3gwv - Revision history

OCA at 07:13, 6 September 2023

OCA — Wed, 06 Sep 2023 07:13:20 GMT

←Older revision		Revision as of 07:13, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3gwv' size='340' side='right'caption='[[3gwv]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='3gwv' size='340' side='right'caption='[[3gwv]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gwv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Aquae Aquae~~]. The August 2013 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Serotonin Receptor'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2013_8 10.2210/rcsb_pdb/mom_2013_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GWV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gwv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus_VF5 Aquifex aeolicus VF5]. The August 2013 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Serotonin Receptor'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2013_8 10.2210/rcsb_pdb/mom_2013_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GWV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RFX:(3R)-N-METHYL-3-PHENYL-3-[4-(TRIFLUOROMETHYL)PHENOXY]PROPAN-1-AMINE'>RFX</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.35Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3gwu\|3gwu]], [[3gww\|3gww]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RFX:(3R)-N-METHYL-3-PHENYL-3-[4-(TRIFLUOROMETHYL)PHENOXY]PROPAN-1-AMINE'>RFX</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aq_2077, LeuT, snf ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224324 AQUAE])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gwv OCA], [https://pdbe.org/3gwv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gwv RCSB], [https://www.ebi.ac.uk/pdbsum/3gwv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gwv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gwv OCA], [https://pdbe.org/3gwv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gwv RCSB], [https://www.ebi.ac.uk/pdbsum/3gwv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gwv ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/O67854_AQUAE O67854_AQUAE]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aquae~~]]	+	[[Category: Aquifex aeolicus VF5]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
	[[Category: Serotonin Receptor]]		[[Category: Serotonin Receptor]]
-	[[Category: Karpowich~~, N K~~]]	+	[[Category: Karpowich NK]]
-	[[Category: Law~~, C J~~]]	+	[[Category: Law CJ]]
-	[[Category: Reith~~, M E.A~~]]	+	[[Category: Reith MEA]]
-	[[Category: Wang~~, D N~~]]	+	[[Category: Wang DN]]
-	[[Category: Zhen, J]]	+	[[Category: Zhen J]]
-	[[Category: Zhou, Z]]	+	[[Category: Zhou Z]]
-	~~[[Category: Antidepressant]]~~	+
-	~~[[Category: Integral membrane protein]]~~	+
-	~~[[Category: Neurotransmitter]]~~	+
-	~~[[Category: Nss]]~~	+
-	~~[[Category: Symport]]~~	+
-	~~[[Category: Transmembrane]]~~	+
-	~~[[Category: Transmembrane transport]]~~	+
-	~~[[Category: Transport]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 07:57, 16 March 2022

OCA — Wed, 16 Mar 2022 07:57:04 GMT

←Older revision		Revision as of 07:57, 16 March 2022
Line 1:		Line 1:

	==Leucine transporter LeuT in complex with R-fluoxetine==		==Leucine transporter LeuT in complex with R-fluoxetine==
-	<StructureSection load='3gwv' size='340' side='right' caption='[[3gwv]], [[Resolution\|resolution]] 2.35Å' scene=''>	+	<StructureSection load='3gwv' size='340' side='right'caption='[[3gwv]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gwv]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Aquae Aquae]. The August 2013 RCSB PDB [~~http~~://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Serotonin Receptor'' by David Goodsell is [~~http~~://dx.doi.org/10.2210/rcsb_pdb/mom_2013_8 10.2210/rcsb_pdb/mom_2013_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3GWV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gwv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquae Aquae]. The August 2013 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Serotonin Receptor'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2013_8 10.2210/rcsb_pdb/mom_2013_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GWV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RFX:(3R)-N-METHYL-3-PHENYL-3-[4-(TRIFLUOROMETHYL)PHENOXY]PROPAN-1-AMINE'>RFX</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RFX:(3R)-N-METHYL-3-PHENYL-3-[4-(TRIFLUOROMETHYL)PHENOXY]PROPAN-1-AMINE'>RFX</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gwu\|3gwu]], [[3gww\|3gww]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3gwu\|3gwu]], [[3gww\|3gww]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aq_2077, LeuT, snf ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224324 AQUAE])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aq_2077, LeuT, snf ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224324 AQUAE])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3gwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gwv OCA], [~~http~~://pdbe.org/3gwv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3gwv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3gwv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3gwv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gwv OCA], [https://pdbe.org/3gwv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gwv RCSB], [https://www.ebi.ac.uk/pdbsum/3gwv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gwv ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gw/3gwv_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gw/3gwv_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 3gwv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3gwv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Leucine transporter\|Leucine transporter]]
		+	*[[Serotonin Transporter\|Serotonin Transporter]]
		+	*[[Symporter 3D structures\|Symporter 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Aquae]]		[[Category: Aquae]]
		+	[[Category: Large Structures]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
	[[Category: Serotonin Receptor]]		[[Category: Serotonin Receptor]]

OCA at 07:15, 1 November 2017

OCA — Wed, 01 Nov 2017 07:15:43 GMT

←Older revision		Revision as of 07:15, 1 November 2017
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 3gwv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3gwv" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Leucine transporter\|Leucine transporter]]
-	*[[Serotonin Transporter\|Serotonin Transporter]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:27, 5 August 2016

OCA — Fri, 05 Aug 2016 18:27:37 GMT

←Older revision		Revision as of 18:27, 5 August 2016
Line 1:		Line 1:
		+
	==Leucine transporter LeuT in complex with R-fluoxetine==		==Leucine transporter LeuT in complex with R-fluoxetine==
	<StructureSection load='3gwv' size='340' side='right' caption='[[3gwv]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='3gwv' size='340' side='right' caption='[[3gwv]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3gwv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Aquifex_aeolicus Aquifex aeolicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GWV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3gwv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquae Aquae]. The August 2013 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Serotonin Receptor'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2013_8 10.2210/rcsb_pdb/mom_2013_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GWV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RFX:(3R)-N-METHYL-3-PHENYL-3-[4-(TRIFLUOROMETHYL)PHENOXY]PROPAN-1-AMINE'>RFX</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RFX:(3R)-N-METHYL-3-PHENYL-3-[4-(TRIFLUOROMETHYL)PHENOXY]PROPAN-1-AMINE'>RFX</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gwu\|3gwu]], [[3gww\|3gww]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gwu\|3gwu]], [[3gww\|3gww]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aq_2077, LeuT, snf ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~63363 Aquifex aeolicus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aq_2077, LeuT, snf ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224324 AQUAE])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gwv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gwv RCSB], [http://www.ebi.ac.uk/pdbsum/3gwv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gwv OCA], [http://pdbe.org/3gwv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gwv RCSB], [http://www.ebi.ac.uk/pdbsum/3gwv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gwv ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gwv ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3gwv" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aquifex aeolicus~~]]	+	[[Category: Aquae]]
		+	[[Category: RCSB PDB Molecule of the Month]]
		+	[[Category: Serotonin Receptor]]
	[[Category: Karpowich, N K]]		[[Category: Karpowich, N K]]
	[[Category: Law, C J]]		[[Category: Law, C J]]

OCA at 06:21, 18 December 2014

OCA — Thu, 18 Dec 2014 06:21:04 GMT

←Older revision		Revision as of 06:21, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3gwv~~\| ~~PDB~~=3gwv \| ~~SCENE~~= }}	+	==Leucine transporter LeuT in complex with R-fluoxetine==
-	===~~Leucine~~ transporter LeuT in complex with R-fluoxetine~~===~~	+	<StructureSection load='3gwv' size='340' side='right' caption='[[3gwv]], [[Resolution\|resolution]] 2.35Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19430461}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3gwv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GWV FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RFX:(3R)-N-METHYL-3-PHENYL-3-[4-(TRIFLUOROMETHYL)PHENOXY]PROPAN-1-AMINE'>RFX</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gwu\|3gwu]], [[3gww\|3gww]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">aq_2077, LeuT, snf ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=63363 Aquifex aeolicus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gwv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gwv RCSB], [http://www.ebi.ac.uk/pdbsum/3gwv PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gw/3gwv_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Sertraline and fluoxetine are selective serotonin re-uptake inhibitors (SSRIs) that are widely prescribed to treat depression. They exert their effects by inhibiting the presynaptic plasma membrane serotonin transporter (SERT). All SSRIs possess halogen atoms at specific positions, which are key determinants for the drugs' specificity for SERT. For the SERT protein, however, the structural basis of its specificity for SSRIs is poorly understood. Here we report the crystal structures of LeuT, a bacterial SERT homolog, in complex with sertraline, R-fluoxetine or S-fluoxetine. The SSRI halogens all bind to exactly the same pocket within LeuT. Mutation at this halogen-binding pocket (HBP) in SERT markedly reduces the transporter's affinity for SSRIs but not for tricyclic antidepressants. Conversely, when the only nonconserved HBP residue in both norepinephrine and dopamine transporters is mutated into that found in SERT, their affinities for all the three SSRIs increase uniformly. Thus, the specificity of SERT for SSRIs is dependent largely on interaction of the drug halogens with the protein's HBP.

-	~~==About this Structure==~~	+	Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.,Zhou Z, Zhen J, Karpowich NK, Law CJ, Reith ME, Wang DN Nat Struct Mol Biol. 2009 Jun;16(6):652-7. Epub 2009 May 10. PMID:19430461<ref>PMID:19430461</ref>
-	~~[[3gwv]] is a 1 chain structure with sequence from [http~~:~~//en~~.~~wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=3GWV OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
		+	*[[Leucine transporter\|Leucine transporter]]
	*[[Serotonin Transporter\|Serotonin Transporter]]		*[[Serotonin Transporter\|Serotonin Transporter]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019430461<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Aquifex aeolicus]]		[[Category: Aquifex aeolicus]]
-	[[Category: Karpowich, N K.]]	+	[[Category: Karpowich, N K]]
-	[[Category: Law, C J.]]	+	[[Category: Law, C J]]
-	[[Category: Reith, M E.A.]]	+	[[Category: Reith, M E.A]]
-	[[Category: Wang, D N.]]	+	[[Category: Wang, D N]]
-	[[Category: Zhen, J.]]	+	[[Category: Zhen, J]]
-	[[Category: Zhou, Z.]]	+	[[Category: Zhou, Z]]
	[[Category: Antidepressant]]		[[Category: Antidepressant]]
	[[Category: Integral membrane protein]]		[[Category: Integral membrane protein]]

OCA at 09:12, 11 March 2013

OCA — Mon, 11 Mar 2013 09:12:32 GMT

←Older revision		Revision as of 09:12, 11 March 2013
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-	[[Image:3gwv.png\|left\|200px]]
-
	{{STRUCTURE_3gwv\| PDB=3gwv \| SCENE= }}		{{STRUCTURE_3gwv\| PDB=3gwv \| SCENE= }}
-
	===Leucine transporter LeuT in complex with R-fluoxetine===		===Leucine transporter LeuT in complex with R-fluoxetine===
-
	{{ABSTRACT_PUBMED_19430461}}		{{ABSTRACT_PUBMED_19430461}}

OCA: Protected "3gwv" [edit=sysop:move=sysop]

OCA — Wed, 27 Feb 2013 15:24:52 GMT

Protected "3gwv" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:24, 27 February 2013

OCA at 15:24, 27 February 2013

OCA — Wed, 27 Feb 2013 15:24:49 GMT

←Older revision		Revision as of 15:24, 27 February 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3gwv.png\|left\|200px]]		[[Image:3gwv.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3gwv", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3gwv\| PDB=3gwv \| SCENE= }}		{{STRUCTURE_3gwv\| PDB=3gwv \| SCENE= }}

	===Leucine transporter LeuT in complex with R-fluoxetine===		===Leucine transporter LeuT in complex with R-fluoxetine===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19430461}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19430461 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19430461}}		{{ABSTRACT_PUBMED_19430461}}

	==About this Structure==		==About this Structure==
-	~~3GWV~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/~~Aquifex_aeolicus_vf5~~ Aquifex aeolicus ~~vf5~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWV OCA].	+	[[3gwv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWV OCA].
		+
		+	==See Also==
		+	*[[Serotonin Transporter\|Serotonin Transporter]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19430461~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019430461</ref><references group="xtra"/>
-	[[Category: Aquifex aeolicus ~~vf5~~]]	+	[[Category: Aquifex aeolicus]]
	[[Category: Karpowich, N K.]]		[[Category: Karpowich, N K.]]
	[[Category: Law, C J.]]		[[Category: Law, C J.]]
Line 40:		Line 31:
	[[Category: Transport]]		[[Category: Transport]]
	[[Category: Transport protein]]		[[Category: Transport protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jan 18 09:00:42 2010''

OCA at 07:00, 18 January 2010

OCA — Mon, 18 Jan 2010 07:00:43 GMT

←Older revision		Revision as of 07:00, 18 January 2010
Line 12:		Line 12:
	===Leucine transporter LeuT in complex with R-fluoxetine===		===Leucine transporter LeuT in complex with R-fluoxetine===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19430461}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19430461 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19430461}}

	==About this Structure==		==About this Structure==
	3GWV is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus_vf5 Aquifex aeolicus vf5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWV OCA].		3GWV is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus_vf5 Aquifex aeolicus vf5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWV OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19430461</ref><references group="xtra"/>
	[[Category: Aquifex aeolicus vf5]]		[[Category: Aquifex aeolicus vf5]]
	[[Category: Karpowich, N K.]]		[[Category: Karpowich, N K.]]
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	[[Category: Transport protein]]		[[Category: Transport protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Oct 21 20~~:12:~~45 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jan 18 09:00:42 2010''

OCA at 18:04, 21 October 2009

OCA — Wed, 21 Oct 2009 18:04:20 GMT

←Older revision		Revision as of 18:04, 21 October 2009
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	===Leucine transporter LeuT in complex with R-fluoxetine===		===Leucine transporter LeuT in complex with R-fluoxetine===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19430461}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19430461 is the PubMed ID number.
-	-->
-	{{ABSTRACT_PUBMED_19430461}}

	==About this Structure==		==About this Structure==
	3GWV is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus_vf5 Aquifex aeolicus vf5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWV OCA].		3GWV is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus_vf5 Aquifex aeolicus vf5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GWV OCA].
-
-	==Reference==
-	<ref group="xtra">PMID:19430461</ref><references group="xtra"/>
	[[Category: Aquifex aeolicus vf5]]		[[Category: Aquifex aeolicus vf5]]
	[[Category: Karpowich, N K.]]		[[Category: Karpowich, N K.]]
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	[[Category: Transport protein]]		[[Category: Transport protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 21 09:50:54 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 21 20:12:45 2009''