3gvv - Revision history

OCA at 09:56, 21 February 2024

OCA — Wed, 21 Feb 2024 09:56:59 GMT

←Older revision		Revision as of 09:56, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='3gvv' size='340' side='right'caption='[[3gvv]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3gvv' size='340' side='right'caption='[[3gvv]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gvv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GVV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GVV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gvv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GVV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GVV FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1uro\|1uro]], [[3gvq\|3gvq]], [[3gvr\|3gvr]], [[3gvw\|3gvw]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">UROD ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Uroporphyrinogen_decarboxylase Uroporphyrinogen decarboxylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.37 4.1.1.37] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gvv OCA], [https://pdbe.org/3gvv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gvv RCSB], [https://www.ebi.ac.uk/pdbsum/3gvv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gvv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gvv OCA], [https://pdbe.org/3gvv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gvv RCSB], [https://www.ebi.ac.uk/pdbsum/3gvv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gvv ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/DCUP_HUMAN DCUP_HUMAN]] Defects in UROD are the cause of familial porphyria cutanea tarda (FPCT) [MIM:[https://omim.org/entry/176100 176100]]; also known as porphyria cutanea tarda type II. FPCT is an autosomal dominant disorder characterized by light-sensitive dermatitis, with onset in later life. It is associated with the excretion of large amounts of uroporphyrin in the urine. Iron overload is often present in association with varying degrees of liver damage. Besides the familial form of PCT, a relatively common idiosyncratic form is known in which only the liver enzyme is reduced. This form is referred to as porphyria cutanea tarda "sporadic" type or type I [MIM:[https://omim.org/entry/176090 176090]]. PCT type I occurs sporadically as an unusual accompaniment of common hepatic disorders such as alcohol-associated liver disease.<ref>PMID:2243121</ref> <ref>PMID:11719352</ref> <ref>PMID:2920211</ref> <ref>PMID:7706766</ref> <ref>PMID:8896428</ref> <ref>PMID:9792863</ref> <ref>PMID:10338097</ref> <ref>PMID:10477430</ref> <ref>PMID:11069625</ref> <ref>PMID:11295834</ref> Defects in UROD are the cause of hepatoerythropoietic porphyria (HEP) [MIM:[https://omim.org/entry/176100 176100]]. HEP is a rare autosomal recessive disorder. It is the severe form of cutaneous porphyria, and presents in infancy. The level of UROD is very low in erythrocytes and cultured skin fibroblasts, suggesting that HEP is the homozygous state for porphyria cutanea tarda.<ref>PMID:8896428</ref> <ref>PMID:8644733</ref> <ref>PMID:3775362</ref> <ref>PMID:1905636</ref> <ref>PMID:1634232</ref> <ref>PMID:8176248</ref> <ref>PMID:12071824</ref> <ref>PMID:15491440</ref> <ref>PMID:17240319</ref> <ref>PMID:21668429</ref>	+	[https://www.uniprot.org/uniprot/DCUP_HUMAN DCUP_HUMAN] Defects in UROD are the cause of familial porphyria cutanea tarda (FPCT) [MIM:[https://omim.org/entry/176100 176100]; also known as porphyria cutanea tarda type II. FPCT is an autosomal dominant disorder characterized by light-sensitive dermatitis, with onset in later life. It is associated with the excretion of large amounts of uroporphyrin in the urine. Iron overload is often present in association with varying degrees of liver damage. Besides the familial form of PCT, a relatively common idiosyncratic form is known in which only the liver enzyme is reduced. This form is referred to as porphyria cutanea tarda "sporadic" type or type I [MIM:[https://omim.org/entry/176090 176090]. PCT type I occurs sporadically as an unusual accompaniment of common hepatic disorders such as alcohol-associated liver disease.<ref>PMID:2243121</ref> <ref>PMID:11719352</ref> <ref>PMID:2920211</ref> <ref>PMID:7706766</ref> <ref>PMID:8896428</ref> <ref>PMID:9792863</ref> <ref>PMID:10338097</ref> <ref>PMID:10477430</ref> <ref>PMID:11069625</ref> <ref>PMID:11295834</ref> Defects in UROD are the cause of hepatoerythropoietic porphyria (HEP) [MIM:[https://omim.org/entry/176100 176100]. HEP is a rare autosomal recessive disorder. It is the severe form of cutaneous porphyria, and presents in infancy. The level of UROD is very low in erythrocytes and cultured skin fibroblasts, suggesting that HEP is the homozygous state for porphyria cutanea tarda.<ref>PMID:8896428</ref> <ref>PMID:8644733</ref> <ref>PMID:3775362</ref> <ref>PMID:1905636</ref> <ref>PMID:1634232</ref> <ref>PMID:8176248</ref> <ref>PMID:12071824</ref> <ref>PMID:15491440</ref> <ref>PMID:17240319</ref> <ref>PMID:21668429</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DCUP_HUMAN DCUP_HUMAN]] Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.	+	[https://www.uniprot.org/uniprot/DCUP_HUMAN DCUP_HUMAN] Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 23:		Line 21:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gvv ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gvv ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Uroporphyrinogen decarboxylase (URO-D; EC 4.1.1.37), the fifth enzyme of the heme biosynthetic pathway, is required for the production of heme, vitamin B12, siroheme, and chlorophyll precursors. URO-D catalyzes the sequential decarboxylation of four acetate side chains in the pyrrole groups of uroporphyrinogen to produce coproporphyrinogen. URO-D is a stable homodimer, with the active-site clefts of the two subunits adjacent to each other. It has been hypothesized that the two catalytic centers interact functionally, perhaps by shuttling of reaction intermediates between subunits. We tested this hypothesis by construction of a single-chain protein (single-chain URO-D) in which the two subunits were connected by a flexible linker. The crystal structure of this protein was shown to be superimposable with wild-type activity and to have comparable catalytic activity. Mutations that impaired one or the other of the two active sites of single-chain URO-D resulted in approximately half of wild-type activity. The distributions of reaction intermediates were the same for mutant and wild-type sequences and were unaltered in a competition experiment using I and III isomer substrates. These observations indicate that communication between active sites is not required for enzyme function and suggest that the dimeric structure of URO-D is required to achieve conformational stability and to create a large active-site cleft.
-
-	Substrate shuttling between active sites of uroporphyrinogen decarboxylase is not required to generate coproporphyrinogen.,Phillips JD, Warby CA, Whitby FG, Kushner JP, Hill CP J Mol Biol. 2009 Jun 5;389(2):306-14. Epub 2009 Apr 10. PMID:19362562<ref>PMID:19362562</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3gvv" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Uroporphyrinogen decarboxylase]]~~	+	[[Category: Hill CP]]
-	[[Category: Hill~~, C P~~]]	+	[[Category: Kushner JP]]
-	[[Category: Kushner~~, J P~~]]	+	[[Category: Phillips JD]]
-	[[Category: Phillips~~, J D~~]]	+	[[Category: Warby C]]
-	[[Category: Warby, C]]	+	[[Category: Whitby FG]]
-	[[Category: Whitby~~, F G]]~~	+
-	~~[[Category: Acetylation]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Decarboxylase]]~~	+
-	~~[[Category: Disease mutation]]~~	+
-	~~[[Category: Heme biosynthesis]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Porphyrin biosynthesis]]~~	+
-	~~[[Category: Uroporphyrinogen~~]]	+

OCA at 11:52, 13 October 2021

OCA — Wed, 13 Oct 2021 11:52:22 GMT

←Older revision		Revision as of 11:52, 13 October 2021
Line 1:		Line 1:

	==Single-chain UROD Y164G (GY) mutation==		==Single-chain UROD Y164G (GY) mutation==
-	<StructureSection load='3gvv' size='340' side='right' caption='[[3gvv]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='3gvv' size='340' side='right'caption='[[3gvv]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gvv]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GVV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3GVV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gvv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GVV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GVV FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uro\|1uro]], [[3gvq\|3gvq]], [[3gvr\|3gvr]], [[3gvw\|3gvw]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1uro\|1uro]], [[3gvq\|3gvq]], [[3gvr\|3gvr]], [[3gvw\|3gvw]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UROD ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UROD ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Uroporphyrinogen_decarboxylase Uroporphyrinogen decarboxylase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.37 4.1.1.37] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Uroporphyrinogen_decarboxylase Uroporphyrinogen decarboxylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.37 4.1.1.37] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3gvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gvv OCA], [~~http~~://pdbe.org/3gvv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3gvv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3gvv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3gvv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gvv OCA], [https://pdbe.org/3gvv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gvv RCSB], [https://www.ebi.ac.uk/pdbsum/3gvv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gvv ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/DCUP_HUMAN DCUP_HUMAN]] Defects in UROD are the cause of familial porphyria cutanea tarda (FPCT) [MIM:[~~http~~://omim.org/entry/176100 176100]]; also known as porphyria cutanea tarda type II. FPCT is an autosomal dominant disorder characterized by light-sensitive dermatitis, with onset in later life. It is associated with the excretion of large amounts of uroporphyrin in the urine. Iron overload is often present in association with varying degrees of liver damage. Besides the familial form of PCT, a relatively common idiosyncratic form is known in which only the liver enzyme is reduced. This form is referred to as porphyria cutanea tarda "sporadic" type or type I [MIM:[~~http~~://omim.org/entry/176090 176090]]. PCT type I occurs sporadically as an unusual accompaniment of common hepatic disorders such as alcohol-associated liver disease.<ref>PMID:2243121</ref> <ref>PMID:11719352</ref> <ref>PMID:2920211</ref> <ref>PMID:7706766</ref> <ref>PMID:8896428</ref> <ref>PMID:9792863</ref> <ref>PMID:10338097</ref> <ref>PMID:10477430</ref> <ref>PMID:11069625</ref> <ref>PMID:11295834</ref> Defects in UROD are the cause of hepatoerythropoietic porphyria (HEP) [MIM:[~~http~~://omim.org/entry/176100 176100]]. HEP is a rare autosomal recessive disorder. It is the severe form of cutaneous porphyria, and presents in infancy. The level of UROD is very low in erythrocytes and cultured skin fibroblasts, suggesting that HEP is the homozygous state for porphyria cutanea tarda.<ref>PMID:8896428</ref> <ref>PMID:8644733</ref> <ref>PMID:3775362</ref> <ref>PMID:1905636</ref> <ref>PMID:1634232</ref> <ref>PMID:8176248</ref> <ref>PMID:12071824</ref> <ref>PMID:15491440</ref> <ref>PMID:17240319</ref> <ref>PMID:21668429</ref>	+	[[https://www.uniprot.org/uniprot/DCUP_HUMAN DCUP_HUMAN]] Defects in UROD are the cause of familial porphyria cutanea tarda (FPCT) [MIM:[https://omim.org/entry/176100 176100]]; also known as porphyria cutanea tarda type II. FPCT is an autosomal dominant disorder characterized by light-sensitive dermatitis, with onset in later life. It is associated with the excretion of large amounts of uroporphyrin in the urine. Iron overload is often present in association with varying degrees of liver damage. Besides the familial form of PCT, a relatively common idiosyncratic form is known in which only the liver enzyme is reduced. This form is referred to as porphyria cutanea tarda "sporadic" type or type I [MIM:[https://omim.org/entry/176090 176090]]. PCT type I occurs sporadically as an unusual accompaniment of common hepatic disorders such as alcohol-associated liver disease.<ref>PMID:2243121</ref> <ref>PMID:11719352</ref> <ref>PMID:2920211</ref> <ref>PMID:7706766</ref> <ref>PMID:8896428</ref> <ref>PMID:9792863</ref> <ref>PMID:10338097</ref> <ref>PMID:10477430</ref> <ref>PMID:11069625</ref> <ref>PMID:11295834</ref> Defects in UROD are the cause of hepatoerythropoietic porphyria (HEP) [MIM:[https://omim.org/entry/176100 176100]]. HEP is a rare autosomal recessive disorder. It is the severe form of cutaneous porphyria, and presents in infancy. The level of UROD is very low in erythrocytes and cultured skin fibroblasts, suggesting that HEP is the homozygous state for porphyria cutanea tarda.<ref>PMID:8896428</ref> <ref>PMID:8644733</ref> <ref>PMID:3775362</ref> <ref>PMID:1905636</ref> <ref>PMID:1634232</ref> <ref>PMID:8176248</ref> <ref>PMID:12071824</ref> <ref>PMID:15491440</ref> <ref>PMID:17240319</ref> <ref>PMID:21668429</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DCUP_HUMAN DCUP_HUMAN]] Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.	+	[[https://www.uniprot.org/uniprot/DCUP_HUMAN DCUP_HUMAN]] Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gv/3gvv_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gv/3gvv_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Uroporphyrinogen decarboxylase]]		[[Category: Uroporphyrinogen decarboxylase]]
	[[Category: Hill, C P]]		[[Category: Hill, C P]]

OCA at 07:14, 1 November 2017

OCA — Wed, 01 Nov 2017 07:14:46 GMT

←Older revision		Revision as of 07:14, 1 November 2017
Line 1:		Line 1:
		+
	==Single-chain UROD Y164G (GY) mutation==		==Single-chain UROD Y164G (GY) mutation==
	<StructureSection load='3gvv' size='340' side='right' caption='[[3gvv]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3gvv' size='340' side='right' caption='[[3gvv]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UROD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UROD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uroporphyrinogen_decarboxylase Uroporphyrinogen decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.37 4.1.1.37] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uroporphyrinogen_decarboxylase Uroporphyrinogen decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.37 4.1.1.37] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gvv OCA], [http://pdbe.org/3gvv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gvv RCSB], [http://www.ebi.ac.uk/pdbsum/3gvv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gvv OCA], [http://pdbe.org/3gvv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gvv RCSB], [http://www.ebi.ac.uk/pdbsum/3gvv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gvv ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 42:		Line 43:
	[[Category: Warby, C]]		[[Category: Warby, C]]
	[[Category: Whitby, F G]]		[[Category: Whitby, F G]]
		+	[[Category: Acetylation]]
		+	[[Category: Cytoplasm]]
	[[Category: Decarboxylase]]		[[Category: Decarboxylase]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]

OCA at 00:57, 10 February 2016

OCA — Wed, 10 Feb 2016 00:57:42 GMT

←Older revision		Revision as of 00:57, 10 February 2016
Line 2:		Line 2:
	<StructureSection load='3gvv' size='340' side='right' caption='[[3gvv]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3gvv' size='340' side='right' caption='[[3gvv]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gvv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GVV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GVV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gvv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GVV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GVV FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uro\|1uro]], [[3gvq\|3gvq]], [[3gvr\|3gvr]], [[3gvw\|3gvw]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uro\|1uro]], [[3gvq\|3gvq]], [[3gvr\|3gvr]], [[3gvw\|3gvw]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UROD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UROD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uroporphyrinogen_decarboxylase Uroporphyrinogen decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.37 4.1.1.37] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uroporphyrinogen_decarboxylase Uroporphyrinogen decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.37 4.1.1.37] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gvv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gvv RCSB], [http://www.ebi.ac.uk/pdbsum/3gvv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gvv OCA], [http://pdbe.org/3gvv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gvv RCSB], [http://www.ebi.ac.uk/pdbsum/3gvv PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gvv ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 30:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3gvv" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Uroporphyrinogen decarboxylase]]		[[Category: Uroporphyrinogen decarboxylase]]
	[[Category: Hill, C P]]		[[Category: Hill, C P]]

OCA at 17:25, 18 December 2014

OCA — Thu, 18 Dec 2014 17:25:58 GMT

←Older revision		Revision as of 17:25, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3gvv\| PDB~~=3gvv \| ~~SCENE~~= }}	+	==Single-chain UROD Y164G (GY) mutation==
-	===~~Single-~~chain UROD ~~Y164G~~ (GY) ~~mutation~~===	+	<StructureSection load='3gvv' size='340' side='right' caption='[[3gvv]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19362562}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3gvv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GVV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GVV FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uro\|1uro]], [[3gvq\|3gvq]], [[3gvr\|3gvr]], [[3gvw\|3gvw]]</td></tr>
-	[[http://www.uniprot.org/uniprot/DCUP_HUMAN DCUP_HUMAN]] Defects in UROD are the cause of familial porphyria cutanea tarda (FPCT) [MIM:[http://omim.org/entry/176100 176100]]; also known as porphyria cutanea tarda type II. FPCT is an autosomal dominant disorder characterized by light-sensitive dermatitis, with onset in later life. It is associated with the excretion of large amounts of uroporphyrin in the urine. Iron overload is often present in association with varying degrees of liver damage. Besides the familial form of PCT, a relatively common idiosyncratic form is known in which only the liver enzyme is reduced. This form is referred to as porphyria cutanea tarda "sporadic" type or type I [MIM:[http://omim.org/entry/176090 176090]]. PCT type I occurs sporadically as an unusual accompaniment of common hepatic disorders such as alcohol-associated liver disease.<ref>PMID:2243121</ref><ref>PMID:11719352</ref><ref>PMID:2920211</ref><ref>PMID:7706766</ref><ref>PMID:8896428</ref><ref>PMID:9792863</ref><ref>PMID:10338097</ref><ref>PMID:10477430</ref><ref>PMID:11069625</ref><ref>PMID:11295834</ref> Defects in UROD are the cause of hepatoerythropoietic porphyria (HEP) [MIM:[http://omim.org/entry/176100 176100]]. HEP is a rare autosomal recessive disorder. It is the severe form of cutaneous porphyria, and presents in infancy. The level of UROD is very low in erythrocytes and cultured skin fibroblasts, suggesting that HEP is the homozygous state for porphyria cutanea tarda.<ref>PMID:8896428</ref><ref>PMID:8644733</ref><ref>PMID:3775362</ref><ref>PMID:1905636</ref><ref>PMID:1634232</ref><ref>PMID:8176248</ref><ref>PMID:12071824</ref><ref>PMID:15491440</ref><ref>PMID:17240319</ref><ref>PMID:21668429</ref>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">UROD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uroporphyrinogen_decarboxylase Uroporphyrinogen decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.37 4.1.1.37] </span></td></tr>
-	==Function==	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gvv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gvv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gvv RCSB], [http://www.ebi.ac.uk/pdbsum/3gvv PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/DCUP_HUMAN DCUP_HUMAN]] Defects in UROD are the cause of familial porphyria cutanea tarda (FPCT) [MIM:[http://omim.org/entry/176100 176100]]; also known as porphyria cutanea tarda type II. FPCT is an autosomal dominant disorder characterized by light-sensitive dermatitis, with onset in later life. It is associated with the excretion of large amounts of uroporphyrin in the urine. Iron overload is often present in association with varying degrees of liver damage. Besides the familial form of PCT, a relatively common idiosyncratic form is known in which only the liver enzyme is reduced. This form is referred to as porphyria cutanea tarda "sporadic" type or type I [MIM:[http://omim.org/entry/176090 176090]]. PCT type I occurs sporadically as an unusual accompaniment of common hepatic disorders such as alcohol-associated liver disease.<ref>PMID:2243121</ref> <ref>PMID:11719352</ref> <ref>PMID:2920211</ref> <ref>PMID:7706766</ref> <ref>PMID:8896428</ref> <ref>PMID:9792863</ref> <ref>PMID:10338097</ref> <ref>PMID:10477430</ref> <ref>PMID:11069625</ref> <ref>PMID:11295834</ref> Defects in UROD are the cause of hepatoerythropoietic porphyria (HEP) [MIM:[http://omim.org/entry/176100 176100]]. HEP is a rare autosomal recessive disorder. It is the severe form of cutaneous porphyria, and presents in infancy. The level of UROD is very low in erythrocytes and cultured skin fibroblasts, suggesting that HEP is the homozygous state for porphyria cutanea tarda.<ref>PMID:8896428</ref> <ref>PMID:8644733</ref> <ref>PMID:3775362</ref> <ref>PMID:1905636</ref> <ref>PMID:1634232</ref> <ref>PMID:8176248</ref> <ref>PMID:12071824</ref> <ref>PMID:15491440</ref> <ref>PMID:17240319</ref> <ref>PMID:21668429</ref>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/DCUP_HUMAN DCUP_HUMAN]] Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.		[[http://www.uniprot.org/uniprot/DCUP_HUMAN DCUP_HUMAN]] Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gv/3gvv_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Uroporphyrinogen decarboxylase (URO-D; EC 4.1.1.37), the fifth enzyme of the heme biosynthetic pathway, is required for the production of heme, vitamin B12, siroheme, and chlorophyll precursors. URO-D catalyzes the sequential decarboxylation of four acetate side chains in the pyrrole groups of uroporphyrinogen to produce coproporphyrinogen. URO-D is a stable homodimer, with the active-site clefts of the two subunits adjacent to each other. It has been hypothesized that the two catalytic centers interact functionally, perhaps by shuttling of reaction intermediates between subunits. We tested this hypothesis by construction of a single-chain protein (single-chain URO-D) in which the two subunits were connected by a flexible linker. The crystal structure of this protein was shown to be superimposable with wild-type activity and to have comparable catalytic activity. Mutations that impaired one or the other of the two active sites of single-chain URO-D resulted in approximately half of wild-type activity. The distributions of reaction intermediates were the same for mutant and wild-type sequences and were unaltered in a competition experiment using I and III isomer substrates. These observations indicate that communication between active sites is not required for enzyme function and suggest that the dimeric structure of URO-D is required to achieve conformational stability and to create a large active-site cleft.

-	~~==About this Structure==~~	+	Substrate shuttling between active sites of uroporphyrinogen decarboxylase is not required to generate coproporphyrinogen.,Phillips JD, Warby CA, Whitby FG, Kushner JP, Hill CP J Mol Biol. 2009 Jun 5;389(2):306-14. Epub 2009 Apr 10. PMID:19362562<ref>PMID:19362562</ref>
-	~~[[3gvv]]~~ is ~~a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3GVV OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:019362562</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Uroporphyrinogen decarboxylase]]		[[Category: Uroporphyrinogen decarboxylase]]
-	[[Category: Hill, C P.]]	+	[[Category: Hill, C P]]
-	[[Category: Kushner, J P.]]	+	[[Category: Kushner, J P]]
-	[[Category: Phillips, J D.]]	+	[[Category: Phillips, J D]]
-	[[Category: Warby, C.]]	+	[[Category: Warby, C]]
-	[[Category: Whitby, F G.]]	+	[[Category: Whitby, F G]]
	[[Category: Decarboxylase]]		[[Category: Decarboxylase]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]

OCA at 21:41, 24 March 2013

OCA — Sun, 24 Mar 2013 21:41:34 GMT

←Older revision		Revision as of 21:41, 24 March 2013
Line 1:		Line 1:
-	[[Image:3gvv.png\|left\|200px]]
-
	{{STRUCTURE_3gvv\| PDB=3gvv \| SCENE= }}		{{STRUCTURE_3gvv\| PDB=3gvv \| SCENE= }}
-
	===Single-chain UROD Y164G (GY) mutation===		===Single-chain UROD Y164G (GY) mutation===
		+	{{ABSTRACT_PUBMED_19362562}}

-	~~{{ABSTRACT_PUBMED_19362562}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/DCUP_HUMAN DCUP_HUMAN]] Defects in UROD are the cause of familial porphyria cutanea tarda (FPCT) [MIM:[http://omim.org/entry/176100 176100]]; also known as porphyria cutanea tarda type II. FPCT is an autosomal dominant disorder characterized by light-sensitive dermatitis, with onset in later life. It is associated with the excretion of large amounts of uroporphyrin in the urine. Iron overload is often present in association with varying degrees of liver damage. Besides the familial form of PCT, a relatively common idiosyncratic form is known in which only the liver enzyme is reduced. This form is referred to as porphyria cutanea tarda "sporadic" type or type I [MIM:[http://omim.org/entry/176090 176090]]. PCT type I occurs sporadically as an unusual accompaniment of common hepatic disorders such as alcohol-associated liver disease.<ref>PMID:2243121</ref><ref>PMID:11719352</ref><ref>PMID:2920211</ref><ref>PMID:7706766</ref><ref>PMID:8896428</ref><ref>PMID:9792863</ref><ref>PMID:10338097</ref><ref>PMID:10477430</ref><ref>PMID:11069625</ref><ref>PMID:11295834</ref> Defects in UROD are the cause of hepatoerythropoietic porphyria (HEP) [MIM:[http://omim.org/entry/176100 176100]]. HEP is a rare autosomal recessive disorder. It is the severe form of cutaneous porphyria, and presents in infancy. The level of UROD is very low in erythrocytes and cultured skin fibroblasts, suggesting that HEP is the homozygous state for porphyria cutanea tarda.<ref>PMID:8896428</ref><ref>PMID:8644733</ref><ref>PMID:3775362</ref><ref>PMID:1905636</ref><ref>PMID:1634232</ref><ref>PMID:8176248</ref><ref>PMID:12071824</ref><ref>PMID:15491440</ref><ref>PMID:17240319</ref><ref>PMID:21668429</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/DCUP_HUMAN DCUP_HUMAN]] Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.

	==About this Structure==		==About this Structure==
Line 11:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:019362562</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019362562</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Uroporphyrinogen decarboxylase]]		[[Category: Uroporphyrinogen decarboxylase]]

OCA: Protected "3gvv" [edit=sysop:move=sysop]

OCA — Wed, 27 Feb 2013 15:18:33 GMT

Protected "3gvv" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:18, 27 February 2013

OCA at 15:18, 27 February 2013

OCA — Wed, 27 Feb 2013 15:18:29 GMT

←Older revision		Revision as of 15:18, 27 February 2013
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3gvv.png\|left\|200px]]
-	[[Image:3gvv.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3gvv", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3gvv\| PDB=3gvv \| SCENE= }}		{{STRUCTURE_3gvv\| PDB=3gvv \| SCENE= }}

	===Single-chain UROD Y164G (GY) mutation===		===Single-chain UROD Y164G (GY) mutation===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19362562}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19362562 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19362562}}		{{ABSTRACT_PUBMED_19362562}}
-
-	==Disease==
-	Known disease associated with this structure: Porphyria cutanea tarda OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176100 176100]], Porphyria, hepatoerythropoietic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176100 176100]]

	==About this Structure==		==About this Structure==
-	~~3GVV~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GVV OCA].	+	[[3gvv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GVV OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19362562~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019362562</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Uroporphyrinogen decarboxylase]]		[[Category: Uroporphyrinogen decarboxylase]]
Line 34:		Line 19:
	[[Category: Warby, C.]]		[[Category: Warby, C.]]
	[[Category: Whitby, F G.]]		[[Category: Whitby, F G.]]
-	[[Category: Acetylation]]
-	[[Category: Cytoplasm]]
	[[Category: Decarboxylase]]		[[Category: Decarboxylase]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]
Line 43:		Line 26:
	[[Category: Porphyrin biosynthesis]]		[[Category: Porphyrin biosynthesis]]
	[[Category: Uroporphyrinogen]]		[[Category: Uroporphyrinogen]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 8 09:30:11 2009''

OCA at 06:30, 8 July 2009

OCA — Wed, 08 Jul 2009 06:30:12 GMT

←Older revision		Revision as of 06:30, 8 July 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3gvv.jpg\|left\|200px]]

-	The ~~entry 3gvv~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3gvv", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3gvv\| PDB=3gvv \| SCENE= }}

-	~~Authors: Hill, C.P., Phillips, J.D., Whitby, F.G., Warby, C., Kushner, J.P.~~	+	===Single-chain UROD Y164G (GY) mutation===

-	Description: Single-chain UROD Y164G (GY) mutation

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Apr 15~~ 09:58:40 2009''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19362562}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19362562 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19362562}}
		+
		+	==Disease==
		+	Known disease associated with this structure: Porphyria cutanea tarda OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176100 176100]], Porphyria, hepatoerythropoietic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176100 176100]]
		+
		+	==About this Structure==
		+	3GVV is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GVV OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19362562</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Uroporphyrinogen decarboxylase]]
		+	[[Category: Hill, C P.]]
		+	[[Category: Kushner, J P.]]
		+	[[Category: Phillips, J D.]]
		+	[[Category: Warby, C.]]
		+	[[Category: Whitby, F G.]]
		+	[[Category: Acetylation]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Decarboxylase]]
		+	[[Category: Disease mutation]]
		+	[[Category: Heme biosynthesis]]
		+	[[Category: Lyase]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Porphyrin biosynthesis]]
		+	[[Category: Uroporphyrinogen]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 8 09:30:11 2009''

OCA: New page: '''Unreleased structure''' The entry 3gvv is ON HOLD until Paper Publication Authors: Hill, C.P., Phillips, J.D., Whitby, F.G., Warby, C., Kushner, J.P. Description: Single-chain UROD ...

OCA — Wed, 15 Apr 2009 06:58:41 GMT

New page: '''Unreleased structure''' The entry 3gvv is ON HOLD until Paper Publication Authors: Hill, C.P., Phillips, J.D., Whitby, F.G., Warby, C., Kushner, J.P. Description: Single-chain UROD ...

New page

'''Unreleased structure'''

The entry 3gvv is ON HOLD until Paper Publication

Authors: Hill, C.P., Phillips, J.D., Whitby, F.G., Warby, C., Kushner, J.P.

Description: Single-chain UROD Y164G (GY) mutation

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 15 09:58:40 2009''