3gjc - Revision history

OCA at 15:40, 1 November 2023

OCA — Wed, 01 Nov 2023 15:40:40 GMT

←Older revision		Revision as of 15:40, 1 November 2023
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	<StructureSection load='3gjc' size='340' side='right'caption='[[3gjc]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3gjc' size='340' side='right'caption='[[3gjc]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gjc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex~~ aeolicus~~" huber and stetter 2001~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GJC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gjc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GJC FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BOG:B~~-~~OCTYLGLUCOSIDE'>BOG</scene>~~, ~~<scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[3gjd\|3gjd]]~~</~~div~~><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">aq_2077, snf ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=63363 "Aquifex aeolicus" Huber and Stetter 2001])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gjc OCA], [https://pdbe.org/3gjc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gjc RCSB], [https://www.ebi.ac.uk/pdbsum/3gjc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gjc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gjc OCA], [https://pdbe.org/3gjc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gjc RCSB], [https://www.ebi.ac.uk/pdbsum/3gjc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gjc ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/O67854_AQUAE O67854_AQUAE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Aquifex aeolicus ~~huber and stetter 2001~~]]	+	[[Category: Aquifex aeolicus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Javitch~~, J A~~]]	+	[[Category: Javitch JA]]
-	[[Category: Nissen, P]]	+	[[Category: Nissen P]]
-	[[Category: Quick, M]]	+	[[Category: Quick M]]
-	[[Category: Winther~~, A M.L]]~~	+	[[Category: Winther AML]]
-	~~[[Category: Aminoacid transport]]~~	+
-	~~[[Category: Neurotransmitter:sodium symport]]~~	+
-	~~[[Category: Nss]]~~	+
-	~~[[Category: Sodium-coupled transport]]~~	+
-	~~[[Category: Symport]]~~	+
-	~~[[Category: Transmembrane]]~~	+
-	~~[[Category: Transmembrane transport]]~~	+
-	~~[[Category: Transport]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 07:41, 10 November 2021

OCA — Wed, 10 Nov 2021 07:41:51 GMT

←Older revision		Revision as of 07:41, 10 November 2021
Line 1:		Line 1:

	==Crystal Structure of the E290S mutant of LeuT with bound OG==		==Crystal Structure of the E290S mutant of LeuT with bound OG==
-	<StructureSection load='3gjc' size='340' side='right' caption='[[3gjc]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='3gjc' size='340' side='right'caption='[[3gjc]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gjc]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3GJC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gjc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GJC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gjd\|3gjd]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3gjd\|3gjd]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aq_2077, snf ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=63363 "Aquifex aeolicus" Huber and Stetter 2001])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aq_2077, snf ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=63363 "Aquifex aeolicus" Huber and Stetter 2001])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3gjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gjc OCA], [~~http~~://pdbe.org/3gjc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3gjc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3gjc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3gjc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gjc OCA], [https://pdbe.org/3gjc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gjc RCSB], [https://www.ebi.ac.uk/pdbsum/3gjc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gjc ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gj/3gjc_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gj/3gjc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 3gjc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3gjc" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Leucine transporter\|Leucine transporter]]
		+	*[[Symporter 3D structures\|Symporter 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Aquifex aeolicus huber and stetter 2001]]		[[Category: Aquifex aeolicus huber and stetter 2001]]
		+	[[Category: Large Structures]]
	[[Category: Javitch, J A]]		[[Category: Javitch, J A]]
	[[Category: Nissen, P]]		[[Category: Nissen, P]]

OCA at 07:06, 1 November 2017

OCA — Wed, 01 Nov 2017 07:06:26 GMT

←Older revision		Revision as of 07:06, 1 November 2017
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 3gjc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3gjc" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Leucine transporter\|Leucine transporter]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:25, 9 December 2016

OCA — Fri, 09 Dec 2016 20:25:56 GMT

←Older revision		Revision as of 20:25, 9 December 2016
Line 1:		Line 1:
		+
	==Crystal Structure of the E290S mutant of LeuT with bound OG==		==Crystal Structure of the E290S mutant of LeuT with bound OG==
	<StructureSection load='3gjc' size='340' side='right' caption='[[3gjc]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3gjc' size='340' side='right' caption='[[3gjc]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gjc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Aquifex_aeolicus Aquifex~~ aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GJC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gjc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GJC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gjd\|3gjd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gjd\|3gjd]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aq_2077, snf ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=63363 Aquifex aeolicus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aq_2077, snf ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=63363 "Aquifex aeolicus" Huber and Stetter 2001])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gjc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gjc RCSB], [http://www.ebi.ac.uk/pdbsum/3gjc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gjc OCA], [http://pdbe.org/3gjc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gjc RCSB], [http://www.ebi.ac.uk/pdbsum/3gjc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gjc ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gjc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3gjc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Aquifex aeolicus]]	+	[[Category: Aquifex aeolicus huber and stetter 2001]]
	[[Category: Javitch, J A]]		[[Category: Javitch, J A]]
	[[Category: Nissen, P]]		[[Category: Nissen, P]]

OCA at 09:25, 8 December 2014

OCA — Mon, 08 Dec 2014 09:25:56 GMT

←Older revision		Revision as of 09:25, 8 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3gjc.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of the E290S mutant of LeuT with bound OG==
		+	<StructureSection load='3gjc' size='340' side='right' caption='[[3gjc]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3gjc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GJC FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gjd\|3gjd]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aq_2077, snf ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=63363 Aquifex aeolicus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gjc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gjc RCSB], [http://www.ebi.ac.uk/pdbsum/3gjc PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gj/3gjc_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The first crystal structure of the neurotransmitter/sodium symporter homolog LeuT revealed an occluded binding pocket containing leucine and 2 Na(+); later structures showed tricyclic antidepressants (TCAs) in an extracellular vestibule approximately 11 A above the bound leucine and 2 Na(+). We recently found this region to be a second binding (S2) site and that binding of substrate to this site triggers Na(+)-coupled substrate symport. Here, we show a profound inhibitory effect of n-octyl-beta-d-glucopyranoside (OG), the detergent used for LeuT crystallization, on substrate binding to the S2 site. In parallel, we determined at 2.8 A the structure of LeuT-E290S, a mutant that, like LeuT-WT, binds 2 substrate molecules. This structure was similar to that of WT and clearly revealed an OG molecule in the S2 site. We also observed electron density at the S2 site in LeuT-WT crystals, and this also was accounted for by an OG molecule in that site. Computational analyses, based on the available crystal structures of LeuT, indicated the nature of structural arrangements in the extracellular region of LeuT that differentiate the actions of substrates from inhibitors bound in the S2 site. We conclude that the current LeuT crystal structures, all of which have been solved in OG, represent functionally blocked forms of the transporter, whereas a substrate bound in the S2 site will promote a different state that is essential for Na(+)-coupled symport.

-	~~{{STRUCTURE_3gjc\| PDB=3gjc \| SCENE= }}~~	+	Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation.,Quick M, Winther AM, Shi L, Nissen P, Weinstein H, Javitch JA Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5563-8. Epub 2009 Mar 23. PMID:19307590<ref>PMID:19307590</ref>

-	~~===Crystal Structure~~ of the ~~E290S mutant~~ of ~~LeuT with bound OG===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_19307590}}~~	+	==See Also==
-		+	*[[Leucine transporter\|Leucine transporter]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~3gjc~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJC OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:019307590<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Aquifex aeolicus]]		[[Category: Aquifex aeolicus]]
-	[[Category: Javitch, J A.]]	+	[[Category: Javitch, J A]]
-	[[Category: Nissen, P.]]	+	[[Category: Nissen, P]]
-	[[Category: Quick, M.]]	+	[[Category: Quick, M]]
-	[[Category: Winther, A M.L.]]	+	[[Category: Winther, A M.L]]
	[[Category: Aminoacid transport]]		[[Category: Aminoacid transport]]
	[[Category: Neurotransmitter:sodium symport]]		[[Category: Neurotransmitter:sodium symport]]

OCA: Protected "3gjc" [edit=sysop:move=sysop]

OCA — Wed, 27 Feb 2013 15:26:08 GMT

Protected "3gjc" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:26, 27 February 2013

OCA at 15:26, 27 February 2013

OCA — Wed, 27 Feb 2013 15:26:03 GMT

←Older revision		Revision as of 15:26, 27 February 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3gjc.png\|left\|200px]]		[[Image:3gjc.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3gjc", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3gjc\| PDB=3gjc \| SCENE= }}		{{STRUCTURE_3gjc\| PDB=3gjc \| SCENE= }}

	===Crystal Structure of the E290S mutant of LeuT with bound OG===		===Crystal Structure of the E290S mutant of LeuT with bound OG===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19307590}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19307590 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_19307590}}		{{ABSTRACT_PUBMED_19307590}}

	==About this Structure==		==About this Structure==
-	~~3GJC~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJC OCA].	+	[[3gjc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJC OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19307590~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019307590</ref><references group="xtra"/>
	[[Category: Aquifex aeolicus]]		[[Category: Aquifex aeolicus]]
	[[Category: Javitch, J A.]]		[[Category: Javitch, J A.]]
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	[[Category: Transport]]		[[Category: Transport]]
	[[Category: Transport protein]]		[[Category: Transport protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 6 10:41:20 2009''

OCA at 07:41, 6 May 2009

OCA — Wed, 06 May 2009 07:41:21 GMT

←Older revision		Revision as of 07:41, 6 May 2009
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	{{Seed}}		{{Seed}}
-	[[Image:3gjc.~~jpg~~\|left\|200px]]	+	[[Image:3gjc.png\|left\|200px]]

	<!--		<!--
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	[[Category: Transport protein]]		[[Category: Transport protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Apr 30~~ 10:05:19 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 6 10:41:20 2009''

OCA at 07:05, 30 April 2009

OCA — Thu, 30 Apr 2009 07:05:19 GMT

←Older revision		Revision as of 07:05, 30 April 2009
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3gjc.jpg\|left\|200px]]

-	The ~~entry 3gjc~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3gjc", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3gjc\| PDB=3gjc \| SCENE= }}

-	~~Authors: Quick, M., Winther, A.M.L., Shi, L., Nissen, P., Weinstein, H., Javitch, J.A.~~	+	===Crystal Structure of the E290S mutant of LeuT with bound OG===

-	Description: Crystal Structure of the E290S mutant of LeuT with bound OG

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed~~ Apr ~~15 09~~:54:13 2009''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19307590}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19307590 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19307590}}
		+
		+	==About this Structure==
		+	3GJC is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GJC OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19307590</ref><references group="xtra"/>
		+	[[Category: Aquifex aeolicus]]
		+	[[Category: Javitch, J A.]]
		+	[[Category: Nissen, P.]]
		+	[[Category: Quick, M.]]
		+	[[Category: Winther, A M.L.]]
		+	[[Category: Aminoacid transport]]
		+	[[Category: Neurotransmitter:sodium symport]]
		+	[[Category: Nss]]
		+	[[Category: Sodium-coupled transport]]
		+	[[Category: Symport]]
		+	[[Category: Transmembrane]]
		+	[[Category: Transmembrane transport]]
		+	[[Category: Transport]]
		+	[[Category: Transport protein]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 30 10:05:19 2009''

OCA at 06:54, 15 April 2009

OCA — Wed, 15 Apr 2009 06:54:13 GMT

←Older revision		Revision as of 06:54, 15 April 2009
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3gjc is ON HOLD	+	The entry 3gjc is ON HOLD until Paper Publication

	Authors: Quick, M., Winther, A.M.L., Shi, L., Nissen, P., Weinstein, H., Javitch, J.A.		Authors: Quick, M., Winther, A.M.L., Shi, L., Nissen, P., Weinstein, H., Javitch, J.A.
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	Description: Crystal Structure of the E290S mutant of LeuT with bound OG		Description: Crystal Structure of the E290S mutant of LeuT with bound OG

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Mar 25 12~~:16:17 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 15 09:54:13 2009''