3gq2 - Revision history

OCA at 09:55, 21 February 2024

OCA — Wed, 21 Feb 2024 09:55:54 GMT

←Older revision		Revision as of 09:55, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='3gq2' size='340' side='right'caption='[[3gq2]], [[Resolution\|resolution]] 2.18Å' scene=''>		<StructureSection load='3gq2' size='340' side='right'caption='[[3gq2]], [[Resolution\|resolution]] 2.18Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gq2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bovin Bovin~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GQ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GQ2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gq2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GQ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GQ2 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~p115~~, ~~USO1, VDP (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9913 BOVIN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.18Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gq2 OCA], [https://pdbe.org/3gq2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gq2 RCSB], [https://www.ebi.ac.uk/pdbsum/3gq2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gq2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gq2 OCA], [https://pdbe.org/3gq2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gq2 RCSB], [https://www.ebi.ac.uk/pdbsum/3gq2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gq2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/USO1_BOVIN USO1_BOVIN]] General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity.	+	[https://www.uniprot.org/uniprot/USO1_BOVIN USO1_BOVIN] General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gq2 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gq2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Molecular tethers have a central role in the organization of the complex membrane architecture of eukaryotic cells. p115 is a ubiquitous, essential tether involved in vesicle transport and the structural organization of the exocytic pathway. We describe two crystal structures of the N-terminal domain of p115 at 2.0 A resolution. The p115 structures show a novel alpha-solenoid architecture constructed of 12 armadillo-like, tether-repeat, alpha-helical tripod motifs. We find that the H1 TR binds the Rab1 GTPase involved in endoplasmic reticulum to Golgi transport. Mutation of the H1 motif results in the dominant negative inhibition of endoplasmic reticulum to Golgi trafficking. We propose that the H1 helical tripod contributes to the assembly of Rab-dependent complexes responsible for the tether and SNARE-dependent fusion of membranes.
-
-	Structural and functional analysis of the globular head domain of p115 provides insight into membrane tethering.,An Y, Chen CY, Moyer B, Rotkiewicz P, Elsliger MA, Godzik A, Wilson IA, Balch WE J Mol Biol. 2009 Aug 7;391(1):26-41. Epub 2009 May 4. PMID:19414022<ref>PMID:19414022</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3gq2" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bovin~~]]	+	[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: An, Y]]	+	[[Category: An Y]]
-	[[Category: Elsliger~~, M A~~]]	+	[[Category: Elsliger MA]]
-	[[Category: Wilson~~, I A]]~~	+	[[Category: Wilson IA]]
-	~~[[Category: Armadillo repeat]]~~	+
-	~~[[Category: Er-golgi transport]]~~	+
-	~~[[Category: Golgi apparatus]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Membrane fusion]]~~	+
-	~~[[Category: Membrane tethering]]~~	+
-	~~[[Category: Membrane trafficking]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Protein transport]]~~	+
-	~~[[Category: Rab gtpase]]~~	+
-	~~[[Category: Snare]]~~	+
-	~~[[Category: Transport]]~~	+
-	~~[[Category: Transport protein]]~~	+
-	~~[[Category: Vesicle transport~~]]	+

OCA at 07:52, 16 March 2022

OCA — Wed, 16 Mar 2022 07:52:03 GMT

←Older revision		Revision as of 07:52, 16 March 2022
Line 1:		Line 1:

	==Crystal Structure of the Dimer of the p115 Tether Globular Head Domain==		==Crystal Structure of the Dimer of the p115 Tether Globular Head Domain==
-	<StructureSection load='3gq2' size='340' side='right' caption='[[3gq2]], [[Resolution\|resolution]] 2.18Å' scene=''>	+	<StructureSection load='3gq2' size='340' side='right'caption='[[3gq2]], [[Resolution\|resolution]] 2.18Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gq2]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GQ2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3GQ2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gq2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GQ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GQ2 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">p115, USO1, VDP ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">p115, USO1, VDP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3gq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gq2 OCA], [~~http~~://pdbe.org/3gq2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3gq2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3gq2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3gq2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gq2 OCA], [https://pdbe.org/3gq2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gq2 RCSB], [https://www.ebi.ac.uk/pdbsum/3gq2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gq2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/USO1_BOVIN USO1_BOVIN]] General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity.	+	[[https://www.uniprot.org/uniprot/USO1_BOVIN USO1_BOVIN]] General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gq/3gq2_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gq/3gq2_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Bovin]]		[[Category: Bovin]]
		+	[[Category: Large Structures]]
	[[Category: An, Y]]		[[Category: An, Y]]
	[[Category: Elsliger, M A]]		[[Category: Elsliger, M A]]

OCA at 07:10, 1 November 2017

OCA — Wed, 01 Nov 2017 07:10:23 GMT

←Older revision		Revision as of 07:10, 1 November 2017
Line 1:		Line 1:
		+
	==Crystal Structure of the Dimer of the p115 Tether Globular Head Domain==		==Crystal Structure of the Dimer of the p115 Tether Globular Head Domain==
	<StructureSection load='3gq2' size='340' side='right' caption='[[3gq2]], [[Resolution\|resolution]] 2.18Å' scene=''>		<StructureSection load='3gq2' size='340' side='right' caption='[[3gq2]], [[Resolution\|resolution]] 2.18Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[3gq2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GQ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GQ2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3gq2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GQ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GQ2 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">p115, USO1, VDP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">p115, USO1, VDP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gq2 OCA], [http://pdbe.org/3gq2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gq2 RCSB], [http://www.ebi.ac.uk/pdbsum/3gq2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gq2 OCA], [http://pdbe.org/3gq2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gq2 RCSB], [http://www.ebi.ac.uk/pdbsum/3gq2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gq2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 00:22, 8 February 2016

OCA — Mon, 08 Feb 2016 00:22:15 GMT

←Older revision		Revision as of 00:22, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3gq2' size='340' side='right' caption='[[3gq2]], [[Resolution\|resolution]] 2.18Å' scene=''>		<StructureSection load='3gq2' size='340' side='right' caption='[[3gq2]], [[Resolution\|resolution]] 2.18Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gq2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bos_taurus Bos taurus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GQ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GQ2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gq2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GQ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GQ2 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">p115, USO1, VDP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 ~~Bos taurus~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">p115, USO1, VDP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gq2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gq2 RCSB], [http://www.ebi.ac.uk/pdbsum/3gq2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gq2 OCA], [http://pdbe.org/3gq2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gq2 RCSB], [http://www.ebi.ac.uk/pdbsum/3gq2 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gq2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3gq2" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bos taurus~~]]	+	[[Category: Bovin]]
	[[Category: An, Y]]		[[Category: An, Y]]
	[[Category: Elsliger, M A]]		[[Category: Elsliger, M A]]

OCA at 19:13, 24 December 2014

OCA — Wed, 24 Dec 2014 19:13:15 GMT

←Older revision		Revision as of 19:13, 24 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gq2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gq2 RCSB], [http://www.ebi.ac.uk/pdbsum/3gq2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gq2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gq2 RCSB], [http://www.ebi.ac.uk/pdbsum/3gq2 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/USO1_BOVIN USO1_BOVIN]] General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:54, 8 December 2014

OCA — Mon, 08 Dec 2014 08:54:49 GMT

←Older revision		Revision as of 08:54, 8 December 2014
Line 1:		Line 1:
-	[[~~Image~~:3gq2.~~png\|left~~\|200px]]	+	==Crystal Structure of the Dimer of the p115 Tether Globular Head Domain==
		+	<StructureSection load='3gq2' size='340' side='right' caption='[[3gq2]], [[Resolution\|resolution]] 2.18Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3gq2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GQ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GQ2 FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">p115, USO1, VDP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gq2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gq2 RCSB], [http://www.ebi.ac.uk/pdbsum/3gq2 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gq/3gq2_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Molecular tethers have a central role in the organization of the complex membrane architecture of eukaryotic cells. p115 is a ubiquitous, essential tether involved in vesicle transport and the structural organization of the exocytic pathway. We describe two crystal structures of the N-terminal domain of p115 at 2.0 A resolution. The p115 structures show a novel alpha-solenoid architecture constructed of 12 armadillo-like, tether-repeat, alpha-helical tripod motifs. We find that the H1 TR binds the Rab1 GTPase involved in endoplasmic reticulum to Golgi transport. Mutation of the H1 motif results in the dominant negative inhibition of endoplasmic reticulum to Golgi trafficking. We propose that the H1 helical tripod contributes to the assembly of Rab-dependent complexes responsible for the tether and SNARE-dependent fusion of membranes.

-	~~{{STRUCTURE_3gq2\| PDB=3gq2 \| SCENE= }}~~	+	Structural and functional analysis of the globular head domain of p115 provides insight into membrane tethering.,An Y, Chen CY, Moyer B, Rotkiewicz P, Elsliger MA, Godzik A, Wilson IA, Balch WE J Mol Biol. 2009 Aug 7;391(1):26-41. Epub 2009 May 4. PMID:19414022<ref>PMID:19414022</ref>

-	~~===Crystal Structure~~ of the ~~Dimer of the p115 Tether Globular Head Domain===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19414022}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3gq2]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3GQ2 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019414022<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: An, Y.]]	+	[[Category: An, Y]]
-	[[Category: Elsliger, M A.]]	+	[[Category: Elsliger, M A]]
-	[[Category: Wilson, I A.]]	+	[[Category: Wilson, I A]]
	[[Category: Armadillo repeat]]		[[Category: Armadillo repeat]]
	[[Category: Er-golgi transport]]		[[Category: Er-golgi transport]]

OCA: Protected "3gq2" [edit=sysop:move=sysop]

OCA — Wed, 27 Feb 2013 15:26:07 GMT

Protected "3gq2" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:26, 27 February 2013

OCA at 15:26, 27 February 2013

OCA — Wed, 27 Feb 2013 15:26:02 GMT

←Older revision		Revision as of 15:26, 27 February 2013
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3gq2.png\|left\|200px]]
-	[[Image:3gq2.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3gq2", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3gq2\| PDB=3gq2 \| SCENE= }}		{{STRUCTURE_3gq2\| PDB=3gq2 \| SCENE= }}

	===Crystal Structure of the Dimer of the p115 Tether Globular Head Domain===		===Crystal Structure of the Dimer of the p115 Tether Globular Head Domain===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19414022}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19414022 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19414022}}		{{ABSTRACT_PUBMED_19414022}}

	==About this Structure==		==About this Structure==
-	~~3GQ2~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GQ2 OCA].	+	[[3gq2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GQ2 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19414022~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019414022</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: An, Y.]]		[[Category: An, Y.]]
Line 29:		Line 17:
	[[Category: Wilson, I A.]]		[[Category: Wilson, I A.]]
	[[Category: Armadillo repeat]]		[[Category: Armadillo repeat]]
-	[[Category: Coiled coil]]
-	[[Category: Cytoplasm]]
	[[Category: Er-golgi transport]]		[[Category: Er-golgi transport]]
	[[Category: Golgi apparatus]]		[[Category: Golgi apparatus]]
Line 44:		Line 30:
	[[Category: Transport protein]]		[[Category: Transport protein]]
	[[Category: Vesicle transport]]		[[Category: Vesicle transport]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 4 10:56:25 2009''

OCA at 08:56, 4 November 2009

OCA — Wed, 04 Nov 2009 08:56:27 GMT

←Older revision		Revision as of 08:56, 4 November 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3gq2.jpg\|left\|200px]]

-	The ~~entry 3gq2~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3gq2", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3gq2\| PDB=3gq2 \| SCENE= }}

-	~~Authors: An, Y., Elsliger, M.A., Wilson, I.A.~~	+	===Crystal Structure of the Dimer of the p115 Tether Globular Head Domain===

-	Description: Crystal Structure of the Dimer of the p115 Tether Globular Head Domain

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Apr 15 09~~:56:06 2009''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19414022}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19414022 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19414022}}
		+
		+	==About this Structure==
		+	3GQ2 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GQ2 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19414022</ref><references group="xtra"/>
		+	[[Category: Bos taurus]]
		+	[[Category: An, Y.]]
		+	[[Category: Elsliger, M A.]]
		+	[[Category: Wilson, I A.]]
		+	[[Category: Armadillo repeat]]
		+	[[Category: Coiled coil]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Er-golgi transport]]
		+	[[Category: Golgi apparatus]]
		+	[[Category: Membrane]]
		+	[[Category: Membrane fusion]]
		+	[[Category: Membrane tethering]]
		+	[[Category: Membrane trafficking]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Protein transport]]
		+	[[Category: Rab gtpase]]
		+	[[Category: Snare]]
		+	[[Category: Transport]]
		+	[[Category: Transport protein]]
		+	[[Category: Vesicle transport]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 4 10:56:25 2009''

OCA: New page: '''Unreleased structure''' The entry 3gq2 is ON HOLD Authors: An, Y., Elsliger, M.A., Wilson, I.A. Description: Crystal Structure of the Dimer of the p115 Tether Globular Head Domain ...

OCA — Wed, 15 Apr 2009 06:56:06 GMT

New page: '''Unreleased structure''' The entry 3gq2 is ON HOLD Authors: An, Y., Elsliger, M.A., Wilson, I.A. Description: Crystal Structure of the Dimer of the p115 Tether Globular Head Domain ...

New page

'''Unreleased structure'''

The entry 3gq2 is ON HOLD

Authors: An, Y., Elsliger, M.A., Wilson, I.A.

Description: Crystal Structure of the Dimer of the p115 Tether Globular Head Domain

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 15 09:56:06 2009''