3gkl - Revision history

OCA at 07:07, 6 September 2023

OCA — Wed, 06 Sep 2023 07:07:19 GMT

←Older revision		Revision as of 07:07, 6 September 2023
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	<StructureSection load='3gkl' size='340' side='right'caption='[[3gkl]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3gkl' size='340' side='right'caption='[[3gkl]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gkl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GKL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GKL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gkl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GKL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GKL FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[3gjn\|3gjn]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>colE7, cea ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~562~~ "~~Bacillus coli~~" ~~Migula 1895]), imm, ceiE9 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gkl OCA], [https://pdbe.org/3gkl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gkl RCSB], [https://www.ebi.ac.uk/pdbsum/3gkl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gkl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gkl OCA], [https://pdbe.org/3gkl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gkl RCSB], [https://www.ebi.ac.uk/pdbsum/3gkl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gkl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CEA7_ECOLX CEA7_ECOLX]] This plasmid-coded bactericidal protein is an endonuclease active on both single- and double-stranded DNA but with undefined specificity. Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria. [[https://www.uniprot.org/uniprot/IMM9_ECOLX IMM9_ECOLX]] This protein is able to protect a cell, which harbors the plasmid ColE9 encoding colicin E9, against colicin E9, it binds specifically to the DNase-type colicin and inhibits its bactericidal activity.	+	[https://www.uniprot.org/uniprot/CEA7_ECOLX CEA7_ECOLX] This plasmid-coded bactericidal protein is an endonuclease active on both single- and double-stranded DNA but with undefined specificity. Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dym, O]]	+	[[Category: Dym O]]
-	~~[[Category: ISPC, Israel Structural Proteomics Center~~]]	+	[[Category: Tawfik DS]]
-	[[Category: Tawfik~~, D S]]~~	+
-	~~[[Category: Antibiotic]]~~	+
-	~~[[Category: Antimicrobial]]~~	+
-	~~[[Category: Bacteriocin]]~~	+
-	~~[[Category: Bacteriocin immunity]]~~	+
-	~~[[Category: Endonuclease]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Nuclease]]~~	+
-	~~[[Category: Plasmid]]~~	+
-	~~[[Category: Protein-protein complex]]~~	+
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Zinc~~]]	+

OCA at 20:07, 20 October 2021

OCA — Wed, 20 Oct 2021 20:07:52 GMT

←Older revision		Revision as of 20:07, 20 October 2021
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	==Following evolutionary paths to high affinity and selectivity protein-protein interactions using Colicin7 and Immunity proteins==		==Following evolutionary paths to high affinity and selectivity protein-protein interactions using Colicin7 and Immunity proteins==
-	<StructureSection load='3gkl' size='340' side='right' caption='[[3gkl]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='3gkl' size='340' side='right'caption='[[3gkl]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gkl]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GKL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3GKL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gkl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GKL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GKL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gjn\|3gjn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3gjn\|3gjn]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">colE7, cea ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895]), imm, ceiE9 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">colE7, cea ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895]), imm, ceiE9 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3gkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gkl OCA], [~~http~~://pdbe.org/3gkl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3gkl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3gkl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3gkl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gkl OCA], [https://pdbe.org/3gkl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gkl RCSB], [https://www.ebi.ac.uk/pdbsum/3gkl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gkl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CEA7_ECOLX CEA7_ECOLX]] This plasmid-coded bactericidal protein is an endonuclease active on both single- and double-stranded DNA but with undefined specificity. Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria. [[~~http~~://www.uniprot.org/uniprot/IMM9_ECOLX IMM9_ECOLX]] This protein is able to protect a cell, which harbors the plasmid ColE9 encoding colicin E9, against colicin E9, it binds specifically to the DNase-type colicin and inhibits its bactericidal activity.	+	[[https://www.uniprot.org/uniprot/CEA7_ECOLX CEA7_ECOLX]] This plasmid-coded bactericidal protein is an endonuclease active on both single- and double-stranded DNA but with undefined specificity. Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria. [[https://www.uniprot.org/uniprot/IMM9_ECOLX IMM9_ECOLX]] This protein is able to protect a cell, which harbors the plasmid ColE9 encoding colicin E9, against colicin E9, it binds specifically to the DNase-type colicin and inhibits its bactericidal activity.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Colicin\|Colicin]]	+	*[[Colicin 3D structures\|Colicin 3D structures]]
	*[[Colicin Immunity Protein\|Colicin Immunity Protein]]		*[[Colicin Immunity Protein\|Colicin Immunity Protein]]
-	*[[Colicin ~~Immunity Protein 7\|Colicin Immunity Protein 7]]~~	+	*[[Colicin immunity protein 3D structures\|Colicin immunity protein 3D structures]]
-	*[[Colicin Immunity Protein 9\|Colicin Immunity Protein 9]]	+
-	*[[Directed evolution\|Directed evolution]]	+
-	*[[Mutant immunity protein ~~9 (variant R12-13)~~\|~~Mutant immunity protein 9 (variant R12-13)]]~~	+
-	*[[Mutant immunity protein 9 (variant R12-2)\|Mutant immunity protein ~~9 (variant R12-2)~~]]	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Dym, O]]		[[Category: Dym, O]]
	[[Category: ISPC, Israel Structural Proteomics Center]]		[[Category: ISPC, Israel Structural Proteomics Center]]

OCA at 06:00, 7 December 2018

OCA — Fri, 07 Dec 2018 06:00:48 GMT

←Older revision		Revision as of 06:00, 7 December 2018
Line 1:		Line 1:
		+
	==Following evolutionary paths to high affinity and selectivity protein-protein interactions using Colicin7 and Immunity proteins==		==Following evolutionary paths to high affinity and selectivity protein-protein interactions using Colicin7 and Immunity proteins==
	<StructureSection load='3gkl' size='340' side='right' caption='[[3gkl]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3gkl' size='340' side='right' caption='[[3gkl]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gjn\|3gjn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gjn\|3gjn]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">colE7, cea ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895]), imm, ceiE9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">colE7, cea ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895]), imm, ceiE9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gkl OCA], [http://pdbe.org/3gkl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gkl RCSB], [http://www.ebi.ac.uk/pdbsum/3gkl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gkl OCA], [http://pdbe.org/3gkl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gkl RCSB], [http://www.ebi.ac.uk/pdbsum/3gkl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gkl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gk/3gkl_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gk/3gkl_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 43:		Line 44:
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
	[[Category: Nuclease]]		[[Category: Nuclease]]
		+	[[Category: Plasmid]]
	[[Category: Protein-protein complex]]		[[Category: Protein-protein complex]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
		+	[[Category: Zinc]]

OCA at 00:12, 9 February 2016

OCA — Tue, 09 Feb 2016 00:12:00 GMT

←Older revision		Revision as of 00:12, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3gkl' size='340' side='right' caption='[[3gkl]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3gkl' size='340' side='right' caption='[[3gkl]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gkl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GKL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GKL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gkl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GKL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GKL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gjn\|3gjn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gjn\|3gjn]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">colE7, cea ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 ~~Escherichia~~ coli]), imm, ceiE9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 ~~Escherichia~~ coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">colE7, cea ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895]), imm, ceiE9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gkl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gkl RCSB], [http://www.ebi.ac.uk/pdbsum/3gkl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gkl OCA], [http://pdbe.org/3gkl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gkl RCSB], [http://www.ebi.ac.uk/pdbsum/3gkl PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gkl ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

Line 31:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Dym, O]]		[[Category: Dym, O]]
	[[Category: ISPC, Israel Structural Proteomics Center]]		[[Category: ISPC, Israel Structural Proteomics Center]]

OCA at 03:06, 25 December 2014

OCA — Thu, 25 Dec 2014 03:06:59 GMT

←Older revision		Revision as of 03:06, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gkl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gkl RCSB], [http://www.ebi.ac.uk/pdbsum/3gkl PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gkl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gkl RCSB], [http://www.ebi.ac.uk/pdbsum/3gkl PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CEA7_ECOLX CEA7_ECOLX]] This plasmid-coded bactericidal protein is an endonuclease active on both single- and double-stranded DNA but with undefined specificity. Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria. [[http://www.uniprot.org/uniprot/IMM9_ECOLX IMM9_ECOLX]] This protein is able to protect a cell, which harbors the plasmid ColE9 encoding colicin E9, against colicin E9, it binds specifically to the DNase-type colicin and inhibits its bactericidal activity.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:33, 18 December 2014

OCA — Thu, 18 Dec 2014 06:33:56 GMT

←Older revision		Revision as of 06:33, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3gkl\| PDB=3gkl \| SCENE= }}~~	+	==Following evolutionary paths to high affinity and selectivity protein-protein interactions using Colicin7 and Immunity proteins==
-	===Following evolutionary paths to high affinity and selectivity protein-protein interactions using Colicin7 and Immunity proteins===	+	<StructureSection load='3gkl' size='340' side='right' caption='[[3gkl]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~{{ABSTRACT_PUBMED_019749752}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3gkl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GKL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GKL FirstGlance]. <br>
-	==~~About this Structure~~==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[3gkl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GKL OCA].	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gjn\|3gjn]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">colE7, cea ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]), imm, ceiE9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gkl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gkl RCSB], [http://www.ebi.ac.uk/pdbsum/3gkl PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gk/3gkl_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

	==See Also==		==See Also==
Line 14:		Line 27:
	*[[Mutant immunity protein 9 (variant R12-13)\|Mutant immunity protein 9 (variant R12-13)]]		*[[Mutant immunity protein 9 (variant R12-13)\|Mutant immunity protein 9 (variant R12-13)]]
	*[[Mutant immunity protein 9 (variant R12-2)\|Mutant immunity protein 9 (variant R12-2)]]		*[[Mutant immunity protein 9 (variant R12-2)\|Mutant immunity protein 9 (variant R12-2)]]
-		+	__TOC__
-	~~==Reference==~~	+	</StructureSection>
-	~~<ref group="xtra">PMID:019749752</ref>~~<~~references group="xtra"~~/>	+
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Dym, O.]]	+	[[Category: Dym, O]]
-	[[Category: ISPC, Israel Structural Proteomics Center.]]	+	[[Category: ISPC, Israel Structural Proteomics Center]]
-	[[Category: Tawfik, D S.]]	+	[[Category: Tawfik, D S]]
	[[Category: Antibiotic]]		[[Category: Antibiotic]]
	[[Category: Antimicrobial]]		[[Category: Antimicrobial]]
Line 27:		Line 39:
	[[Category: Endonuclease]]		[[Category: Endonuclease]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
-	[[Category: ISPC]]
-	[[Category: Israel Structural Proteomics Center]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
	[[Category: Nuclease]]		[[Category: Nuclease]]
	[[Category: Protein-protein complex]]		[[Category: Protein-protein complex]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 09:35, 11 March 2013

OCA — Mon, 11 Mar 2013 09:35:05 GMT

←Older revision		Revision as of 09:35, 11 March 2013
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-	[[Image:3gkl.png\|left\|200px]]
-
	{{STRUCTURE_3gkl\| PDB=3gkl \| SCENE= }}		{{STRUCTURE_3gkl\| PDB=3gkl \| SCENE= }}
-
	===Following evolutionary paths to high affinity and selectivity protein-protein interactions using Colicin7 and Immunity proteins===		===Following evolutionary paths to high affinity and selectivity protein-protein interactions using Colicin7 and Immunity proteins===
-
	{{ABSTRACT_PUBMED_019749752}}		{{ABSTRACT_PUBMED_019749752}}

OCA at 11:57, 20 October 2012

OCA — Sat, 20 Oct 2012 11:57:22 GMT

←Older revision		Revision as of 11:57, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[3gkl]] is a 4 chain structure ~~of [[Colicin]] and [[Colicin Immunity Protein]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GKL OCA].	+	[[3gkl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GKL OCA].

	==See Also==		==See Also==

OCA at 07:09, 26 July 2012

OCA — Thu, 26 Jul 2012 07:09:32 GMT

←Older revision		Revision as of 07:09, 26 July 2012
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	[[Image:3gkl.png\|left\|200px]]		[[Image:3gkl.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3gkl", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3gkl\| PDB=3gkl \| SCENE= }}		{{STRUCTURE_3gkl\| PDB=3gkl \| SCENE= }}

	===Following evolutionary paths to high affinity and selectivity protein-protein interactions using Colicin7 and Immunity proteins===		===Following evolutionary paths to high affinity and selectivity protein-protein interactions using Colicin7 and Immunity proteins===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_019749752}}, adds the Publication Abstract to the page
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	{{ABSTRACT_PUBMED_019749752}}		{{ABSTRACT_PUBMED_019749752}}

Line 24:		Line 13:
	*[[Colicin\|Colicin]]		*[[Colicin\|Colicin]]
	*[[Colicin Immunity Protein\|Colicin Immunity Protein]]		*[[Colicin Immunity Protein\|Colicin Immunity Protein]]
		+	*[[Colicin Immunity Protein 7\|Colicin Immunity Protein 7]]
		+	*[[Colicin Immunity Protein 9\|Colicin Immunity Protein 9]]
	*[[Directed evolution\|Directed evolution]]		*[[Directed evolution\|Directed evolution]]
		+	*[[Mutant immunity protein 9 (variant R12-13)\|Mutant immunity protein 9 (variant R12-13)]]
		+	*[[Mutant immunity protein 9 (variant R12-2)\|Mutant immunity protein 9 (variant R12-2)]]

	==Reference==		==Reference==

OCA: Protected "3gkl" [edit=sysop:move=sysop]

OCA — Wed, 13 Jun 2012 10:40:10 GMT

Protected "3gkl" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:40, 13 June 2012