3gqh - Revision history

OCA at 09:56, 21 February 2024

OCA — Wed, 21 Feb 2024 09:56:01 GMT

←Older revision		Revision as of 09:56, 21 February 2024
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	<StructureSection load='3gqh' size='340' side='right'caption='[[3gqh]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3gqh' size='340' side='right'caption='[[3gqh]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gqh]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bpph2 Bpph2~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GQH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gqh]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_virus_phi29 Bacillus virus phi29]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GQH FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3gq7\|3gq7]], [[3gq8\|3gq8]], [[3gq9\|3gq9]], [[3gqa\|3gqa]], [[3gqk\|3gqk]], [[3gqn\|3gqn]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">12, gene product 12 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10756 BPPH2])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gqh OCA], [https://pdbe.org/3gqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gqh RCSB], [https://www.ebi.ac.uk/pdbsum/3gqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gqh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gqh OCA], [https://pdbe.org/3gqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gqh RCSB], [https://www.ebi.ac.uk/pdbsum/3gqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gqh ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FIB12_BPPH2 FIB12_BPPH2] Structural component of the 12 appendages that hang from the lower collar. Adhesion protein that binds to the host cell surface during virus attachment and mediates teichoic acids degradation.<ref>PMID:7241648</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gqh ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gqh ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The tailed bacteriophage phi29 has 12 "appendages" (gene product 12, gp12) attached to its neck region that participate in host cell recognition and entry. In the cell, monomeric gp12 undergoes proteolytic processing that releases the C-terminal domain during assembly into trimers. We report here crystal structures of the protein before and after catalytic processing and show that the C-terminal domain of gp12 is an "autochaperone" that aids trimerization. We also show that autocleavage of the C-terminal domain is a posttrimerization event that is followed by a unique ATP-dependent release. The posttranslationally modified N-terminal part has three domains that function to attach the appendages to the phage, digest the cell wall teichoic acids, and bind irreversibly to the host, respectively. Structural and sequence comparisons suggest that some eukaryotic and bacterial viruses as well as bacterial adhesins might have a similar maturation mechanism as is performed by phi29 gp12 for Bacillus subtilis.
-
-	Crystallographic insights into the autocatalytic assembly mechanism of a bacteriophage tail spike.,Xiang Y, Leiman PG, Li L, Grimes S, Anderson DL, Rossmann MG Mol Cell. 2009 May 15;34(3):375-86. PMID:19450535<ref>PMID:19450535</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3gqh" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bpph2~~]]	+	[[Category: Bacillus virus phi29]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Rossmann~~, M G~~]]	+	[[Category: Rossmann MG]]
-	[[Category: Xiang, Y]]	+	[[Category: Xiang Y]]
-	~~[[Category: Beta barrel]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 07:52, 16 March 2022

OCA — Wed, 16 Mar 2022 07:52:15 GMT

←Older revision		Revision as of 07:52, 16 March 2022
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	==Crystal Structure of the Bacteriophage phi29 gene product 12 C-terminal fragment==		==Crystal Structure of the Bacteriophage phi29 gene product 12 C-terminal fragment==
-	<StructureSection load='3gqh' size='340' side='right' caption='[[3gqh]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3gqh' size='340' side='right'caption='[[3gqh]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gqh]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bpph2 Bpph2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GQH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3GQH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gqh]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bpph2 Bpph2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GQH FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gq7\|3gq7]], [[3gq8\|3gq8]], [[3gq9\|3gq9]], [[3gqa\|3gqa]], [[3gqk\|3gqk]], [[3gqn\|3gqn]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3gq7\|3gq7]], [[3gq8\|3gq8]], [[3gq9\|3gq9]], [[3gqa\|3gqa]], [[3gqk\|3gqk]], [[3gqn\|3gqn]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">12, gene product 12 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10756 BPPH2])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">12, gene product 12 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10756 BPPH2])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3gqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gqh OCA], [~~http~~://pdbe.org/3gqh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3gqh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3gqh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3gqh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gqh OCA], [https://pdbe.org/3gqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gqh RCSB], [https://www.ebi.ac.uk/pdbsum/3gqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gqh ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</StructureSection>		</StructureSection>
	[[Category: Bpph2]]		[[Category: Bpph2]]
		+	[[Category: Large Structures]]
	[[Category: Rossmann, M G]]		[[Category: Rossmann, M G]]
	[[Category: Xiang, Y]]		[[Category: Xiang, Y]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 05:18, 7 December 2018

OCA — Fri, 07 Dec 2018 05:18:14 GMT

←Older revision		Revision as of 05:18, 7 December 2018
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		+
	==Crystal Structure of the Bacteriophage phi29 gene product 12 C-terminal fragment==		==Crystal Structure of the Bacteriophage phi29 gene product 12 C-terminal fragment==
	<StructureSection load='3gqh' size='340' side='right' caption='[[3gqh]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3gqh' size='340' side='right' caption='[[3gqh]], [[Resolution\|resolution]] 1.80Å' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gq7\|3gq7]], [[3gq8\|3gq8]], [[3gq9\|3gq9]], [[3gqa\|3gqa]], [[3gqk\|3gqk]], [[3gqn\|3gqn]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gq7\|3gq7]], [[3gq8\|3gq8]], [[3gq9\|3gq9]], [[3gqa\|3gqa]], [[3gqk\|3gqk]], [[3gqn\|3gqn]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">12, gene product 12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10756 BPPH2])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">12, gene product 12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10756 BPPH2])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gqh OCA], [http://pdbe.org/3gqh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gqh RCSB], [http://www.ebi.ac.uk/pdbsum/3gqh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gqh OCA], [http://pdbe.org/3gqh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gqh RCSB], [http://www.ebi.ac.uk/pdbsum/3gqh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gqh ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gq/3gqh_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gq/3gqh_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 22:18, 7 February 2016

OCA — Sun, 07 Feb 2016 22:18:22 GMT

←Older revision		Revision as of 22:18, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3gqh' size='340' side='right' caption='[[3gqh]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3gqh' size='340' side='right' caption='[[3gqh]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gqh]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_phage_phi29 Bacillus phage phi29~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GQH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GQH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gqh]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpph2 Bpph2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GQH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GQH FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gq7\|3gq7]], [[3gq8\|3gq8]], [[3gq9\|3gq9]], [[3gqa\|3gqa]], [[3gqk\|3gqk]], [[3gqn\|3gqn]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gq7\|3gq7]], [[3gq8\|3gq8]], [[3gq9\|3gq9]], [[3gqa\|3gqa]], [[3gqk\|3gqk]], [[3gqn\|3gqn]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">12, gene product 12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10756 ~~Bacillus phage phi29~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">12, gene product 12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10756 BPPH2])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gqh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gqh RCSB], [http://www.ebi.ac.uk/pdbsum/3gqh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gqh OCA], [http://pdbe.org/3gqh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gqh RCSB], [http://www.ebi.ac.uk/pdbsum/3gqh PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gqh ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3gqh" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus phage phi29~~]]	+	[[Category: Bpph2]]
	[[Category: Rossmann, M G]]		[[Category: Rossmann, M G]]
	[[Category: Xiang, Y]]		[[Category: Xiang, Y]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 21:18, 3 January 2015

OCA — Sat, 03 Jan 2015 21:18:41 GMT

←Older revision		Revision as of 21:18, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3gqh]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_phage_phi29 Bacillus phage phi29]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GQH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GQH FirstGlance]. <br>		<table><tr><td colspan='2'>[[3gqh]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_phage_phi29 Bacillus phage phi29]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GQH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GQH FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gq7\|3gq7]], [[3gq8\|3gq8]], [[3gq9\|3gq9]], [[3gqa\|3gqa]], [[3gqk\|3gqk]], [[3gqn\|3gqn]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gq7\|3gq7]], [[3gq8\|3gq8]], [[3gq9\|3gq9]], [[3gqa\|3gqa]], [[3gqk\|3gqk]], [[3gqn\|3gqn]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">12, gene product 12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10756 Bacillus phage phi29])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">12, gene product 12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10756 Bacillus phage phi29])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gqh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gqh RCSB], [http://www.ebi.ac.uk/pdbsum/3gqh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gqh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gqh RCSB], [http://www.ebi.ac.uk/pdbsum/3gqh PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	Crystallographic insights into the autocatalytic assembly mechanism of a bacteriophage tail spike.,Xiang Y, Leiman PG, Li L, Grimes S, Anderson DL, Rossmann MG Mol Cell. 2009 May 15;34(3):375-86. PMID:19450535<ref>PMID:19450535</ref>		Crystallographic insights into the autocatalytic assembly mechanism of a bacteriophage tail spike.,Xiang Y, Leiman PG, Li L, Grimes S, Anderson DL, Rossmann MG Mol Cell. 2009 May 15;34(3):375-86. PMID:19450535<ref>PMID:19450535</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus phage phi29]]		[[Category: Bacillus phage phi29]]
-	[[Category: Rossmann, M G.]]	+	[[Category: Rossmann, M G]]
-	[[Category: Xiang, Y.]]	+	[[Category: Xiang, Y]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 09:43, 21 May 2014

OCA — Wed, 21 May 2014 09:43:23 GMT

←Older revision		Revision as of 09:43, 21 May 2014
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-	[[~~Image:~~3gqh.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of the Bacteriophage phi29 gene product 12 C-terminal fragment==
		+	<StructureSection load='3gqh' size='340' side='right' caption='[[3gqh]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3gqh]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_phage_phi29 Bacillus phage phi29]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GQH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GQH FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gq7\|3gq7]], [[3gq8\|3gq8]], [[3gq9\|3gq9]], [[3gqa\|3gqa]], [[3gqk\|3gqk]], [[3gqn\|3gqn]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">12, gene product 12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10756 Bacillus phage phi29])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gqh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gqh RCSB], [http://www.ebi.ac.uk/pdbsum/3gqh PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gq/3gqh_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The tailed bacteriophage phi29 has 12 "appendages" (gene product 12, gp12) attached to its neck region that participate in host cell recognition and entry. In the cell, monomeric gp12 undergoes proteolytic processing that releases the C-terminal domain during assembly into trimers. We report here crystal structures of the protein before and after catalytic processing and show that the C-terminal domain of gp12 is an "autochaperone" that aids trimerization. We also show that autocleavage of the C-terminal domain is a posttrimerization event that is followed by a unique ATP-dependent release. The posttranslationally modified N-terminal part has three domains that function to attach the appendages to the phage, digest the cell wall teichoic acids, and bind irreversibly to the host, respectively. Structural and sequence comparisons suggest that some eukaryotic and bacterial viruses as well as bacterial adhesins might have a similar maturation mechanism as is performed by phi29 gp12 for Bacillus subtilis.

-	~~<!--~~	+	Crystallographic insights into the autocatalytic assembly mechanism of a bacteriophage tail spike.,Xiang Y, Leiman PG, Li L, Grimes S, Anderson DL, Rossmann MG Mol Cell. 2009 May 15;34(3):375-86. PMID:19450535<ref>PMID:19450535</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3gqh"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3gqh\| PDB=3gqh \| SCENE= }}~~	+

-	~~===Crystal Structure~~ of the ~~Bacteriophage phi29 gene product 12 C-terminal fragment===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_19450535}}, adds the Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 19450535 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_19450535}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3gqh]] is a 3 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Bacillus_phage_phi29 Bacillus phage phi29]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GQH OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019450535<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Bacillus phage phi29]]		[[Category: Bacillus phage phi29]]
	[[Category: Rossmann, M G.]]		[[Category: Rossmann, M G.]]

OCA: Protected "3gqh" [edit=sysop:move=sysop]

OCA — Wed, 21 Mar 2012 06:23:52 GMT

Protected "3gqh" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:23, 21 March 2012

OCA at 06:23, 21 March 2012

OCA — Wed, 21 Mar 2012 06:23:51 GMT

←Older revision		Revision as of 06:23, 21 March 2012
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-	~~{{Seed}}~~	+	[[Image:3gqh.png\|left\|200px]]
-	[[Image:3gqh.~~jpg~~\|left\|200px]]	+

	<!--		<!--
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	===Crystal Structure of the Bacteriophage phi29 gene product 12 C-terminal fragment===		===Crystal Structure of the Bacteriophage phi29 gene product 12 C-terminal fragment===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19450535}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19450535 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19450535}}

	==About this Structure==		==About this Structure==
-	~~3GQH~~ is a 3 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Bacillus_phage_phi29 Bacillus phage phi29]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GQH OCA].	+	[[3gqh]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_phage_phi29 Bacillus phage phi29]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GQH OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:019450535</ref><references group="xtra"/>
	[[Category: Bacillus phage phi29]]		[[Category: Bacillus phage phi29]]
	[[Category: Rossmann, M G.]]		[[Category: Rossmann, M G.]]
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	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Viral protein]]		[[Category: Viral protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 27 15:25:13 2009''

OCA at 12:25, 27 May 2009

OCA — Wed, 27 May 2009 12:25:15 GMT

←Older revision		Revision as of 12:25, 27 May 2009
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3gqh.jpg\|left\|200px]]

-	The ~~entry 3gqh~~ is ~~ON HOLD~~ ~~until May 24 2010~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3gqh", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3gqh\| PDB=3gqh \| SCENE= }}

-	~~Authors: Xiang, Y., Rossmann, M.G.~~	+	===Crystal Structure of the Bacteriophage phi29 gene product 12 C-terminal fragment===

-	Description: Crystal Structure of the Bacteriophage phi29 gene product 12 C-terminal fragment

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Apr 22 11~~:08:26 2009''	+	==About this Structure==
		+	3GQH is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Bacillus_phage_phi29 Bacillus phage phi29]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GQH OCA].
		+	[[Category: Bacillus phage phi29]]
		+	[[Category: Rossmann, M G.]]
		+	[[Category: Xiang, Y.]]
		+	[[Category: Beta barrel]]
		+	[[Category: Viral protein]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 27 15:25:13 2009''

OCA at 08:08, 22 April 2009

OCA — Wed, 22 Apr 2009 08:08:27 GMT

←Older revision		Revision as of 08:08, 22 April 2009
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3gqh is ON HOLD	+	The entry 3gqh is ON HOLD until May 24 2010

	Authors: Xiang, Y., Rossmann, M.G.		Authors: Xiang, Y., Rossmann, M.G.
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	Description: Crystal Structure of the Bacteriophage phi29 gene product 12 C-terminal fragment		Description: Crystal Structure of the Bacteriophage phi29 gene product 12 C-terminal fragment

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr ~~15 09~~:56:19 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 22 11:08:26 2009''