3h1p - Revision history

OCA at 07:14, 6 September 2023

OCA — Wed, 06 Sep 2023 07:14:59 GMT

←Older revision		Revision as of 07:14, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3h1p' size='340' side='right'caption='[[3h1p]], [[Resolution\|resolution]] 2.61Å' scene=''>		<StructureSection load='3h1p' size='340' side='right'caption='[[3h1p]], [[Resolution\|resolution]] 2.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3h1p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H1P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3h1p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H1P FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ASJ:(3S)-3-AMINO-4-HYDROXYBUTANOIC+ACID'>ASJ</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.61Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;'>[[1f1j\|1f1j]]~~, [[~~2qlf~~\|~~2qlf~~]]~~, [[1shj\|1shj]], [[1k86\|1k86]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ASJ:(3S)-3-AMINO-4-HYDROXYBUTANOIC+ACID'>ASJ</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>CASP7, MCH3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Caspase~~-~~7 Caspase~~-~~7], with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=3.~~4~~.22.60 3.4.22.60]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h1p OCA], [https://pdbe.org/3h1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h1p RCSB], [https://www.ebi.ac.uk/pdbsum/3h1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h1p ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h1p OCA], [https://pdbe.org/3h1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h1p RCSB], [https://www.ebi.ac.uk/pdbsum/3h1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h1p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Overexpression promotes programmed cell death.	+	[https://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Overexpression promotes programmed cell death.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Caspase-7]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hardy~~, J A~~]]	+	[[Category: Hardy JA]]
-	[[Category: Witkowski~~, W A]]~~	+	[[Category: Witkowski WA]]
-	~~[[Category: Apoptosis]]~~	+
-	~~[[Category: Cell death]]~~	+
-	~~[[Category: Compensatory mechanism]]~~	+
-	~~[[Category: Cysteine protease]]~~	+
-	~~[[Category: Hydrolase-inhibitor complex]]~~	+
-	~~[[Category: Protease]]~~	+
-	~~[[Category: Thiol protease]]~~	+
-	~~[[Category: Zymogen~~]]	+

OCA at 11:53, 13 October 2021

OCA — Wed, 13 Oct 2021 11:53:53 GMT

←Older revision		Revision as of 11:53, 13 October 2021
Line 1:		Line 1:

	==Mature Caspase-7 I213A with DEVD-CHO inhibitor bound to active site==		==Mature Caspase-7 I213A with DEVD-CHO inhibitor bound to active site==
-	<StructureSection load='3h1p' size='340' side='right' caption='[[3h1p]], [[Resolution\|resolution]] 2.61Å' scene=''>	+	<StructureSection load='3h1p' size='340' side='right'caption='[[3h1p]], [[Resolution\|resolution]] 2.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3h1p]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H1P OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3H1P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3h1p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H1P FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ASJ:(3S)-3-AMINO-4-HYDROXYBUTANOIC+ACID'>ASJ</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ASJ:(3S)-3-AMINO-4-HYDROXYBUTANOIC+ACID'>ASJ</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f1j\|1f1j]], [[2qlf\|2qlf]], [[1shj\|1shj]], [[1k86\|1k86]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1f1j\|1f1j]], [[2qlf\|2qlf]], [[1shj\|1shj]], [[1k86\|1k86]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP7, MCH3 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP7, MCH3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Caspase-7 Caspase-7], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.60 3.4.22.60] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Caspase-7 Caspase-7], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.60 3.4.22.60] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3h1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h1p OCA], [~~http~~://pdbe.org/3h1p PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3h1p RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3h1p PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3h1p ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h1p OCA], [https://pdbe.org/3h1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h1p RCSB], [https://www.ebi.ac.uk/pdbsum/3h1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h1p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Overexpression promotes programmed cell death.	+	[[https://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Overexpression promotes programmed cell death.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h1/3h1p_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h1/3h1p_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 3h1p" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3h1p" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Caspase 3D structures\|Caspase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 40:
	[[Category: Caspase-7]]		[[Category: Caspase-7]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Hardy, J A]]		[[Category: Hardy, J A]]
	[[Category: Witkowski, W A]]		[[Category: Witkowski, W A]]

OCA at 07:18, 1 November 2017

OCA — Wed, 01 Nov 2017 07:18:57 GMT

←Older revision		Revision as of 07:18, 1 November 2017
Line 1:		Line 1:
		+
	==Mature Caspase-7 I213A with DEVD-CHO inhibitor bound to active site==		==Mature Caspase-7 I213A with DEVD-CHO inhibitor bound to active site==
	<StructureSection load='3h1p' size='340' side='right' caption='[[3h1p]], [[Resolution\|resolution]] 2.61Å' scene=''>		<StructureSection load='3h1p' size='340' side='right' caption='[[3h1p]], [[Resolution\|resolution]] 2.61Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP7, MCH3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP7, MCH3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-7 Caspase-7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.60 3.4.22.60] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-7 Caspase-7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.60 3.4.22.60] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h1p OCA], [http://pdbe.org/3h1p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3h1p RCSB], [http://www.ebi.ac.uk/pdbsum/3h1p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h1p OCA], [http://pdbe.org/3h1p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3h1p RCSB], [http://www.ebi.ac.uk/pdbsum/3h1p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3h1p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 3h1p" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3h1p" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Caspase\|Caspase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:55, 9 February 2016

OCA — Tue, 09 Feb 2016 07:55:06 GMT

←Older revision		Revision as of 07:55, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3h1p' size='340' side='right' caption='[[3h1p]], [[Resolution\|resolution]] 2.61Å' scene=''>		<StructureSection load='3h1p' size='340' side='right' caption='[[3h1p]], [[Resolution\|resolution]] 2.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3h1p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H1P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H1P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3h1p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H1P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H1P FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ASJ:(3S)-3-AMINO-4-HYDROXYBUTANOIC+ACID'>ASJ</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ASJ:(3S)-3-AMINO-4-HYDROXYBUTANOIC+ACID'>ASJ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f1j\|1f1j]], [[2qlf\|2qlf]], [[1shj\|1shj]], [[1k86\|1k86]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f1j\|1f1j]], [[2qlf\|2qlf]], [[1shj\|1shj]], [[1k86\|1k86]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP7, MCH3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP7, MCH3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-7 Caspase-7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.60 3.4.22.60] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-7 Caspase-7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.60 3.4.22.60] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h1p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h1p RCSB], [http://www.ebi.ac.uk/pdbsum/3h1p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h1p OCA], [http://pdbe.org/3h1p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3h1p RCSB], [http://www.ebi.ac.uk/pdbsum/3h1p PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h1p ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3h1p" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 37:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Caspase-7]]		[[Category: Caspase-7]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Hardy, J A]]		[[Category: Hardy, J A]]
	[[Category: Witkowski, W A]]		[[Category: Witkowski, W A]]

OCA at 05:31, 25 December 2014

OCA — Thu, 25 Dec 2014 05:31:47 GMT

←Older revision		Revision as of 05:31, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h1p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h1p RCSB], [http://www.ebi.ac.uk/pdbsum/3h1p PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h1p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h1p RCSB], [http://www.ebi.ac.uk/pdbsum/3h1p PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Overexpression promotes programmed cell death.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:12, 8 December 2014

OCA — Mon, 08 Dec 2014 09:12:43 GMT

←Older revision		Revision as of 09:12, 8 December 2014
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-	[[~~Image:~~3h1p.~~png~~\|~~left~~\|200px]]	+	==Mature Caspase-7 I213A with DEVD-CHO inhibitor bound to active site==
		+	<StructureSection load='3h1p' size='340' side='right' caption='[[3h1p]], [[Resolution\|resolution]] 2.61Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3h1p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H1P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H1P FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ASJ:(3S)-3-AMINO-4-HYDROXYBUTANOIC+ACID'>ASJ</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1f1j\|1f1j]], [[2qlf\|2qlf]], [[1shj\|1shj]], [[1k86\|1k86]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP7, MCH3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-7 Caspase-7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.60 3.4.22.60] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h1p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h1p RCSB], [http://www.ebi.ac.uk/pdbsum/3h1p PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h1/3h1p_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The active sites of caspases are composed of four mobile loops. A loop (L2) from one half of the dimer interacts with a loop (L2') from the other half of the dimer to bind substrate. In an inactive form, the two L2' loops form a cross-dimer hydrogen-bond network over the dimer interface. Although the L2' loop has been implicated as playing a central role in the formation of the active-site loop bundle, its precise role in catalysis has not been shown. A detailed understanding of the active and inactive conformations is essential to control the caspase function. We have interrogated the contributions of the residues in the L2' loop to catalytic function and enzyme stability. In wild-type and all mutants, active-site binding results in substantial stabilization of the complex. One mutation, P214A, is significantly destabilized in the ligand-free conformation, but is as stable as wild type when bound to substrate, indicating that caspase-7 rests in different conformations in the absence and presence of substrate. Residues K212 and I213 in the L2' loop are shown to be essential for substrate-binding and thus proper catalytic function of the caspase. In the crystal structure of I213A, the void created by side-chain deletion is compensated for by rearrangement of tyrosine 211 to fill the void, suggesting that the requirements of substrate-binding are sufficiently strong to induce the active conformation. Thus, although the L2' loop makes no direct contacts with substrate, it is essential for buttressing the substrate-binding groove and is central to native catalytic efficiency.

-	~~{{STRUCTURE_3h1p\| PDB=3h1p \| SCENE= }}~~	+	L2' loop is critical for caspase-7 active site formation.,Witkowski WA, Hardy JA Protein Sci. 2009 Jul;18(7):1459-68. PMID:19530232<ref>PMID:19530232</ref>

-	~~===Mature Caspase-7 I213A with DEVD-CHO inhibitor bound to active site===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19530232}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3h1p]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3H1P OCA].~~	+

	==See Also==		==See Also==
	*[[Caspase\|Caspase]]		*[[Caspase\|Caspase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019530232<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Caspase-7]]		[[Category: Caspase-7]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Hardy, J A.]]	+	[[Category: Hardy, J A]]
-	[[Category: Witkowski, W A.]]	+	[[Category: Witkowski, W A]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Cell death]]		[[Category: Cell death]]

OCA at 13:11, 20 October 2012

OCA — Sat, 20 Oct 2012 13:11:30 GMT

←Older revision		Revision as of 13:11, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[3h1p]] is a 4 chain structure ~~of [[Caspase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H1P OCA].	+	[[3h1p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H1P OCA].

	==See Also==		==See Also==

OCA at 11:10, 26 July 2012

OCA — Thu, 26 Jul 2012 11:10:50 GMT

←Older revision		Revision as of 11:10, 26 July 2012
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	[[Image:3h1p.png\|left\|200px]]		[[Image:3h1p.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3h1p", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3h1p\| PDB=3h1p \| SCENE= }}		{{STRUCTURE_3h1p\| PDB=3h1p \| SCENE= }}

	===Mature Caspase-7 I213A with DEVD-CHO inhibitor bound to active site===		===Mature Caspase-7 I213A with DEVD-CHO inhibitor bound to active site===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19530232}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19530232 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_19530232}}		{{ABSTRACT_PUBMED_19530232}}

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	==See Also==		==See Also==
-	*[[Caspase]]	+	*[[Caspase\|Caspase]]

	==Reference==		==Reference==

OCA: Protected "3h1p" [edit=sysop:move=sysop]

OCA — Wed, 05 Oct 2011 05:55:24 GMT

Protected "3h1p" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:55, 5 October 2011

OCA at 05:55, 5 October 2011

OCA — Wed, 05 Oct 2011 05:55:22 GMT

←Older revision		Revision as of 05:55, 5 October 2011
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-	~~{{Seed}}~~	+	[[Image:3h1p.png\|left\|200px]]
-	[[Image:3h1p.~~jpg~~\|left\|200px]]	+

	<!--		<!--
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	==About this Structure==		==About this Structure==
-	~~3H1P~~ is a ~~2 chains~~ structure of ~~sequences from~~ [~~http://en.wikipedia.org/wiki/~~ ] ~~and~~ [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H1P OCA].	+	[[3h1p]] is a 4 chain structure of [[Caspase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H1P OCA].
		+
		+	==See Also==
		+	*[[Caspase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19530232~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019530232</ref><references group="xtra"/>
	[[Category: Caspase-7]]		[[Category: Caspase-7]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hardy, J A.]]		[[Category: Hardy, J A.]]
	[[Category: Witkowski, W A.]]		[[Category: Witkowski, W A.]]
-	[[Category: Alternative splicing]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
-	[[Category: Caspase-7]]
	[[Category: Cell death]]		[[Category: Cell death]]
	[[Category: Compensatory mechanism]]		[[Category: Compensatory mechanism]]
	[[Category: Cysteine protease]]		[[Category: Cysteine protease]]
-	~~[[Category: Cytoplasm]]~~	+	[[Category: Hydrolase-inhibitor complex]]
-	[[Category: Hydrolase]]	+
-	~~[[Category: Polymorphism~~]]	+
	[[Category: Protease]]		[[Category: Protease]]
	[[Category: Thiol protease]]		[[Category: Thiol protease]]
	[[Category: Zymogen]]		[[Category: Zymogen]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 1 09:19:21 2009''