3h90 - Revision history

OCA at 09:58, 21 February 2024

OCA — Wed, 21 Feb 2024 09:58:41 GMT

←Older revision		Revision as of 09:58, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='3h90' size='340' side='right'caption='[[3h90]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='3h90' size='340' side='right'caption='[[3h90]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3h90]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H90 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H90 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3h90]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H90 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H90 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~fieF, yiiP, b3915, JW3886~~ (~~[https:~~/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=83333 ECOLI])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h90 OCA], [https://pdbe.org/3h90 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h90 RCSB], [https://www.ebi.ac.uk/pdbsum/3h90 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h90 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h90 OCA], [https://pdbe.org/3h90 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h90 RCSB], [https://www.ebi.ac.uk/pdbsum/3h90 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h90 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FIEF_ECOLI FIEF_ECOLI]] Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2+) in a proton-dependent manner.<ref>PMID:15549269</ref>	+	[https://www.uniprot.org/uniprot/FIEF_ECOLI FIEF_ECOLI] Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2+) in a proton-dependent manner.<ref>PMID:15549269</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h90 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h90 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Zinc transporters have crucial roles in cellular zinc homeostatic control. The 2.9-A resolution structure of the zinc transporter YiiP from Escherichia coli reveals a richly charged dimer interface stabilized by zinc binding. Site-directed fluorescence resonance energy transfer (FRET) measurements and mutation-activity analysis suggest that zinc binding triggers hinge movements of two electrically repulsive cytoplasmic domains pivoting around four salt bridges situated at the juncture of the cytoplasmic and transmembrane domains. These highly conserved salt bridges interlock transmembrane helices at the dimer interface, where they are well positioned to transmit zinc-induced interdomain movements to reorient transmembrane helices, thereby modulating coordination geometry of the active site for zinc transport. The cytoplasmic domain of YiiP is a structural mimic of metal-trafficking proteins and the metal-binding domains of metal-transporting P-type ATPases. The use of this common structural module to regulate metal coordination chemistry may enable a tunable transport activity in response to cytoplasmic metal fluctuations.
-
-	Structural basis for autoregulation of the zinc transporter YiiP.,Lu M, Chai J, Fu D Nat Struct Mol Biol. 2009 Oct;16(10):1063-7. Epub 2009 Sep 13. PMID:19749753<ref>PMID:19749753</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3h90" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ecoli~~]]	+	[[Category: Escherichia coli K-12]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lu, M]]	+	[[Category: Lu M]]
-	~~[[Category: Cell inner membrane]]~~	+
-	~~[[Category: Cell membrane]]~~	+
-	~~[[Category: Ion transport]]~~	+
-	~~[[Category: Iron]]~~	+
-	~~[[Category: Iron transport]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Transmembrane]]~~	+
-	~~[[Category: Transport]]~~	+
-	~~[[Category: Transport protein]]~~	+
-	~~[[Category: Zinc transporter~~]]	+

OCA at 08:06, 16 March 2022

OCA — Wed, 16 Mar 2022 08:06:29 GMT

←Older revision		Revision as of 08:06, 16 March 2022
Line 1:		Line 1:

	==Structural basis for the autoregulation of the zinc transporter YiiP==		==Structural basis for the autoregulation of the zinc transporter YiiP==
-	<StructureSection load='3h90' size='340' side='right' caption='[[3h90]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='3h90' size='340' side='right'caption='[[3h90]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3h90]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H90 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3H90 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3h90]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H90 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H90 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fieF, yiiP, b3915, JW3886 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fieF, yiiP, b3915, JW3886 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3h90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h90 OCA], [~~http~~://pdbe.org/3h90 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3h90 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3h90 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3h90 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h90 OCA], [https://pdbe.org/3h90 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h90 RCSB], [https://www.ebi.ac.uk/pdbsum/3h90 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h90 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FIEF_ECOLI FIEF_ECOLI]] Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2+) in a proton-dependent manner.<ref>PMID:15549269</ref>	+	[[https://www.uniprot.org/uniprot/FIEF_ECOLI FIEF_ECOLI]] Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2+) in a proton-dependent manner.<ref>PMID:15549269</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Ecoli]]		[[Category: Ecoli]]
		+	[[Category: Large Structures]]
	[[Category: Lu, M]]		[[Category: Lu, M]]
	[[Category: Cell inner membrane]]		[[Category: Cell inner membrane]]

OCA at 05:41, 7 December 2018

OCA — Fri, 07 Dec 2018 05:41:43 GMT

←Older revision		Revision as of 05:41, 7 December 2018
Line 1:		Line 1:
		+
	==Structural basis for the autoregulation of the zinc transporter YiiP==		==Structural basis for the autoregulation of the zinc transporter YiiP==
	<StructureSection load='3h90' size='340' side='right' caption='[[3h90]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='3h90' size='340' side='right' caption='[[3h90]], [[Resolution\|resolution]] 2.90Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fieF, yiiP, b3915, JW3886 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fieF, yiiP, b3915, JW3886 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h90 OCA], [http://pdbe.org/3h90 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3h90 RCSB], [http://www.ebi.ac.uk/pdbsum/3h90 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h90 OCA], [http://pdbe.org/3h90 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3h90 RCSB], [http://www.ebi.ac.uk/pdbsum/3h90 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3h90 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h9/3h90_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h9/3h90_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 08:04, 9 February 2016

OCA — Tue, 09 Feb 2016 08:04:20 GMT

←Older revision		Revision as of 08:04, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3h90' size='340' side='right' caption='[[3h90]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='3h90' size='340' side='right' caption='[[3h90]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3h90]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli_k-12 Escherichia coli k-12~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H90 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H90 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3h90]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H90 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H90 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fieF, yiiP, b3915, JW3886 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ~~Escherichia coli K-12~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fieF, yiiP, b3915, JW3886 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h90 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h90 RCSB], [http://www.ebi.ac.uk/pdbsum/3h90 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h90 OCA], [http://pdbe.org/3h90 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3h90 RCSB], [http://www.ebi.ac.uk/pdbsum/3h90 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h90 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3h90" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia coli k-12~~]]	+	[[Category: Ecoli]]
	[[Category: Lu, M]]		[[Category: Lu, M]]
	[[Category: Cell inner membrane]]		[[Category: Cell inner membrane]]

OCA at 05:34, 25 December 2014

OCA — Thu, 25 Dec 2014 05:34:34 GMT

←Older revision		Revision as of 05:34, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h90 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h90 RCSB], [http://www.ebi.ac.uk/pdbsum/3h90 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h90 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h90 RCSB], [http://www.ebi.ac.uk/pdbsum/3h90 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FIEF_ECOLI FIEF_ECOLI]] Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2+) in a proton-dependent manner.<ref>PMID:15549269</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:17, 8 December 2014

OCA — Mon, 08 Dec 2014 09:17:18 GMT

←Older revision		Revision as of 09:17, 8 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3h90.~~png~~\|~~left~~\|200px]]	+	==Structural basis for the autoregulation of the zinc transporter YiiP==
		+	<StructureSection load='3h90' size='340' side='right' caption='[[3h90]], [[Resolution\|resolution]] 2.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3h90]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H90 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H90 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fieF, yiiP, b3915, JW3886 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 Escherichia coli K-12])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h90 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h90 RCSB], [http://www.ebi.ac.uk/pdbsum/3h90 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h9/3h90_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Zinc transporters have crucial roles in cellular zinc homeostatic control. The 2.9-A resolution structure of the zinc transporter YiiP from Escherichia coli reveals a richly charged dimer interface stabilized by zinc binding. Site-directed fluorescence resonance energy transfer (FRET) measurements and mutation-activity analysis suggest that zinc binding triggers hinge movements of two electrically repulsive cytoplasmic domains pivoting around four salt bridges situated at the juncture of the cytoplasmic and transmembrane domains. These highly conserved salt bridges interlock transmembrane helices at the dimer interface, where they are well positioned to transmit zinc-induced interdomain movements to reorient transmembrane helices, thereby modulating coordination geometry of the active site for zinc transport. The cytoplasmic domain of YiiP is a structural mimic of metal-trafficking proteins and the metal-binding domains of metal-transporting P-type ATPases. The use of this common structural module to regulate metal coordination chemistry may enable a tunable transport activity in response to cytoplasmic metal fluctuations.

-	~~{{STRUCTURE_3h90\| PDB=3h90 \| SCENE= }}~~	+	Structural basis for autoregulation of the zinc transporter YiiP.,Lu M, Chai J, Fu D Nat Struct Mol Biol. 2009 Oct;16(10):1063-7. Epub 2009 Sep 13. PMID:19749753<ref>PMID:19749753</ref>

-	~~===Structural basis for the autoregulation~~ of the ~~zinc transporter YiiP===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19749753}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3h90]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3H90 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019749753<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Escherichia coli k-12]]		[[Category: Escherichia coli k-12]]
-	[[Category: Lu, M.]]	+	[[Category: Lu, M]]
	[[Category: Cell inner membrane]]		[[Category: Cell inner membrane]]
	[[Category: Cell membrane]]		[[Category: Cell membrane]]

OCA: Protected "3h90" [edit=sysop:move=sysop]

OCA — Wed, 06 Mar 2013 14:41:07 GMT

Protected "3h90" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:41, 6 March 2013

OCA at 14:41, 6 March 2013

OCA — Wed, 06 Mar 2013 14:41:04 GMT

←Older revision		Revision as of 14:41, 6 March 2013
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-	{{Seed}}
	[[Image:3h90.png\|left\|200px]]		[[Image:3h90.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3h90", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3h90\| PDB=3h90 \| SCENE= }}		{{STRUCTURE_3h90\| PDB=3h90 \| SCENE= }}

	===Structural basis for the autoregulation of the zinc transporter YiiP===		===Structural basis for the autoregulation of the zinc transporter YiiP===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19749753}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19749753 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19749753}}		{{ABSTRACT_PUBMED_19749753}}

	==About this Structure==		==About this Structure==
-	~~3H90~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H90 OCA].	+	[[3h90]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H90 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19749753~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019749753</ref><references group="xtra"/>
	[[Category: Escherichia coli k-12]]		[[Category: Escherichia coli k-12]]
	[[Category: Lu, M.]]		[[Category: Lu, M.]]
Line 37:		Line 25:
	[[Category: Transport protein]]		[[Category: Transport protein]]
	[[Category: Zinc transporter]]		[[Category: Zinc transporter]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 21 09:39:29 2009''

OCA at 07:39, 21 October 2009

OCA — Wed, 21 Oct 2009 07:39:29 GMT

←Older revision		Revision as of 07:39, 21 October 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3h90.~~jpg~~\|left\|200px]]	+	[[Image:3h90.png\|left\|200px]]

	<!--		<!--
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	===Structural basis for the autoregulation of the zinc transporter YiiP===		===Structural basis for the autoregulation of the zinc transporter YiiP===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19749753}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19749753 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19749753}}

	==About this Structure==		==About this Structure==
	3H90 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H90 OCA].		3H90 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H90 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19749753</ref><references group="xtra"/>
	[[Category: Escherichia coli k-12]]		[[Category: Escherichia coli k-12]]
	[[Category: Lu, M.]]		[[Category: Lu, M.]]
Line 29:		Line 38:
	[[Category: Zinc transporter]]		[[Category: Zinc transporter]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 9~~ 09:46:58 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 21 09:39:29 2009''

OCA at 06:46, 9 September 2009

OCA — Wed, 09 Sep 2009 06:46:59 GMT

←Older revision		Revision as of 06:46, 9 September 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3h90.jpg\|left\|200px]]

-	The ~~entry 3h90~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3h90", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3h90\| PDB=3h90 \| SCENE= }}

-	~~Authors: Lu, M.~~	+	===Structural basis for the autoregulation of the zinc transporter YiiP===

-	Description: Structural basis for the autoregulation of the zinc transporter YiiP

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~May 20 16~~:38:30 2009''	+	==About this Structure==
		+	3H90 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H90 OCA].
		+	[[Category: Escherichia coli k-12]]
		+	[[Category: Lu, M.]]
		+	[[Category: Cell inner membrane]]
		+	[[Category: Cell membrane]]
		+	[[Category: Ion transport]]
		+	[[Category: Iron]]
		+	[[Category: Iron transport]]
		+	[[Category: Membrane]]
		+	[[Category: Membrane protein]]
		+	[[Category: Transmembrane]]
		+	[[Category: Transport]]
		+	[[Category: Transport protein]]
		+	[[Category: Zinc transporter]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 9 09:46:58 2009''