3gpn - Revision history

OCA at 07:09, 6 September 2023

OCA — Wed, 06 Sep 2023 07:09:37 GMT

←Older revision		Revision as of 07:09, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3gpn' size='340' side='right'caption='[[3gpn]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3gpn' size='340' side='right'caption='[[3gpn]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gpn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GPN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gpn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GPN FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3gpm\|3gpm]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">POL30, YBR0811, YBR088C ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=~~5&~~id=4932 ATCC 18824])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gpn OCA], [https://pdbe.org/3gpn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gpn RCSB], [https://www.ebi.ac.uk/pdbsum/3gpn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gpn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gpn OCA], [https://pdbe.org/3gpn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gpn RCSB], [https://www.ebi.ac.uk/pdbsum/3gpn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gpn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PCNA_YEAST PCNA_YEAST]] This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.<ref>PMID:11545742</ref> <ref>PMID:12226657</ref>	+	[https://www.uniprot.org/uniprot/PCNA_YEAST PCNA_YEAST] This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.<ref>PMID:11545742</ref> <ref>PMID:12226657</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Freudenthal, B D~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Gakhar, L~~]]	+	[[Category: Freudenthal BD]]
-	[[Category: ~~Ramaswamy, S~~]]	+	[[Category: Gakhar L]]
-	[[Category: ~~Washington, M T~~]]	+	[[Category: Ramaswamy S]]
-	[[Category: ~~Dna binding protein]]~~	+	[[Category: Washington MT]]
-	~~[[Category: Dna damage]]~~	+
-	~~[[Category: Dna repair]]~~	+
-	~~[[Category: Dna replication]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Isopeptide bond]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Replication]]~~	+
-	~~[[Category: Ubl conjugation~~]]	+

OCA at 20:08, 20 October 2021

OCA — Wed, 20 Oct 2021 20:08:37 GMT

←Older revision		Revision as of 20:08, 20 October 2021
Line 1:		Line 1:

	==Structure of the non-trimeric form of the E113G PCNA mutant protein==		==Structure of the non-trimeric form of the E113G PCNA mutant protein==
-	<StructureSection load='3gpn' size='340' side='right' caption='[[3gpn]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='3gpn' size='340' side='right'caption='[[3gpn]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gpn]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GPN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3GPN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gpn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GPN FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gpm\|3gpm]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3gpm\|3gpm]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POL30, YBR0811, YBR088C ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POL30, YBR0811, YBR088C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3gpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gpn OCA], [~~http~~://pdbe.org/3gpn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3gpn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3gpn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3gpn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gpn OCA], [https://pdbe.org/3gpn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gpn RCSB], [https://www.ebi.ac.uk/pdbsum/3gpn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gpn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PCNA_YEAST PCNA_YEAST]] This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.<ref>PMID:11545742</ref> <ref>PMID:12226657</ref>	+	[[https://www.uniprot.org/uniprot/PCNA_YEAST PCNA_YEAST]] This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.<ref>PMID:11545742</ref> <ref>PMID:12226657</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Proliferating ~~Cell Nuclear Antigen~~\|Proliferating ~~Cell Nuclear Antigen~~]]	+	*[[Proliferating cell nuclear antigen 3D structures\|Proliferating cell nuclear antigen 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Freudenthal, B D]]		[[Category: Freudenthal, B D]]
	[[Category: Gakhar, L]]		[[Category: Gakhar, L]]

OCA at 05:29, 7 December 2018

OCA — Fri, 07 Dec 2018 05:29:40 GMT

←Older revision		Revision as of 05:29, 7 December 2018
Line 1:		Line 1:
		+
	==Structure of the non-trimeric form of the E113G PCNA mutant protein==		==Structure of the non-trimeric form of the E113G PCNA mutant protein==
	<StructureSection load='3gpn' size='340' side='right' caption='[[3gpn]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3gpn' size='340' side='right' caption='[[3gpn]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gpm\|3gpm]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gpm\|3gpm]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POL30, YBR0811, YBR088C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POL30, YBR0811, YBR088C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gpn OCA], [http://pdbe.org/3gpn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gpn RCSB], [http://www.ebi.ac.uk/pdbsum/3gpn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gpn OCA], [http://pdbe.org/3gpn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gpn RCSB], [http://www.ebi.ac.uk/pdbsum/3gpn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gpn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gp/3gpn_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gp/3gpn_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 48:		Line 49:
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Replication]]		[[Category: Replication]]
		+	[[Category: Ubl conjugation]]

OCA at 09:20, 8 February 2016

OCA — Mon, 08 Feb 2016 09:20:29 GMT

←Older revision		Revision as of 09:20, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3gpn' size='340' side='right' caption='[[3gpn]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='3gpn' size='340' side='right' caption='[[3gpn]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gpn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GPN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GPN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gpn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GPN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GPN FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gpm\|3gpm]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gpm\|3gpm]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POL30, YBR0811, YBR088C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POL30, YBR0811, YBR088C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gpn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gpn RCSB], [http://www.ebi.ac.uk/pdbsum/3gpn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gpn OCA], [http://pdbe.org/3gpn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gpn RCSB], [http://www.ebi.ac.uk/pdbsum/3gpn PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gpn ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3gpn" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Freudenthal, B D]]		[[Category: Freudenthal, B D]]
	[[Category: Gakhar, L]]		[[Category: Gakhar, L]]

OCA at 22:16, 24 December 2014

OCA — Wed, 24 Dec 2014 22:16:29 GMT

←Older revision		Revision as of 22:16, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3gpn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GPN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GPN FirstGlance]. <br>		<table><tr><td colspan='2'>[[3gpn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GPN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GPN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gpm\|3gpm]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gpm\|3gpm]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POL30, YBR0811, YBR088C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POL30, YBR0811, YBR088C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gpn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gpn RCSB], [http://www.ebi.ac.uk/pdbsum/3gpn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gpn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gpn RCSB], [http://www.ebi.ac.uk/pdbsum/3gpn PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PCNA_YEAST PCNA_YEAST]] This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.<ref>PMID:11545742</ref> <ref>PMID:12226657</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Freudenthal, B D.]]	+	[[Category: Freudenthal, B D]]
-	[[Category: Gakhar, L.]]	+	[[Category: Gakhar, L]]
-	[[Category: Ramaswamy, S.]]	+	[[Category: Ramaswamy, S]]
-	[[Category: Washington, M T.]]	+	[[Category: Washington, M T]]
	[[Category: Dna binding protein]]		[[Category: Dna binding protein]]
	[[Category: Dna damage]]		[[Category: Dna damage]]

OCA at 11:00, 29 September 2014

OCA — Mon, 29 Sep 2014 11:00:38 GMT

←Older revision		Revision as of 11:00, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3gpn.~~png~~\|~~left~~\|200px]]	+	==Structure of the non-trimeric form of the E113G PCNA mutant protein==
		+	<StructureSection load='3gpn' size='340' side='right' caption='[[3gpn]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3gpn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GPN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GPN FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gpm\|3gpm]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POL30, YBR0811, YBR088C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gpn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gpn RCSB], [http://www.ebi.ac.uk/pdbsum/3gpn PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gp/3gpn_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Eukaryotic proliferating cell nuclear antigen (PCNA) is an essential replication accessory factor that interacts with a variety of proteins involved in DNA replication and repair. Each monomer of PCNA has an N-terminal domain A and a C-terminal domain B. In the structure of the wild-type PCNA protein, domain A of one monomer interacts with domain B of a neighboring monomer to form a ring-shaped trimer. Glu113 is a conserved residue at the subunit interface in domain A. Two distinct X-ray crystal structures have been determined of a mutant form of PCNA with a substitution at this position (E113G) that has previously been studied because of its effect on translesion synthesis. The first structure was the expected ring-shaped trimer. The second structure was an unanticipated nontrimeric form of the protein. In this nontrimeric form, domain A of one PCNA monomer interacts with domain A of a neighboring monomer, while domain B of this monomer interacts with domain B of a different neighboring monomer. The B-B interface is stabilized by an antiparallel beta-sheet and appears to be structurally similar to the A-B interface observed in the trimeric form of PCNA. The A-A interface, in contrast, is primarily stabilized by hydrophobic interactions. Because the E113G substitution is located on this hydrophobic surface, the A-A interface should be less favorable in the case of the wild-type protein. This suggests that the side chain of Glu113 promotes trimer formation by destabilizing these possible alternate subunit interactions.

-	~~{{STRUCTURE_3gpn\| PDB=3gpn \| SCENE= }}~~	+	A charged residue at the subunit interface of PCNA promotes trimer formation by destabilizing alternate subunit interactions.,Freudenthal BD, Gakhar L, Ramaswamy S, Washington MT Acta Crystallogr D Biol Crystallogr. 2009 Jun;65(Pt 6):560-6. Epub 2009, May 15. PMID:19465770<ref>PMID:19465770</ref>

-	~~===Structure~~ of the ~~non-trimeric form of the E113G PCNA mutant protein===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19465770}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3gpn]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3GPN OCA].~~	+

	==See Also==		==See Also==
	*[[Proliferating Cell Nuclear Antigen\|Proliferating Cell Nuclear Antigen]]		*[[Proliferating Cell Nuclear Antigen\|Proliferating Cell Nuclear Antigen]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019465770<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Freudenthal, B D.]]		[[Category: Freudenthal, B D.]]

OCA at 09:41, 20 October 2012

OCA — Sat, 20 Oct 2012 09:41:20 GMT

←Older revision		Revision as of 09:41, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3gpn]] is a 1 chain structure ~~of [[Proliferating Cell Nuclear Antigen]]~~ with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GPN OCA].	+	[[3gpn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GPN OCA].

	==See Also==		==See Also==

OCA: Protected "3gpn" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 23:39:31 GMT

Protected "3gpn" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:39, 25 July 2012

OCA at 23:39, 25 July 2012

OCA — Wed, 25 Jul 2012 23:39:28 GMT

←Older revision		Revision as of 23:39, 25 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3gpn.png\|left\|200px]]		[[Image:3gpn.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3gpn", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3gpn\| PDB=3gpn \| SCENE= }}		{{STRUCTURE_3gpn\| PDB=3gpn \| SCENE= }}

	===Structure of the non-trimeric form of the E113G PCNA mutant protein===		===Structure of the non-trimeric form of the E113G PCNA mutant protein===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19465770}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19465770 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19465770}}		{{ABSTRACT_PUBMED_19465770}}

	==About this Structure==		==About this Structure==
-	~~3GPN~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GPN OCA].	+	[[3gpn]] is a 1 chain structure of [[Proliferating Cell Nuclear Antigen]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GPN OCA].
		+
		+	==See Also==
		+	*[[Proliferating Cell Nuclear Antigen\|Proliferating Cell Nuclear Antigen]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19465770~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019465770</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Freudenthal, B D.]]		[[Category: Freudenthal, B D.]]
Line 37:		Line 28:
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Replication]]		[[Category: Replication]]
-	[[Category: Ubl conjugation]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 25 08:24:29 2009''

OCA at 05:24, 25 June 2009

OCA — Thu, 25 Jun 2009 05:24:33 GMT

←Older revision		Revision as of 05:24, 25 June 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3gpn.~~jpg~~\|left\|200px]]	+	[[Image:3gpn.png\|left\|200px]]

	<!--		<!--
Line 39:		Line 39:
	[[Category: Ubl conjugation]]		[[Category: Ubl conjugation]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed~~ Jun ~~17 10~~:12:06 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 25 08:24:29 2009''