3gak - Revision history

OCA at 07:02, 6 September 2023

OCA — Wed, 06 Sep 2023 07:02:25 GMT

←Older revision		Revision as of 07:02, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3gak' size='340' side='right'caption='[[3gak]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='3gak' size='340' side='right'caption='[[3gak]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gak]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Giain Giain~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GAK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GAK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gak]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Giardia_intestinalis Giardia intestinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GAK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GAK FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[2isv\|2isv]], [[2isw\|2isw]], [[3gay\|3gay]], [[3gb6\|3gb6]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>ald, FBPA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~5741 GIAIN])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Fructose-bisphosphate_aldolase Fructose-bisphosphate aldolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.13 4.1.2.13]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gak OCA], [https://pdbe.org/3gak PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gak RCSB], [https://www.ebi.ac.uk/pdbsum/3gak PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gak ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gak OCA], [https://pdbe.org/3gak PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gak RCSB], [https://www.ebi.ac.uk/pdbsum/3gak PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gak ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A8B2U2_GIAIC A8B2U2_GIAIC]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Fructose-bisphosphate aldolase]]~~	+	[[Category: Giardia intestinalis]]
-	~~[[Category: Giain~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Galkin, A]]	+	[[Category: Galkin A]]
-	[[Category: Herzberg, O]]	+	[[Category: Herzberg O]]
-	~~[[Category: 6-bisphosphate aldolase]]~~	+
-	~~[[Category: Class ii fructose-1]]~~	+
-	~~[[Category: Drug target]]~~	+
-	~~[[Category: Giardia lamblia]]~~	+
-	~~[[Category: Glycolysis]]~~	+
-	~~[[Category: Glycolytic pathway]]~~	+
-	~~[[Category: Lyase~~]]	+

OCA at 08:00, 9 March 2022

OCA — Wed, 09 Mar 2022 08:00:15 GMT

←Older revision		Revision as of 08:00, 9 March 2022
Line 1:		Line 1:

	==Structure of Giardia fructose-1,6-biphosphate aldolase==		==Structure of Giardia fructose-1,6-biphosphate aldolase==
-	<StructureSection load='3gak' size='340' side='right' caption='[[3gak]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='3gak' size='340' side='right'caption='[[3gak]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gak]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Giain Giain]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GAK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3GAK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gak]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Giain Giain]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GAK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GAK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2isv\|2isv]], [[2isw\|2isw]], [[3gay\|3gay]], [[3gb6\|3gb6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2isv\|2isv]], [[2isw\|2isw]], [[3gay\|3gay]], [[3gb6\|3gb6]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ald, FBPA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5741 GIAIN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ald, FBPA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5741 GIAIN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Fructose-bisphosphate_aldolase Fructose-bisphosphate aldolase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.13 4.1.2.13] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Fructose-bisphosphate_aldolase Fructose-bisphosphate aldolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.13 4.1.2.13] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3gak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gak OCA], [~~http~~://pdbe.org/3gak PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3gak RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3gak PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3gak ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gak OCA], [https://pdbe.org/3gak PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gak RCSB], [https://www.ebi.ac.uk/pdbsum/3gak PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gak ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Aldolase\|Aldolase]]	+	*[[Aldolase 3D structures\|Aldolase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 38:
	[[Category: Fructose-bisphosphate aldolase]]		[[Category: Fructose-bisphosphate aldolase]]
	[[Category: Giain]]		[[Category: Giain]]
		+	[[Category: Large Structures]]
	[[Category: Galkin, A]]		[[Category: Galkin, A]]
	[[Category: Herzberg, O]]		[[Category: Herzberg, O]]

OCA at 05:22, 7 December 2018

OCA — Fri, 07 Dec 2018 05:22:58 GMT

←Older revision		Revision as of 05:22, 7 December 2018
Line 1:		Line 1:
		+
	==Structure of Giardia fructose-1,6-biphosphate aldolase==		==Structure of Giardia fructose-1,6-biphosphate aldolase==
	<StructureSection load='3gak' size='340' side='right' caption='[[3gak]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='3gak' size='340' side='right' caption='[[3gak]], [[Resolution\|resolution]] 2.90Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ald, FBPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5741 GIAIN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ald, FBPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5741 GIAIN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphate_aldolase Fructose-bisphosphate aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.13 4.1.2.13] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphate_aldolase Fructose-bisphosphate aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.13 4.1.2.13] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gak OCA], [http://pdbe.org/3gak PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gak RCSB], [http://www.ebi.ac.uk/pdbsum/3gak PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gak OCA], [http://pdbe.org/3gak PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gak RCSB], [http://www.ebi.ac.uk/pdbsum/3gak PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gak ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ga/3gak_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ga/3gak_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 02:08, 7 February 2016

OCA — Sun, 07 Feb 2016 02:08:21 GMT

←Older revision		Revision as of 02:08, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3gak' size='340' side='right' caption='[[3gak]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='3gak' size='340' side='right' caption='[[3gak]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gak]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Giardia_intestinalis Giardia intestinalis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GAK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GAK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gak]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Giain Giain]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GAK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GAK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2isv\|2isv]], [[2isw\|2isw]], [[3gay\|3gay]], [[3gb6\|3gb6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2isv\|2isv]], [[2isw\|2isw]], [[3gay\|3gay]], [[3gb6\|3gb6]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ald, FBPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5741 ~~Giardia intestinalis~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ald, FBPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5741 GIAIN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphate_aldolase Fructose-bisphosphate aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.13 4.1.2.13] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphate_aldolase Fructose-bisphosphate aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.13 4.1.2.13] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gak OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gak RCSB], [http://www.ebi.ac.uk/pdbsum/3gak PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gak OCA], [http://pdbe.org/3gak PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gak RCSB], [http://www.ebi.ac.uk/pdbsum/3gak PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gak ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3gak" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Fructose-bisphosphate aldolase]]		[[Category: Fructose-bisphosphate aldolase]]
-	[[Category: ~~Giardia intestinalis~~]]	+	[[Category: Giain]]
	[[Category: Galkin, A]]		[[Category: Galkin, A]]
	[[Category: Herzberg, O]]		[[Category: Herzberg, O]]

OCA at 07:52, 20 January 2015

OCA — Tue, 20 Jan 2015 07:52:59 GMT

OCA at 10:56, 29 September 2014

OCA — Mon, 29 Sep 2014 10:56:49 GMT

←Older revision		Revision as of 10:56, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3gak.~~png~~\|~~left~~\|200px]]	+	==Structure of Giardia fructose-1,6-biphosphate aldolase==
		+	<StructureSection load='3gak' size='340' side='right' caption='[[3gak]], [[Resolution\|resolution]] 2.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3gak]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Giardia_intestinalis Giardia intestinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GAK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GAK FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2isv\|2isv]], [[2isw\|2isw]], [[3gay\|3gay]], [[3gb6\|3gb6]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ald, FBPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5741 Giardia intestinalis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphate_aldolase Fructose-bisphosphate aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.13 4.1.2.13] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gak OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gak RCSB], [http://www.ebi.ac.uk/pdbsum/3gak PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ga/3gak_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Giardia lamblia fructose-1,6-bisphosphate aldolase (FBPA) is a member of the class II zinc-dependent aldolase family that catalyzes the cleavage of d-fructose 1,6-bisphosphate (FBP) into dihydroxyacetone phosphate (DHAP) and d-glyceraldehyde 3-phosphate (G3P). In addition to the active site zinc, the catalytic apparatus of FBPA employs an aspartic acid, Asp83 in the G. lamblia enzyme, which when replaced with an alanine residue renders the enzyme inactive. A comparison of the crystal structures of D83A FBPA in complex with FBP and of wild-type FBPA in the unbound state revealed a substrate-induced conformational transition of loops in the vicinity of the active site and a shift in the location of Zn(2+). When FBP binds, the Zn(2+) shifts up to 4.6 A toward the catalytic Asp83, which brings the metal within coordination distance of the Asp83 carboxylate group. In addition, the structure of wild-type FBPA was determined in complex with the competitive inhibitor d-tagatose 1,6-bisphosphate (TBP), a FBP stereoisomer. In this structure, the zinc binds in a site close to that previously seen in the structure of FBPA in complex with phosphoglycolohydroxamate, an analogue of the postulated DHAP ene-diolate intermediate. Together, the ensemble of structures suggests that the zinc mobility is necessary to orient the Asp83 side chain and to polarize the substrate for proton transfer from the FBP C(4) hydroxyl group to the Asp83 carboxyl group. In the absence of FBP, the alternative zinc position is too remote for coordinating the Asp83. We propose a modification of the catalytic mechanism that incorporates the novel features observed in the FBPA-FBP structure. The mechanism invokes coordination and coplanarity of the Zn(2+) with the FBP's O-C(3)-C(4)-O group concomitant with coordination of the Asp83 carboxylic group. Catalysis is accompanied by movement of Zn(2+) to a site coplanar with the O-C(2)-C(3)-O group of the DHAP. glFBPA exhibits strict substrate specificity toward FBP and does not cleave TBP. The active sites of FBPAs contain an aspartate residue equivalent to Asp255 of glFBPA, whereas tagatose-1,6-bisphosphate aldolase contains an alanine in this position. We and others hypothesized that this aspartic acid is a likely determinant of FBP versus TBP specificity. Replacement of Asp255 with an alanine resulted in an enzyme that possesses double specificity, now cleaving TBP (albeit with low efficacy; k(cat)/K(m) = 80 M(-1) s(-1)) while maintaining activity toward FBP at a 50-fold lower catalytic efficacy compared with that of wild-type FBPA. The collection of structures and sequence analyses highlighted additional residues that may be involved in substrate discrimination.

-	~~{{STRUCTURE_3gak\| PDB=3gak \| SCENE= }}~~	+	Structural Insights into the Substrate Binding and Stereoselectivity of Giardia Fructose-1,6-bisphosphate Aldolase (dagger) (,) (double dagger).,Galkin A, Li Z, Li L, Kulakova L, Pal LR, Dunaway-Mariano D, Herzberg O Biochemistry. 2009 Mar 18. PMID:19236002<ref>PMID:19236002</ref>

-	~~===Structure of Giardia fructose-1~~,~~6-biphosphate aldolase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19236002}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3gak]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Giardia_intestinalis Giardia intestinalis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3GAK OCA].~~	+

	==See Also==		==See Also==
	*[[Aldolase\|Aldolase]]		*[[Aldolase\|Aldolase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019236002<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Fructose-bisphosphate aldolase]]		[[Category: Fructose-bisphosphate aldolase]]
	[[Category: Giardia intestinalis]]		[[Category: Giardia intestinalis]]

OCA at 05:18, 20 October 2012

OCA — Sat, 20 Oct 2012 05:18:21 GMT

←Older revision		Revision as of 05:18, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3gak]] is a 2 chain structure ~~of [[Aldolase]]~~ with sequence from [http://en.wikipedia.org/wiki/Giardia_intestinalis Giardia intestinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GAK OCA].	+	[[3gak]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Giardia_intestinalis Giardia intestinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GAK OCA].

	==See Also==		==See Also==

OCA: Protected "3gak" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 09:36:59 GMT

Protected "3gak" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:36, 25 July 2012

OCA at 09:36, 25 July 2012

OCA — Wed, 25 Jul 2012 09:36:58 GMT

←Older revision		Revision as of 09:36, 25 July 2012
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-	{{Seed}}
	[[Image:3gak.png\|left\|200px]]		[[Image:3gak.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3gak", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3gak\| PDB=3gak \| SCENE= }}		{{STRUCTURE_3gak\| PDB=3gak \| SCENE= }}

	===Structure of Giardia fructose-1,6-biphosphate aldolase===		===Structure of Giardia fructose-1,6-biphosphate aldolase===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19236002}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19236002 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19236002}}		{{ABSTRACT_PUBMED_19236002}}

	==About this Structure==		==About this Structure==
-	~~3GAK~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Giardia_intestinalis Giardia intestinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GAK OCA].	+	[[3gak]] is a 2 chain structure of [[Aldolase]] with sequence from [http://en.wikipedia.org/wiki/Giardia_intestinalis Giardia intestinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GAK OCA].
		+
		+	==See Also==
		+	*[[Aldolase\|Aldolase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19236002~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019236002</ref><references group="xtra"/>
	[[Category: Fructose-bisphosphate aldolase]]		[[Category: Fructose-bisphosphate aldolase]]
	[[Category: Giardia intestinalis]]		[[Category: Giardia intestinalis]]
Line 35:		Line 26:
	[[Category: Glycolytic pathway]]		[[Category: Glycolytic pathway]]
	[[Category: Lyase]]		[[Category: Lyase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 10 10:54:57 2010''

OCA at 06:50, 10 June 2010

OCA — Thu, 10 Jun 2010 06:50:10 GMT

←Older revision		Revision as of 06:50, 10 June 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3gak.png\|left\|200px]]

-	The ~~entry 3gak~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3gak", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3gak\| PDB=3gak \| SCENE= }}

-	~~Authors: Galkin~~, ~~A., Herzberg, O.~~	+	===Structure of Giardia fructose-1,6-biphosphate aldolase===

-	Description: Structure of Giardia fructose-1,6-biphosphate aldolase

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu ~~Apr 9 12~~:17:~~04 2009~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19236002}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19236002 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19236002}}
		+
		+	==About this Structure==
		+	3GAK is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Giardia_intestinalis Giardia intestinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GAK OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19236002</ref><references group="xtra"/>
		+	[[Category: Fructose-bisphosphate aldolase]]
		+	[[Category: Giardia intestinalis]]
		+	[[Category: Galkin, A.]]
		+	[[Category: Herzberg, O.]]
		+	[[Category: 6-bisphosphate aldolase]]
		+	[[Category: Class ii fructose-1]]
		+	[[Category: Drug target]]
		+	[[Category: Giardia lamblia]]
		+	[[Category: Glycolysis]]
		+	[[Category: Glycolytic pathway]]
		+	[[Category: Lyase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 10 10:54:57 2010''

←Older revision		Revision as of 07:52, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3gak]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Giardia_intestinalis Giardia intestinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GAK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GAK FirstGlance]. <br>		<table><tr><td colspan='2'>[[3gak]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Giardia_intestinalis Giardia intestinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GAK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GAK FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2isv\|2isv]], [[2isw\|2isw]], [[3gay\|3gay]], [[3gb6\|3gb6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2isv\|2isv]], [[2isw\|2isw]], [[3gay\|3gay]], [[3gb6\|3gb6]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ald, FBPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5741 Giardia intestinalis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ald, FBPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5741 Giardia intestinalis])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphate_aldolase Fructose-bisphosphate aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.13 4.1.2.13] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphate_aldolase Fructose-bisphosphate aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.13 4.1.2.13] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gak OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gak RCSB], [http://www.ebi.ac.uk/pdbsum/3gak PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gak OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gak RCSB], [http://www.ebi.ac.uk/pdbsum/3gak PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	[[Category: Fructose-bisphosphate aldolase]]		[[Category: Fructose-bisphosphate aldolase]]
	[[Category: Giardia intestinalis]]		[[Category: Giardia intestinalis]]
-	[[Category: Galkin, A.]]	+	[[Category: Galkin, A]]
-	[[Category: Herzberg, O.]]	+	[[Category: Herzberg, O]]
	[[Category: 6-bisphosphate aldolase]]		[[Category: 6-bisphosphate aldolase]]
	[[Category: Class ii fructose-1]]		[[Category: Class ii fructose-1]]