3h68 - Revision history

OCA at 15:47, 1 November 2023

OCA — Wed, 01 Nov 2023 15:47:58 GMT

←Older revision		Revision as of 15:47, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3h68' size='340' side='right'caption='[[3h68]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3h68' size='340' side='right'caption='[[3h68]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3h68]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H68 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3h68]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H68 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NHC:(1R,2S,3R,4S)~~-2,~~3-DIMETHYL-7-OXABICYCLO~~[2.~~2.1]HEPTANE-2,3-DICARBOXYLIC+ACID'>NHC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;'>[[3h60\|3h60]]~~, ~~[[3h61\|3h61]]~~, ~~[[3h62\|3h62]]~~, ~~[[3h63\|3h63]]~~, [~~[3h64\|3h64]~~], ~~[[3h66\|3h66]], [[3h67\|3h67]], [[3h69\|3h69]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NHC:(1R,2S,3R,4S)-2,3-DIMETHYL-7-OXABICYCLO[2.2.1]HEPTANE-2,3-DICARBOXYLIC+ACID'>NHC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='gene~~'>~~<td class="sblockLbl"><b>[[Gene\|Gene:]]~~</b>~~</td><td class="sblockDat">PPP5C~~, ~~PPP5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~<~~/td></tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h68 OCA], [https://pdbe.org/3h68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h68 RCSB], [https://www.ebi.ac.uk/pdbsum/3h68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h68 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h68 OCA], [https://pdbe.org/3h68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h68 RCSB], [https://www.ebi.ac.uk/pdbsum/3h68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h68 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PPP5_HUMAN PPP5_HUMAN]] May play a role in the regulation of RNA biogenesis and/or mitosis. In vitro, dephosphorylates serine residues of skeletal muscle phosphorylase and histone H1.	+	[https://www.uniprot.org/uniprot/PPP5_HUMAN PPP5_HUMAN] May play a role in the regulation of RNA biogenesis and/or mitosis. In vitro, dephosphorylates serine residues of skeletal muscle phosphorylase and histone H1.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Phosphoprotein phosphatase]]~~	+	[[Category: Bertini I]]
-	[[Category: Bertini, I]]	+	[[Category: Calderone V]]
-	[[Category: Calderone, V]]	+	[[Category: Fragai M]]
-	[[Category: Fragai, M]]	+	[[Category: Luchinat C]]
-	[[Category: Luchinat, C]]	+	[[Category: Talluri E]]
-	[[Category: Talluri, E]]	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Drug design]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Iron]]~~	+
-	~~[[Category: Manganese]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Metalloenzyme]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Phosphatase]]~~	+
-	~~[[Category: Protein phosphatase]]~~	+
-	~~[[Category: Tpr repeat~~]]	+

OCA at 08:04, 16 March 2022

OCA — Wed, 16 Mar 2022 08:04:21 GMT

←Older revision		Revision as of 08:04, 16 March 2022
Line 1:		Line 1:

	==Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c)with two Zn2+ atoms originally soaked with cantharidin (which is present in the structure in the hydrolyzed form)==		==Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c)with two Zn2+ atoms originally soaked with cantharidin (which is present in the structure in the hydrolyzed form)==
-	<StructureSection load='3h68' size='340' side='right' caption='[[3h68]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='3h68' size='340' side='right'caption='[[3h68]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3h68]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H68 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3H68 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3h68]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H68 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NHC:(1R,2S,3R,4S)-2,3-DIMETHYL-7-OXABICYCLO[2.2.1]HEPTANE-2,3-DICARBOXYLIC+ACID'>NHC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NHC:(1R,2S,3R,4S)-2,3-DIMETHYL-7-OXABICYCLO[2.2.1]HEPTANE-2,3-DICARBOXYLIC+ACID'>NHC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3h60\|3h60]], [[3h61\|3h61]], [[3h62\|3h62]], [[3h63\|3h63]], [[3h64\|3h64]], [[3h66\|3h66]], [[3h67\|3h67]], [[3h69\|3h69]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3h60\|3h60]], [[3h61\|3h61]], [[3h62\|3h62]], [[3h63\|3h63]], [[3h64\|3h64]], [[3h66\|3h66]], [[3h67\|3h67]], [[3h69\|3h69]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPP5C, PPP5 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPP5C, PPP5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3h68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h68 OCA], [~~http~~://pdbe.org/3h68 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3h68 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3h68 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3h68 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h68 OCA], [https://pdbe.org/3h68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h68 RCSB], [https://www.ebi.ac.uk/pdbsum/3h68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h68 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PPP5_HUMAN PPP5_HUMAN]] May play a role in the regulation of RNA biogenesis and/or mitosis. In vitro, dephosphorylates serine residues of skeletal muscle phosphorylase and histone H1.	+	[[https://www.uniprot.org/uniprot/PPP5_HUMAN PPP5_HUMAN]] May play a role in the regulation of RNA biogenesis and/or mitosis. In vitro, dephosphorylates serine residues of skeletal muscle phosphorylase and histone H1.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h6/3h68_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h6/3h68_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 33:

	==See Also==		==See Also==
-	*[[~~Serine/threonine protein~~ phosphatase\|~~Serine/threonine protein~~ phosphatase]]	+	*[[Protein phosphatase 3D structures\|Protein phosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Phosphoprotein phosphatase]]		[[Category: Phosphoprotein phosphatase]]
	[[Category: Bertini, I]]		[[Category: Bertini, I]]
Line 45:		Line 46:
	[[Category: Luchinat, C]]		[[Category: Luchinat, C]]
	[[Category: Talluri, E]]		[[Category: Talluri, E]]
		+	[[Category: Cytoplasm]]
	[[Category: Drug design]]		[[Category: Drug design]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 17:38, 5 August 2016

OCA — Fri, 05 Aug 2016 17:38:55 GMT

←Older revision		Revision as of 17:38, 5 August 2016
Line 1:		Line 1:
		+
	==Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c)with two Zn2+ atoms originally soaked with cantharidin (which is present in the structure in the hydrolyzed form)==		==Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c)with two Zn2+ atoms originally soaked with cantharidin (which is present in the structure in the hydrolyzed form)==
	<StructureSection load='3h68' size='340' side='right' caption='[[3h68]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='3h68' size='340' side='right' caption='[[3h68]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3h68]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H68 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3h68]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H68 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NHC:(1R,2S,3R,4S)-2,3-DIMETHYL-7-OXABICYCLO[2.2.1]HEPTANE-2,3-DICARBOXYLIC+ACID'>NHC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NHC:(1R,2S,3R,4S)-2,3-DIMETHYL-7-OXABICYCLO[2.2.1]HEPTANE-2,3-DICARBOXYLIC+ACID'>NHC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3h60\|3h60]], [[3h61\|3h61]], [[3h62\|3h62]], [[3h63\|3h63]], [[3h64\|3h64]], [[3h66\|3h66]], [[3h67\|3h67]], [[3h69\|3h69]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3h60\|3h60]], [[3h61\|3h61]], [[3h62\|3h62]], [[3h63\|3h63]], [[3h64\|3h64]], [[3h66\|3h66]], [[3h67\|3h67]], [[3h69\|3h69]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPP5C, PPP5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPP5C, PPP5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h68 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h68 RCSB], [http://www.ebi.ac.uk/pdbsum/3h68 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h68 OCA], [http://pdbe.org/3h68 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3h68 RCSB], [http://www.ebi.ac.uk/pdbsum/3h68 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3h68 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h68 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3h68" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[Protein phosphatase\|Protein phosphatase]]
	*[[Serine/threonine protein phosphatase\|Serine/threonine protein phosphatase]]		*[[Serine/threonine protein phosphatase\|Serine/threonine protein phosphatase]]
	== References ==		== References ==
Line 37:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Phosphoprotein phosphatase]]		[[Category: Phosphoprotein phosphatase]]
	[[Category: Bertini, I]]		[[Category: Bertini, I]]

OCA at 20:41, 25 December 2014

OCA — Thu, 25 Dec 2014 20:41:58 GMT

←Older revision		Revision as of 20:41, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h68 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h68 RCSB], [http://www.ebi.ac.uk/pdbsum/3h68 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h68 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h68 RCSB], [http://www.ebi.ac.uk/pdbsum/3h68 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PPP5_HUMAN PPP5_HUMAN]] May play a role in the regulation of RNA biogenesis and/or mitosis. In vitro, dephosphorylates serine residues of skeletal muscle phosphorylase and histone H1.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:20, 8 December 2014

OCA — Mon, 08 Dec 2014 09:20:13 GMT

←Older revision		Revision as of 09:20, 8 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3h68.~~png~~\|~~left~~\|200px]]	+	==Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c)with two Zn2+ atoms originally soaked with cantharidin (which is present in the structure in the hydrolyzed form)==
		+	<StructureSection load='3h68' size='340' side='right' caption='[[3h68]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3h68]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H68 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NHC:(1R,2S,3R,4S)-2,3-DIMETHYL-7-OXABICYCLO[2.2.1]HEPTANE-2,3-DICARBOXYLIC+ACID'>NHC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3h60\|3h60]], [[3h61\|3h61]], [[3h62\|3h62]], [[3h63\|3h63]], [[3h64\|3h64]], [[3h66\|3h66]], [[3h67\|3h67]], [[3h69\|3h69]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PPP5C, PPP5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h68 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h68 RCSB], [http://www.ebi.ac.uk/pdbsum/3h68 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h6/3h68_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The inhibition of a subgroup of human serine/threonine protein phosphatases is responsible for the cytotoxicity of cantharidin and norcantharidin against tumor cells. It is shown that the anhydride rings of cantharidin and norcantharidin are hydrolyzed when bound to the catalytic domain of the human serine/threonine protein phosphatases 5 (PP5c), and the high-resolution crystal structures of PP5c complexed with the corresponding dicarboxylic acid derivatives of the two molecules are reported. Norcantharidin shows a unique binding conformation with the catalytically active Mn2PP5c, while cantharidin is characterized by a double conformation in its binding mode to the protein. Different binding modes of norcantharidin are observed depending of whether the starting ligand is in the anhydride or in the dicarboxylic acid form. All these structures will provide the basis for the rational design of new cantharidin-based drugs.

-	~~{{STRUCTURE_3h68\| PDB=3h68 \| SCENE= }}~~	+	Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin.,Bertini I, Calderone V, Fragai M, Luchinat C, Talluri E J Med Chem. 2009 Aug 13;52(15):4838-43. PMID:19601647<ref>PMID:19601647</ref>

-	~~===Catalytic domain of human Serine~~/~~Threonine Phosphatase 5 (PP5c)with two Zn2+ atoms originally soaked with cantharidin (which is present in~~ the ~~structure in the hydrolyzed form)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_19601647}}~~	+	==See Also==
-		+	*[[Protein phosphatase\|Protein phosphatase]]
-	==~~About this Structure~~==	+	*[[Serine/threonine protein phosphatase\|Serine/threonine protein phosphatase]]
-	[[~~3h68~~]] ~~is a 2 chain structure with sequence from~~ [~~http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from~~ [~~http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=3H68 OCA~~].	+	== References ==
-		+	<references/>
-	==~~Reference~~==	+	__TOC__
-	<~~ref group="xtra">PMID:019601647<~~/~~ref~~><~~references group="xtra"~~/>	+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phosphoprotein phosphatase]]		[[Category: Phosphoprotein phosphatase]]
-	[[Category: Bertini, I.]]	+	[[Category: Bertini, I]]
-	[[Category: Calderone, V.]]	+	[[Category: Calderone, V]]
-	[[Category: Fragai, M.]]	+	[[Category: Fragai, M]]
-	[[Category: Luchinat, C.]]	+	[[Category: Luchinat, C]]
-	[[Category: Talluri, E.]]	+	[[Category: Talluri, E]]
	[[Category: Drug design]]		[[Category: Drug design]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA: Protected "3h68" [edit=sysop:move=sysop]

OCA — Wed, 27 Feb 2013 15:17:35 GMT

Protected "3h68" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:17, 27 February 2013

OCA at 15:17, 27 February 2013

OCA — Wed, 27 Feb 2013 15:17:31 GMT

←Older revision		Revision as of 15:17, 27 February 2013
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3h68.png\|left\|200px]]
-	[[Image:3h68.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3h68", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3h68\| PDB=3h68 \| SCENE= }}		{{STRUCTURE_3h68\| PDB=3h68 \| SCENE= }}

	===Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c)with two Zn2+ atoms originally soaked with cantharidin (which is present in the structure in the hydrolyzed form)===		===Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c)with two Zn2+ atoms originally soaked with cantharidin (which is present in the structure in the hydrolyzed form)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19601647}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19601647 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19601647}}		{{ABSTRACT_PUBMED_19601647}}

	==About this Structure==		==About this Structure==
-	~~3H68~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H68 OCA].	+	[[3h68]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H68 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19601647~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019601647</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phosphoprotein phosphatase]]		[[Category: Phosphoprotein phosphatase]]
Line 31:		Line 19:
	[[Category: Luchinat, C.]]		[[Category: Luchinat, C.]]
	[[Category: Talluri, E.]]		[[Category: Talluri, E.]]
-	[[Category: Cytoplasm]]
	[[Category: Drug design]]		[[Category: Drug design]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
Line 43:		Line 30:
	[[Category: Protein phosphatase]]		[[Category: Protein phosphatase]]
	[[Category: Tpr repeat]]		[[Category: Tpr repeat]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 30 09:15:13 2009''

OCA at 07:15, 30 September 2009

OCA — Wed, 30 Sep 2009 07:15:15 GMT

←Older revision		Revision as of 07:15, 30 September 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3h68.jpg\|left\|200px]]

-	The ~~entry 3h68~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3h68", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3h68\| PDB=3h68 \| SCENE= }}

-	~~Authors: Bertini, I., Calderone, V., Fragai, M., Luchinat, C., Talluri, E.~~	+	===Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c)with two Zn2+ atoms originally soaked with cantharidin (which is present in the structure in the hydrolyzed form)===

-	Description: Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c)with two Zn2+ atoms originally soaked with cantharidin (which is present in the structure in the hydrolyzed form)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~May 27 14~~:38:28 2009''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19601647}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19601647 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19601647}}
		+
		+	==About this Structure==
		+	3H68 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H68 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19601647</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Phosphoprotein phosphatase]]
		+	[[Category: Bertini, I.]]
		+	[[Category: Calderone, V.]]
		+	[[Category: Fragai, M.]]
		+	[[Category: Luchinat, C.]]
		+	[[Category: Talluri, E.]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Drug design]]
		+	[[Category: Hydrolase]]
		+	[[Category: Inhibitor]]
		+	[[Category: Iron]]
		+	[[Category: Manganese]]
		+	[[Category: Metal-binding]]
		+	[[Category: Metalloenzyme]]
		+	[[Category: Nucleus]]
		+	[[Category: Phosphatase]]
		+	[[Category: Protein phosphatase]]
		+	[[Category: Tpr repeat]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 30 09:15:13 2009''

OCA at 11:38, 27 May 2009

OCA — Wed, 27 May 2009 11:38:28 GMT

←Older revision		Revision as of 11:38, 27 May 2009
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3h68 is ON HOLD	+	The entry 3h68 is ON HOLD until Paper Publication

	Authors: Bertini, I., Calderone, V., Fragai, M., Luchinat, C., Talluri, E.		Authors: Bertini, I., Calderone, V., Fragai, M., Luchinat, C., Talluri, E.

-	Description: Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c)with two Zn2+ atoms originally soaked with cantharidin	+	Description: Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c)with two Zn2+ atoms originally soaked with cantharidin (which is present in the structure in the hydrolyzed form)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May ~~20 16~~:37:58 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 27 14:38:28 2009''

OCA at 13:37, 20 May 2009

OCA — Wed, 20 May 2009 13:37:59 GMT

←Older revision		Revision as of 13:37, 20 May 2009
Line 5:		Line 5:
	Authors: Bertini, I., Calderone, V., Fragai, M., Luchinat, C., Talluri, E.		Authors: Bertini, I., Calderone, V., Fragai, M., Luchinat, C., Talluri, E.

-	Description: Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c)with two Zn2+ atoms ~~complexed~~ with cantharidin	+	Description: Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c)with two Zn2+ atoms originally soaked with cantharidin

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Apr 30 08~~:48:31 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 20 16:37:58 2009''