3gsw - Revision history

OCA at 11:50, 13 October 2021

OCA — Wed, 13 Oct 2021 11:50:39 GMT

←Older revision		Revision as of 11:50, 13 October 2021
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	==Crystal structure of the binary complex between HLA-A2 and HCMV NLV-T8A peptide variant==		==Crystal structure of the binary complex between HLA-A2 and HCMV NLV-T8A peptide variant==
-	<StructureSection load='3gsw' size='340' side='right' caption='[[3gsw]], [[Resolution\|resolution]] 1.81Å' scene=''>	+	<StructureSection load='3gsw' size='340' side='right'caption='[[3gsw]], [[Resolution\|resolution]] 1.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gsw]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GSW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3GSW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gsw]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GSW FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gsn\|3gsn]], [[3gso\|3gso]], [[3gsq\|3gsq]], [[3gsr\|3gsr]], [[3gsu\|3gsu]], [[3gsv\|3gsv]], [[3gsx\|3gsx]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3gsn\|3gsn]], [[3gso\|3gso]], [[3gsq\|3gsq]], [[3gsr\|3gsr]], [[3gsu\|3gsu]], [[3gsv\|3gsv]], [[3gsx\|3gsx]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA, HLA-A, HLAA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M, Beta-2 microglubulin, CDABP0092, HDCMA22P ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA, HLA-A, HLAA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M, Beta-2 microglubulin, CDABP0092, HDCMA22P ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3gsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gsw OCA], [~~http~~://pdbe.org/3gsw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3gsw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3gsw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3gsw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gsw OCA], [https://pdbe.org/3gsw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gsw RCSB], [https://www.ebi.ac.uk/pdbsum/3gsw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gsw ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[~~http~~://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>	+	[[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[https://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[~~http~~://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	+	[[https://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
-	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]	+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
-	*[[~~Major histocompatibility complex~~\|~~Major histocompatibility complex~~]]	+	*[[MHC 3D structures\|MHC 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bonneville, M]]		[[Category: Bonneville, M]]
	[[Category: Chouquet, A]]		[[Category: Chouquet, A]]

OCA at 05:22, 7 December 2018

OCA — Fri, 07 Dec 2018 05:22:34 GMT

←Older revision		Revision as of 05:22, 7 December 2018
Line 1:		Line 1:
		+
	==Crystal structure of the binary complex between HLA-A2 and HCMV NLV-T8A peptide variant==		==Crystal structure of the binary complex between HLA-A2 and HCMV NLV-T8A peptide variant==
	<StructureSection load='3gsw' size='340' side='right' caption='[[3gsw]], [[Resolution\|resolution]] 1.81Å' scene=''>		<StructureSection load='3gsw' size='340' side='right' caption='[[3gsw]], [[Resolution\|resolution]] 1.81Å' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gsn\|3gsn]], [[3gso\|3gso]], [[3gsq\|3gsq]], [[3gsr\|3gsr]], [[3gsu\|3gsu]], [[3gsv\|3gsv]], [[3gsx\|3gsx]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gsn\|3gsn]], [[3gso\|3gso]], [[3gsq\|3gsq]], [[3gsr\|3gsr]], [[3gsu\|3gsu]], [[3gsv\|3gsv]], [[3gsx\|3gsx]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA, HLA-A, HLAA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M, Beta-2 microglubulin, CDABP0092, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA, HLA-A, HLAA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M, Beta-2 microglubulin, CDABP0092, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gsw OCA], [http://pdbe.org/3gsw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gsw RCSB], [http://www.ebi.ac.uk/pdbsum/3gsw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gsw OCA], [http://pdbe.org/3gsw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gsw RCSB], [http://www.ebi.ac.uk/pdbsum/3gsw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gsw ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gs/3gsw_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gs/3gsw_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 63:		Line 64:
	[[Category: Membrane]]		[[Category: Membrane]]
	[[Category: Mhc i]]		[[Category: Mhc i]]
		+	[[Category: Polymorphism]]
	[[Category: Pp65]]		[[Category: Pp65]]
	[[Category: Public response]]		[[Category: Public response]]
	[[Category: Restrained response]]		[[Category: Restrained response]]

OCA at 02:07, 7 February 2016

OCA — Sun, 07 Feb 2016 02:07:45 GMT

←Older revision		Revision as of 02:07, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3gsw' size='340' side='right' caption='[[3gsw]], [[Resolution\|resolution]] 1.81Å' scene=''>		<StructureSection load='3gsw' size='340' side='right' caption='[[3gsw]], [[Resolution\|resolution]] 1.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gsw]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GSW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GSW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gsw]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GSW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GSW FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gsn\|3gsn]], [[3gso\|3gso]], [[3gsq\|3gsq]], [[3gsr\|3gsr]], [[3gsu\|3gsu]], [[3gsv\|3gsv]], [[3gsx\|3gsx]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gsn\|3gsn]], [[3gso\|3gso]], [[3gsq\|3gsq]], [[3gsr\|3gsr]], [[3gsu\|3gsu]], [[3gsv\|3gsv]], [[3gsx\|3gsx]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA, HLA-A, HLAA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), B2M, Beta-2 microglubulin, CDABP0092, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA, HLA-A, HLAA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M, Beta-2 microglubulin, CDABP0092, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gsw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gsw RCSB], [http://www.ebi.ac.uk/pdbsum/3gsw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gsw OCA], [http://pdbe.org/3gsw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gsw RCSB], [http://www.ebi.ac.uk/pdbsum/3gsw PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gsw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3gsw" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bonneville, M]]		[[Category: Bonneville, M]]
	[[Category: Chouquet, A]]		[[Category: Chouquet, A]]

OCA at 14:57, 18 December 2014

OCA — Thu, 18 Dec 2014 14:57:34 GMT

←Older revision		Revision as of 14:57, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3gsw\| PDB=3gsw \| SCENE= }}~~	+	==Crystal structure of the binary complex between HLA-A2 and HCMV NLV-T8A peptide variant==
-	===Crystal structure of the binary complex between HLA-A2 and HCMV NLV-T8A peptide variant===	+	<StructureSection load='3gsw' size='340' side='right' caption='[[3gsw]], [[Resolution\|resolution]] 1.81Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19542454}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3gsw]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GSW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GSW FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gsn\|3gsn]], [[3gso\|3gso]], [[3gsq\|3gsq]], [[3gsr\|3gsr]], [[3gsu\|3gsu]], [[3gsv\|3gsv]], [[3gsx\|3gsx]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA, HLA-A, HLAA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), B2M, Beta-2 microglubulin, CDABP0092, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gsw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gsw RCSB], [http://www.ebi.ac.uk/pdbsum/3gsw PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gs/3gsw_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Protective T cell responses elicited along chronic human CMV (HCMV) infections are sometimes dominated by CD8 T cell clones bearing highly related or identical public TCR in unrelated individuals. To understand the principles that guide emergence of these public T cell responses, we have performed structural, biophysical, and functional analyses of an immunodominant public TCR (RA14) directed against a major HLA-A*0201-restricted HCMV Ag (pp65(495-503)) and selected in vivo from a diverse repertoire after chronic stimulations. Unlike the two immunodominant public TCRs crystallized so far, which focused on one peptide hotspot, the HCMV-specific RA14 TCR interacts with the full array of available peptide residues. The conservation of some peptide-MHC complex-contacting amino acids by lower-affinity TCRs suggests a shared TCR-peptide-MHC complex docking mode and supports an Ag-driven selection of optimal TCRs. Therefore, the emergence of a public TCR of an oligoclonal Ag-specific response after repeated viral stimulations is based on a receptor displaying a high structural complementarity with the entire peptide and focusing on three peptide hotspots. This highlights key parameters underlying the selection of a protective T cell response against HCMV infection, which remains a major health issue in patients undergoing bone marrow transplantation.

-	~~==Disease==~~	+	Structural bases for the affinity-driven selection of a public TCR against a dominant human cytomegalovirus epitope.,Gras S, Saulquin X, Reiser JB, Debeaupuis E, Echasserieau K, Kissenpfennig A, Legoux F, Chouquet A, Le Gorrec M, Machillot P, Neveu B, Thielens N, Malissen B, Bonneville M, Housset D J Immunol. 2009 Jul 1;183(1):430-7. PMID:19542454<ref>PMID:19542454</ref>
-	~~[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are~~ the ~~cause~~ of ~~hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim~~.~~org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin~~, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. ~~Persistently high beta~~(2)-~~microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis~~.~~<ref>~~PMID:3532124</ref><ref>PMID:1336137</ref><ref>PMID:7554280</ref><ref>PMID:4586824</ref><ref>PMID:8084451</ref><ref>PMID:12119416</ref><ref>PMID:12796775</ref><ref>PMID:16901902</ref><ref>PMID:16491088</ref><ref>PMID:17646174</ref><ref>PMID:18835253</ref><ref>PMID:18395224</ref><ref>PMID:~~19284997~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation~~ of ~~foreign antigens to~~ the ~~immune system~~. ~~[[http://www~~.~~uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component~~ of ~~the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system~~.	+	</div>
-		+
-	~~==About this Structure==~~	+
-	~~[[3gsw]] is a 3 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GSW OCA].~~	+

	==See Also==		==See Also==
	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]		*[[Beta-2 microglobulin\|Beta-2 microglobulin]]
	*[[Major histocompatibility complex\|Major histocompatibility complex]]		*[[Major histocompatibility complex\|Major histocompatibility complex]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:019542454</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bonneville, M.]]	+	[[Category: Bonneville, M]]
-	[[Category: Chouquet, A.]]	+	[[Category: Chouquet, A]]
-	[[Category: Debeaupuis, E.]]	+	[[Category: Debeaupuis, E]]
-	[[Category: Echasserieau, K.]]	+	[[Category: Echasserieau, K]]
-	[[Category: Gorrec, M Le.]]	+	[[Category: Gorrec, M Le]]
-	[[Category: Gras, S.]]	+	[[Category: Gras, S]]
-	[[Category: Housset, D.]]	+	[[Category: Housset, D]]
-	[[Category: Kissenpfennig, A.]]	+	[[Category: Kissenpfennig, A]]
-	[[Category: Legoux, F.]]	+	[[Category: Legoux, F]]
-	[[Category: Machillot, P.]]	+	[[Category: Machillot, P]]
-	[[Category: Malissen, B.]]	+	[[Category: Malissen, B]]
-	[[Category: Neveu, B.]]	+	[[Category: Neveu, B]]
-	[[Category: Reiser, J B.]]	+	[[Category: Reiser, J B]]
-	[[Category: Saulquin, X.]]	+	[[Category: Saulquin, X]]
-	[[Category: Thielens, N.]]	+	[[Category: Thielens, N]]
	[[Category: Hla]]		[[Category: Hla]]
	[[Category: Host-virus interaction]]		[[Category: Host-virus interaction]]

OCA at 09:14, 24 March 2013

OCA — Sun, 24 Mar 2013 09:14:49 GMT

←Older revision		Revision as of 09:14, 24 March 2013
Line 1:		Line 1:
-	[[Image:3gsw.png\|left\|200px]]
-
	{{STRUCTURE_3gsw\| PDB=3gsw \| SCENE= }}		{{STRUCTURE_3gsw\| PDB=3gsw \| SCENE= }}
-
	===Crystal structure of the binary complex between HLA-A2 and HCMV NLV-T8A peptide variant===		===Crystal structure of the binary complex between HLA-A2 and HCMV NLV-T8A peptide variant===
		+	{{ABSTRACT_PUBMED_19542454}}

-	~~{{ABSTRACT_PUBMED_19542454}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref><ref>PMID:1336137</ref><ref>PMID:7554280</ref><ref>PMID:4586824</ref><ref>PMID:8084451</ref><ref>PMID:12119416</ref><ref>PMID:12796775</ref><ref>PMID:16901902</ref><ref>PMID:16491088</ref><ref>PMID:17646174</ref><ref>PMID:18835253</ref><ref>PMID:18395224</ref><ref>PMID:19284997</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

	==About this Structure==		==About this Structure==
Line 15:		Line 17:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:019542454</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019542454</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bonneville, M.]]		[[Category: Bonneville, M.]]

OCA at 05:18, 20 October 2012

OCA — Sat, 20 Oct 2012 05:18:12 GMT

←Older revision		Revision as of 05:18, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3gsw]] is a 3 chain structure ~~of [[Beta-2 microglobulin]] and [[Major histocompatibility complex]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GSW OCA].	+	[[3gsw]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GSW OCA].

	==See Also==		==See Also==

OCA: Protected "3gsw" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 09:36:52 GMT

Protected "3gsw" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:36, 25 July 2012

OCA at 09:36, 25 July 2012

OCA — Wed, 25 Jul 2012 09:36:49 GMT

←Older revision		Revision as of 09:36, 25 July 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3gsw.png\|left\|200px]]
-	[[Image:3gsw.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3gsw", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3gsw\| PDB=3gsw \| SCENE= }}		{{STRUCTURE_3gsw\| PDB=3gsw \| SCENE= }}

	===Crystal structure of the binary complex between HLA-A2 and HCMV NLV-T8A peptide variant===		===Crystal structure of the binary complex between HLA-A2 and HCMV NLV-T8A peptide variant===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19542454}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19542454 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19542454}}		{{ABSTRACT_PUBMED_19542454}}

	==About this Structure==		==About this Structure==
-	~~3GSW~~ is a 3 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GSW OCA].	+	[[3gsw]] is a 3 chain structure of [[Beta-2 microglobulin]] and [[Major histocompatibility complex]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GSW OCA].
		+
		+	==See Also==
		+	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]
		+	*[[Major histocompatibility complex\|Major histocompatibility complex]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19542454~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019542454</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bonneville, M.]]		[[Category: Bonneville, M.]]
Line 49:		Line 41:
	[[Category: Membrane]]		[[Category: Membrane]]
	[[Category: Mhc i]]		[[Category: Mhc i]]
-	[[Category: Polymorphism]]
	[[Category: Pp65]]		[[Category: Pp65]]
	[[Category: Public response]]		[[Category: Public response]]
	[[Category: Restrained response]]		[[Category: Restrained response]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 5 10:33:55 2009''

OCA at 07:33, 5 August 2009

OCA — Wed, 05 Aug 2009 07:33:59 GMT

←Older revision		Revision as of 07:33, 5 August 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3gsw.jpg\|left\|200px]]

-	The ~~entry 3gsw~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3gsw", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3gsw\| PDB=3gsw \| SCENE= }}

-	~~Authors: Reiser, J.~~-B., Saulquin, X., Gras, S., Debeaupuis, E., Echasserieau, K., Kissenpfennig, A., Legoux, F., Chouquet, A., Le Gorrec, M., Machillot, P., Neveu, B., Thielens, N., Malissen, B., Bonneville, M., Housset, D.	+	===Crystal structure of the binary complex between HLA-A2 and HCMV NLV-T8A peptide variant===

-	Description: Crystal structure of the binary complex between HLA-A2 and HCMV NLV-T8A peptide variant

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Apr 22 11~~:08:39 2009''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19542454}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19542454 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19542454}}
		+
		+	==About this Structure==
		+	3GSW is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GSW OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19542454</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Bonneville, M.]]
		+	[[Category: Chouquet, A.]]
		+	[[Category: Debeaupuis, E.]]
		+	[[Category: Echasserieau, K.]]
		+	[[Category: Gorrec, M Le.]]
		+	[[Category: Gras, S.]]
		+	[[Category: Housset, D.]]
		+	[[Category: Kissenpfennig, A.]]
		+	[[Category: Legoux, F.]]
		+	[[Category: Machillot, P.]]
		+	[[Category: Malissen, B.]]
		+	[[Category: Neveu, B.]]
		+	[[Category: Reiser, J B.]]
		+	[[Category: Saulquin, X.]]
		+	[[Category: Thielens, N.]]
		+	[[Category: Hla]]
		+	[[Category: Host-virus interaction]]
		+	[[Category: Human cytomegalovirus]]
		+	[[Category: Immune response]]
		+	[[Category: Immune system]]
		+	[[Category: Immunodominance]]
		+	[[Category: Immunoglobulin domain]]
		+	[[Category: Membrane]]
		+	[[Category: Mhc i]]
		+	[[Category: Polymorphism]]
		+	[[Category: Pp65]]
		+	[[Category: Public response]]
		+	[[Category: Restrained response]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 5 10:33:55 2009''

OCA at 08:08, 22 April 2009

OCA — Wed, 22 Apr 2009 08:08:40 GMT

←Older revision		Revision as of 08:08, 22 April 2009
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3gsw is ON HOLD	+	The entry 3gsw is ON HOLD until Paper Publication

	Authors: Reiser, J.-B., Saulquin, X., Gras, S., Debeaupuis, E., Echasserieau, K., Kissenpfennig, A., Legoux, F., Chouquet, A., Le Gorrec, M., Machillot, P., Neveu, B., Thielens, N., Malissen, B., Bonneville, M., Housset, D.		Authors: Reiser, J.-B., Saulquin, X., Gras, S., Debeaupuis, E., Echasserieau, K., Kissenpfennig, A., Legoux, F., Chouquet, A., Le Gorrec, M., Machillot, P., Neveu, B., Thielens, N., Malissen, B., Bonneville, M., Housset, D.
Line 7:		Line 7:
	Description: Crystal structure of the binary complex between HLA-A2 and HCMV NLV-T8A peptide variant		Description: Crystal structure of the binary complex between HLA-A2 and HCMV NLV-T8A peptide variant

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr ~~15 09~~:57:09 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 22 11:08:39 2009''