3gf5 - Revision history

OCA at 08:26, 20 March 2024

OCA — Wed, 20 Mar 2024 08:26:20 GMT

←Older revision		Revision as of 08:26, 20 March 2024
Line 3:		Line 3:
	<StructureSection load='3gf5' size='340' side='right'caption='[[3gf5]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3gf5' size='340' side='right'caption='[[3gf5]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gf5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GF5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GF5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gf5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GF5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GF5 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[3gnf\|3gnf]], [[3gng\|3gng]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">MVP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gf5 OCA], [https://pdbe.org/3gf5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gf5 RCSB], [https://www.ebi.ac.uk/pdbsum/3gf5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gf5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gf5 OCA], [https://pdbe.org/3gf5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gf5 RCSB], [https://www.ebi.ac.uk/pdbsum/3gf5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gf5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MVP_MOUSE MVP_MOUSE]] Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases (By similarity).	+	[https://www.uniprot.org/uniprot/MVP_MOUSE MVP_MOUSE] Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 21:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gf5 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gf5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Vaults are ubiquitous ribonucleoprotein complexes involved in a diversity of cellular processes, including multidrug resistance, transport mechanisms and signal transmission. The vault particle shows a barrel-shaped structure organized in two identical moieties, each consisting of 39 copies of the major vault protein MVP. Earlier data indicated that vault halves can dissociate at acidic pH. The crystal structure of the vault particle solved at 8 A resolution, together with the 2.1-A structure of the seven N-terminal domains (R1-R7) of MVP, reveal the interactions governing vault association and provide an explanation for a reversible dissociation induced by low pH. The structural comparison with the recently published 3.5 A model shows major discrepancies, both in the main chain tracing and in the side chain assignment of the two terminal domains R1 and R2.
-
-	The mechanism of vault opening from the high resolution structure of the N-terminal repeats of MVP.,Querol-Audi J, Casanas A, Uson I, Luque D, Caston JR, Fita I, Verdaguer N EMBO J. 2009 Nov 4;28(21):3450-7. Epub 2009 Sep 24. PMID:19779459<ref>PMID:19779459</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3gf5" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Casanas, A]]	+	[[Category: Casanas A]]
-	[[Category: Caston~~, J R~~]]	+	[[Category: Caston JR]]
-	[[Category: Fita, I]]	+	[[Category: Fita I]]
-	[[Category: Luque, D]]	+	[[Category: Luque D]]
-	[[Category: Querol-Audi, J]]	+	[[Category: Querol-Audi J]]
-	[[Category: Verdaguer, N]]	+	[[Category: Verdaguer N]]
-	~~[[Category: Beta sheet]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Ribonucleoprotein]]~~	+
-	~~[[Category: Structural protein~~]]	+

OCA at 08:03, 9 March 2022

OCA — Wed, 09 Mar 2022 08:03:20 GMT

←Older revision		Revision as of 08:03, 9 March 2022
Line 1:		Line 1:

	==Crystal structure of the P21 R1-R7 N-terminal domain of murine MVP==		==Crystal structure of the P21 R1-R7 N-terminal domain of murine MVP==
-	<StructureSection load='3gf5' size='340' side='right' caption='[[3gf5]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='3gf5' size='340' side='right'caption='[[3gf5]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gf5]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GF5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3GF5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gf5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GF5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GF5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gnf\|3gnf]], [[3gng\|3gng]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3gnf\|3gnf]], [[3gng\|3gng]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MVP ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MVP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3gf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gf5 OCA], [~~http~~://pdbe.org/3gf5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3gf5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3gf5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3gf5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gf5 OCA], [https://pdbe.org/3gf5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gf5 RCSB], [https://www.ebi.ac.uk/pdbsum/3gf5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gf5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MVP_MOUSE MVP_MOUSE]] Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases (By similarity).	+	[[https://www.uniprot.org/uniprot/MVP_MOUSE MVP_MOUSE]] Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Casanas, A]]		[[Category: Casanas, A]]

OCA at 05:10, 7 December 2018

OCA — Fri, 07 Dec 2018 05:10:57 GMT

←Older revision		Revision as of 05:10, 7 December 2018
Line 1:		Line 1:
		+
	==Crystal structure of the P21 R1-R7 N-terminal domain of murine MVP==		==Crystal structure of the P21 R1-R7 N-terminal domain of murine MVP==
	<StructureSection load='3gf5' size='340' side='right' caption='[[3gf5]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3gf5' size='340' side='right' caption='[[3gf5]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gnf\|3gnf]], [[3gng\|3gng]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gnf\|3gnf]], [[3gng\|3gng]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MVP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MVP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gf5 OCA], [http://pdbe.org/3gf5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gf5 RCSB], [http://www.ebi.ac.uk/pdbsum/3gf5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gf5 OCA], [http://pdbe.org/3gf5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gf5 RCSB], [http://www.ebi.ac.uk/pdbsum/3gf5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gf5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gf/3gf5_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gf/3gf5_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 17:57, 7 February 2016

OCA — Sun, 07 Feb 2016 17:57:27 GMT

←Older revision		Revision as of 17:57, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3gf5' size='340' side='right' caption='[[3gf5]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3gf5' size='340' side='right' caption='[[3gf5]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gf5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GF5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GF5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gf5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GF5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GF5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gnf\|3gnf]], [[3gng\|3gng]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gnf\|3gnf]], [[3gng\|3gng]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MVP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MVP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gf5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gf5 RCSB], [http://www.ebi.ac.uk/pdbsum/3gf5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gf5 OCA], [http://pdbe.org/3gf5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gf5 RCSB], [http://www.ebi.ac.uk/pdbsum/3gf5 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gf5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3gf5" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Casanas, A]]		[[Category: Casanas, A]]
	[[Category: Caston, J R]]		[[Category: Caston, J R]]

OCA at 17:15, 24 December 2014

OCA — Wed, 24 Dec 2014 17:15:33 GMT

←Older revision		Revision as of 17:15, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gf5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gf5 RCSB], [http://www.ebi.ac.uk/pdbsum/3gf5 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gf5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gf5 RCSB], [http://www.ebi.ac.uk/pdbsum/3gf5 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MVP_MOUSE MVP_MOUSE]] Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:42, 8 December 2014

OCA — Mon, 08 Dec 2014 08:42:06 GMT

←Older revision		Revision as of 08:42, 8 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3gf5.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the P21 R1-R7 N-terminal domain of murine MVP==
		+	<StructureSection load='3gf5' size='340' side='right' caption='[[3gf5]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3gf5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GF5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GF5 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gnf\|3gnf]], [[3gng\|3gng]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MVP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gf5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gf5 RCSB], [http://www.ebi.ac.uk/pdbsum/3gf5 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gf/3gf5_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Vaults are ubiquitous ribonucleoprotein complexes involved in a diversity of cellular processes, including multidrug resistance, transport mechanisms and signal transmission. The vault particle shows a barrel-shaped structure organized in two identical moieties, each consisting of 39 copies of the major vault protein MVP. Earlier data indicated that vault halves can dissociate at acidic pH. The crystal structure of the vault particle solved at 8 A resolution, together with the 2.1-A structure of the seven N-terminal domains (R1-R7) of MVP, reveal the interactions governing vault association and provide an explanation for a reversible dissociation induced by low pH. The structural comparison with the recently published 3.5 A model shows major discrepancies, both in the main chain tracing and in the side chain assignment of the two terminal domains R1 and R2.

-	~~{{STRUCTURE_3gf5\| PDB=3gf5 \| SCENE= }}~~	+	The mechanism of vault opening from the high resolution structure of the N-terminal repeats of MVP.,Querol-Audi J, Casanas A, Uson I, Luque D, Caston JR, Fita I, Verdaguer N EMBO J. 2009 Nov 4;28(21):3450-7. Epub 2009 Sep 24. PMID:19779459<ref>PMID:19779459</ref>

-	~~===Crystal structure~~ of the ~~P21 R1-R7 N-terminal domain of murine MVP===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19779459}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3gf5]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3GF5 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019779459<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Casanas, A.]]	+	[[Category: Casanas, A]]
-	[[Category: Caston, J R.]]	+	[[Category: Caston, J R]]
-	[[Category: Fita, I.]]	+	[[Category: Fita, I]]
-	[[Category: Luque, D.]]	+	[[Category: Luque, D]]
-	[[Category: Querol-Audi, J.]]	+	[[Category: Querol-Audi, J]]
-	[[Category: Verdaguer, N.]]	+	[[Category: Verdaguer, N]]
	[[Category: Beta sheet]]		[[Category: Beta sheet]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
	[[Category: Ribonucleoprotein]]		[[Category: Ribonucleoprotein]]
	[[Category: Structural protein]]		[[Category: Structural protein]]

OCA: Protected "3gf5" [edit=sysop:move=sysop]

OCA — Wed, 20 Feb 2013 12:39:10 GMT

Protected "3gf5" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:39, 20 February 2013

OCA at 12:39, 20 February 2013

OCA — Wed, 20 Feb 2013 12:39:08 GMT

←Older revision		Revision as of 12:39, 20 February 2013
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-	{{Seed}}
	[[Image:3gf5.png\|left\|200px]]		[[Image:3gf5.png\|left\|200px]]

-	<!--
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-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
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	{{STRUCTURE_3gf5\| PDB=3gf5 \| SCENE= }}		{{STRUCTURE_3gf5\| PDB=3gf5 \| SCENE= }}

	===Crystal structure of the P21 R1-R7 N-terminal domain of murine MVP===		===Crystal structure of the P21 R1-R7 N-terminal domain of murine MVP===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19779459}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_19779459}}		{{ABSTRACT_PUBMED_19779459}}

	==About this Structure==		==About this Structure==
-	~~3GF5~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GF5 OCA].	+	[[3gf5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GF5 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19779459~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019779459</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Casanas, A.]]		[[Category: Casanas, A.]]
Line 35:		Line 23:
	[[Category: Ribonucleoprotein]]		[[Category: Ribonucleoprotein]]
	[[Category: Structural protein]]		[[Category: Structural protein]]
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OCA at 05:52, 22 December 2010

OCA — Wed, 22 Dec 2010 05:52:08 GMT

←Older revision		Revision as of 05:52, 22 December 2010
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	[[Category: Querol-Audi, J.]]		[[Category: Querol-Audi, J.]]
	[[Category: Verdaguer, N.]]		[[Category: Verdaguer, N.]]
-	[[Category: Acetylation]]
	[[Category: Beta sheet]]		[[Category: Beta sheet]]
-	[[Category: Cytoplasm]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
	[[Category: Ribonucleoprotein]]		[[Category: Ribonucleoprotein]]
	[[Category: Structural protein]]		[[Category: Structural protein]]

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OCA at 12:27, 28 January 2010

OCA — Thu, 28 Jan 2010 12:27:32 GMT

←Older revision		Revision as of 12:27, 28 January 2010
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	{{Seed}}		{{Seed}}
-	[[Image:3gf5.~~jpg~~\|left\|200px]]	+	[[Image:3gf5.png\|left\|200px]]

	<!--		<!--
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	==About this Structure==		==About this Structure==
-	3GF5 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GF5 OCA].	+	3GF5 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GF5 OCA].

	==Reference==		==Reference==
Line 38:		Line 38:
	[[Category: Structural protein]]		[[Category: Structural protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Nov 11 22~~:22:~~29 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 28 14:27:31 2010''