3h7r - Revision history

OCA at 07:17, 6 September 2023

OCA — Wed, 06 Sep 2023 07:17:32 GMT

←Older revision		Revision as of 07:17, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3h7r' size='340' side='right'caption='[[3h7r]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='3h7r' size='340' side='right'caption='[[3h7r]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3h7r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H7R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3h7r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H7R FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>~~, ~~<scene name='pdbligand=EDO:~~1~~,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.4Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[3h7u\|3h7u]]~~</~~div~~><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">At2g37760, DQ837653 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h7r OCA], [https://pdbe.org/3h7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h7r RCSB], [https://www.ebi.ac.uk/pdbsum/3h7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h7r ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h7r OCA], [https://pdbe.org/3h7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h7r RCSB], [https://www.ebi.ac.uk/pdbsum/3h7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h7r ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/AKRC8_ARATH AKRC8_ARATH]] Oxidoreductase acting on a broad range of substrates: reduces ketosteroids, aromatic aldehydes, ketones, sugars and other aliphatic aldehydes, and oxidizes hydroxysteroids. May function as detoxifiying enzyme by reducing a range of toxic aldehydes and ketones produced during stress.<ref>PMID:19616008</ref>	+	[https://www.uniprot.org/uniprot/AKRC8_ARATH AKRC8_ARATH] Oxidoreductase acting on a broad range of substrates: reduces ketosteroids, aromatic aldehydes, ketones, sugars and other aliphatic aldehydes, and oxidizes hydroxysteroids. May function as detoxifiying enzyme by reducing a range of toxic aldehydes and ketones produced during stress.<ref>PMID:19616008</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arath~~]]	+	[[Category: Arabidopsis thaliana]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ride~~, J P~~]]	+	[[Category: Ride JP]]
-	[[Category: Simpson~~, P J~~]]	+	[[Category: Simpson PJ]]
-	[[Category: White~~, S A]]~~	+	[[Category: White SA]]
-	~~[[Category: Aldo-keto reductase]]~~	+
-	~~[[Category: Drought tolerance]]~~	+
-	~~[[Category: Nadp]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Stress response~~]]	+

OCA at 08:05, 16 March 2022

OCA — Wed, 16 Mar 2022 08:05:25 GMT

←Older revision		Revision as of 08:05, 16 March 2022
Line 1:		Line 1:

	==Crystal structure of the plant stress-response enzyme AKR4C8==		==Crystal structure of the plant stress-response enzyme AKR4C8==
-	<StructureSection load='3h7r' size='340' side='right' caption='[[3h7r]], [[Resolution\|resolution]] 1.40Å' scene=''>	+	<StructureSection load='3h7r' size='340' side='right'caption='[[3h7r]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3h7r]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H7R OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3H7R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3h7r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H7R FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3h7u\|3h7u]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3h7u\|3h7u]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At2g37760, DQ837653 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At2g37760, DQ837653 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3h7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h7r OCA], [~~http~~://pdbe.org/3h7r PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3h7r RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3h7r PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3h7r ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h7r OCA], [https://pdbe.org/3h7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h7r RCSB], [https://www.ebi.ac.uk/pdbsum/3h7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h7r ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/AKRC8_ARATH AKRC8_ARATH]] Oxidoreductase acting on a broad range of substrates: reduces ketosteroids, aromatic aldehydes, ketones, sugars and other aliphatic aldehydes, and oxidizes hydroxysteroids. May function as detoxifiying enzyme by reducing a range of toxic aldehydes and ketones produced during stress.<ref>PMID:19616008</ref>	+	[[https://www.uniprot.org/uniprot/AKRC8_ARATH AKRC8_ARATH]] Oxidoreductase acting on a broad range of substrates: reduces ketosteroids, aromatic aldehydes, ketones, sugars and other aliphatic aldehydes, and oxidizes hydroxysteroids. May function as detoxifiying enzyme by reducing a range of toxic aldehydes and ketones produced during stress.<ref>PMID:19616008</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h7/3h7r_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h7/3h7r_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 3h7r" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3h7r" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aldo-keto reductase 3D structures\|Aldo-keto reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Arath]]		[[Category: Arath]]
		+	[[Category: Large Structures]]
	[[Category: Ride, J P]]		[[Category: Ride, J P]]
	[[Category: Simpson, P J]]		[[Category: Simpson, P J]]

OCA at 07:24, 1 November 2017

OCA — Wed, 01 Nov 2017 07:24:01 GMT

←Older revision		Revision as of 07:24, 1 November 2017
Line 1:		Line 1:
		+
	==Crystal structure of the plant stress-response enzyme AKR4C8==		==Crystal structure of the plant stress-response enzyme AKR4C8==
	<StructureSection load='3h7r' size='340' side='right' caption='[[3h7r]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='3h7r' size='340' side='right' caption='[[3h7r]], [[Resolution\|resolution]] 1.40Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3h7u\|3h7u]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3h7u\|3h7u]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At2g37760, DQ837653 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At2g37760, DQ837653 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h7r OCA], [http://pdbe.org/3h7r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3h7r RCSB], [http://www.ebi.ac.uk/pdbsum/3h7r PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h7r OCA], [http://pdbe.org/3h7r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3h7r RCSB], [http://www.ebi.ac.uk/pdbsum/3h7r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3h7r ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 01:59, 9 February 2016

OCA — Tue, 09 Feb 2016 01:59:57 GMT

←Older revision		Revision as of 01:59, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3h7r' size='340' side='right' caption='[[3h7r]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='3h7r' size='340' side='right' caption='[[3h7r]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3h7r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Arabidopsis_thaliana Arabidopsis thaliana~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H7R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H7R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3h7r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H7R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H7R FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3h7u\|3h7u]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3h7u\|3h7u]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At2g37760, DQ837653 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ~~Arabidopsis thaliana~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At2g37760, DQ837653 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h7r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h7r RCSB], [http://www.ebi.ac.uk/pdbsum/3h7r PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h7r OCA], [http://pdbe.org/3h7r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3h7r RCSB], [http://www.ebi.ac.uk/pdbsum/3h7r PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~O80944_ARATH O80944_ARATH~~]] Oxidoreductase acting on a broad range of substrates: reduces ketosteroids, aromatic aldehydes, ketones, sugars and other aliphatic aldehydes, and oxidizes hydroxysteroids. May function as detoxifiying enzyme by reducing a range of toxic aldehydes and ketones produced during stress.<ref>PMID:19616008</ref>	+	[[http://www.uniprot.org/uniprot/AKRC8_ARATH AKRC8_ARATH]] Oxidoreductase acting on a broad range of substrates: reduces ketosteroids, aromatic aldehydes, ketones, sugars and other aliphatic aldehydes, and oxidizes hydroxysteroids. May function as detoxifiying enzyme by reducing a range of toxic aldehydes and ketones produced during stress.<ref>PMID:19616008</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h7r ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3h7r" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arabidopsis thaliana~~]]	+	[[Category: Arath]]
	[[Category: Ride, J P]]		[[Category: Ride, J P]]
	[[Category: Simpson, P J]]		[[Category: Simpson, P J]]

OCA at 03:38, 25 December 2014

OCA — Thu, 25 Dec 2014 03:38:52 GMT

←Older revision		Revision as of 03:38, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h7r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h7r RCSB], [http://www.ebi.ac.uk/pdbsum/3h7r PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h7r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h7r RCSB], [http://www.ebi.ac.uk/pdbsum/3h7r PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/O80944_ARATH O80944_ARATH]] Oxidoreductase acting on a broad range of substrates: reduces ketosteroids, aromatic aldehydes, ketones, sugars and other aliphatic aldehydes, and oxidizes hydroxysteroids. May function as detoxifiying enzyme by reducing a range of toxic aldehydes and ketones produced during stress.<ref>PMID:19616008</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:41, 8 December 2014

OCA — Mon, 08 Dec 2014 09:41:28 GMT

←Older revision		Revision as of 09:41, 8 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3h7r.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of the plant stress-response enzyme AKR4C8==
		+	<StructureSection load='3h7r' size='340' side='right' caption='[[3h7r]], [[Resolution\|resolution]] 1.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3h7r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H7R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H7R FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3h7u\|3h7u]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At2g37760, DQ837653 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h7r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h7r RCSB], [http://www.ebi.ac.uk/pdbsum/3h7r PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h7/3h7r_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aldo-keto reductases (AKRs) are widely distributed in nature and play numerous roles in the metabolism of steroids, sugars, and other carbonyls. They have also frequently been implicated in the metabolism of exogenous and endogenous toxicants, including those stimulated by stress. Although the Arabidopsis genome includes at least 21 genes with the AKR signature, very little is known of their functions. In this study, we have screened the Arabidopsis thaliana genomic sequence for genes with significant homology to members of the mammalian AKR1 family and identified four homologues for further study. Following alignment of the predicted protein sequences with representatives from the AKR superfamily, the proteins were ascribed not to the AKR1 family but to the AKR4C subfamily, with the individual designations of AKR4C8, AKR4C9, AKR4C10, and AKR4C11. Expression of two of the genes, AKR4C8 and AKR4C9, has been shown to be coordinately regulated and markedly induced by various forms of stress. The genes have been overexpressed in bacteria, and recombinant proteins have been purified and crystallized. Both enzymes display NADPH-dependent reduction of carbonyl compounds, typical of the superfamily, but will accept a very wide range of substrates, reducing a range of steroids, sugars, and aliphatic and aromatic aldehydes/ketones, although there are distinct differences between the two enzymes. We have obtained high-resolution crystal structures of AKR4C8 (1.4 A) and AKR4C9 (1.25 A) in ternary complexes with NADP(+) and acetate. Three extended loops, present in all AKRs and responsible for defining the cofactor- and substrate-binding sites, are shorter in the 4C subfamily compared to other AKRs. Consequently, the crystal structures reveal open and accommodative substrate-binding sites, which correlates with their broad substrate specificity. It is suggested that the primary role of these enzymes may be to detoxify a range of toxic aldehydes and ketones produced during stress, although the precise nature of the principal natural substrates remains to be determined.

-	~~{{STRUCTURE_3h7r\| PDB=3h7r \| SCENE= }}~~	+	Characterization of two novel aldo-keto reductases from Arabidopsis: expression patterns, broad substrate specificity, and an open active-site structure suggest a role in toxicant metabolism following stress.,Simpson PJ, Tantitadapitak C, Reed AM, Mather OC, Bunce CM, White SA, Ride JP J Mol Biol. 2009 Sep 18;392(2):465-80. Epub 2009 Jul 15. PMID:19616008<ref>PMID:19616008</ref>

-	~~===Crystal structure~~ of the ~~plant stress-response enzyme AKR4C8===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19616008}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3h7r]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3H7R OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019616008<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
-	[[Category: Ride, J P.]]	+	[[Category: Ride, J P]]
-	[[Category: Simpson, P J.]]	+	[[Category: Simpson, P J]]
-	[[Category: White, S A.]]	+	[[Category: White, S A]]
	[[Category: Aldo-keto reductase]]		[[Category: Aldo-keto reductase]]
	[[Category: Drought tolerance]]		[[Category: Drought tolerance]]

OCA: Protected "3h7r" [edit=sysop:move=sysop]

OCA — Wed, 06 Mar 2013 15:05:25 GMT

Protected "3h7r" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:05, 6 March 2013

OCA at 15:05, 6 March 2013

OCA — Wed, 06 Mar 2013 15:05:22 GMT

←Older revision		Revision as of 15:05, 6 March 2013
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-	{{Seed}}
	[[Image:3h7r.png\|left\|200px]]		[[Image:3h7r.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3h7r", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3h7r\| PDB=3h7r \| SCENE= }}		{{STRUCTURE_3h7r\| PDB=3h7r \| SCENE= }}

	===Crystal structure of the plant stress-response enzyme AKR4C8===		===Crystal structure of the plant stress-response enzyme AKR4C8===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19616008}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19616008 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19616008}}		{{ABSTRACT_PUBMED_19616008}}

	==About this Structure==		==About this Structure==
-	~~3H7R~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H7R OCA].	+	[[3h7r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H7R OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19616008~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019616008</ref><references group="xtra"/>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Ride, J P.]]		[[Category: Ride, J P.]]
Line 33:		Line 21:
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Stress response]]		[[Category: Stress response]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:36:37 2009''

OCA at 05:36, 16 September 2009

OCA — Wed, 16 Sep 2009 05:36:38 GMT

←Older revision		Revision as of 05:36, 16 September 2009
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	{{Seed}}		{{Seed}}
-	[[Image:3h7r.~~jpg~~\|left\|200px]]	+	[[Image:3h7r.png\|left\|200px]]

	<!--		<!--
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	[[Category: Stress response]]		[[Category: Stress response]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug 5 10~~:32:52 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:36:37 2009''

OCA at 07:32, 5 August 2009

OCA — Wed, 05 Aug 2009 07:32:57 GMT

←Older revision		Revision as of 07:32, 5 August 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3h7r.jpg\|left\|200px]]

-	The ~~entry 3h7r~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3h7r", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3h7r\| PDB=3h7r \| SCENE= }}

-	~~Authors: White, S.A., Simpson, P.J., Ride, J.P.~~	+	===Crystal structure of the plant stress-response enzyme AKR4C8===

-	Description: Crystal structure of the plant stress-response enzyme AKR4C8

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jun 17 09~~:44:27 2009''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19616008}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19616008 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19616008}}
		+
		+	==About this Structure==
		+	3H7R is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H7R OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19616008</ref><references group="xtra"/>
		+	[[Category: Arabidopsis thaliana]]
		+	[[Category: Ride, J P.]]
		+	[[Category: Simpson, P J.]]
		+	[[Category: White, S A.]]
		+	[[Category: Aldo-keto reductase]]
		+	[[Category: Drought tolerance]]
		+	[[Category: Nadp]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Stress response]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 5 10:32:52 2009''