3g8b - Revision history

OCA at 07:58, 9 March 2022

OCA — Wed, 09 Mar 2022 07:58:19 GMT

OCA at 08:12, 24 July 2019

OCA — Wed, 24 Jul 2019 08:12:23 GMT

←Older revision		Revision as of 08:12, 24 July 2019
Line 1:		Line 1:

	==T. thermophilus 16S rRNA G527 methyltransferase in complex with AdoMet in space group I222==		==T. thermophilus 16S rRNA G527 methyltransferase in complex with AdoMet in space group I222==
-	<StructureSection load='3g8b' size='340' side='right' caption='[[3g8b]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='3g8b' size='340' side='right'caption='[[3g8b]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3g8b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G8B FirstGlance]. <br>		<table><tr><td colspan='2'>[[3g8b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G8B FirstGlance]. <br>
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Thet8]]		[[Category: Thet8]]
	[[Category: Belardinelli, R]]		[[Category: Belardinelli, R]]

OCA at 05:09, 7 December 2018

OCA — Fri, 07 Dec 2018 05:09:15 GMT

←Older revision		Revision as of 05:09, 7 December 2018
Line 1:		Line 1:
		+
	==T. thermophilus 16S rRNA G527 methyltransferase in complex with AdoMet in space group I222==		==T. thermophilus 16S rRNA G527 methyltransferase in complex with AdoMet in space group I222==
	<StructureSection load='3g8b' size='340' side='right' caption='[[3g8b]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3g8b' size='340' side='right' caption='[[3g8b]], [[Resolution\|resolution]] 2.10Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g88\|3g88]], [[3g89\|3g89]], [[3g8a\|3g8a]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g88\|3g88]], [[3g89\|3g89]], [[3g8a\|3g8a]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gidB, rsmG, TTHA1971 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gidB, rsmG, TTHA1971 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g8b OCA], [http://pdbe.org/3g8b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g8b RCSB], [http://www.ebi.ac.uk/pdbsum/3g8b PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g8b OCA], [http://pdbe.org/3g8b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g8b RCSB], [http://www.ebi.ac.uk/pdbsum/3g8b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3g8b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g8/3g8b_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g8/3g8b_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 42:		Line 43:
	[[Category: Jogl, G]]		[[Category: Jogl, G]]
	[[Category: 16s rrna methyltransferase]]		[[Category: 16s rrna methyltransferase]]
		+	[[Category: Cytoplasm]]
	[[Category: Methyltransferase]]		[[Category: Methyltransferase]]
	[[Category: Rrna processing]]		[[Category: Rrna processing]]

OCA at 01:34, 7 February 2016

OCA — Sun, 07 Feb 2016 01:34:18 GMT

←Older revision		Revision as of 01:34, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3g8b' size='340' side='right' caption='[[3g8b]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3g8b' size='340' side='right' caption='[[3g8b]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3g8b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermus_thermophilus Thermus thermophilus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G8B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3g8b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G8B FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g88\|3g88]], [[3g89\|3g89]], [[3g8a\|3g8a]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g88\|3g88]], [[3g89\|3g89]], [[3g8a\|3g8a]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gidB, rsmG, TTHA1971 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~274 Thermus thermophilus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gidB, rsmG, TTHA1971 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g8b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g8b RCSB], [http://www.ebi.ac.uk/pdbsum/3g8b PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g8b OCA], [http://pdbe.org/3g8b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g8b RCSB], [http://www.ebi.ac.uk/pdbsum/3g8b PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g8b ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3g8b" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Thermus thermophilus~~]]	+	[[Category: Thet8]]
	[[Category: Belardinelli, R]]		[[Category: Belardinelli, R]]
	[[Category: Dahlberg, A E]]		[[Category: Dahlberg, A E]]

OCA at 05:42, 24 December 2014

OCA — Wed, 24 Dec 2014 05:42:10 GMT

←Older revision		Revision as of 05:42, 24 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g8b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g8b RCSB], [http://www.ebi.ac.uk/pdbsum/3g8b PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g8b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g8b RCSB], [http://www.ebi.ac.uk/pdbsum/3g8b PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RSMG_THET8 RSMG_THET8]] Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. Shows a marked preference for deproteinized 16S rRNA as substrate and is completely inactive with native 30S subunits as substrate.[HAMAP-Rule:MF_00074]<ref>PMID:19622680</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:03, 3 December 2014

OCA — Wed, 03 Dec 2014 10:03:23 GMT

←Older revision		Revision as of 10:03, 3 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3g8b.~~png~~\|~~left~~\|200px]]	+	==T. thermophilus 16S rRNA G527 methyltransferase in complex with AdoMet in space group I222==
		+	<StructureSection load='3g8b' size='340' side='right' caption='[[3g8b]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3g8b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G8B FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g88\|3g88]], [[3g89\|3g89]], [[3g8a\|3g8a]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gidB, rsmG, TTHA1971 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g8b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g8b RCSB], [http://www.ebi.ac.uk/pdbsum/3g8b PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g8/3g8b_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The RsmG methyltransferase is responsible for N(7) methylation of G527 of 16S rRNA in bacteria. Here, we report the identification of the Thermus thermophilus rsmG gene, the isolation of rsmG mutants, and the solution of RsmG X-ray crystal structures at up to 1.5 A resolution. Like their counterparts in other species, T. thermophilus rsmG mutants are weakly resistant to the aminoglycoside antibiotic streptomycin. Growth competition experiments indicate a physiological cost to loss of RsmG activity, consistent with the conservation of the modification site in the decoding region of the ribosome. In contrast to Escherichia coli RsmG, which has been reported to recognize only intact 30S subunits, T. thermophilus RsmG shows no in vitro methylation activity against native 30S subunits, only low activity with 30S subunits at low magnesium concentration, and maximum activity with deproteinized 16S rRNA. Cofactor-bound crystal structures of RsmG reveal a positively charged surface area remote from the active site that binds an adenosine monophosphate molecule. We conclude that an early assembly intermediate is the most likely candidate for the biological substrate of RsmG.

-	~~{{STRUCTURE_3g8b\| PDB=3g8b \| SCENE= }}~~	+	Structural and functional studies of the Thermus thermophilus 16S rRNA methyltransferase RsmG.,Gregory ST, Demirci H, Belardinelli R, Monshupanee T, Gualerzi C, Dahlberg AE, Jogl G RNA. 2009 Sep;15(9):1693-704. Epub 2009 Jul 21. PMID:19622680<ref>PMID:19622680</ref>

-	~~===T. thermophilus 16S rRNA G527 methyltransferase in complex with AdoMet in space group I222===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19622680}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3g8b]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Thermus_thermophilus Thermus thermophilus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3G8B OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019622680<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
-	[[Category: Belardinelli, R.]]	+	[[Category: Belardinelli, R]]
-	[[Category: Dahlberg, A E.]]	+	[[Category: Dahlberg, A E]]
-	[[Category: Demirci, H.]]	+	[[Category: Demirci, H]]
-	[[Category: Gregory, S T.]]	+	[[Category: Gregory, S T]]
-	[[Category: Gualerzi, C.]]	+	[[Category: Gualerzi, C]]
-	[[Category: Jogl, G.]]	+	[[Category: Jogl, G]]
	[[Category: 16s rrna methyltransferase]]		[[Category: 16s rrna methyltransferase]]
	[[Category: Methyltransferase]]		[[Category: Methyltransferase]]

OCA: Protected "3g8b" [edit=sysop:move=sysop]

OCA — Wed, 20 Feb 2013 14:09:45 GMT

Protected "3g8b" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:09, 20 February 2013

OCA at 14:09, 20 February 2013

OCA — Wed, 20 Feb 2013 14:09:41 GMT

←Older revision		Revision as of 14:09, 20 February 2013
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-	{{Seed}}
	[[Image:3g8b.png\|left\|200px]]		[[Image:3g8b.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3g8b", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3g8b\| PDB=3g8b \| SCENE= }}		{{STRUCTURE_3g8b\| PDB=3g8b \| SCENE= }}

	===T. thermophilus 16S rRNA G527 methyltransferase in complex with AdoMet in space group I222===		===T. thermophilus 16S rRNA G527 methyltransferase in complex with AdoMet in space group I222===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19622680}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19622680 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19622680}}		{{ABSTRACT_PUBMED_19622680}}

	==About this Structure==		==About this Structure==
-	~~3G8B~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G8B OCA].	+	[[3g8b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G8B OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19622680~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019622680</ref><references group="xtra"/>
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
	[[Category: Belardinelli, R.]]		[[Category: Belardinelli, R.]]
Line 32:		Line 20:
	[[Category: Jogl, G.]]		[[Category: Jogl, G.]]
	[[Category: 16s rrna methyltransferase]]		[[Category: 16s rrna methyltransferase]]
-	[[Category: Cytoplasm]]
	[[Category: Methyltransferase]]		[[Category: Methyltransferase]]
	[[Category: Rrna processing]]		[[Category: Rrna processing]]
Line 38:		Line 25:
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Translation]]		[[Category: Translation]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 9 08:20:07 2009''

OCA at 05:20, 9 September 2009

OCA — Wed, 09 Sep 2009 05:20:08 GMT

←Older revision		Revision as of 05:20, 9 September 2009
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	===T. thermophilus 16S rRNA G527 methyltransferase in complex with AdoMet in space group I222===		===T. thermophilus 16S rRNA G527 methyltransferase in complex with AdoMet in space group I222===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19622680}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19622680 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19622680}}

	==About this Structure==		==About this Structure==
	3G8B is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G8B OCA].		3G8B is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G8B OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19622680</ref><references group="xtra"/>
	[[Category: Thermus thermophilus]]		[[Category: Thermus thermophilus]]
	[[Category: Belardinelli, R.]]		[[Category: Belardinelli, R.]]
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	[[Category: Translation]]		[[Category: Translation]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug 19 13~~:57:59 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 9 08:20:07 2009''

OCA at 10:58, 19 August 2009

OCA — Wed, 19 Aug 2009 10:58:02 GMT

←Older revision		Revision as of 10:58, 19 August 2009
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-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jul 1 09~~:39:33 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 19 13:57:59 2009''

←Older revision		Revision as of 07:58, 9 March 2022
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	<StructureSection load='3g8b' size='340' side='right'caption='[[3g8b]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3g8b' size='340' side='right'caption='[[3g8b]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3g8b]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G8B OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3G8B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3g8b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G8B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G8B FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3g88\|3g88]], [[3g89\|3g89]], [[3g8a\|3g8a]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3g88\|3g88]], [[3g89\|3g89]], [[3g8a\|3g8a]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gidB, rsmG, TTHA1971 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gidB, rsmG, TTHA1971 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3g8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g8b OCA], [~~http~~://pdbe.org/3g8b PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3g8b RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3g8b PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3g8b ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g8b OCA], [https://pdbe.org/3g8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g8b RCSB], [https://www.ebi.ac.uk/pdbsum/3g8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g8b ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RSMG_THET8 RSMG_THET8]] Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. Shows a marked preference for deproteinized 16S rRNA as substrate and is completely inactive with native 30S subunits as substrate.[HAMAP-Rule:MF_00074]<ref>PMID:19622680</ref>	+	[[https://www.uniprot.org/uniprot/RSMG_THET8 RSMG_THET8]] Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. Shows a marked preference for deproteinized 16S rRNA as substrate and is completely inactive with native 30S subunits as substrate.[HAMAP-Rule:MF_00074]<ref>PMID:19622680</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]