3gbw - Revision history

OCA at 08:01, 9 March 2022

OCA — Wed, 09 Mar 2022 08:01:21 GMT

←Older revision		Revision as of 08:01, 9 March 2022
Line 1:		Line 1:

	==Crystal structure of the first PHR domain of the Mouse Myc-binding protein 2 (MYCBP-2)==		==Crystal structure of the first PHR domain of the Mouse Myc-binding protein 2 (MYCBP-2)==
-	<StructureSection load='3gbw' size='340' side='right' caption='[[3gbw]]~~, [[Resolution\|resolution]] 1.32Å~~' scene=''>	+	<StructureSection load='3gbw' size='340' side='right'caption='[[3gbw]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>~~[[3gbw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice].~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3GBW FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GBW FirstGlance]. <br>
-	</td></tr>~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbw OCA], [https://pdbe.org/3gbw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gbw RCSB], [https://www.ebi.ac.uk/pdbsum/3gbw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gbw ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/3gbw TOPSAN]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mycbp2, Pam, Rpm-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3gbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbw OCA], [~~http~~://pdbe.org/3gbw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3gbw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3gbw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3gbw ProSAT], [~~http~~://www.topsan.org/Proteins/NYSGXRC/3gbw TOPSAN]</span></td></tr>	+
	</table>		</table>
-	== Function ==
-	[[http://www.uniprot.org/uniprot/MYCB2_MOUSE MYCB2_MOUSE]] Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. May have a role during synaptogenesis; candidate for respiratory distress and ventilatory disorders that arise from defective neuronal control of breathing. May function as a facilitator or regulator of transcriptional activation by MYC.<ref>PMID:14729956</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gb/3gbw_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gb/3gbw_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 20:		Line 16:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gbw ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gbw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	PHR [PAM (protein associated with Myc)-HIW (Highwire)-RPM-1 (regulator of presynaptic morphology 1)] proteins are conserved, large multi-domain E3 ubiquitin ligases with modular architecture. PHR proteins presynaptically control synaptic growth and axon guidance and postsynaptically regulate endocytosis of glutamate receptors. Dysfunction of neuronal ubiquitin-mediated proteasomal degradation is implicated in various neurodegenerative diseases. PHR proteins are characterized by the presence of two PHR domains near the N-terminus, which are essential for proper localization and function. Structures of both the first and second PHR domains of Mus musculus (mouse) Phr1 (MYC binding protein 2, Mycbp2) have been determined, revealing a novel beta sandwich fold composed of 11 antiparallel beta-strands. Conserved loops decorate the apical side of the first PHR domain (MmPHR1), yielding a distinct conserved surface feature. The surface of the second PHR domain (MmPHR2), in contrast, lacks significant conservation. Importantly, the structure of MmPHR1 provides insights into a loss-of-function mutation, Gly1092-->Glu, observed in the Caenorhabditis elegans ortholog RPM-1.

-	Structures of PHR domains from Mus musculus Phr1 (Mycbp2) explain the loss-of-function mutation (Gly1092-->Glu) of the C. elegans ortholog RPM-1.,Sampathkumar P, Ozyurt SA, Miller SA, Bain KT, Rutter ME, Gheyi T, Abrams B, Wang Y, Atwell S, Luz JG, Thompson DA, Wasserman SR, Emtage JS, Park EC, Rongo C, Jin Y, Klemke RL, Sauder JM, Burley SK J Mol Biol. 2010 Apr 9;397(4):883-92. Epub 2010 Feb 13. PMID:20156452<ref>PMID:20156452</ref>	+	==See Also==
-		+	*[[Ubiquitin protein ligase 3D structures\|Ubiquitin protein ligase 3D structures]]
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 3gbw" style="background-color:#fffaf0;"></div>~~	+
-	== ~~References~~ ==	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Large Structures]]
-	[[Category: Atwell, S]]	+	[[Category: Atwell S]]
-	[[Category: Bain~~, K T~~]]	+	[[Category: Bain KT]]
-	[[Category: Burley~~, S K~~]]	+	[[Category: Burley SK]]
-	[[Category: Klemke~~, R L~~]]	+	[[Category: Klemke RL]]
-	[[Category: Miller~~, S A]]~~	+	[[Category: Miller SA]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Ozyurt SA]]
-	[[Category: Ozyurt~~, S A~~]]	+	[[Category: Rutter ME]]
-	[[Category: Rutter~~, M E~~]]	+	[[Category: Sampathkumar P]]
-	[[Category: Sampathkumar, P]]	+	[[Category: Sauder JM]]
-	[[Category: Sauder~~, J M~~]]	+	[[Category: Tarun G]]
-	[[Category: Tarun, G]]	+	[[Category: Wasserman SR]]
-	[[Category: Wasserman~~, S R]]~~	+
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Myc-binding protein 2]]~~	+
-	~~[[Category: Mycbp2]]~~	+
-	~~[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Pam]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Phr domain]]~~	+
-	~~[[Category: Probable e3 ubiquitin-protein ligase mycbp2]]~~	+
-	~~[[Category: Protein associated with myc]]~~	+
-	~~[[Category: PSI, Protein structure initiative]]~~	+
-	~~[[Category: Rpm-1]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation]]~~	+
-	~~[[Category: Ubl conjugation pathway]]~~	+
-	~~[[Category: Zinc]]~~	+
-	~~[[Category: Zinc-finger~~]]	+

OCA at 07:02, 1 November 2017

OCA — Wed, 01 Nov 2017 07:02:21 GMT

←Older revision		Revision as of 07:02, 1 November 2017
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 3gbw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3gbw" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]
	== References ==		== References ==
	<references/>		<references/>
Line 49:		Line 46:
	[[Category: Tarun, G]]		[[Category: Tarun, G]]
	[[Category: Wasserman, S R]]		[[Category: Wasserman, S R]]
		+	[[Category: Alternative splicing]]
	[[Category: Ligase]]		[[Category: Ligase]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
Line 65:		Line 63:
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
	[[Category: Ubl conjugation pathway]]		[[Category: Ubl conjugation pathway]]
		+	[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

OCA at 13:30, 5 August 2016

OCA — Fri, 05 Aug 2016 13:30:17 GMT

←Older revision		Revision as of 13:30, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the first PHR domain of the Mouse Myc-binding protein 2 (MYCBP-2)==		==Crystal structure of the first PHR domain of the Mouse Myc-binding protein 2 (MYCBP-2)==
	<StructureSection load='3gbw' size='340' side='right' caption='[[3gbw]], [[Resolution\|resolution]] 1.32Å' scene=''>		<StructureSection load='3gbw' size='340' side='right' caption='[[3gbw]], [[Resolution\|resolution]] 1.32Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gbw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GBW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gbw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GBW FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mycbp2, Pam, Rpm-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mycbp2, Pam, Rpm-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gbw RCSB], [http://www.ebi.ac.uk/pdbsum/3gbw PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/3gbw TOPSAN]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbw OCA], [http://pdbe.org/3gbw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gbw RCSB], [http://www.ebi.ac.uk/pdbsum/3gbw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gbw ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/3gbw TOPSAN]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gbw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3gbw" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Atwell, S]]		[[Category: Atwell, S]]
	[[Category: Bain, K T]]		[[Category: Bain, K T]]

OCA at 19:12, 25 December 2014

OCA — Thu, 25 Dec 2014 19:12:59 GMT

←Older revision		Revision as of 19:12, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gbw RCSB], [http://www.ebi.ac.uk/pdbsum/3gbw PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/3gbw TOPSAN]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gbw RCSB], [http://www.ebi.ac.uk/pdbsum/3gbw PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/3gbw TOPSAN]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MYCB2_MOUSE MYCB2_MOUSE]] Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. May have a role during synaptogenesis; candidate for respiratory distress and ventilatory disorders that arise from defective neuronal control of breathing. May function as a facilitator or regulator of transcriptional activation by MYC.<ref>PMID:14729956</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 12:38, 6 November 2014

OCA — Thu, 06 Nov 2014 12:38:14 GMT

←Older revision		Revision as of 12:38, 6 November 2014
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Mus musculus]]
		+	[[Category: Atwell, S]]
		+	[[Category: Bain, K T]]
		+	[[Category: Burley, S K]]
	[[Category: Klemke, R L]]		[[Category: Klemke, R L]]
	[[Category: Miller, S A]]		[[Category: Miller, S A]]
		+	[[Category: Structural genomic]]
	[[Category: Ozyurt, S A]]		[[Category: Ozyurt, S A]]
		+	[[Category: Rutter, M E]]
		+	[[Category: Sampathkumar, P]]
		+	[[Category: Sauder, J M]]
	[[Category: Tarun, G]]		[[Category: Tarun, G]]
		+	[[Category: Wasserman, S R]]
		+	[[Category: Ligase]]
		+	[[Category: Metal-binding]]
	[[Category: Myc-binding protein 2]]		[[Category: Myc-binding protein 2]]
	[[Category: Mycbp2]]		[[Category: Mycbp2]]
		+	[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Pam]]		[[Category: Pam]]
		+	[[Category: Phosphoprotein]]
	[[Category: Phr domain]]		[[Category: Phr domain]]
	[[Category: Probable e3 ubiquitin-protein ligase mycbp2]]		[[Category: Probable e3 ubiquitin-protein ligase mycbp2]]
	[[Category: Protein associated with myc]]		[[Category: Protein associated with myc]]
		+	[[Category: PSI, Protein structure initiative]]
	[[Category: Rpm-1]]		[[Category: Rpm-1]]
		+	[[Category: Transcription]]
		+	[[Category: Transcription regulation]]
	[[Category: Ubl conjugation pathway]]		[[Category: Ubl conjugation pathway]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

OCA at 11:58, 6 November 2014

OCA — Thu, 06 Nov 2014 11:58:07 GMT

←Older revision		Revision as of 11:58, 6 November 2014
Line 1:		Line 1:
-	[[~~Image:~~3gbw.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the first PHR domain of the Mouse Myc-binding protein 2 (MYCBP-2)==
		+	<StructureSection load='3gbw' size='340' side='right' caption='[[3gbw]], [[Resolution\|resolution]] 1.32Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3gbw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GBW FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mycbp2, Pam, Rpm-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gbw RCSB], [http://www.ebi.ac.uk/pdbsum/3gbw PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/3gbw TOPSAN]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gb/3gbw_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	PHR [PAM (protein associated with Myc)-HIW (Highwire)-RPM-1 (regulator of presynaptic morphology 1)] proteins are conserved, large multi-domain E3 ubiquitin ligases with modular architecture. PHR proteins presynaptically control synaptic growth and axon guidance and postsynaptically regulate endocytosis of glutamate receptors. Dysfunction of neuronal ubiquitin-mediated proteasomal degradation is implicated in various neurodegenerative diseases. PHR proteins are characterized by the presence of two PHR domains near the N-terminus, which are essential for proper localization and function. Structures of both the first and second PHR domains of Mus musculus (mouse) Phr1 (MYC binding protein 2, Mycbp2) have been determined, revealing a novel beta sandwich fold composed of 11 antiparallel beta-strands. Conserved loops decorate the apical side of the first PHR domain (MmPHR1), yielding a distinct conserved surface feature. The surface of the second PHR domain (MmPHR2), in contrast, lacks significant conservation. Importantly, the structure of MmPHR1 provides insights into a loss-of-function mutation, Gly1092-->Glu, observed in the Caenorhabditis elegans ortholog RPM-1.

-	~~{{STRUCTURE_3gbw\| PDB=3gbw \| SCENE= }}~~	+	Structures of PHR domains from Mus musculus Phr1 (Mycbp2) explain the loss-of-function mutation (Gly1092-->Glu) of the C. elegans ortholog RPM-1.,Sampathkumar P, Ozyurt SA, Miller SA, Bain KT, Rutter ME, Gheyi T, Abrams B, Wang Y, Atwell S, Luz JG, Thompson DA, Wasserman SR, Emtage JS, Park EC, Rongo C, Jin Y, Klemke RL, Sauder JM, Burley SK J Mol Biol. 2010 Apr 9;397(4):883-92. Epub 2010 Feb 13. PMID:20156452<ref>PMID:20156452</ref>

-	~~===Crystal structure~~ of the ~~first PHR domain~~ of ~~the Mouse Myc-binding protein 2 (MYCBP-2)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_20156452}}~~	+	==See Also==
-		+	*[[Ubiquitin protein ligase\|Ubiquitin protein ligase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~3gbw~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBW OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:020156452<~~/~~ref~~><~~references group="xtra"~~/>	+	[[Category: Klemke, R L]]
-	~~[[Category: Mus musculus]]~~	+	[[Category: Miller, S A]]
-	~~[[Category: Atwell, S.]]~~	+	[[Category: Ozyurt, S A]]
-	~~[[Category: Bain, K T.]]~~	+	[[Category: Tarun, G]]
-	~~[[Category: Burley, S K.]]~~	+
-	[[Category: Klemke, R L.]]	+
-	[[Category: Miller, S A~~.]]~~	+
-	~~[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics.~~]]	+
-	[[Category: Ozyurt, S A~~.]]~~	+
-	~~[[Category: Rutter, M E.]]~~	+
-	~~[[Category: Sampathkumar, P.]]~~	+
-	~~[[Category: Sauder, J M.~~]]	+
-	[[Category: Tarun, G~~.]]~~	+
-	~~[[Category: Wasserman, S R.]]~~	+
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Metal-binding~~]]	+
	[[Category: Myc-binding protein 2]]		[[Category: Myc-binding protein 2]]
	[[Category: Mycbp2]]		[[Category: Mycbp2]]
-	[[Category: New york sgx research center for structural genomic]]
-	[[Category: New york structural genomix research consortium]]
	[[Category: Nucleus]]		[[Category: Nucleus]]
-	[[Category: Nysgxrc]]
	[[Category: Pam]]		[[Category: Pam]]
-	[[Category: Phosphoprotein]]
	[[Category: Phr domain]]		[[Category: Phr domain]]
	[[Category: Probable e3 ubiquitin-protein ligase mycbp2]]		[[Category: Probable e3 ubiquitin-protein ligase mycbp2]]
	[[Category: Protein associated with myc]]		[[Category: Protein associated with myc]]
-	[[Category: Protein structure initiative]]
-	[[Category: Psi-2]]
	[[Category: Rpm-1]]		[[Category: Rpm-1]]
-	[[Category: Structural genomic]]
-	[[Category: Transcription]]
-	[[Category: Transcription regulation]]
	[[Category: Ubl conjugation pathway]]		[[Category: Ubl conjugation pathway]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

OCA: Protected "3gbw" [edit=sysop:move=sysop]

OCA — Wed, 20 Feb 2013 14:47:00 GMT

Protected "3gbw" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:47, 20 February 2013

OCA at 14:46, 20 February 2013

OCA — Wed, 20 Feb 2013 14:46:58 GMT

←Older revision		Revision as of 14:46, 20 February 2013
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-	{{Seed}}
	[[Image:3gbw.png\|left\|200px]]		[[Image:3gbw.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3gbw", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3gbw\| PDB=3gbw \| SCENE= }}		{{STRUCTURE_3gbw\| PDB=3gbw \| SCENE= }}

	===Crystal structure of the first PHR domain of the Mouse Myc-binding protein 2 (MYCBP-2)===		===Crystal structure of the first PHR domain of the Mouse Myc-binding protein 2 (MYCBP-2)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20156452}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20156452 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20156452}}		{{ABSTRACT_PUBMED_20156452}}

	==About this Structure==		==About this Structure==
-	~~3GBW~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBW OCA].	+	[[3gbw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBW OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20156452~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020156452</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Atwell, S.]]		[[Category: Atwell, S.]]
Line 37:		Line 25:
	[[Category: Tarun, G.]]		[[Category: Tarun, G.]]
	[[Category: Wasserman, S R.]]		[[Category: Wasserman, S R.]]
-	[[Category: Alternative splicing]]
	[[Category: Ligase]]		[[Category: Ligase]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
Line 58:		Line 45:
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
	[[Category: Ubl conjugation pathway]]		[[Category: Ubl conjugation pathway]]
-	[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 7 10:09:37 2010''

OCA at 07:09, 7 April 2010

OCA — Wed, 07 Apr 2010 07:09:38 GMT

←Older revision		Revision as of 07:09, 7 April 2010
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	===Crystal structure of the first PHR domain of the Mouse Myc-binding protein 2 (MYCBP-2)===		===Crystal structure of the first PHR domain of the Mouse Myc-binding protein 2 (MYCBP-2)===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20156452}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20156452 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20156452}}

	==About this Structure==		==About this Structure==
-	3GBW is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBW OCA].	+	3GBW is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBW OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20156452</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Atwell, S.]]		[[Category: Atwell, S.]]
-	[[Category: Bain, K.]]	+	[[Category: Bain, K T.]]
	[[Category: Burley, S K.]]		[[Category: Burley, S K.]]
	[[Category: Klemke, R L.]]		[[Category: Klemke, R L.]]
-	[[Category: Miller, S.]]	+	[[Category: Miller, S A.]]
	[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics.]]		[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics.]]
-	[[Category: Ozyurt, S.]]	+	[[Category: Ozyurt, S A.]]
-	[[Category: Rutter, M.]]	+	[[Category: Rutter, M E.]]
	[[Category: Sampathkumar, P.]]		[[Category: Sampathkumar, P.]]
	[[Category: Sauder, J M.]]		[[Category: Sauder, J M.]]
	[[Category: Tarun, G.]]		[[Category: Tarun, G.]]
-	[[Category: Wasserman, S.]]	+	[[Category: Wasserman, S R.]]
	[[Category: Alternative splicing]]		[[Category: Alternative splicing]]
	[[Category: Ligase]]		[[Category: Ligase]]
Line 52:		Line 61:
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~May 20 15~~:49:~~31 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 7 10:09:37 2010''

OCA at 12:49, 20 May 2009

OCA — Wed, 20 May 2009 12:49:32 GMT

←Older revision		Revision as of 12:49, 20 May 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3gbw.~~jpg~~\|left\|200px]]	+	[[Image:3gbw.png\|left\|200px]]

	<!--		<!--
Line 16:		Line 16:
	3GBW is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBW OCA].		3GBW is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBW OCA].
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
		+	[[Category: Atwell, S.]]
	[[Category: Bain, K.]]		[[Category: Bain, K.]]
	[[Category: Burley, S K.]]		[[Category: Burley, S K.]]
Line 51:		Line 52:
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Mar 25 12~~:41:48 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 20 15:49:31 2009''