3gbz - Revision history

OCA at 07:02, 6 September 2023

OCA — Wed, 06 Sep 2023 07:02:59 GMT

←Older revision		Revision as of 07:02, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3gbz' size='340' side='right'caption='[[3gbz]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='3gbz' size='340' side='right'caption='[[3gbz]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gbz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Giaic Giaic~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GBZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gbz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Giardia_lamblia_ATCC_50803 Giardia lamblia ATCC 50803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GBZ FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>GL50803_8037 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=184922 GIAIC])</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~">~~<b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cyclin~~-~~dependent_kinase Cyclin-dependent kinase]~~, ~~with EC number~~ [~~https://www~~.~~brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbz OCA], [https://pdbe.org/3gbz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gbz RCSB], [https://www.ebi.ac.uk/pdbsum/3gbz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gbz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbz OCA], [https://pdbe.org/3gbz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gbz RCSB], [https://www.ebi.ac.uk/pdbsum/3gbz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gbz ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A8BZ95_GIAIC A8BZ95_GIAIC]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cyclin-dependent kinase]]~~	+	[[Category: Giardia lamblia ATCC 50803]]
-	~~[[Category: Giaic~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Structural genomic]]
-	[[Category: Atp-binding]]
-	[[Category: Cmgc cdk]]
-	[[Category: Kinase]]
-	[[Category: Nucleotide-binding]]
-	[[Category: Serine/threonine-protein kinase]]
-	[[Category: Ssgcid]]
-	[[Category: Transferase]]

OCA at 08:01, 9 March 2022

OCA — Wed, 09 Mar 2022 08:01:23 GMT

←Older revision		Revision as of 08:01, 9 March 2022
Line 1:		Line 1:

	==Structure of the CMGC CDK Kinase from Giardia lamblia==		==Structure of the CMGC CDK Kinase from Giardia lamblia==
-	<StructureSection load='3gbz' size='340' side='right' caption='[[3gbz]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='3gbz' size='340' side='right'caption='[[3gbz]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gbz]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Giaic Giaic]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3GBZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gbz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Giaic Giaic]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GBZ FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GL50803_8037 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=184922 GIAIC])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GL50803_8037 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=184922 GIAIC])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3gbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbz OCA], [~~http~~://pdbe.org/3gbz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3gbz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3gbz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3gbz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbz OCA], [https://pdbe.org/3gbz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gbz RCSB], [https://www.ebi.ac.uk/pdbsum/3gbz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gbz ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	[[Category: Cyclin-dependent kinase]]		[[Category: Cyclin-dependent kinase]]
	[[Category: Giaic]]		[[Category: Giaic]]
		+	[[Category: Large Structures]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]

OCA at 05:44, 7 December 2018

OCA — Fri, 07 Dec 2018 05:44:58 GMT

←Older revision		Revision as of 05:44, 7 December 2018
Line 1:		Line 1:
		+
	==Structure of the CMGC CDK Kinase from Giardia lamblia==		==Structure of the CMGC CDK Kinase from Giardia lamblia==
	<StructureSection load='3gbz' size='340' side='right' caption='[[3gbz]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='3gbz' size='340' side='right' caption='[[3gbz]], [[Resolution\|resolution]] 1.85Å' scene=''>
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	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GL50803_8037 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=184922 GIAIC])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GL50803_8037 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=184922 GIAIC])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbz OCA], [http://pdbe.org/3gbz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gbz RCSB], [http://www.ebi.ac.uk/pdbsum/3gbz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbz OCA], [http://pdbe.org/3gbz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gbz RCSB], [http://www.ebi.ac.uk/pdbsum/3gbz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gbz ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gb/3gbz_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gb/3gbz_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 17:10, 7 February 2016

OCA — Sun, 07 Feb 2016 17:10:44 GMT

←Older revision		Revision as of 17:10, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3gbz' size='340' side='right' caption='[[3gbz]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='3gbz' size='340' side='right' caption='[[3gbz]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gbz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Giardia_intestinalis Giardia intestinalis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GBZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gbz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Giaic Giaic]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GBZ FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GL50803_8037 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~5741 Giardia intestinalis~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GL50803_8037 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=184922 GIAIC])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gbz RCSB], [http://www.ebi.ac.uk/pdbsum/3gbz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbz OCA], [http://pdbe.org/3gbz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gbz RCSB], [http://www.ebi.ac.uk/pdbsum/3gbz PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gbz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3gbz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Cyclin-dependent kinase]]		[[Category: Cyclin-dependent kinase]]
-	[[Category: ~~Giardia intestinalis~~]]	+	[[Category: Giaic]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]

OCA at 23:07, 3 January 2015

OCA — Sat, 03 Jan 2015 23:07:48 GMT

←Older revision		Revision as of 23:07, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3gbz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Giardia_intestinalis Giardia intestinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GBZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[3gbz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Giardia_intestinalis Giardia intestinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GBZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GL50803_8037 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5741 Giardia intestinalis])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GL50803_8037 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5741 Giardia intestinalis])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gbz RCSB], [http://www.ebi.ac.uk/pdbsum/3gbz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gbz RCSB], [http://www.ebi.ac.uk/pdbsum/3gbz PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 23:		Line 23:
	Structure of a cyclin-dependent kinase from Giardia lamblia.,Leibly DJ, Newling PA, Abendroth J, Guo W, Kelley A, Stewart LJ, Van Voorhis W Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt, 9):1084-9. Epub 2011 Aug 16. PMID:21904054<ref>PMID:21904054</ref>		Structure of a cyclin-dependent kinase from Giardia lamblia.,Leibly DJ, Newling PA, Abendroth J, Guo W, Kelley A, Stewart LJ, Van Voorhis W Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt, 9):1084-9. Epub 2011 Aug 16. PMID:21904054<ref>PMID:21904054</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 31:		Line 31:
	[[Category: Cyclin-dependent kinase]]		[[Category: Cyclin-dependent kinase]]
	[[Category: Giardia intestinalis]]		[[Category: Giardia intestinalis]]
-	[[Category: ~~SSGCID, Seattle~~ Structural ~~Genomics Center for Infectious Disease.~~]]	+	[[Category: Structural genomic]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Cmgc cdk]]		[[Category: Cmgc cdk]]
	[[Category: Kinase]]		[[Category: Kinase]]
	[[Category: Nucleotide-binding]]		[[Category: Nucleotide-binding]]
-	[[Category: Seattle structural genomics center for infectious disease]]
	[[Category: Serine/threonine-protein kinase]]		[[Category: Serine/threonine-protein kinase]]
	[[Category: Ssgcid]]		[[Category: Ssgcid]]
-	[[Category: Structural genomic]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 09:41, 21 May 2014

OCA — Wed, 21 May 2014 09:41:38 GMT

←Older revision		Revision as of 09:41, 21 May 2014
Line 1:		Line 1:
-	[[~~Image~~:3gbz.~~png\|left~~\|200px]]	+	==Structure of the CMGC CDK Kinase from Giardia lamblia==
		+	<StructureSection load='3gbz' size='340' side='right' caption='[[3gbz]], [[Resolution\|resolution]] 1.85Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3gbz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Giardia_intestinalis Giardia intestinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GBZ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GL50803_8037 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5741 Giardia intestinalis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gbz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gbz RCSB], [http://www.ebi.ac.uk/pdbsum/3gbz PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gb/3gbz_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Giardia lamblia is the etiologic agent of giardiasis, a water-borne infection that is prevalent throughout the world. The need for new therapeutics for the treatment of giardiasis is of paramount importance. Owing to the ubiquitous nature of kinases and their vital importance in organisms, they are potential drug targets. In this paper, the first structure of a cyclin-dependent kinase (CDK) from G. lamblia (GlCDK; UniProt A8BZ95) is presented. CDKs are cell-cycle-associated kinases that are actively being pursued as targets for anticancer drugs as well as for antiparasitic chemotherapy. Generally, a CDK forms a complex with its associated cyclin. This CDK-cyclin complex is active and acts as a serine/threonine protein kinase. Typically, CDKs are responsible for the transition to the next phase of the cell cycle. Although the structure of GlCDK with its associated cyclin was not solved, the 1.85 A resolution structure of apo GlCDK and a 2.0 A resolution structure of GlCDK in complex with adenosine monophosphate are presented and the structural differences from the orthologous human CDK2 and CDK3 are discussed.

-	<!--	+	Structure of a cyclin-dependent kinase from Giardia lamblia.,Leibly DJ, Newling PA, Abendroth J, Guo W, Kelley A, Stewart LJ, Van Voorhis W Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt, 9):1084-9. Epub 2011 Aug 16. PMID:21904054<ref>PMID:21904054</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3gbz"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet)~~	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded)~~,	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3gbz\| PDB=3gbz \| SCENE= }}~~	+

-	~~===Structure~~ of the ~~CMGC CDK Kinase from Giardia lamblia===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21904054}}, adds the Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21904054 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21904054}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3gbz]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Giardia_intestinalis Giardia intestinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBZ OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021904054<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Cyclin-dependent kinase]]		[[Category: Cyclin-dependent kinase]]
	[[Category: Giardia intestinalis]]		[[Category: Giardia intestinalis]]

OCA: Protected "3gbz" [edit=sysop:move=sysop]

OCA — Wed, 21 Sep 2011 05:05:43 GMT

Protected "3gbz" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:05, 21 September 2011

OCA at 05:05, 21 September 2011

OCA — Wed, 21 Sep 2011 05:05:40 GMT

←Older revision		Revision as of 05:05, 21 September 2011
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3gbz.png\|left\|200px]]
-	[[Image:3gbz.~~jpg~~\|left\|200px]]	+

	<!--		<!--
Line 12:		Line 11:
	===Structure of the CMGC CDK Kinase from Giardia lamblia===		===Structure of the CMGC CDK Kinase from Giardia lamblia===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21904054}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21904054 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21904054}}

	==About this Structure==		==About this Structure==
-	~~3GBZ~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/~~Giardia_lamblia_atcc_50803~~ Giardia ~~lamblia atcc 50803~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBZ OCA].	+	[[3gbz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Giardia_intestinalis Giardia intestinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBZ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021904054</ref><references group="xtra"/>
	[[Category: Cyclin-dependent kinase]]		[[Category: Cyclin-dependent kinase]]
-	[[Category: Giardia ~~lamblia atcc 50803~~]]	+	[[Category: Giardia intestinalis]]
	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]		[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
Line 27:		Line 35:
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 25 12:42:18 2009''

OCA at 10:42, 25 March 2009

OCA — Wed, 25 Mar 2009 10:42:21 GMT

←Older revision		Revision as of 10:42, 25 March 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3gbz.jpg\|left\|200px]]

-	The ~~entry 3gbz~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3gbz", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3gbz\| PDB=3gbz \| SCENE= }}

-	~~Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)~~	+	===Structure of the CMGC CDK Kinase from Giardia lamblia===

-	Description: Structure of the CMGC CDK Kinase from Giardia lamblia

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar ~~11 11~~:11:10 2009''	+	==About this Structure==
		+	3GBZ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Giardia_lamblia_atcc_50803 Giardia lamblia atcc 50803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GBZ OCA].
		+	[[Category: Cyclin-dependent kinase]]
		+	[[Category: Giardia lamblia atcc 50803]]
		+	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
		+	[[Category: Atp-binding]]
		+	[[Category: Cmgc cdk]]
		+	[[Category: Kinase]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Seattle structural genomics center for infectious disease]]
		+	[[Category: Serine/threonine-protein kinase]]
		+	[[Category: Ssgcid]]
		+	[[Category: Structural genomic]]
		+	[[Category: Transferase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 25 12:42:18 2009''

OCA: New page: '''Unreleased structure''' The entry 3gbz is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Description: Structure of the CMGC CDK Kinase from Giar...

OCA — Wed, 11 Mar 2009 09:11:10 GMT

New page: '''Unreleased structure''' The entry 3gbz is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Description: Structure of the CMGC CDK Kinase from Giar...

New page

'''Unreleased structure'''

The entry 3gbz is ON HOLD

Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Description: Structure of the CMGC CDK Kinase from Giardia lamblia

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 11 11:11:10 2009''