[Category: Sugar binding protein]]
		+	[[Category: Surface film]]
		+	[[Category: Surfactant protein]]
		+	[[Category: Trimeric]]

OCA: Protected "3g83" [edit=sysop:move=sysop]

OCA — Wed, 12 Jan 2011 05:23:04 GMT

Protected "3g83" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:23, 12 January 2011

OCA at 05:23, 12 January 2011

OCA — Wed, 12 Jan 2011 05:23:01 GMT

←Older revision		Revision as of 05:23, 12 January 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3g83.png\|left\|200px]]

-	The ~~entry 3g83~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3g83", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3g83\| PDB=3g83 \| SCENE= }}

-	~~Authors: Head~~, ~~J.F~~.	+	===Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with alpha 1,2 dimannose.===

-	Description: Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with alpha 1,2 dimannose.

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Sun Mar 22 10~~:24:~~05 2009''~~	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19249874}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19249874 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19249874}}
		+
		+	==About this Structure==
		+	[[3g83]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G83 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19249874</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Head, J F.]]

OCA at 08:24, 22 March 2009

OCA — Sun, 22 Mar 2009 08:24:06 GMT

←Older revision		Revision as of 08:24, 22 March 2009
Line 5:		Line 5:
	Authors: Head, J.F.		Authors: Head, J.F.

-	Description: ~~crystal~~ structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with alpha 1,2 dimannose.	+	Description: Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with alpha 1,2 dimannose.

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Feb 25 09~~:27:45 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 22 10:24:05 2009''

OCA: New page: '''Unreleased structure''' The entry 3g83 is ON HOLD Authors: Head, J.F. Description: crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant pro...

OCA — Wed, 25 Feb 2009 07:27:45 GMT

New page: '''Unreleased structure''' The entry 3g83 is ON HOLD Authors: Head, J.F. Description: crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant pro...

New page

'''Unreleased structure'''

The entry 3g83 is ON HOLD

Authors: Head, J.F.

Description: crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with alpha 1,2 dimannose.

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 25 09:27:45 2009''