3gbb - Revision history

OCA at 15:38, 1 November 2023

OCA — Wed, 01 Nov 2023 15:38:01 GMT

←Older revision		Revision as of 15:38, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3gbb' size='340' side='right'caption='[[3gbb]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3gbb' size='340' side='right'caption='[[3gbb]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gbb]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3GBB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gbb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GBB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MS8:(2R,3AR,7AR)-2-[(2S)-2-AMINO-3-HYDROXY-3-OXO-PROPYL]-3,3A,5,6,7,7A-HEXAHYDROFURO[4,5-B]PYRAN-2-CARBOXYLIC+ACID'>MS8</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ycj\|1ycj]], [[3gba\|3gba]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MS8:(2R,3AR,7AR)-2-[(2S)-2-AMINO-3-HYDROXY-3-OXO-PROPYL]-3,3A,5,6,7,7A-HEXAHYDROFURO[4,5-B]PYRAN-2-CARBOXYLIC+ACID'>MS8</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Glur5, Grik1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbb OCA], [https://pdbe.org/3gbb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gbb RCSB], [https://www.ebi.ac.uk/pdbsum/3gbb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gbb ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3gbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbb OCA], [~~http~~://pdbe.org/3gbb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3gbb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3gbb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3gbb ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GRIK1_RAT GRIK1_RAT]] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.<ref>PMID:16540562</ref>	+	[https://www.uniprot.org/uniprot/GRIK1_RAT GRIK1_RAT] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.<ref>PMID:16540562</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Frydenvang, K]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Gajhede, M]]	+	[[Category: Frydenvang K]]
-	[[Category: Kastrup~~, J S~~]]	+	[[Category: Gajhede M]]
-	[[Category: Naur, P]]	+	[[Category: Kastrup JS]]
-	~~[[Category: Iglur5]]~~	+	[[Category: Naur P]]
-	~~[[Category: Ionotropic glutamate receptor]]~~	+
-	~~[[Category: Ligand-binding core]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Weak agonist~~]]	+

OCA at 09:42, 9 September 2020

OCA — Wed, 09 Sep 2020 09:42:50 GMT

←Older revision		Revision as of 09:42, 9 September 2020
Line 1:		Line 1:

-	==X-ray ~~strucutre~~ of iGluR5 ligand-binding core (S1S2) in complex with MSVIII-19 at 2.10A resolution==	+	==X-ray structure of iGluR5 ligand-binding core (S1S2) in complex with MSVIII-19 at 2.10A resolution==
-	<StructureSection load='3gbb' size='340' side='right' caption='[[3gbb]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='3gbb' size='340' side='right'caption='[[3gbb]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gbb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBB OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3GBB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gbb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3GBB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MS8:(2R,3AR,7AR)-2-[(2S)-2-AMINO-3-HYDROXY-3-OXO-PROPYL]-3,3A,5,6,7,7A-HEXAHYDROFURO[4,5-B]PYRAN-2-CARBOXYLIC+ACID'>MS8</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MS8:(2R,3AR,7AR)-2-[(2S)-2-AMINO-3-HYDROXY-3-OXO-PROPYL]-3,3A,5,6,7,7A-HEXAHYDROFURO[4,5-B]PYRAN-2-CARBOXYLIC+ACID'>MS8</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ycj\|1ycj]], [[3gba\|3gba]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ycj\|1ycj]], [[3gba\|3gba]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Glur5, Grik1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Glur5, Grik1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3gbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbb OCA], [http://pdbe.org/3gbb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gbb RCSB], [http://www.ebi.ac.uk/pdbsum/3gbb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gbb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3gbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbb OCA], [http://pdbe.org/3gbb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gbb RCSB], [http://www.ebi.ac.uk/pdbsum/3gbb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gbb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gb/3gbb_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gb/3gbb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 3gbb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3gbb" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Glutamate receptor 3D structures\|Glutamate receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Frydenvang, K]]		[[Category: Frydenvang, K]]
	[[Category: Gajhede, M]]		[[Category: Gajhede, M]]

OCA at 07:02, 1 November 2017

OCA — Wed, 01 Nov 2017 07:02:10 GMT

←Older revision		Revision as of 07:02, 1 November 2017
Line 1:		Line 1:
		+
	==X-ray strucutre of iGluR5 ligand-binding core (S1S2) in complex with MSVIII-19 at 2.10A resolution==		==X-ray strucutre of iGluR5 ligand-binding core (S1S2) in complex with MSVIII-19 at 2.10A resolution==
	<StructureSection load='3gbb' size='340' side='right' caption='[[3gbb]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3gbb' size='340' side='right' caption='[[3gbb]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ycj\|1ycj]], [[3gba\|3gba]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ycj\|1ycj]], [[3gba\|3gba]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Glur5, Grik1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Glur5, Grik1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbb OCA], [http://pdbe.org/3gbb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gbb RCSB], [http://www.ebi.ac.uk/pdbsum/3gbb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbb OCA], [http://pdbe.org/3gbb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gbb RCSB], [http://www.ebi.ac.uk/pdbsum/3gbb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gbb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 3gbb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3gbb" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Ionotropic Glutamate Receptors\|Ionotropic Glutamate Receptors]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:39, 7 February 2016

OCA — Sun, 07 Feb 2016 06:39:59 GMT

←Older revision		Revision as of 06:39, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3gbb' size='340' side='right' caption='[[3gbb]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3gbb' size='340' side='right' caption='[[3gbb]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gbb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GBB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gbb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GBB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MS8:(2R,3AR,7AR)-2-[(2S)-2-AMINO-3-HYDROXY-3-OXO-PROPYL]-3,3A,5,6,7,7A-HEXAHYDROFURO[4,5-B]PYRAN-2-CARBOXYLIC+ACID'>MS8</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MS8:(2R,3AR,7AR)-2-[(2S)-2-AMINO-3-HYDROXY-3-OXO-PROPYL]-3,3A,5,6,7,7A-HEXAHYDROFURO[4,5-B]PYRAN-2-CARBOXYLIC+ACID'>MS8</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ycj\|1ycj]], [[3gba\|3gba]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ycj\|1ycj]], [[3gba\|3gba]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Glur5, Grik1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Glur5, Grik1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gbb RCSB], [http://www.ebi.ac.uk/pdbsum/3gbb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbb OCA], [http://pdbe.org/3gbb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gbb RCSB], [http://www.ebi.ac.uk/pdbsum/3gbb PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gbb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3gbb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Frydenvang, K]]		[[Category: Frydenvang, K]]
	[[Category: Gajhede, M]]		[[Category: Gajhede, M]]

OCA at 08:41, 24 December 2014

OCA — Wed, 24 Dec 2014 08:41:51 GMT

←Older revision		Revision as of 08:41, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3gbb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GBB FirstGlance]. <br>		<table><tr><td colspan='2'>[[3gbb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GBB FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MS8:(2R,3AR,7AR)-2-[(2S)-2-AMINO-3-HYDROXY-3-OXO-PROPYL]-3,3A,5,6,7,7A-HEXAHYDROFURO[4,5-B]PYRAN-2-CARBOXYLIC+ACID'>MS8</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MS8:(2R,3AR,7AR)-2-[(2S)-2-AMINO-3-HYDROXY-3-OXO-PROPYL]-3,3A,5,6,7,7A-HEXAHYDROFURO[4,5-B]PYRAN-2-CARBOXYLIC+ACID'>MS8</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ycj\|1ycj]], [[3gba\|3gba]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ycj\|1ycj]], [[3gba\|3gba]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Glur5, Grik1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Glur5, Grik1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gbb RCSB], [http://www.ebi.ac.uk/pdbsum/3gbb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gbb RCSB], [http://www.ebi.ac.uk/pdbsum/3gbb PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GRIK1_RAT GRIK1_RAT]] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.<ref>PMID:16540562</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Frydenvang, K.]]	+	[[Category: Frydenvang, K]]
-	[[Category: Gajhede, M.]]	+	[[Category: Gajhede, M]]
-	[[Category: Kastrup, J S.]]	+	[[Category: Kastrup, J S]]
-	[[Category: Naur, P.]]	+	[[Category: Naur, P]]
	[[Category: Iglur5]]		[[Category: Iglur5]]
	[[Category: Ionotropic glutamate receptor]]		[[Category: Ionotropic glutamate receptor]]

OCA at 12:20, 29 September 2014

OCA — Mon, 29 Sep 2014 12:20:01 GMT

←Older revision		Revision as of 12:20, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3gbb.~~png~~\|~~left~~\|200px]]	+	==X-ray strucutre of iGluR5 ligand-binding core (S1S2) in complex with MSVIII-19 at 2.10A resolution==
		+	<StructureSection load='3gbb' size='340' side='right' caption='[[3gbb]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3gbb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GBB FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MS8:(2R,3AR,7AR)-2-[(2S)-2-AMINO-3-HYDROXY-3-OXO-PROPYL]-3,3A,5,6,7,7A-HEXAHYDROFURO[4,5-B]PYRAN-2-CARBOXYLIC+ACID'>MS8</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ycj\|1ycj]], [[3gba\|3gba]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Glur5, Grik1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gbb RCSB], [http://www.ebi.ac.uk/pdbsum/3gbb PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gb/3gbb_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The prevailing structural model for ligand activation of ionotropic glutamate receptors posits that agonist efficacy arises from the stability and magnitude of induced domain closure in the ligand-binding core structure. Here we describe an exception to the correlation between ligand efficacy and domain closure. A weakly efficacious partial agonist of very low potency for homomeric iGluR5 kainate receptors, 8,9-dideoxyneodysiherbaine (MSVIII-19), induced a fully closed iGluR5 ligand-binding core. The degree of relative domain closure, approximately 30 degrees , was similar to that we resolved with the structurally related high affinity agonist dysiherbaine and to that of l-glutamate. The pharmacological activity of MSVIII-19 was confirmed in patch clamp recordings from transfected HEK293 cells, where MSVIII-19 predominantly inhibits iGluR5-2a, with little activation apparent at a high concentration (1 mm) of MSVIII-19 (<1% of mean glutamate-evoked currents). To determine the efficacy of the ligand quantitatively, we constructed concentration-response relationships for MSVIII-19 following potentiation of steady-state currents with concanavalin A (EC(50) = 3.6 microm) and on the nondesensitizing receptor mutant iGluR5-2b(Y506C/L768C) (EC(50) = 8.1 microm). MSVIII-19 exhibited a maximum of 16% of full agonist efficacy, as measured in parallel recordings with glutamate. Molecular dynamics simulations and electrophysiological recordings confirm that the specificity of MSVIII-19 for iGluR5 is partly attributable to interdomain hydrogen bond residues Glu(441) and Ser(721) in the iGluR5-S1S2 structure. The weaker interactions of MSVIII-19 with iGluR5 compared with dysiherbaine, together with altered stability of the interdomain interaction, may be responsible for the apparent uncoupling of domain closure and channel opening in this kainate receptor subunit.

-	~~{{STRUCTURE_3gbb\| PDB=3gbb \| SCENE= }}~~	+	Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine.,Frydenvang K, Lash LL, Naur P, Postila PA, Pickering DS, Smith CM, Gajhede M, Sasaki M, Sakai R, Pentikainen OT, Swanson GT, Kastrup JS J Biol Chem. 2009 May 22;284(21):14219-29. Epub 2009 Mar 18. PMID:19297335<ref>PMID:19297335</ref>

-	~~===X-ray strucutre~~ of ~~iGluR5 ligand-binding core (S1S2) in complex with MSVIII-19 at 2~~.~~10A resolution===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19297335}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3gbb]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBB OCA].~~	+

	==See Also==		==See Also==
	*[[Ionotropic Glutamate Receptors\|Ionotropic Glutamate Receptors]]		*[[Ionotropic Glutamate Receptors\|Ionotropic Glutamate Receptors]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019297335<~~/~~ref~~><~~ref group="xtra">PMID:015710405</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Frydenvang, K.]]		[[Category: Frydenvang, K.]]

OCA at 05:53, 20 October 2012

OCA — Sat, 20 Oct 2012 05:53:01 GMT

←Older revision		Revision as of 05:53, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3gbb]] is a 2 chain structure ~~of [[Ionotropic Glutamate Receptors]]~~ with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBB OCA].	+	[[3gbb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBB OCA].

	==See Also==		==See Also==

OCA at 11:25, 25 July 2012

OCA — Wed, 25 Jul 2012 11:25:25 GMT

←Older revision		Revision as of 11:25, 25 July 2012
Line 1:		Line 1:
	[[Image:3gbb.png\|left\|200px]]		[[Image:3gbb.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3gbb", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3gbb\| PDB=3gbb \| SCENE= }}		{{STRUCTURE_3gbb\| PDB=3gbb \| SCENE= }}

	===X-ray strucutre of iGluR5 ligand-binding core (S1S2) in complex with MSVIII-19 at 2.10A resolution===		===X-ray strucutre of iGluR5 ligand-binding core (S1S2) in complex with MSVIII-19 at 2.10A resolution===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19297335}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19297335 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19297335}}		{{ABSTRACT_PUBMED_19297335}}

OCA: Protected "3gbb" [edit=sysop:move=sysop]

OCA — Wed, 13 Jun 2012 10:41:49 GMT

Protected "3gbb" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:41, 13 June 2012