3g8e - Revision history

OCA at 15:37, 1 November 2023

OCA — Wed, 01 Nov 2023 15:37:12 GMT

←Older revision		Revision as of 15:37, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3g8e' size='340' side='right'caption='[[3g8e]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='3g8e' size='340' side='right'caption='[[3g8e]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3g8e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G8E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3g8e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G8E FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=IS1:3~~-[~~(1E)-3-OXO-3-({4-~~[~~1-(PHENYLCARBONYL)PIPERIDIN-4-YL]BUTYL}AMINO)PROP-1-EN-1-YL]-1-BETA-D-RIBOFURANOSYLPYRIDINIUM'>IS1</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[2g97\|2g97]], [[2g96\|2g96]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IS1:3-[(1E)-3-OXO-3-({4-[1-(PHENYLCARBONYL)PIPERIDIN-4-YL]BUTYL}AMINO)PROP-1-EN-1-YL]-1-BETA-D-RIBOFURANOSYLPYRIDINIUM'>IS1</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>visfatin ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=10116 Buffalo rat])</td></tr>~~	+
-	~~<tr id='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number~~ [~~https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=2.~~4~~.2.12 2.~~4~~.2.12~~] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g8e OCA], [https://pdbe.org/3g8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g8e RCSB], [https://www.ebi.ac.uk/pdbsum/3g8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g8e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g8e OCA], [https://pdbe.org/3g8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g8e RCSB], [https://www.ebi.ac.uk/pdbsum/3g8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g8e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NAMPT_RAT NAMPT_RAT]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).	+	[https://www.uniprot.org/uniprot/NAMPT_RAT NAMPT_RAT] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Nicotinamide phosphoribosyltransferase~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Bae~~, M H~~]]	+	[[Category: Bae MH]]
-	[[Category: Eom~~, S H~~]]	+	[[Category: Eom SH]]
-	[[Category: Im, I]]	+	[[Category: Im I]]
-	[[Category: Kang~~, G B~~]]	+	[[Category: Kang GB]]
-	[[Category: Kim~~, M K~~]]	+	[[Category: Kim MK]]
-	[[Category: Kim~~, Y C]]~~	+	[[Category: Kim YC]]
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Glycosyltransferase]]~~	+
-	~~[[Category: Is001]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Protein-ligand complex]]~~	+
-	~~[[Category: Pyridine nucleotide biosynthesis]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:58, 9 March 2022

OCA — Wed, 09 Mar 2022 07:58:23 GMT

←Older revision		Revision as of 07:58, 9 March 2022
Line 1:		Line 1:

	==Crystal Structure of Rattus norvegicus Visfatin/PBEF/Nampt in Complex with an FK866-based inhibitor==		==Crystal Structure of Rattus norvegicus Visfatin/PBEF/Nampt in Complex with an FK866-based inhibitor==
-	<StructureSection load='3g8e' size='340' side='right' caption='[[3g8e]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='3g8e' size='340' side='right'caption='[[3g8e]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3g8e]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G8E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3G8E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3g8e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G8E FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IS1:3-[(1E)-3-OXO-3-({4-[1-(PHENYLCARBONYL)PIPERIDIN-4-YL]BUTYL}AMINO)PROP-1-EN-1-YL]-1-BETA-D-RIBOFURANOSYLPYRIDINIUM'>IS1</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IS1:3-[(1E)-3-OXO-3-({4-[1-(PHENYLCARBONYL)PIPERIDIN-4-YL]BUTYL}AMINO)PROP-1-EN-1-YL]-1-BETA-D-RIBOFURANOSYLPYRIDINIUM'>IS1</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g97\|2g97]], [[2g96\|2g96]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2g97\|2g97]], [[2g96\|2g96]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">visfatin ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">visfatin ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3g8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g8e OCA], [~~http~~://pdbe.org/3g8e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3g8e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3g8e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3g8e ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g8e OCA], [https://pdbe.org/3g8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g8e RCSB], [https://www.ebi.ac.uk/pdbsum/3g8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g8e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NAMPT_RAT NAMPT_RAT]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).	+	[[https://www.uniprot.org/uniprot/NAMPT_RAT NAMPT_RAT]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:

	==See Also==		==See Also==
-	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]	+	*[[Phosphoribosyltransferase 3D structures\|Phosphoribosyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Nicotinamide phosphoribosyltransferase]]		[[Category: Nicotinamide phosphoribosyltransferase]]
	[[Category: Bae, M H]]		[[Category: Bae, M H]]

OCA at 05:41, 7 December 2018

OCA — Fri, 07 Dec 2018 05:41:58 GMT

←Older revision		Revision as of 05:41, 7 December 2018
Line 16:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g8/3g8e_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g8/3g8e_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 46:		Line 46:
	[[Category: Kim, M K]]		[[Category: Kim, M K]]
	[[Category: Kim, Y C]]		[[Category: Kim, Y C]]
		+	[[Category: Cytoplasm]]
	[[Category: Glycosyltransferase]]		[[Category: Glycosyltransferase]]
	[[Category: Is001]]		[[Category: Is001]]

OCA at 08:37, 5 August 2016

OCA — Fri, 05 Aug 2016 08:37:36 GMT

←Older revision		Revision as of 08:37, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Rattus norvegicus Visfatin/PBEF/Nampt in Complex with an FK866-based inhibitor==		==Crystal Structure of Rattus norvegicus Visfatin/PBEF/Nampt in Complex with an FK866-based inhibitor==
	<StructureSection load='3g8e' size='340' side='right' caption='[[3g8e]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='3g8e' size='340' side='right' caption='[[3g8e]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3g8e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G8E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G8E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3g8e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G8E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G8E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IS1:3-[(1E)-3-OXO-3-({4-[1-(PHENYLCARBONYL)PIPERIDIN-4-YL]BUTYL}AMINO)PROP-1-EN-1-YL]-1-BETA-D-RIBOFURANOSYLPYRIDINIUM'>IS1</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IS1:3-[(1E)-3-OXO-3-({4-[1-(PHENYLCARBONYL)PIPERIDIN-4-YL]BUTYL}AMINO)PROP-1-EN-1-YL]-1-BETA-D-RIBOFURANOSYLPYRIDINIUM'>IS1</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g97\|2g97]], [[2g96\|2g96]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g97\|2g97]], [[2g96\|2g96]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">visfatin ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">visfatin ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g8e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g8e RCSB], [http://www.ebi.ac.uk/pdbsum/3g8e PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g8e OCA], [http://pdbe.org/3g8e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3g8e RCSB], [http://www.ebi.ac.uk/pdbsum/3g8e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3g8e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g8e ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3g8e" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
	[[Category: Nicotinamide phosphoribosyltransferase]]		[[Category: Nicotinamide phosphoribosyltransferase]]
-	[[Category: Rattus norvegicus]]
	[[Category: Bae, M H]]		[[Category: Bae, M H]]
	[[Category: Eom, S H]]		[[Category: Eom, S H]]

OCA at 17:20, 25 December 2014

OCA — Thu, 25 Dec 2014 17:20:18 GMT

←Older revision		Revision as of 17:20, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g8e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g8e RCSB], [http://www.ebi.ac.uk/pdbsum/3g8e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g8e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g8e RCSB], [http://www.ebi.ac.uk/pdbsum/3g8e PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NAMPT_RAT NAMPT_RAT]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:06, 3 December 2014

OCA — Wed, 03 Dec 2014 10:06:40 GMT

←Older revision		Revision as of 10:06, 3 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3g8e.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of Rattus norvegicus Visfatin/PBEF/Nampt in Complex with an FK866-based inhibitor==
		+	<StructureSection load='3g8e' size='340' side='right' caption='[[3g8e]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3g8e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G8E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G8E FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IS1:3-[(1E)-3-OXO-3-({4-[1-(PHENYLCARBONYL)PIPERIDIN-4-YL]BUTYL}AMINO)PROP-1-EN-1-YL]-1-BETA-D-RIBOFURANOSYLPYRIDINIUM'>IS1</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2g97\|2g97]], [[2g96\|2g96]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">visfatin ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g8e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g8e RCSB], [http://www.ebi.ac.uk/pdbsum/3g8e PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g8/3g8e_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Visfatin (Nampt/PBEF) plays a pivotal role in the salvage pathway for NAD(+) biosynthesis. Its potent inhibitor, FK866, causes cellular NAD(+) levels to decline, thereby inducing apoptosis in tumor cells. In an effort to improve the solubility and binding interactions of FK866, we designed and synthesized IS001, in which a ribose group is attached to the FK866 pyridyl ring. Here, we report the crystal structure of rat visfatin in complex with IS001. Like FK866, IS001 is positioned at the dimer interface, and all of the residues that interact with IS001 are involved in hydrophobic or pi-pi-stacking interactions. However, we were unable to detect any strong interactions between the added ribose ring of IS001 and visfatin, which implies that a bulkier modifying group is necessary for a tight interaction. This study provides additional structure-based information needed to optimize the design of visfatin inhibitors.

-	~~{{STRUCTURE_3g8e\| PDB=3g8e \| SCENE= }}~~	+	Crystal structure of Rattus norvegicus Visfatin/PBEF/Nampt in complex with an FK866-based inhibitor.,Kang GB, Bae MH, Kim MK, Im I, Kim YC, Eom SH Mol Cells. 2009 Jun;27(6):667-71. Epub 2009 Jun 12. PMID:19533035<ref>PMID:19533035</ref>

-	~~===Crystal Structure of Rattus norvegicus Visfatin~~/~~PBEF/Nampt in Complex with an FK866-based inhibitor===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19533035}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3g8e]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3G8E OCA].~~	+

	==See Also==		==See Also==
	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]		*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019533035<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Nicotinamide phosphoribosyltransferase]]		[[Category: Nicotinamide phosphoribosyltransferase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Bae, M H.]]	+	[[Category: Bae, M H]]
-	[[Category: Eom, S H.]]	+	[[Category: Eom, S H]]
-	[[Category: Im, I.]]	+	[[Category: Im, I]]
-	[[Category: Kang, G B.]]	+	[[Category: Kang, G B]]
-	[[Category: Kim, M K.]]	+	[[Category: Kim, M K]]
-	[[Category: Kim, Y C.]]	+	[[Category: Kim, Y C]]
	[[Category: Glycosyltransferase]]		[[Category: Glycosyltransferase]]
	[[Category: Is001]]		[[Category: Is001]]

OCA: Protected "3g8e" [edit=sysop:move=sysop]

OCA — Wed, 20 Feb 2013 14:21:21 GMT

Protected "3g8e" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:21, 20 February 2013

OCA at 14:21, 20 February 2013

OCA — Wed, 20 Feb 2013 14:21:17 GMT

←Older revision		Revision as of 14:21, 20 February 2013
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3g8e.png\|left\|200px]]
-	[[Image:3g8e.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3g8e", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3g8e\| PDB=3g8e \| SCENE= }}		{{STRUCTURE_3g8e\| PDB=3g8e \| SCENE= }}

	===Crystal Structure of Rattus norvegicus Visfatin/PBEF/Nampt in Complex with an FK866-based inhibitor===		===Crystal Structure of Rattus norvegicus Visfatin/PBEF/Nampt in Complex with an FK866-based inhibitor===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19533035}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19533035 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19533035}}		{{ABSTRACT_PUBMED_19533035}}

	==About this Structure==		==About this Structure==
-	~~3G8E~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G8E OCA].	+	[[3g8e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G8E OCA].
		+
		+	==See Also==
		+	*[[Phosphoribosyltransferase\|Phosphoribosyltransferase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19533035~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019533035</ref><references group="xtra"/>
	[[Category: Nicotinamide phosphoribosyltransferase]]		[[Category: Nicotinamide phosphoribosyltransferase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
Line 32:		Line 23:
	[[Category: Kim, M K.]]		[[Category: Kim, M K.]]
	[[Category: Kim, Y C.]]		[[Category: Kim, Y C.]]
-	[[Category: Cytoplasm]]
	[[Category: Glycosyltransferase]]		[[Category: Glycosyltransferase]]
	[[Category: Is001]]		[[Category: Is001]]
Line 40:		Line 30:
	[[Category: Pyridine nucleotide biosynthesis]]		[[Category: Pyridine nucleotide biosynthesis]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 19 12:57:21 2009''

OCA at 09:57, 19 August 2009

OCA — Wed, 19 Aug 2009 09:57:27 GMT

←Older revision		Revision as of 09:57, 19 August 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3g8e.jpg\|left\|200px]]

-	The ~~entry 3g8e~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3g8e", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3g8e\| PDB=3g8e \| SCENE= }}

-	~~Authors: Kang, G.B., Bae, M.H., Kim, M.K., Im, I., Kim, Y.C., Eom, S.H.~~	+	===Crystal Structure of Rattus norvegicus Visfatin/PBEF/Nampt in Complex with an FK866-based inhibitor===

-	Description: Crystal Structure of Rattus norvegicus Visfatin/PBEF/Nampt in Complex with an FK866-based inhibitor

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Mar 22 10~~:24:07 2009''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19533035}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19533035 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19533035}}
		+
		+	==About this Structure==
		+	3G8E is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G8E OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19533035</ref><references group="xtra"/>
		+	[[Category: Nicotinamide phosphoribosyltransferase]]
		+	[[Category: Rattus norvegicus]]
		+	[[Category: Bae, M H.]]
		+	[[Category: Eom, S H.]]
		+	[[Category: Im, I.]]
		+	[[Category: Kang, G B.]]
		+	[[Category: Kim, M K.]]
		+	[[Category: Kim, Y C.]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Glycosyltransferase]]
		+	[[Category: Is001]]
		+	[[Category: Nucleus]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Protein-ligand complex]]
		+	[[Category: Pyridine nucleotide biosynthesis]]
		+	[[Category: Transferase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 19 12:57:21 2009''

OCA at 08:24, 22 March 2009

OCA — Sun, 22 Mar 2009 08:24:07 GMT

←Older revision		Revision as of 08:24, 22 March 2009
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3g8e is ON HOLD	+	The entry 3g8e is ON HOLD until Paper Publication

	Authors: Kang, G.B., Bae, M.H., Kim, M.K., Im, I., Kim, Y.C., Eom, S.H.		Authors: Kang, G.B., Bae, M.H., Kim, M.K., Im, I., Kim, Y.C., Eom, S.H.
Line 7:		Line 7:
	Description: Crystal Structure of Rattus norvegicus Visfatin/PBEF/Nampt in Complex with an FK866-based inhibitor		Description: Crystal Structure of Rattus norvegicus Visfatin/PBEF/Nampt in Complex with an FK866-based inhibitor

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Feb 25 09~~:27:53 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 22 10:24:07 2009''