3gvo - Revision history

OCA at 15:45, 1 November 2023

OCA — Wed, 01 Nov 2023 15:45:34 GMT

←Older revision		Revision as of 15:45, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3gvo' size='340' side='right'caption='[[3gvo]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3gvo' size='340' side='right'caption='[[3gvo]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gvo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GVO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gvo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GVO FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[3gvt\|3gvt]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">Pum2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gvo OCA], [https://pdbe.org/3gvo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gvo RCSB], [https://www.ebi.ac.uk/pdbsum/3gvo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gvo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gvo OCA], [https://pdbe.org/3gvo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gvo RCSB], [https://www.ebi.ac.uk/pdbsum/3gvo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gvo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PUM2_MOUSE PUM2_MOUSE]] Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts (By similarity).	+	[https://www.uniprot.org/uniprot/PUM2_MOUSE PUM2_MOUSE] Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Edwards~~, T A~~]]	+	[[Category: Edwards TA]]
-	[[Category: Jenkins~~, H T]]~~	+	[[Category: Jenkins HT]]
-	~~[[Category: Puf domain]]~~	+
-	~~[[Category: Pumilio]]~~	+
-	~~[[Category: Rna binding protein]]~~	+
-	~~[[Category: Rna-binding~~]]	+

OCA at 07:55, 16 March 2022

OCA — Wed, 16 Mar 2022 07:55:53 GMT

←Older revision		Revision as of 07:55, 16 March 2022
Line 1:		Line 1:

	==Structure and RNA binding of the mouse Pumilio-2 Puf Domain==		==Structure and RNA binding of the mouse Pumilio-2 Puf Domain==
-	<StructureSection load='3gvo' size='340' side='right' caption='[[3gvo]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='3gvo' size='340' side='right'caption='[[3gvo]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gvo]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GVO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3GVO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gvo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GVO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gvt\|3gvt]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3gvt\|3gvt]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pum2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pum2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3gvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gvo OCA], [~~http~~://pdbe.org/3gvo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3gvo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3gvo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3gvo ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gvo OCA], [https://pdbe.org/3gvo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gvo RCSB], [https://www.ebi.ac.uk/pdbsum/3gvo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gvo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PUM2_MOUSE PUM2_MOUSE]] Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts (By similarity).	+	[[https://www.uniprot.org/uniprot/PUM2_MOUSE PUM2_MOUSE]] Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gv/3gvo_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gv/3gvo_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 34:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Edwards, T A]]		[[Category: Edwards, T A]]

OCA at 07:14, 1 November 2017

OCA — Wed, 01 Nov 2017 07:14:36 GMT

←Older revision		Revision as of 07:14, 1 November 2017
Line 1:		Line 1:
		+
	==Structure and RNA binding of the mouse Pumilio-2 Puf Domain==		==Structure and RNA binding of the mouse Pumilio-2 Puf Domain==
	<StructureSection load='3gvo' size='340' side='right' caption='[[3gvo]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3gvo' size='340' side='right' caption='[[3gvo]], [[Resolution\|resolution]] 1.60Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gvt\|3gvt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gvt\|3gvt]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pum2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pum2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gvo OCA], [http://pdbe.org/3gvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gvo RCSB], [http://www.ebi.ac.uk/pdbsum/3gvo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gvo OCA], [http://pdbe.org/3gvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gvo RCSB], [http://www.ebi.ac.uk/pdbsum/3gvo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gvo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 01:03, 8 February 2016

OCA — Mon, 08 Feb 2016 01:03:27 GMT

←Older revision		Revision as of 01:03, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3gvo' size='340' side='right' caption='[[3gvo]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3gvo' size='340' side='right' caption='[[3gvo]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gvo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GVO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gvo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GVO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gvt\|3gvt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gvt\|3gvt]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pum2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pum2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gvo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gvo RCSB], [http://www.ebi.ac.uk/pdbsum/3gvo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gvo OCA], [http://pdbe.org/3gvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gvo RCSB], [http://www.ebi.ac.uk/pdbsum/3gvo PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gvo ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3gvo" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Edwards, T A]]		[[Category: Edwards, T A]]
	[[Category: Jenkins, H T]]		[[Category: Jenkins, H T]]

OCA at 19:26, 24 December 2014

OCA — Wed, 24 Dec 2014 19:26:25 GMT

←Older revision		Revision as of 19:26, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gvo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gvo RCSB], [http://www.ebi.ac.uk/pdbsum/3gvo PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gvo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gvo RCSB], [http://www.ebi.ac.uk/pdbsum/3gvo PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PUM2_MOUSE PUM2_MOUSE]] Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:19, 8 December 2014

OCA — Mon, 08 Dec 2014 09:19:13 GMT

←Older revision		Revision as of 09:19, 8 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3gvo.~~png~~\|~~left~~\|200px]]	+	==Structure and RNA binding of the mouse Pumilio-2 Puf Domain==
		+	<StructureSection load='3gvo' size='340' side='right' caption='[[3gvo]], [[Resolution\|resolution]] 1.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3gvo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GVO FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gvt\|3gvt]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pum2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gvo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gvo RCSB], [http://www.ebi.ac.uk/pdbsum/3gvo PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gv/3gvo_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Puf proteins control translation through the interaction of a C-terminal Puf domain with specific sequences present in the 3' untranslated region of messenger RNAs. In Drosophila, binding of the protein Pumilio to mRNA leads to translational repression which is required for anterior/posterior patterning during embryogenesis. The vertebrate Pumilio homologue 2 (Pum2) has been implicated in controlling germ cell development through interactions with the RNA binding proteins deleted in azoospermia (DAZ), DAZ-like (DAZL) and BOULE. We present the 1.6A resolution X-ray crystal structure of the Puf domain from murine Pum2 and demonstrate that this domain is capable of binding with nanomolar affinity to RNA sequences from the hunchback Nanos response element (NRE) and a previously identified Pum2 binding element (PBE).

-	~~{{STRUCTURE_3gvo\| PDB=3gvo \| SCENE= }}~~	+	Structure and RNA binding of the mouse Pumilio-2 Puf domain.,Jenkins HT, Baker-Wilding R, Edwards TA J Struct Biol. 2009 Sep;167(3):271-6. Epub 2009 Jun 18. PMID:19540345<ref>PMID:19540345</ref>

-	~~===Structure and RNA binding~~ of the ~~mouse Pumilio-2 Puf Domain===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19540345}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3gvo]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3GVO OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019540345<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Edwards, T A.]]	+	[[Category: Edwards, T A]]
-	[[Category: Jenkins, H T.]]	+	[[Category: Jenkins, H T]]
	[[Category: Puf domain]]		[[Category: Puf domain]]
	[[Category: Pumilio]]		[[Category: Pumilio]]
	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]
	[[Category: Rna-binding]]		[[Category: Rna-binding]]

OCA: Protected "3gvo" [edit=sysop:move=sysop]

OCA — Wed, 27 Feb 2013 15:15:44 GMT

Protected "3gvo" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:15, 27 February 2013

OCA at 15:15, 27 February 2013

OCA — Wed, 27 Feb 2013 15:15:42 GMT

←Older revision		Revision as of 15:15, 27 February 2013
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-	{{Seed}}
	[[Image:3gvo.png\|left\|200px]]		[[Image:3gvo.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3gvo", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3gvo\| PDB=3gvo \| SCENE= }}		{{STRUCTURE_3gvo\| PDB=3gvo \| SCENE= }}

	===Structure and RNA binding of the mouse Pumilio-2 Puf Domain===		===Structure and RNA binding of the mouse Pumilio-2 Puf Domain===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19540345}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19540345 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19540345}}		{{ABSTRACT_PUBMED_19540345}}

	==About this Structure==		==About this Structure==
-	~~3GVO~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GVO OCA].	+	[[3gvo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GVO OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19540345~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019540345</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Edwards, T A.]]		[[Category: Edwards, T A.]]
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	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]
	[[Category: Rna-binding]]		[[Category: Rna-binding]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Sep 3 16:31:48 2009''

OCA at 13:31, 3 September 2009

OCA — Thu, 03 Sep 2009 13:31:51 GMT

←Older revision		Revision as of 13:31, 3 September 2009
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	{{Seed}}		{{Seed}}
-	[[Image:3gvo.~~jpg~~\|left\|200px]]	+	[[Image:3gvo.png\|left\|200px]]

	<!--		<!--
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	[[Category: Rna-binding]]		[[Category: Rna-binding]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul~~ ~~1 09~~:10:42 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Sep 3 16:31:48 2009''

OCA at 06:10, 1 July 2009

OCA — Wed, 01 Jul 2009 06:10:45 GMT

←Older revision		Revision as of 06:10, 1 July 2009
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3gvo.jpg\|left\|200px]]

-	The ~~entry 3gvo~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3gvo", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3gvo\| PDB=3gvo \| SCENE= }}

-	~~Authors: Jenkins, H.T., Baker~~-~~Wilding, R., Edwards, T.A.~~	+	===Structure and RNA binding of the mouse Pumilio-2 Puf Domain===

-	Description: Structure and RNA binding of the mouse Pumilio-2 Puf Domain

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Apr 15~~ 09:58:34 2009''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19540345}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19540345 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19540345}}
		+
		+	==About this Structure==
		+	3GVO is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GVO OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19540345</ref><references group="xtra"/>
		+	[[Category: Mus musculus]]
		+	[[Category: Edwards, T A.]]
		+	[[Category: Jenkins, H T.]]
		+	[[Category: Puf domain]]
		+	[[Category: Pumilio]]
		+	[[Category: Rna binding protein]]
		+	[[Category: Rna-binding]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 1 09:10:42 2009''