3gbg - Revision history

OCA at 09:53, 21 February 2024

OCA — Wed, 21 Feb 2024 09:53:46 GMT

←Older revision		Revision as of 09:53, 21 February 2024
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	<StructureSection load='3gbg' size='340' side='right'caption='[[3gbg]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3gbg' size='340' side='right'caption='[[3gbg]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gbg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Vibc3 Vibc3~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GBG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gbg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O395 Vibrio cholerae O395]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GBG FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~tcpN, toxT, VC0395_A0363 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=345073 VIBC3])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbg OCA], [https://pdbe.org/3gbg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gbg RCSB], [https://www.ebi.ac.uk/pdbsum/3gbg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gbg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbg OCA], [https://pdbe.org/3gbg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gbg RCSB], [https://www.ebi.ac.uk/pdbsum/3gbg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gbg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TCPN_VIBC3 TCPN_VIBC3]] Probable regulatory protein for the tcp operon.	+	[https://www.uniprot.org/uniprot/TCPN_VIBC3 TCPN_VIBC3] Probable regulatory protein for the tcp operon.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gbg ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gbg ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Cholera is an acute intestinal infection caused by the bacterium Vibrio cholerae. In order for V. cholerae to cause disease, it must produce two virulence factors, the toxin-coregulated pilus (TCP) and cholera toxin (CT), whose expression is controlled by a transcriptional cascade culminating with the expression of the AraC-family regulator, ToxT. We have solved the 1.9 A resolution crystal structure of ToxT, which reveals folds in the N- and C-terminal domains that share a number of features in common with AraC, MarA, and Rob as well as the unexpected presence of a buried 16-carbon fatty acid, cis-palmitoleate. The finding that cis-palmitoleic acid reduces TCP and CT expression in V. cholerae and prevents ToxT from binding to DNA in vitro provides a direct link between the host environment of V. cholerae and regulation of virulence gene expression.
-
-	Structure of Vibrio cholerae ToxT reveals a mechanism for fatty acid regulation of virulence genes.,Lowden MJ, Skorupski K, Pellegrini M, Chiorazzo MG, Taylor RK, Kull FJ Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2860-5. Epub 2010 Feb 1. PMID:20133655<ref>PMID:20133655</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3gbg" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[ToxT\|ToxT]]		*[[ToxT\|ToxT]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Vibc3~~]]	+	[[Category: Vibrio cholerae O395]]
-	[[Category: Kull~~, F J~~]]	+	[[Category: Kull FJ]]
-	[[Category: Lowden~~, M J]]~~	+	[[Category: Lowden MJ]]
-	~~[[Category: Activator]]~~	+
-	~~[[Category: Arac family]]~~	+
-	~~[[Category: Cupin]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Helix-turn-helix]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation]]~~	+
-	~~[[Category: Transcription regulator]]~~	+
-	~~[[Category: Virulence~~]]	+

OCA at 08:00, 9 March 2022

OCA — Wed, 09 Mar 2022 08:00:49 GMT

←Older revision		Revision as of 08:00, 9 March 2022
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	==Crystal Structure of ToxT from Vibrio Cholerae O395==		==Crystal Structure of ToxT from Vibrio Cholerae O395==
-	<StructureSection load='3gbg' size='340' side='right' caption='[[3gbg]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='3gbg' size='340' side='right'caption='[[3gbg]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gbg]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Vibc3 Vibc3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3GBG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gbg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibc3 Vibc3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GBG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tcpN, toxT, VC0395_A0363 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=345073 VIBC3])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tcpN, toxT, VC0395_A0363 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=345073 VIBC3])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3gbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbg OCA], [~~http~~://pdbe.org/3gbg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3gbg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3gbg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3gbg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbg OCA], [https://pdbe.org/3gbg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gbg RCSB], [https://www.ebi.ac.uk/pdbsum/3gbg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gbg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TCPN_VIBC3 TCPN_VIBC3]] Probable regulatory protein for the tcp operon.	+	[[https://www.uniprot.org/uniprot/TCPN_VIBC3 TCPN_VIBC3]] Probable regulatory protein for the tcp operon.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Vibc3]]		[[Category: Vibc3]]
	[[Category: Kull, F J]]		[[Category: Kull, F J]]

OCA at 05:17, 7 December 2018

OCA — Fri, 07 Dec 2018 05:17:56 GMT

←Older revision		Revision as of 05:17, 7 December 2018
Line 1:		Line 1:
		+
	==Crystal Structure of ToxT from Vibrio Cholerae O395==		==Crystal Structure of ToxT from Vibrio Cholerae O395==
	<StructureSection load='3gbg' size='340' side='right' caption='[[3gbg]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3gbg' size='340' side='right' caption='[[3gbg]], [[Resolution\|resolution]] 1.90Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tcpN, toxT, VC0395_A0363 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=345073 VIBC3])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tcpN, toxT, VC0395_A0363 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=345073 VIBC3])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbg OCA], [http://pdbe.org/3gbg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gbg RCSB], [http://www.ebi.ac.uk/pdbsum/3gbg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbg OCA], [http://pdbe.org/3gbg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gbg RCSB], [http://www.ebi.ac.uk/pdbsum/3gbg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gbg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gb/3gbg_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gb/3gbg_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 31:

	==See Also==		==See Also==
-	*[[ToxT ~~Transcriptional Regulator in Vibrio cholerae~~\|ToxT ~~Transcriptional Regulator in Vibrio cholerae~~]]	+	*[[ToxT\|ToxT]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:59, 8 February 2016

OCA — Mon, 08 Feb 2016 17:59:01 GMT

←Older revision		Revision as of 17:59, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3gbg' size='340' side='right' caption='[[3gbg]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3gbg' size='340' side='right' caption='[[3gbg]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gbg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Vibrio_cholerae Vibrio cholerae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GBG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gbg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibc3 Vibc3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GBG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tcpN, toxT, VC0395_A0363 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~666 Vibrio cholerae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tcpN, toxT, VC0395_A0363 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=345073 VIBC3])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gbg RCSB], [http://www.ebi.ac.uk/pdbsum/3gbg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbg OCA], [http://pdbe.org/3gbg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gbg RCSB], [http://www.ebi.ac.uk/pdbsum/3gbg PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gbg ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3gbg" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Vibrio cholerae~~]]	+	[[Category: Vibc3]]
	[[Category: Kull, F J]]		[[Category: Kull, F J]]
	[[Category: Lowden, M J]]		[[Category: Lowden, M J]]

OCA at 01:09, 25 December 2014

OCA — Thu, 25 Dec 2014 01:09:37 GMT

←Older revision		Revision as of 01:09, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gbg RCSB], [http://www.ebi.ac.uk/pdbsum/3gbg PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gbg RCSB], [http://www.ebi.ac.uk/pdbsum/3gbg PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TCPN_VIBC3 TCPN_VIBC3]] Probable regulatory protein for the tcp operon.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:54, 17 December 2014

OCA — Wed, 17 Dec 2014 13:54:34 GMT

←Older revision		Revision as of 13:54, 17 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3gbg~~\| ~~PDB~~=3gbg \| ~~SCENE~~= }}	+	==Crystal Structure of ToxT from Vibrio Cholerae O395==
-	===~~Crystal Structure~~ of ~~ToxT~~ from ~~Vibrio Cholerae O395~~===	+	<StructureSection load='3gbg' size='340' side='right' caption='[[3gbg]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20133655}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3gbg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GBG FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tcpN, toxT, VC0395_A0363 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=666 Vibrio cholerae])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gbg RCSB], [http://www.ebi.ac.uk/pdbsum/3gbg PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gb/3gbg_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cholera is an acute intestinal infection caused by the bacterium Vibrio cholerae. In order for V. cholerae to cause disease, it must produce two virulence factors, the toxin-coregulated pilus (TCP) and cholera toxin (CT), whose expression is controlled by a transcriptional cascade culminating with the expression of the AraC-family regulator, ToxT. We have solved the 1.9 A resolution crystal structure of ToxT, which reveals folds in the N- and C-terminal domains that share a number of features in common with AraC, MarA, and Rob as well as the unexpected presence of a buried 16-carbon fatty acid, cis-palmitoleate. The finding that cis-palmitoleic acid reduces TCP and CT expression in V. cholerae and prevents ToxT from binding to DNA in vitro provides a direct link between the host environment of V. cholerae and regulation of virulence gene expression.

-	~~==About this~~ Structure==	+	Structure of Vibrio cholerae ToxT reveals a mechanism for fatty acid regulation of virulence genes.,Lowden MJ, Skorupski K, Pellegrini M, Chiorazzo MG, Taylor RK, Kull FJ Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2860-5. Epub 2010 Feb 1. PMID:20133655<ref>PMID:20133655</ref>
-	~~[[3gbg]] is~~ a ~~1 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=3GBG OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[ToxT Transcriptional Regulator in Vibrio cholerae\|ToxT Transcriptional Regulator in Vibrio cholerae]]		*[[ToxT Transcriptional Regulator in Vibrio cholerae\|ToxT Transcriptional Regulator in Vibrio cholerae]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020133655<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Vibrio cholerae]]		[[Category: Vibrio cholerae]]
-	[[Category: Kull, F J.]]	+	[[Category: Kull, F J]]
-	[[Category: Lowden, M J.]]	+	[[Category: Lowden, M J]]
	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Arac family]]		[[Category: Arac family]]

OCA at 09:43, 11 March 2013

OCA — Mon, 11 Mar 2013 09:43:54 GMT

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	{{STRUCTURE_3gbg\| PDB=3gbg \| SCENE= }}		{{STRUCTURE_3gbg\| PDB=3gbg \| SCENE= }}
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	===Crystal Structure of ToxT from Vibrio Cholerae O395===		===Crystal Structure of ToxT from Vibrio Cholerae O395===
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	{{ABSTRACT_PUBMED_20133655}}		{{ABSTRACT_PUBMED_20133655}}

OCA: Protected "3gbg" [edit=sysop:move=sysop]

OCA — Wed, 20 Feb 2013 14:27:41 GMT

Protected "3gbg" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:27, 20 February 2013

OCA at 14:27, 20 February 2013

OCA — Wed, 20 Feb 2013 14:27:38 GMT

←Older revision		Revision as of 14:27, 20 February 2013
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	[[Image:3gbg.png\|left\|200px]]		[[Image:3gbg.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3gbg", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_3gbg\| PDB=3gbg \| SCENE= }}		{{STRUCTURE_3gbg\| PDB=3gbg \| SCENE= }}

	===Crystal Structure of ToxT from Vibrio Cholerae O395===		===Crystal Structure of ToxT from Vibrio Cholerae O395===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20133655}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_20133655}}		{{ABSTRACT_PUBMED_20133655}}

	==About this Structure==		==About this Structure==
-	~~3GBG~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Vibrio_cholerae_o395~~ Vibrio cholerae ~~o395~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBG OCA].	+	[[3gbg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBG OCA].
		+
		+	==See Also==
		+	*[[ToxT Transcriptional Regulator in Vibrio cholerae\|ToxT Transcriptional Regulator in Vibrio cholerae]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20133655~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020133655</ref><references group="xtra"/>
-	[[Category: Vibrio cholerae ~~o395~~]]	+	[[Category: Vibrio cholerae]]
	[[Category: Kull, F J.]]		[[Category: Kull, F J.]]
	[[Category: Lowden, M J.]]		[[Category: Lowden, M J.]]
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	[[Category: Arac family]]		[[Category: Arac family]]
	[[Category: Cupin]]		[[Category: Cupin]]
-	[[Category: Cytoplasm]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
	[[Category: Helix-turn-helix]]		[[Category: Helix-turn-helix]]
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	[[Category: Transcription regulator]]		[[Category: Transcription regulator]]
	[[Category: Virulence]]		[[Category: Virulence]]
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OCA at 08:16, 28 April 2010

OCA — Wed, 28 Apr 2010 08:16:56 GMT

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