3h0t - Revision history

OCA at 07:14, 6 September 2023

OCA — Wed, 06 Sep 2023 07:14:36 GMT

←Older revision		Revision as of 07:14, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3h0t' size='340' side='right'caption='[[3h0t]], [[Resolution\|resolution]] 1.89Å' scene=''>		<StructureSection load='3h0t' size='340' side='right'caption='[[3h0t]], [[Resolution\|resolution]] 1.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3h0t]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H0T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3h0t]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H0T FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~HAMP~~, ~~HEPC, hepcidin, LEAP1 (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.89Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h0t OCA], [https://pdbe.org/3h0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h0t RCSB], [https://www.ebi.ac.uk/pdbsum/3h0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h0t ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h0t OCA], [https://pdbe.org/3h0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h0t RCSB], [https://www.ebi.ac.uk/pdbsum/3h0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h0t ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/HEPC_HUMAN HEPC_HUMAN]] Defects in HAMP are the cause of hemochromatosis type 2B (HFE2B) [MIM:[https://omim.org/entry/613313 613313]]; also known as juvenile hemochromatosis (JH). HFE2B is a disorder of iron metabolism with excess deposition of iron in the tissues, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of hemochromatosis type 2 at presentation are hypogonadism and cardiomyopathy.<ref>PMID:14633868</ref> <ref>PMID:12915468</ref> <ref>PMID:14630809</ref> <ref>PMID:14670915</ref> <ref>PMID:15099344</ref>	+	[https://www.uniprot.org/uniprot/HEPC_HUMAN HEPC_HUMAN] Defects in HAMP are the cause of hemochromatosis type 2B (HFE2B) [MIM:[https://omim.org/entry/613313 613313]; also known as juvenile hemochromatosis (JH). HFE2B is a disorder of iron metabolism with excess deposition of iron in the tissues, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of hemochromatosis type 2 at presentation are hypogonadism and cardiomyopathy.<ref>PMID:14633868</ref> <ref>PMID:12915468</ref> <ref>PMID:14630809</ref> <ref>PMID:14670915</ref> <ref>PMID:15099344</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HEPC_HUMAN HEPC_HUMAN]] Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity).<ref>PMID:11034317</ref> Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa.<ref>PMID:11034317</ref>	+	[https://www.uniprot.org/uniprot/HEPC_HUMAN HEPC_HUMAN] Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity).<ref>PMID:11034317</ref> Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa.<ref>PMID:11034317</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Li, V]]	+	[[Category: Li V]]
-	[[Category: Syed, R]]	+	[[Category: Syed R]]
-	~~[[Category: Antibiotic]]~~	+
-	~~[[Category: Antimicrobial]]~~	+
-	~~[[Category: Cleavage on pair of basic residue]]~~	+
-	~~[[Category: Disease mutation]]~~	+
-	~~[[Category: Disulfide bond]]~~	+
-	~~[[Category: Fungicide]]~~	+
-	~~[[Category: Hormone]]~~	+
-	~~[[Category: Immune system-antimicrobial protein complex]]~~	+
-	~~[[Category: Peptide-fab complex]]~~	+
-	~~[[Category: Secreted~~]]	+

OCA at 07:59, 16 March 2022

OCA — Wed, 16 Mar 2022 07:59:58 GMT

←Older revision		Revision as of 07:59, 16 March 2022
Line 1:		Line 1:

	==Hepcidin-Fab complex==		==Hepcidin-Fab complex==
-	<StructureSection load='3h0t' size='340' side='right' caption='[[3h0t]], [[Resolution\|resolution]] 1.89Å' scene=''>	+	<StructureSection load='3h0t' size='340' side='right'caption='[[3h0t]], [[Resolution\|resolution]] 1.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3h0t]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H0T OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3H0T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3h0t]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H0T FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HAMP, HEPC, hepcidin, LEAP1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HAMP, HEPC, hepcidin, LEAP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3h0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h0t OCA], [~~http~~://pdbe.org/3h0t PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3h0t RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3h0t PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3h0t ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h0t OCA], [https://pdbe.org/3h0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h0t RCSB], [https://www.ebi.ac.uk/pdbsum/3h0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h0t ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/HEPC_HUMAN HEPC_HUMAN]] Defects in HAMP are the cause of hemochromatosis type 2B (HFE2B) [MIM:[~~http~~://omim.org/entry/613313 613313]]; also known as juvenile hemochromatosis (JH). HFE2B is a disorder of iron metabolism with excess deposition of iron in the tissues, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of hemochromatosis type 2 at presentation are hypogonadism and cardiomyopathy.<ref>PMID:14633868</ref> <ref>PMID:12915468</ref> <ref>PMID:14630809</ref> <ref>PMID:14670915</ref> <ref>PMID:15099344</ref>	+	[[https://www.uniprot.org/uniprot/HEPC_HUMAN HEPC_HUMAN]] Defects in HAMP are the cause of hemochromatosis type 2B (HFE2B) [MIM:[https://omim.org/entry/613313 613313]]; also known as juvenile hemochromatosis (JH). HFE2B is a disorder of iron metabolism with excess deposition of iron in the tissues, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of hemochromatosis type 2 at presentation are hypogonadism and cardiomyopathy.<ref>PMID:14633868</ref> <ref>PMID:12915468</ref> <ref>PMID:14630809</ref> <ref>PMID:14670915</ref> <ref>PMID:15099344</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HEPC_HUMAN HEPC_HUMAN]] Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity).<ref>PMID:11034317</ref> Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa.<ref>PMID:11034317</ref>	+	[[https://www.uniprot.org/uniprot/HEPC_HUMAN HEPC_HUMAN]] Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity).<ref>PMID:11034317</ref> Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa.<ref>PMID:11034317</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[3D structures of human antibody\|3D structures of human antibody]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Li, V]]		[[Category: Li, V]]
	[[Category: Syed, R]]		[[Category: Syed, R]]

OCA at 05:24, 7 December 2018

OCA — Fri, 07 Dec 2018 05:24:14 GMT

←Older revision		Revision as of 05:24, 7 December 2018
Line 1:		Line 1:
		+
	==Hepcidin-Fab complex==		==Hepcidin-Fab complex==
	<StructureSection load='3h0t' size='340' side='right' caption='[[3h0t]], [[Resolution\|resolution]] 1.89Å' scene=''>		<StructureSection load='3h0t' size='340' side='right' caption='[[3h0t]], [[Resolution\|resolution]] 1.89Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[3h0t]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H0T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H0T FirstGlance]. <br>		<table><tr><td colspan='2'>[[3h0t]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H0T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H0T FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HAMP, HEPC, hepcidin, LEAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HAMP, HEPC, hepcidin, LEAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h0t OCA], [http://pdbe.org/3h0t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3h0t RCSB], [http://www.ebi.ac.uk/pdbsum/3h0t PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h0t OCA], [http://pdbe.org/3h0t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3h0t RCSB], [http://www.ebi.ac.uk/pdbsum/3h0t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3h0t ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h0/3h0t_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h0/3h0t_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 32:

	==See Also==		==See Also==
-	*[[Antibody\|Antibody]]	+	*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:05, 8 February 2016

OCA — Mon, 08 Feb 2016 11:05:23 GMT

←Older revision		Revision as of 11:05, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3h0t' size='340' side='right' caption='[[3h0t]], [[Resolution\|resolution]] 1.89Å' scene=''>		<StructureSection load='3h0t' size='340' side='right' caption='[[3h0t]], [[Resolution\|resolution]] 1.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3h0t]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H0T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H0T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3h0t]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H0T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H0T FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HAMP, HEPC, hepcidin, LEAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HAMP, HEPC, hepcidin, LEAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h0t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h0t RCSB], [http://www.ebi.ac.uk/pdbsum/3h0t PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h0t OCA], [http://pdbe.org/3h0t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3h0t RCSB], [http://www.ebi.ac.uk/pdbsum/3h0t PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h0t ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3h0t" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Li, V]]		[[Category: Li, V]]
	[[Category: Syed, R]]		[[Category: Syed, R]]

OCA at 15:58, 18 December 2014

OCA — Thu, 18 Dec 2014 15:58:05 GMT

←Older revision		Revision as of 15:58, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3h0t~~\| ~~PDB~~=3h0t \| ~~SCENE~~= }}	+	==Hepcidin-Fab complex==
-	===~~Hepcidin~~-~~Fab complex~~===	+	<StructureSection load='3h0t' size='340' side='right' caption='[[3h0t]], [[Resolution\|resolution]] 1.89Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19553669}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3h0t]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H0T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H0T FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HAMP, HEPC, hepcidin, LEAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h0t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h0t RCSB], [http://www.ebi.ac.uk/pdbsum/3h0t PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/HEPC_HUMAN HEPC_HUMAN]] Defects in HAMP are the cause of hemochromatosis type 2B (HFE2B) [MIM:[http://omim.org/entry/613313 613313]]; also known as juvenile hemochromatosis (JH). HFE2B is a disorder of iron metabolism with excess deposition of iron in the tissues, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of hemochromatosis type 2 at presentation are hypogonadism and cardiomyopathy.<ref>PMID:14633868</ref> <ref>PMID:12915468</ref> <ref>PMID:14630809</ref> <ref>PMID:14670915</ref> <ref>PMID:15099344</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HEPC_HUMAN HEPC_HUMAN]] Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity).<ref>PMID:11034317</ref> Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa.<ref>PMID:11034317</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h0/3h0t_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hepcidin is a tightly folded 25-residue peptide hormone containing four disulfide bonds, which has been shown to act as the principal regulator of iron homeostasis in vertebrates. We used multiple techniques to demonstrate a disulfide bonding pattern for hepcidin different from that previously published. All techniques confirmed the following disulfide bond connectivity: Cys(1)-Cys(8), Cys(3)-Cys(6), Cys(2)-Cys(4), and Cys(5)-Cys(7). NMR studies reveal a new model for hepcidin that, at ambient temperatures, interconverts between two different conformations, which could be individually resolved by temperature variation. Using these methods, the solution structure of hepcidin was determined at 325 and 253 K in supercooled water. X-ray analysis of a co-crystal with Fab appeared to stabilize a hepcidin conformation similar to the high temperature NMR structure.

-	~~==Disease==~~	+	Hepcidin revisited, disulfide connectivity, dynamics, and structure.,Jordan JB, Poppe L, Haniu M, Arvedson T, Syed R, Li V, Kohno H, Kim H, Schnier PD, Harvey TS, Miranda LP, Cheetham J, Sasu BJ J Biol Chem. 2009 Sep 4;284(36):24155-67. Epub 2009 Jun 24. PMID:19553669<ref>PMID:19553669</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/HEPC_HUMAN HEPC_HUMAN]] Defects in HAMP are the cause of hemochromatosis type 2B~~ (~~HFE2B~~) ~~[MIM~~:~~[http://omim~~.~~org/entry/613313 613313]]; also known as juvenile hemochromatosis (JH)~~. HFE2B is a disorder of iron metabolism with excess deposition of iron in the tissues, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of hemochromatosis type 2 at presentation are hypogonadism and cardiomyopathy.<ref>PMID:~~14633868</ref><ref>PMID:12915468</ref><ref>PMID:14630809</ref><ref>PMID:14670915</ref>~~<ref>PMID:~~15099344~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/HEPC_HUMAN HEPC_HUMAN]] Seems to act as~~ a ~~signaling molecule involved in~~ the ~~maintenance of iron homeostasis~~. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity).<ref>PMID:11034317</ref> Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.~~epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa~~.<~~ref~~>~~PMID:11034317~~</~~ref~~>	+	</div>
-		+
-	~~==About this Structure==~~	+
-	[[3h0t]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H0T OCA].	+

	==See Also==		==See Also==
	*[[Antibody\|Antibody]]		*[[Antibody\|Antibody]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:019553669</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Li, V.]]	+	[[Category: Li, V]]
-	[[Category: Syed, R.]]	+	[[Category: Syed, R]]
	[[Category: Antibiotic]]		[[Category: Antibiotic]]
	[[Category: Antimicrobial]]		[[Category: Antimicrobial]]

OCA at 10:55, 24 March 2013

OCA — Sun, 24 Mar 2013 10:55:05 GMT

←Older revision		Revision as of 10:55, 24 March 2013
Line 1:		Line 1:
-	[[Image:3h0t.png\|left\|200px]]
-
	{{STRUCTURE_3h0t\| PDB=3h0t \| SCENE= }}		{{STRUCTURE_3h0t\| PDB=3h0t \| SCENE= }}
-
	===Hepcidin-Fab complex===		===Hepcidin-Fab complex===
		+	{{ABSTRACT_PUBMED_19553669}}

-	~~{{ABSTRACT_PUBMED_19553669}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/HEPC_HUMAN HEPC_HUMAN]] Defects in HAMP are the cause of hemochromatosis type 2B (HFE2B) [MIM:[http://omim.org/entry/613313 613313]]; also known as juvenile hemochromatosis (JH). HFE2B is a disorder of iron metabolism with excess deposition of iron in the tissues, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of hemochromatosis type 2 at presentation are hypogonadism and cardiomyopathy.<ref>PMID:14633868</ref><ref>PMID:12915468</ref><ref>PMID:14630809</ref><ref>PMID:14670915</ref><ref>PMID:15099344</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/HEPC_HUMAN HEPC_HUMAN]] Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity).<ref>PMID:11034317</ref> Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa.<ref>PMID:11034317</ref>

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:019553669</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019553669</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Li, V.]]		[[Category: Li, V.]]

OCA at 09:56, 20 October 2012

OCA — Sat, 20 Oct 2012 09:56:25 GMT

←Older revision		Revision as of 09:56, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3h0t]] is a 3 chain structure ~~of [[Antibody]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H0T OCA].	+	[[3h0t]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H0T OCA].

	==See Also==		==See Also==

OCA: Protected "3h0t" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 00:26:56 GMT

Protected "3h0t" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:26, 26 July 2012

OCA at 00:26, 26 July 2012

OCA — Thu, 26 Jul 2012 00:26:55 GMT

←Older revision		Revision as of 00:26, 26 July 2012
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-	{{Seed}}
	[[Image:3h0t.png\|left\|200px]]		[[Image:3h0t.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3h0t", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3h0t\| PDB=3h0t \| SCENE= }}		{{STRUCTURE_3h0t\| PDB=3h0t \| SCENE= }}

	===Hepcidin-Fab complex===		===Hepcidin-Fab complex===

		+	{{ABSTRACT_PUBMED_19553669}}

	==About this Structure==		==About this Structure==
-	~~3H0T~~ is a 3 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H0T OCA].	+	[[3h0t]] is a 3 chain structure of [[Antibody]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H0T OCA].
		+
		+	==See Also==
		+	*[[Antibody\|Antibody]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:019553669</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Li, V.]]		[[Category: Li, V.]]
Line 25:		Line 25:
	[[Category: Fungicide]]		[[Category: Fungicide]]
	[[Category: Hormone]]		[[Category: Hormone]]
-	[[Category: Immune system/antimicrobial protein complex]]	+	[[Category: Immune system-antimicrobial protein complex]]
	[[Category: Peptide-fab complex]]		[[Category: Peptide-fab complex]]
	[[Category: Secreted]]		[[Category: Secreted]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 14 20:03:53 2009''

OCA at 17:55, 14 October 2009

OCA — Wed, 14 Oct 2009 17:55:40 GMT

←Older revision		Revision as of 17:55, 14 October 2009
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	===Hepcidin-Fab complex===		===Hepcidin-Fab complex===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19553669}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19553669 is the PubMed ID number.
-	-->
-	{{ABSTRACT_PUBMED_19553669}}

	==About this Structure==		==About this Structure==
	3H0T is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H0T OCA].		3H0T is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H0T OCA].
-
-	==Reference==
-	<ref group="xtra">PMID:19553669</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Li, V.]]		[[Category: Li, V.]]
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	[[Category: Secreted]]		[[Category: Secreted]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 14 09:49:01 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 14 20:03:53 2009''