3gj7 - Revision history

OCA at 07:07, 6 September 2023

OCA — Wed, 06 Sep 2023 07:07:04 GMT

←Older revision		Revision as of 07:07, 6 September 2023
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	<StructureSection load='3gj7' size='340' side='right'caption='[[3gj7]], [[Resolution\|resolution]] 1.93Å' scene=''>		<StructureSection load='3gj7' size='340' side='right'caption='[[3gj7]], [[Resolution\|resolution]] 1.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gj7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~] and [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GJ7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gj7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GJ7 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GDP:GUANOSINE~~-~~5-DIPHOSPHATE'>GDP</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.93Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3ch5\|3ch5]], [[2gqe\|2gqe]], [[1byu\|1byu]], [[3gj0\|3gj0]], [[3gj3\|3gj3]], [[3gj4\|3gj4]], [[3gj5\|3gj5]], [[3gj6\|3gj6]], [[3gj8\|3gj8]]~~</~~div~~><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td><td class="sblockDat">RAN, ARA24, OK/SW-cl.81 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Nup153 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gj7 OCA], [https://pdbe.org/3gj7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gj7 RCSB], [https://www.ebi.ac.uk/pdbsum/3gj7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gj7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gj7 OCA], [https://pdbe.org/3gj7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gj7 RCSB], [https://www.ebi.ac.uk/pdbsum/3gj7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gj7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN]] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> [[https://www.uniprot.org/uniprot/NU153_RAT NU153_RAT]] Possible DNA-binding subunit of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane.	+	[https://www.uniprot.org/uniprot/NU153_RAT NU153_RAT] Possible DNA-binding subunit of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Buffalo rat]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Partridge, J R~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Schwartz, T U~~]]	+	[[Category: Partridge JR]]
-	[[Category: ~~Acetylation]]~~	+	[[Category: Schwartz TU]]
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: G protein]]~~	+
-	~~[[Category: Gdp]]~~	+
-	~~[[Category: Gtp-binding]]~~	+
-	~~[[Category: Host-virus interaction]]~~	+
-	~~[[Category: Isopeptide bond]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Mrna transport]]~~	+
-	~~[[Category: Nuclear pore]]~~	+
-	~~[[Category: Nuclear pore complex]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Nup153]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Protein transport]]~~	+
-	~~[[Category: Ran]]~~	+
-	~~[[Category: Translocation]]~~	+
-	~~[[Category: Transport]]~~	+
-	~~[[Category: Transport protein]]~~	+
-	~~[[Category: Ubl conjugation]]~~	+
-	~~[[Category: Zinc]]~~	+
-	~~[[Category: Zinc finger]]~~	+
-	~~[[Category: Zinc-finger~~]]	+

OCA at 20:07, 20 October 2021

OCA — Wed, 20 Oct 2021 20:07:27 GMT

←Older revision

Revision as of 20:07, 20 October 2021

OCA at 05:55, 7 December 2018

OCA — Fri, 07 Dec 2018 05:55:11 GMT

←Older revision		Revision as of 05:55, 7 December 2018
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		+
	==Crystal structure of human RanGDP-Nup153ZnF12 complex==		==Crystal structure of human RanGDP-Nup153ZnF12 complex==
	<StructureSection load='3gj7' size='340' side='right' caption='[[3gj7]], [[Resolution\|resolution]] 1.93Å' scene=''>		<StructureSection load='3gj7' size='340' side='right' caption='[[3gj7]], [[Resolution\|resolution]] 1.93Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ch5\|3ch5]], [[2gqe\|2gqe]], [[1byu\|1byu]], [[3gj0\|3gj0]], [[3gj3\|3gj3]], [[3gj4\|3gj4]], [[3gj5\|3gj5]], [[3gj6\|3gj6]], [[3gj8\|3gj8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ch5\|3ch5]], [[2gqe\|2gqe]], [[1byu\|1byu]], [[3gj0\|3gj0]], [[3gj3\|3gj3]], [[3gj4\|3gj4]], [[3gj5\|3gj5]], [[3gj6\|3gj6]], [[3gj8\|3gj8]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RAN, ARA24, OK/SW-cl.81 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Nup153 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RAN, ARA24, OK/SW-cl.81 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Nup153 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gj7 OCA], [http://pdbe.org/3gj7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gj7 RCSB], [http://www.ebi.ac.uk/pdbsum/3gj7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gj7 OCA], [http://pdbe.org/3gj7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gj7 RCSB], [http://www.ebi.ac.uk/pdbsum/3gj7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gj7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gj/3gj7_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gj/3gj7_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 41:		Line 42:
	[[Category: Partridge, J R]]		[[Category: Partridge, J R]]
	[[Category: Schwartz, T U]]		[[Category: Schwartz, T U]]
		+	[[Category: Acetylation]]
		+	[[Category: Cytoplasm]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
	[[Category: G protein]]		[[Category: G protein]]
Line 55:		Line 58:
	[[Category: Nup153]]		[[Category: Nup153]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
		+	[[Category: Polymorphism]]
	[[Category: Protein transport]]		[[Category: Protein transport]]
	[[Category: Ran]]		[[Category: Ran]]
Line 60:		Line 64:
	[[Category: Transport]]		[[Category: Transport]]
	[[Category: Transport protein]]		[[Category: Transport protein]]
		+	[[Category: Ubl conjugation]]
		+	[[Category: Zinc]]
	[[Category: Zinc finger]]		[[Category: Zinc finger]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

OCA at 07:37, 7 February 2016

OCA — Sun, 07 Feb 2016 07:37:32 GMT

←Older revision		Revision as of 07:37, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3gj7' size='340' side='right' caption='[[3gj7]], [[Resolution\|resolution]] 1.93Å' scene=''>		<StructureSection load='3gj7' size='340' side='right' caption='[[3gj7]], [[Resolution\|resolution]] 1.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gj7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GJ7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gj7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GJ7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ch5\|3ch5]], [[2gqe\|2gqe]], [[1byu\|1byu]], [[3gj0\|3gj0]], [[3gj3\|3gj3]], [[3gj4\|3gj4]], [[3gj5\|3gj5]], [[3gj6\|3gj6]], [[3gj8\|3gj8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ch5\|3ch5]], [[2gqe\|2gqe]], [[1byu\|1byu]], [[3gj0\|3gj0]], [[3gj3\|3gj3]], [[3gj4\|3gj4]], [[3gj5\|3gj5]], [[3gj6\|3gj6]], [[3gj8\|3gj8]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RAN, ARA24, OK/SW-cl.81 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), Nup153 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RAN, ARA24, OK/SW-cl.81 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Nup153 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gj7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gj7 RCSB], [http://www.ebi.ac.uk/pdbsum/3gj7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gj7 OCA], [http://pdbe.org/3gj7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gj7 RCSB], [http://www.ebi.ac.uk/pdbsum/3gj7 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gj7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3gj7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Buffalo rat]]
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Human]]
	[[Category: Partridge, J R]]		[[Category: Partridge, J R]]
	[[Category: Schwartz, T U]]		[[Category: Schwartz, T U]]

OCA at 09:02, 24 December 2014

OCA — Wed, 24 Dec 2014 09:02:31 GMT

←Older revision		Revision as of 09:02, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3gj7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GJ7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3gj7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GJ7 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ch5\|3ch5]], [[2gqe\|2gqe]], [[1byu\|1byu]], [[3gj0\|3gj0]], [[3gj3\|3gj3]], [[3gj4\|3gj4]], [[3gj5\|3gj5]], [[3gj6\|3gj6]], [[3gj8\|3gj8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ch5\|3ch5]], [[2gqe\|2gqe]], [[1byu\|1byu]], [[3gj0\|3gj0]], [[3gj3\|3gj3]], [[3gj4\|3gj4]], [[3gj5\|3gj5]], [[3gj6\|3gj6]], [[3gj8\|3gj8]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RAN, ARA24, OK/SW-cl.81 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), Nup153 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RAN, ARA24, OK/SW-cl.81 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), Nup153 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gj7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gj7 RCSB], [http://www.ebi.ac.uk/pdbsum/3gj7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gj7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gj7 RCSB], [http://www.ebi.ac.uk/pdbsum/3gj7 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN]] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> [[http://www.uniprot.org/uniprot/NU153_RAT NU153_RAT]] Possible DNA-binding subunit of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Partridge, J R.]]	+	[[Category: Partridge, J R]]
-	[[Category: Schwartz, T U.]]	+	[[Category: Schwartz, T U]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
	[[Category: G protein]]		[[Category: G protein]]

OCA at 12:36, 29 September 2014

OCA — Mon, 29 Sep 2014 12:36:04 GMT

←Older revision		Revision as of 12:36, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3gj7.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of human RanGDP-Nup153ZnF12 complex==
		+	<StructureSection load='3gj7' size='340' side='right' caption='[[3gj7]], [[Resolution\|resolution]] 1.93Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3gj7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GJ7 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ch5\|3ch5]], [[2gqe\|2gqe]], [[1byu\|1byu]], [[3gj0\|3gj0]], [[3gj3\|3gj3]], [[3gj4\|3gj4]], [[3gj5\|3gj5]], [[3gj6\|3gj6]], [[3gj8\|3gj8]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RAN, ARA24, OK/SW-cl.81 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), Nup153 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gj7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gj7 RCSB], [http://www.ebi.ac.uk/pdbsum/3gj7 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gj/3gj7_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The nuclear pore complex (NPC) resides in circular openings within the nuclear envelope and serves as the sole conduit to facilitate nucleocytoplasmic transport in eukaryotes. The asymmetric distribution of the small G protein Ran across the nuclear envelope regulates directionality of protein transport. Ran interacts with the NPC of metazoa via two asymmetrically localized components, Nup153 at the nuclear face and Nup358 at the cytoplasmic face. Both nucleoporins contain a stretch of distinct, Ran-binding zinc finger domains. Here, we present six crystal structures of Nup153-zinc fingers in complex with Ran and a 1.48 A crystal structure of RanGDP. Crystal engineering allowed us to obtain well diffracting crystals so that all ZnF-Ran complex structures are refined to high resolution. Each of the four zinc finger modules of Nup153 binds one Ran molecule in apparently non-allosteric fashion. The affinity is measurably higher for RanGDP than for RanGTP and varies modestly between the individual zinc fingers. By microcalorimetric and mutational analysis, we determined that one specific hydrogen bond accounts for most of the differences in the binding affinity of individual zinc fingers. Genomic analysis reveals that only in animals do NPCs contain Ran-binding zinc fingers. We speculate that these organisms evolved a mechanism to maintain a high local concentration of Ran at the vicinity of the NPC, using this zinc finger domain as a sink.

-	~~{{STRUCTURE_3gj7\| PDB=3gj7 \| SCENE= }}~~	+	Crystallographic and biochemical analysis of the Ran-binding zinc finger domain.,Partridge JR, Schwartz TU J Mol Biol. 2009 Aug 14;391(2):375-89. Epub 2009 Jun 6. PMID:19505478<ref>PMID:19505478</ref>

-	~~===Crystal structure~~ of ~~human RanGDP-Nup153ZnF12 complex===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19505478}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3gj7]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens] and [http://en~~.~~wikipedia.org~~/~~wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJ7 OCA].~~	+

	==See Also==		==See Also==
		+	*[[GTP-binding protein\|GTP-binding protein]]
	*[[Nucleoporin\|Nucleoporin]]		*[[Nucleoporin\|Nucleoporin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019505478<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]

OCA at 06:00, 20 October 2012

OCA — Sat, 20 Oct 2012 06:00:50 GMT

←Older revision		Revision as of 06:00, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3gj7]] is a 4 chain structure ~~of [[Nucleoporin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJ7 OCA].	+	[[3gj7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJ7 OCA].

	==See Also==		==See Also==

OCA at 11:49, 25 July 2012

OCA — Wed, 25 Jul 2012 11:49:56 GMT

←Older revision		Revision as of 11:49, 25 July 2012
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	[[Image:3gj7.png\|left\|200px]]		[[Image:3gj7.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3gj7", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3gj7\| PDB=3gj7 \| SCENE= }}		{{STRUCTURE_3gj7\| PDB=3gj7 \| SCENE= }}

	===Crystal structure of human RanGDP-Nup153ZnF12 complex===		===Crystal structure of human RanGDP-Nup153ZnF12 complex===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19505478}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19505478 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_19505478}}		{{ABSTRACT_PUBMED_19505478}}

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	==See Also==		==See Also==
-	*[[Nucleoporin]]	+	*[[Nucleoporin\|Nucleoporin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19505478~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019505478</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Partridge, J R.]]		[[Category: Partridge, J R.]]
	[[Category: Schwartz, T U.]]		[[Category: Schwartz, T U.]]
-	[[Category: Acetylation]]
-	[[Category: Cytoplasm]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
	[[Category: G protein]]		[[Category: G protein]]
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	[[Category: Nup153]]		[[Category: Nup153]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
-	[[Category: Polymorphism]]
	[[Category: Protein transport]]		[[Category: Protein transport]]
	[[Category: Ran]]		[[Category: Ran]]
Line 52:		Line 38:
	[[Category: Transport]]		[[Category: Transport]]
	[[Category: Transport protein]]		[[Category: Transport protein]]
-	[[Category: Ubl conjugation]]
-	[[Category: Zinc]]
	[[Category: Zinc finger]]		[[Category: Zinc finger]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

OCA: Protected "3gj7" [edit=sysop:move=sysop]

OCA — Sun, 26 Dec 2010 21:59:23 GMT

Protected "3gj7" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:59, 26 December 2010

OCA at 21:59, 26 December 2010

OCA — Sun, 26 Dec 2010 21:59:22 GMT

←Older revision		Revision as of 21:59, 26 December 2010
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-	~~{{Seed}}~~	+	[[Image:3gj7.png\|left\|200px]]
-	[[Image:3gj7.~~jpg~~\|left\|200px]]	+

	<!--		<!--
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	==About this Structure==		==About this Structure==
-	~~3GJ7~~ is a 4 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJ7 OCA].	+	[[3gj7]] is a 4 chain structure of [[Nucleoporin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJ7 OCA].
		+
		+	==See Also==
		+	*[[Nucleoporin]]

	==Reference==		==Reference==
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	[[Category: Zinc finger]]		[[Category: Zinc finger]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 5 10:15:55 2009''