3hbx - Revision history

OCA at 07:19, 6 September 2023

OCA — Wed, 06 Sep 2023 07:19:39 GMT

←Older revision		Revision as of 07:19, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3hbx' size='340' side='right'caption='[[3hbx]], [[Resolution\|resolution]] 2.67Å' scene=''>		<StructureSection load='3hbx' size='340' side='right'caption='[[3hbx]], [[Resolution\|resolution]] 2.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hbx]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HBX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hbx]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HBX FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=LLP:(2S)-2-AMINO-6~~-[[~~3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL~~]~~METHYLIDENEAMINO~~]~~HEXANOIC+ACID'>LLP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.672Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>At5g17330, GAD, GAD1, GDH1, MKP11.30, MKP11_18 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=3702 ARATH])</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Glutamate_decarboxylase Glutamate decarboxylase], with EC number~~ [~~https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=~~4~~.1.1.15 4.1.1.15~~] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hbx OCA], [https://pdbe.org/3hbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hbx RCSB], [https://www.ebi.ac.uk/pdbsum/3hbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hbx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hbx OCA], [https://pdbe.org/3hbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hbx RCSB], [https://www.ebi.ac.uk/pdbsum/3hbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hbx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DCE1_ARATH DCE1_ARATH]] Catalyzes the production of GABA. The calmodulin-binding is calcium-dependent and it is proposed that this may, directly or indirectly, form a calcium regulated control of GABA biosynthesis.<ref>PMID:9700069</ref>	+	[https://www.uniprot.org/uniprot/DCE1_ARATH DCE1_ARATH] Catalyzes the production of GABA. The calmodulin-binding is calcium-dependent and it is proposed that this may, directly or indirectly, form a calcium regulated control of GABA biosynthesis.<ref>PMID:9700069</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arath]]~~	+	[[Category: Arabidopsis thaliana]]
-	~~[[Category: Glutamate decarboxylase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Capitani, G]]	+	[[Category: Capitani G]]
-	[[Category: Dominici, P]]	+	[[Category: Dominici P]]
-	[[Category: Gruetter~~, M G~~]]	+	[[Category: Gruetter MG]]
-	[[Category: Gut, H]]	+	[[Category: Gut H]]
-	[[Category: Pilati, S]]	+	[[Category: Pilati S]]
-	~~[[Category: Calmodulin-binding]]~~	+
-	~~[[Category: Decarboxylase]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Pyridoxal phosphate~~]]	+

OCA at 08:08, 16 March 2022

OCA — Wed, 16 Mar 2022 08:08:22 GMT

←Older revision		Revision as of 08:08, 16 March 2022
Line 1:		Line 1:

	==Crystal structure of GAD1 from Arabidopsis thaliana==		==Crystal structure of GAD1 from Arabidopsis thaliana==
-	<StructureSection load='3hbx' size='340' side='right' caption='[[3hbx]], [[Resolution\|resolution]] 2.67Å' scene=''>	+	<StructureSection load='3hbx' size='340' side='right'caption='[[3hbx]], [[Resolution\|resolution]] 2.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hbx]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HBX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3HBX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hbx]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HBX FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At5g17330, GAD, GAD1, GDH1, MKP11.30, MKP11_18 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At5g17330, GAD, GAD1, GDH1, MKP11.30, MKP11_18 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glutamate_decarboxylase Glutamate decarboxylase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.15 4.1.1.15] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutamate_decarboxylase Glutamate decarboxylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.15 4.1.1.15] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3hbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hbx OCA], [~~http~~://pdbe.org/3hbx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3hbx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3hbx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3hbx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hbx OCA], [https://pdbe.org/3hbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hbx RCSB], [https://www.ebi.ac.uk/pdbsum/3hbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hbx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DCE1_ARATH DCE1_ARATH]] Catalyzes the production of GABA. The calmodulin-binding is calcium-dependent and it is proposed that this may, directly or indirectly, form a calcium regulated control of GABA biosynthesis.<ref>PMID:9700069</ref>	+	[[https://www.uniprot.org/uniprot/DCE1_ARATH DCE1_ARATH]] Catalyzes the production of GABA. The calmodulin-binding is calcium-dependent and it is proposed that this may, directly or indirectly, form a calcium regulated control of GABA biosynthesis.<ref>PMID:9700069</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hb/3hbx_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hb/3hbx_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 36:		Line 36:
	[[Category: Arath]]		[[Category: Arath]]
	[[Category: Glutamate decarboxylase]]		[[Category: Glutamate decarboxylase]]
		+	[[Category: Large Structures]]
	[[Category: Capitani, G]]		[[Category: Capitani, G]]
	[[Category: Dominici, P]]		[[Category: Dominici, P]]

OCA at 22:08, 5 August 2016

OCA — Fri, 05 Aug 2016 22:08:56 GMT

←Older revision		Revision as of 22:08, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of GAD1 from Arabidopsis thaliana==		==Crystal structure of GAD1 from Arabidopsis thaliana==
	<StructureSection load='3hbx' size='340' side='right' caption='[[3hbx]], [[Resolution\|resolution]] 2.67Å' scene=''>		<StructureSection load='3hbx' size='340' side='right' caption='[[3hbx]], [[Resolution\|resolution]] 2.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hbx]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Arabidopsis_thaliana Arabidopsis thaliana~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HBX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hbx]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HBX FirstGlance]. <br>
-	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:2-~~LYSINE(~~3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-~~YLMETHANE)~~'>LLP</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At5g17330, GAD, GAD1, GDH1, MKP11.30, MKP11_18 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ~~Arabidopsis thaliana~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At5g17330, GAD, GAD1, GDH1, MKP11.30, MKP11_18 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate_decarboxylase Glutamate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.15 4.1.1.15] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate_decarboxylase Glutamate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.15 4.1.1.15] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hbx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hbx RCSB], [http://www.ebi.ac.uk/pdbsum/3hbx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hbx OCA], [http://pdbe.org/3hbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hbx RCSB], [http://www.ebi.ac.uk/pdbsum/3hbx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hbx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hbx ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3hbx" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arabidopsis thaliana~~]]	+	[[Category: Arath]]
	[[Category: Glutamate decarboxylase]]		[[Category: Glutamate decarboxylase]]
	[[Category: Capitani, G]]		[[Category: Capitani, G]]

OCA at 22:20, 25 December 2014

OCA — Thu, 25 Dec 2014 22:20:45 GMT

←Older revision		Revision as of 22:20, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hbx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hbx RCSB], [http://www.ebi.ac.uk/pdbsum/3hbx PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hbx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hbx RCSB], [http://www.ebi.ac.uk/pdbsum/3hbx PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DCE1_ARATH DCE1_ARATH]] Catalyzes the production of GABA. The calmodulin-binding is calcium-dependent and it is proposed that this may, directly or indirectly, form a calcium regulated control of GABA biosynthesis.<ref>PMID:9700069</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 17:19, 18 December 2014

OCA — Thu, 18 Dec 2014 17:19:39 GMT

←Older revision		Revision as of 17:19, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3hbx\| PDB~~=3hbx \| ~~SCENE~~= }}	+	==Crystal structure of GAD1 from Arabidopsis thaliana==
-	===~~Crystal~~ structure ~~of GAD1~~ from Arabidopsis thaliana===	+	<StructureSection load='3hbx' size='340' side='right' caption='[[3hbx]], [[Resolution\|resolution]] 2.67Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19580813}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3hbx]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HBX FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE)'>LLP</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">At5g17330, GAD, GAD1, GDH1, MKP11.30, MKP11_18 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate_decarboxylase Glutamate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.15 4.1.1.15] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hbx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hbx RCSB], [http://www.ebi.ac.uk/pdbsum/3hbx PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hb/3hbx_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Glutamate decarboxylase (Gad) catalyzes glutamate to gamma-aminobutyrate conversion. Plant Gad is a approximately 340 kDa hexamer, involved in development and stress response, and regulated by pH and binding of Ca(2+)/calmodulin (CaM) to the C-terminal domain. We determined the crystal structure of Arabidopsis thaliana Gad1 in its CaM-free state, obtained a low-resolution structure of the calmodulin-activated Gad complex by small-angle X-ray scattering and identified the crucial residues, in the C-terminal domain, for regulation by pH and CaM binding. CaM activates Gad1 in a unique way by relieving two C-terminal autoinhibition domains of adjacent active sites, forming a 393 kDa Gad1-CaM complex with an unusual 1:3 stoichiometry. The complex is loosely packed: thanks to the flexible linkers connecting the enzyme core with the six C-terminal regulatory domains, the CaM molecules retain considerable positional and orientational freedom with respect to Gad1. The complex thus represents a prototype for a novel CaM-target interaction mode. Thanks to its two levels of regulation, both targeting the C-terminal domain, Gad can respond flexibly to different kinds of cellular stress occurring at different pH values.

-	~~==Function==~~	+	A common structural basis for pH- and calmodulin-mediated regulation in plant glutamate decarboxylase.,Gut H, Dominici P, Pilati S, Astegno A, Petoukhov MV, Svergun DI, Grutter MG, Capitani G J Mol Biol. 2009 Sep 18;392(2):334-51. Epub 2009 Jul 4. PMID:19580813<ref>PMID:19580813</ref>
-	~~[[http://www.uniprot.org/uniprot/DCE1_ARATH DCE1_ARATH]] Catalyzes the production of GABA. The calmodulin~~-~~binding is calcium-dependent~~ and ~~it is proposed that this may~~, ~~directly or indirectly~~, ~~form a calcium regulated control of GABA biosynthesis~~.<ref>PMID:~~9700069~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3hbx]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3HBX OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:019580813</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Glutamate decarboxylase]]		[[Category: Glutamate decarboxylase]]
-	[[Category: Capitani, G.]]	+	[[Category: Capitani, G]]
-	[[Category: Dominici, P.]]	+	[[Category: Dominici, P]]
-	[[Category: Gruetter, M G.]]	+	[[Category: Gruetter, M G]]
-	[[Category: Gut, H.]]	+	[[Category: Gut, H]]
-	[[Category: Pilati, S.]]	+	[[Category: Pilati, S]]
	[[Category: Calmodulin-binding]]		[[Category: Calmodulin-binding]]
	[[Category: Decarboxylase]]		[[Category: Decarboxylase]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Pyridoxal phosphate]]		[[Category: Pyridoxal phosphate]]

OCA at 09:42, 27 March 2013

OCA — Wed, 27 Mar 2013 09:42:35 GMT

←Older revision		Revision as of 09:42, 27 March 2013
Line 1:		Line 1:
-	[[Image:3hbx.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3hbx", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3hbx\| PDB=3hbx \| SCENE= }}		{{STRUCTURE_3hbx\| PDB=3hbx \| SCENE= }}
-
	===Crystal structure of GAD1 from Arabidopsis thaliana===		===Crystal structure of GAD1 from Arabidopsis thaliana===
		+	{{ABSTRACT_PUBMED_19580813}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/DCE1_ARATH DCE1_ARATH]] Catalyzes the production of GABA. The calmodulin-binding is calcium-dependent and it is proposed that this may, directly or indirectly, form a calcium regulated control of GABA biosynthesis.<ref>PMID:9700069</ref>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_19580813}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 19580813 is~~ the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_19580813}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:019580813</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019580813</ref><references group="xtra"/><references/>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Glutamate decarboxylase]]		[[Category: Glutamate decarboxylase]]

OCA: Protected "3hbx" [edit=sysop:move=sysop]

OCA — Thu, 26 May 2011 11:48:33 GMT

Protected "3hbx" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:48, 26 May 2011

OCA at 11:48, 26 May 2011

OCA — Thu, 26 May 2011 11:48:31 GMT

←Older revision		Revision as of 11:48, 26 May 2011
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-	{{Seed}}
	[[Image:3hbx.png\|left\|200px]]		[[Image:3hbx.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	~~3HBX~~ is a 6 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HBX OCA].	+	[[3hbx]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HBX OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19580813~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019580813</ref><references group="xtra"/>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Glutamate decarboxylase]]		[[Category: Glutamate decarboxylase]]
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	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Pyridoxal phosphate]]		[[Category: Pyridoxal phosphate]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:35:38 2009''

OCA at 05:35, 16 September 2009

OCA — Wed, 16 Sep 2009 05:35:38 GMT

←Older revision		Revision as of 05:35, 16 September 2009
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3hbx.png\|left\|200px]]

-	The ~~entry 3hbx~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3hbx", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3hbx\| PDB=3hbx \| SCENE= }}

-	~~Authors: Gut, H., Dominici, P., Pilati, S., Gruetter, M.G., Capitani, G.~~	+	===Crystal structure of GAD1 from Arabidopsis thaliana===

-	Description: Crystal structure of GAD1 from Arabidopsis thaliana

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Jun 4 07~~:18:12 2009''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19580813}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19580813 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19580813}}
		+
		+	==About this Structure==
		+	3HBX is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HBX OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19580813</ref><references group="xtra"/>
		+	[[Category: Arabidopsis thaliana]]
		+	[[Category: Glutamate decarboxylase]]
		+	[[Category: Capitani, G.]]
		+	[[Category: Dominici, P.]]
		+	[[Category: Gruetter, M G.]]
		+	[[Category: Gut, H.]]
		+	[[Category: Pilati, S.]]
		+	[[Category: Calmodulin-binding]]
		+	[[Category: Decarboxylase]]
		+	[[Category: Lyase]]
		+	[[Category: Pyridoxal phosphate]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:35:38 2009''

OCA at 04:18, 4 June 2009

OCA — Thu, 04 Jun 2009 04:18:12 GMT

←Older revision		Revision as of 04:18, 4 June 2009
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3hbx is ON HOLD	+	The entry 3hbx is ON HOLD until Paper Publication

	Authors: Gut, H., Dominici, P., Pilati, S., Gruetter, M.G., Capitani, G.		Authors: Gut, H., Dominici, P., Pilati, S., Gruetter, M.G., Capitani, G.
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	Description: Crystal structure of GAD1 from Arabidopsis thaliana		Description: Crystal structure of GAD1 from Arabidopsis thaliana

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed May 13 09~~:37:48 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 4 07:18:12 2009''