3gky - Revision history

OCA at 07:07, 6 September 2023

OCA — Wed, 06 Sep 2023 07:07:20 GMT

←Older revision		Revision as of 07:07, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3gky' size='340' side='right'caption='[[3gky]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3gky' size='340' side='right'caption='[[3gky]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gky]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GKY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gky]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GKY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IPH:PHENOL'>IPH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1trz\|1trz]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IPH:PHENOL'>IPH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gky OCA], [https://pdbe.org/3gky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gky RCSB], [https://www.ebi.ac.uk/pdbsum/3gky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gky ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gky OCA], [https://pdbe.org/3gky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gky RCSB], [https://www.ebi.ac.uk/pdbsum/3gky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gky ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/INS_PIG INS_PIG]] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	+	[https://www.uniprot.org/uniprot/INS_PIG INS_PIG] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Alddin, H]]	+	[[Category: Sus scrofa]]
-	[[Category: Chu~~, Y C~~]]	+	[[Category: Alddin H]]
-	[[Category: Klaproth, B]]	+	[[Category: Chu YC]]
-	[[Category: Liu, M]]	+	[[Category: Klaproth B]]
-	[[Category: Wan~~, Z L~~]]	+	[[Category: Liu M]]
-	[[Category: Weiss~~, M A]]~~	+	[[Category: Wan ZL]]
-	~~[[Category: Carbohydrate metabolism]]~~	+	[[Category: Weiss MA]]
-	~~[[Category: Cleavage on pair of basic residue]]~~	+
-	~~[[Category: Diabetes mellitus]]~~	+
-	~~[[Category: Disease mutation]]~~	+
-	~~[[Category: Disulfide bond]]~~	+
-	~~[[Category: Er stress-associated]]~~	+
-	~~[[Category: Glucose metabolism]]~~	+
-	~~[[Category: Hormone]]~~	+
-	~~[[Category: Pharmaceutical]]~~	+
-	~~[[Category: Protein folding]]~~	+
-	~~[[Category: Secreted]]~~	+
-	~~[[Category: Tr transition receptor binding~~]]	+

OCA at 08:07, 9 March 2022

OCA — Wed, 09 Mar 2022 08:07:35 GMT

←Older revision		Revision as of 08:07, 9 March 2022
Line 3:		Line 3:
	<StructureSection load='3gky' size='340' side='right'caption='[[3gky]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3gky' size='340' side='right'caption='[[3gky]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gky]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GKY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3GKY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gky]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GKY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IPH:PHENOL'>IPH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IPH:PHENOL'>IPH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1trz\|1trz]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1trz\|1trz]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3gky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gky OCA], [~~http~~://pdbe.org/3gky PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3gky RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3gky PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3gky ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gky OCA], [https://pdbe.org/3gky PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gky RCSB], [https://www.ebi.ac.uk/pdbsum/3gky PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gky ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/INS_PIG INS_PIG]] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	+	[[https://www.uniprot.org/uniprot/INS_PIG INS_PIG]] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:50, 25 December 2019

OCA — Wed, 25 Dec 2019 13:50:04 GMT

←Older revision		Revision as of 13:50, 25 December 2019
Line 1:		Line 1:

	==The Structural Basis of an ER Stress-Associated Bottleneck in a Protein Folding Landscape==		==The Structural Basis of an ER Stress-Associated Bottleneck in a Protein Folding Landscape==
-	<StructureSection load='3gky' size='340' side='right' caption='[[3gky]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3gky' size='340' side='right'caption='[[3gky]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3gky]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GKY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GKY FirstGlance]. <br>		<table><tr><td colspan='2'>[[3gky]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GKY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GKY FirstGlance]. <br>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 3gky" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3gky" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Insulin 3D Structures\|Insulin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Alddin, H]]		[[Category: Alddin, H]]
	[[Category: Chu, Y C]]		[[Category: Chu, Y C]]

OCA at 19:18, 24 January 2018

OCA — Wed, 24 Jan 2018 19:18:54 GMT

←Older revision		Revision as of 19:18, 24 January 2018
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gk/3gky_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gk/3gky_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 3gky" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3gky" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Molecular Playground/Insulin\|Molecular Playground/Insulin]]
	== References ==		== References ==
	<references/>		<references/>
Line 50:		Line 47:
	[[Category: Glucose metabolism]]		[[Category: Glucose metabolism]]
	[[Category: Hormone]]		[[Category: Hormone]]
		+	[[Category: Pharmaceutical]]
	[[Category: Protein folding]]		[[Category: Protein folding]]
	[[Category: Secreted]]		[[Category: Secreted]]
	[[Category: Tr transition receptor binding]]		[[Category: Tr transition receptor binding]]

OCA at 21:45, 4 August 2016

OCA — Thu, 04 Aug 2016 21:45:54 GMT

←Older revision		Revision as of 21:45, 4 August 2016
Line 1:		Line 1:
		+
	==The Structural Basis of an ER Stress-Associated Bottleneck in a Protein Folding Landscape==		==The Structural Basis of an ER Stress-Associated Bottleneck in a Protein Folding Landscape==
	<StructureSection load='3gky' size='340' side='right' caption='[[3gky]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3gky' size='340' side='right' caption='[[3gky]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IPH:PHENOL'>IPH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IPH:PHENOL'>IPH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1trz\|1trz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1trz\|1trz]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gky OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gky RCSB], [http://www.ebi.ac.uk/pdbsum/3gky PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gky OCA], [http://pdbe.org/3gky PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gky RCSB], [http://www.ebi.ac.uk/pdbsum/3gky PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gky ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gky ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3gky" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 13:24, 25 December 2014

OCA — Thu, 25 Dec 2014 13:24:39 GMT

←Older revision		Revision as of 13:24, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3gky]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GKY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GKY FirstGlance]. <br>		<table><tr><td colspan='2'>[[3gky]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GKY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GKY FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IPH:PHENOL'>IPH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IPH:PHENOL'>IPH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1trz\|1trz]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1trz\|1trz]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gky OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gky RCSB], [http://www.ebi.ac.uk/pdbsum/3gky PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gky OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gky RCSB], [http://www.ebi.ac.uk/pdbsum/3gky PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/INS_PIG INS_PIG]] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Alddin, H.]]	+	[[Category: Alddin, H]]
-	[[Category: Chu, Y C.]]	+	[[Category: Chu, Y C]]
	[[Category: Klaproth, B]]		[[Category: Klaproth, B]]
-	[[Category: Liu, M.]]	+	[[Category: Liu, M]]
-	[[Category: Wan, Z L.]]	+	[[Category: Wan, Z L]]
-	[[Category: Weiss, M A.]]	+	[[Category: Weiss, M A]]
	[[Category: Carbohydrate metabolism]]		[[Category: Carbohydrate metabolism]]
	[[Category: Cleavage on pair of basic residue]]		[[Category: Cleavage on pair of basic residue]]

OCA at 11:03, 29 September 2014

OCA — Mon, 29 Sep 2014 11:03:18 GMT

←Older revision		Revision as of 11:03, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3gky.~~png~~\|~~left~~\|200px]]	+	==The Structural Basis of an ER Stress-Associated Bottleneck in a Protein Folding Landscape==
		+	<StructureSection load='3gky' size='340' side='right' caption='[[3gky]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3gky]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GKY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GKY FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IPH:PHENOL'>IPH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1trz\|1trz]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gky OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gky RCSB], [http://www.ebi.ac.uk/pdbsum/3gky PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gk/3gky_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Protein evolution is constrained by folding efficiency ("foldability") and the implicit threat of toxic misfolding. A model is provided by proinsulin, whose misfolding is associated with beta-cell dysfunction and diabetes mellitus. An insulin analogue containing a subtle core substitution (Leu(A16) --> Val) is biologically active, and its crystal structure recapitulates that of the wild-type protein. As a seeming paradox, however, Val(A16) blocks both insulin chain combination and the in vitro refolding of proinsulin. Disulfide pairing in mammalian cell culture is likewise inefficient, leading to misfolding, endoplasmic reticular stress, and proteosome-mediated degradation. Val(A16) destabilizes the native state and so presumably perturbs a partial fold that directs initial disulfide pairing. Substitutions elsewhere in the core similarly destabilize the native state but, unlike Val(A16), preserve folding efficiency. We propose that Leu(A16) stabilizes nonlocal interactions between nascent alpha-helices in the A- and B-domains to facilitate initial pairing of Cys(A20) and Cys(B19), thus surmounting their wide separation in sequence. Although Val(A16) is likely to destabilize this proto-core, its structural effects are mitigated once folding is achieved. Classical studies of insulin chain combination in vitro have illuminated the impact of off-pathway reactions on the efficiency of native disulfide pairing. The capability of a polypeptide sequence to fold within the endoplasmic reticulum may likewise be influenced by kinetic or thermodynamic partitioning among on- and off-pathway disulfide intermediates. The properties of [Val(A16)]insulin and [Val(A16)]proinsulin demonstrate that essential contributions of conserved residues to folding may be inapparent once the native state is achieved.

-	~~{{STRUCTURE_3gky\| PDB=3gky \| SCENE= }}~~	+	Crystal structure of a "nonfoldable" insulin: impaired folding efficiency despite native activity.,Liu M, Wan ZL, Chu YC, Aladdin H, Klaproth B, Choquette M, Hua QX, Mackin RB, Rao JS, De Meyts P, Katsoyannis PG, Arvan P, Weiss MA J Biol Chem. 2009 Dec 11;284(50):35259-72. Epub 2009 Oct 22. PMID:19850922<ref>PMID:19850922</ref>

-	~~===The Structural Basis~~ of ~~an ER Stress-Associated Bottleneck in a Protein Folding Landscape===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19850922}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3gky]] is a 4 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3GKY OCA].~~	+

	==See Also==		==See Also==
	*[[Molecular Playground/Insulin\|Molecular Playground/Insulin]]		*[[Molecular Playground/Insulin\|Molecular Playground/Insulin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019850922<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Alddin, H.]]		[[Category: Alddin, H.]]
	[[Category: Chu, Y C.]]		[[Category: Chu, Y C.]]

OCA at 17:12, 20 October 2012

OCA — Sat, 20 Oct 2012 17:12:24 GMT

←Older revision		Revision as of 17:12, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[3gky]] is a 4 chain structure ~~of [[Molecular Playground/Insulin]]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GKY OCA].	+	[[3gky]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GKY OCA].

	==See Also==		==See Also==

OCA: Protected "3gky" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 00:10:46 GMT

Protected "3gky" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:10, 27 July 2012

OCA at 00:10, 27 July 2012

OCA — Fri, 27 Jul 2012 00:10:44 GMT

←Older revision		Revision as of 00:10, 27 July 2012
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-	{{Seed}}
	[[Image:3gky.png\|left\|200px]]		[[Image:3gky.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3gky", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_3gky\| PDB=3gky \| SCENE= }}		{{STRUCTURE_3gky\| PDB=3gky \| SCENE= }}

	===The Structural Basis of an ER Stress-Associated Bottleneck in a Protein Folding Landscape===		===The Structural Basis of an ER Stress-Associated Bottleneck in a Protein Folding Landscape===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19850922}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19850922 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19850922}}		{{ABSTRACT_PUBMED_19850922}}

	==About this Structure==		==About this Structure==
-	~~3GKY~~ is a 4 ~~chains~~ structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GKY OCA].	+	[[3gky]] is a 4 chain structure of [[Molecular Playground/Insulin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GKY OCA].
		+
		+	==See Also==
		+	*[[Molecular Playground/Insulin\|Molecular Playground/Insulin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19850922~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019850922</ref><references group="xtra"/>
	[[Category: Alddin, H.]]		[[Category: Alddin, H.]]
	[[Category: Chu, Y C.]]		[[Category: Chu, Y C.]]
Line 38:		Line 29:
	[[Category: Glucose metabolism]]		[[Category: Glucose metabolism]]
	[[Category: Hormone]]		[[Category: Hormone]]
-	[[Category: Pharmaceutical]]
	[[Category: Protein folding]]		[[Category: Protein folding]]
	[[Category: Secreted]]		[[Category: Secreted]]
	[[Category: Tr transition receptor binding]]		[[Category: Tr transition receptor binding]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Dec 24 07:37:06 2009''