3hc8 - Revision history

OCA at 12:44, 26 July 2023

OCA — Wed, 26 Jul 2023 12:44:53 GMT

←Older revision		Revision as of 12:44, 26 July 2023
Line 3:		Line 3:
	<StructureSection load='3hc8' size='340' side='right'caption='[[3hc8]], [[Resolution\|resolution]] 1.79Å' scene=''>		<StructureSection load='3hc8' size='340' side='right'caption='[[3hc8]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hc8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HC8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hc8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HC8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PD4:6-(6-METHOXYPYRIDIN-3-YL)-2-[(2-MORPHOLIN-4-YLETHYL)AMINO]-4-(2-PROPOXYETHYL)PYRIDO[2,3-B]PYRAZIN-3(4H)-ONE'>PD4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.79Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2h40\|2h40]], [[2h42\|2h42]], [[2h44\|2h44]], [[3bjc\|3bjc]], [[1uho\|1uho]], [[2chm\|2chm]], [[3hdz\|3hdz]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PD4:6-(6-METHOXYPYRIDIN-3-YL)-2-[(2-MORPHOLIN-4-YLETHYL)AMINO]-4-(2-PROPOXYETHYL)PYRIDO[2,3-B]PYRAZIN-3(4H)-ONE'>PD4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE5A, PDE5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hc8 OCA], [https://pdbe.org/3hc8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hc8 RCSB], [https://www.ebi.ac.uk/pdbsum/3hc8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hc8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hc8 OCA], [https://pdbe.org/3hc8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hc8 RCSB], [https://www.ebi.ac.uk/pdbsum/3hc8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hc8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.	+	[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.[https://www.uniprot.org/uniprot/PDE4A_HUMAN PDE4A_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.<ref>PMID:11566027</ref> <ref>PMID:17727341</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cubbage~~, J W~~]]	+	[[Category: Cubbage JW]]
-	[[Category: Hughes~~, R O~~]]	+	[[Category: Hughes RO]]
-	[[Category: Stallings~~, W C~~]]	+	[[Category: Stallings WC]]
-	[[Category: Williams~~, J M]]~~	+	[[Category: Williams JM]]
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Camp]]~~	+
-	~~[[Category: Cgmp]]~~	+
-	~~[[Category: Cgmp-binding]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Inhibition]]~~	+
-	~~[[Category: Magnesium]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Pde-5]]~~	+
-	~~[[Category: Pde5]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Polymorphism allosteric enzyme]]~~	+
-	~~[[Category: Zinc~~]]	+

OCA at 08:08, 16 March 2022

OCA — Wed, 16 Mar 2022 08:08:32 GMT

←Older revision		Revision as of 08:08, 16 March 2022
Line 1:		Line 1:

	==Investigation of Aminopyridiopyrazinones as PDE5 Inhibitors: Evaluation of Modifications to the Central Ring System.==		==Investigation of Aminopyridiopyrazinones as PDE5 Inhibitors: Evaluation of Modifications to the Central Ring System.==
-	<StructureSection load='3hc8' size='340' side='right' caption='[[3hc8]], [[Resolution\|resolution]] 1.79Å' scene=''>	+	<StructureSection load='3hc8' size='340' side='right'caption='[[3hc8]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hc8]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HC8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3HC8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hc8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HC8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PD4:6-(6-METHOXYPYRIDIN-3-YL)-2-[(2-MORPHOLIN-4-YLETHYL)AMINO]-4-(2-PROPOXYETHYL)PYRIDO[2,3-B]PYRAZIN-3(4H)-ONE'>PD4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PD4:6-(6-METHOXYPYRIDIN-3-YL)-2-[(2-MORPHOLIN-4-YLETHYL)AMINO]-4-(2-PROPOXYETHYL)PYRIDO[2,3-B]PYRAZIN-3(4H)-ONE'>PD4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2h40\|2h40]], [[2h42\|2h42]], [[2h44\|2h44]], [[3bjc\|3bjc]], [[1uho\|1uho]], [[2chm\|2chm]], [[3hdz\|3hdz]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2h40\|2h40]], [[2h42\|2h42]], [[2h44\|2h44]], [[3bjc\|3bjc]], [[1uho\|1uho]], [[2chm\|2chm]], [[3hdz\|3hdz]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE5A, PDE5 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE5A, PDE5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3hc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hc8 OCA], [~~http~~://pdbe.org/3hc8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3hc8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3hc8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3hc8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hc8 OCA], [https://pdbe.org/3hc8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hc8 RCSB], [https://www.ebi.ac.uk/pdbsum/3hc8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hc8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.	+	[[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 3hc8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3hc8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phosphodiesterase 3D structures\|Phosphodiesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Cubbage, J W]]		[[Category: Cubbage, J W]]
	[[Category: Hughes, R O]]		[[Category: Hughes, R O]]

OCA at 19:19, 24 January 2018

OCA — Wed, 24 Jan 2018 19:19:46 GMT

←Older revision		Revision as of 19:19, 24 January 2018
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hc/3hc8_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hc/3hc8_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:28, 1 November 2017

OCA — Wed, 01 Nov 2017 07:28:31 GMT

←Older revision		Revision as of 07:28, 1 November 2017
Line 3:		Line 3:
	<StructureSection load='3hc8' size='340' side='right' caption='[[3hc8]], [[Resolution\|resolution]] 1.79Å' scene=''>		<StructureSection load='3hc8' size='340' side='right' caption='[[3hc8]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hc8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HC8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hc8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HC8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PD4:6-(6-METHOXYPYRIDIN-3-YL)-2-[(2-MORPHOLIN-4-YLETHYL)AMINO]-4-(2-PROPOXYETHYL)PYRIDO[2,3-B]PYRAZIN-3(4H)-ONE'>PD4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PD4:6-(6-METHOXYPYRIDIN-3-YL)-2-[(2-MORPHOLIN-4-YLETHYL)AMINO]-4-(2-PROPOXYETHYL)PYRIDO[2,3-B]PYRAZIN-3(4H)-ONE'>PD4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2h40\|2h40]], [[2h42\|2h42]], [[2h44\|2h44]], [[3bjc\|3bjc]], [[1uho\|1uho]], [[2chm\|2chm]], [[3hdz\|3hdz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2h40\|2h40]], [[2h42\|2h42]], [[2h44\|2h44]], [[3bjc\|3bjc]], [[1uho\|1uho]], [[2chm\|2chm]], [[3hdz\|3hdz]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE5A, PDE5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hc8 OCA], [http://pdbe.org/3hc8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hc8 RCSB], [http://www.ebi.ac.uk/pdbsum/3hc8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hc8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hc8 OCA], [http://pdbe.org/3hc8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hc8 RCSB], [http://www.ebi.ac.uk/pdbsum/3hc8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hc8 ProSAT]</span></td></tr>
	</table>		</table>
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 3hc8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3hc8" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Phosphodiesterase\|Phosphodiesterase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Cubbage, J W]]		[[Category: Cubbage, J W]]
	[[Category: Hughes, R O]]		[[Category: Hughes, R O]]

OCA at 11:06, 3 August 2017

OCA — Thu, 03 Aug 2017 11:06:47 GMT

←Older revision		Revision as of 11:06, 3 August 2017
Line 1:		Line 1:
		+
	==Investigation of Aminopyridiopyrazinones as PDE5 Inhibitors: Evaluation of Modifications to the Central Ring System.==		==Investigation of Aminopyridiopyrazinones as PDE5 Inhibitors: Evaluation of Modifications to the Central Ring System.==
	<StructureSection load='3hc8' size='340' side='right' caption='[[3hc8]], [[Resolution\|resolution]] 1.79Å' scene=''>		<StructureSection load='3hc8' size='340' side='right' caption='[[3hc8]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hc8]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HC8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hc8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HC8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PD4:6-(6-METHOXYPYRIDIN-3-YL)-2-[(2-MORPHOLIN-4-YLETHYL)AMINO]-4-(2-PROPOXYETHYL)PYRIDO[2,3-B]PYRAZIN-3(4H)-ONE'>PD4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PD4:6-(6-METHOXYPYRIDIN-3-YL)-2-[(2-MORPHOLIN-4-YLETHYL)AMINO]-4-(2-PROPOXYETHYL)PYRIDO[2,3-B]PYRAZIN-3(4H)-ONE'>PD4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2h40\|2h40]], [[2h42\|2h42]], [[2h44\|2h44]], [[3bjc\|3bjc]], [[1uho\|1uho]], [[2chm\|2chm]], [[3hdz\|3hdz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2h40\|2h40]], [[2h42\|2h42]], [[2h44\|2h44]], [[3bjc\|3bjc]], [[1uho\|1uho]], [[2chm\|2chm]], [[3hdz\|3hdz]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE5A, PDE5, PDE4B, DPDE4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hc8 OCA], [http://pdbe.org/3hc8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hc8 RCSB], [http://www.ebi.ac.uk/pdbsum/3hc8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hc8 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hc8 OCA], [http://pdbe.org/3hc8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hc8 RCSB], [http://www.ebi.ac.uk/pdbsum/3hc8 PDBsum]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]
	[[Category: Cubbage, J W]]		[[Category: Cubbage, J W]]
	[[Category: Hughes, R O]]		[[Category: Hughes, R O]]
	[[Category: Stallings, W C]]		[[Category: Stallings, W C]]
	[[Category: Williams, J M]]		[[Category: Williams, J M]]
		+	[[Category: Alternative splicing]]
	[[Category: Camp]]		[[Category: Camp]]
	[[Category: Cgmp]]		[[Category: Cgmp]]
Line 53:		Line 53:
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
	[[Category: Polymorphism allosteric enzyme]]		[[Category: Polymorphism allosteric enzyme]]
		+	[[Category: Zinc]]

OCA at 04:56, 10 February 2016

OCA — Wed, 10 Feb 2016 04:56:30 GMT

←Older revision		Revision as of 04:56, 10 February 2016
Line 2:		Line 2:
	<StructureSection load='3hc8' size='340' side='right' caption='[[3hc8]], [[Resolution\|resolution]] 1.79Å' scene=''>		<StructureSection load='3hc8' size='340' side='right' caption='[[3hc8]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hc8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HC8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hc8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HC8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PD4:6-(6-METHOXYPYRIDIN-3-YL)-2-[(2-MORPHOLIN-4-YLETHYL)AMINO]-4-(2-PROPOXYETHYL)PYRIDO[2,3-B]PYRAZIN-3(4H)-ONE'>PD4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PD4:6-(6-METHOXYPYRIDIN-3-YL)-2-[(2-MORPHOLIN-4-YLETHYL)AMINO]-4-(2-PROPOXYETHYL)PYRIDO[2,3-B]PYRAZIN-3(4H)-ONE'>PD4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2h40\|2h40]], [[2h42\|2h42]], [[2h44\|2h44]], [[3bjc\|3bjc]], [[1uho\|1uho]], [[2chm\|2chm]], [[3hdz\|3hdz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2h40\|2h40]], [[2h42\|2h42]], [[2h44\|2h44]], [[3bjc\|3bjc]], [[1uho\|1uho]], [[2chm\|2chm]], [[3hdz\|3hdz]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE5A, PDE5, PDE4B, DPDE4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE5A, PDE5, PDE4B, DPDE4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hc8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hc8 RCSB], [http://www.ebi.ac.uk/pdbsum/3hc8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hc8 OCA], [http://pdbe.org/3hc8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hc8 RCSB], [http://www.ebi.ac.uk/pdbsum/3hc8 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hc8 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3hc8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Cubbage, J W]]		[[Category: Cubbage, J W]]
	[[Category: Hughes, R O]]		[[Category: Hughes, R O]]

OCA at 11:55, 25 December 2014

OCA — Thu, 25 Dec 2014 11:55:49 GMT

←Older revision		Revision as of 11:55, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3hc8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HC8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3hc8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HC8 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PD4:6-(6-METHOXYPYRIDIN-3-YL)-2-[(2-MORPHOLIN-4-YLETHYL)AMINO]-4-(2-PROPOXYETHYL)PYRIDO[2,3-B]PYRAZIN-3(4H)-ONE'>PD4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PD4:6-(6-METHOXYPYRIDIN-3-YL)-2-[(2-MORPHOLIN-4-YLETHYL)AMINO]-4-(2-PROPOXYETHYL)PYRIDO[2,3-B]PYRAZIN-3(4H)-ONE'>PD4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2h40\|2h40]], [[2h42\|2h42]], [[2h44\|2h44]], [[3bjc\|3bjc]], [[1uho\|1uho]], [[2chm\|2chm]], [[3hdz\|3hdz]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2h40\|2h40]], [[2h42\|2h42]], [[2h44\|2h44]], [[3bjc\|3bjc]], [[1uho\|1uho]], [[2chm\|2chm]], [[3hdz\|3hdz]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE5A, PDE5, PDE4B, DPDE4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE5A, PDE5, PDE4B, DPDE4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hc8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hc8 RCSB], [http://www.ebi.ac.uk/pdbsum/3hc8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hc8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hc8 RCSB], [http://www.ebi.ac.uk/pdbsum/3hc8 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Cubbage, J W.]]	+	[[Category: Cubbage, J W]]
-	[[Category: Hughes, R O.]]	+	[[Category: Hughes, R O]]
	[[Category: Stallings, W C]]		[[Category: Stallings, W C]]
-	[[Category: Williams, J M.]]	+	[[Category: Williams, J M]]
	[[Category: Camp]]		[[Category: Camp]]
	[[Category: Cgmp]]		[[Category: Cgmp]]

OCA at 13:14, 29 September 2014

OCA — Mon, 29 Sep 2014 13:14:11 GMT

←Older revision		Revision as of 13:14, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3hc8.~~png~~\|~~left~~\|200px]]	+	==Investigation of Aminopyridiopyrazinones as PDE5 Inhibitors: Evaluation of Modifications to the Central Ring System.==
		+	<StructureSection load='3hc8' size='340' side='right' caption='[[3hc8]], [[Resolution\|resolution]] 1.79Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3hc8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HC8 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PD4:6-(6-METHOXYPYRIDIN-3-YL)-2-[(2-MORPHOLIN-4-YLETHYL)AMINO]-4-(2-PROPOXYETHYL)PYRIDO[2,3-B]PYRAZIN-3(4H)-ONE'>PD4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2h40\|2h40]], [[2h42\|2h42]], [[2h44\|2h44]], [[3bjc\|3bjc]], [[1uho\|1uho]], [[2chm\|2chm]], [[3hdz\|3hdz]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE5A, PDE5, PDE4B, DPDE4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hc8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hc8 RCSB], [http://www.ebi.ac.uk/pdbsum/3hc8 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hc/3hc8_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Efforts to improve the potency and physical properties of the aminopyridiopyrazinone class of PDE5 inhibitors through modification of the core ring system are described. Five new ring systems are evaluated and features that impart improved potency and improved solubility are delineated.

-	~~{{STRUCTURE_3hc8\| PDB=3hc8 \| SCENE= }}~~	+	Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system.,Hughes RO, Walker JK, Cubbage JW, Fobian YM, Rogier DJ, Heasley SE, Blevis-Bal RM, Benson AG, Owen DR, Jacobsen EJ, Freskos JN, Molyneaux JM, Brown DL, Stallings WC, Acker BA, Maddux TM, Tollefson MB, Williams JM, Moon JB, Mischke BV, Rumsey JM, Zheng Y, Macinnes A, Bond BR, Yu Y Bioorg Med Chem Lett. 2009 Aug 1;19(15):4092-6. Epub 2009 Jun 6. PMID:19539468<ref>PMID:19539468</ref>

-	~~===Investigation~~ of ~~Aminopyridiopyrazinones as PDE5 Inhibitors: Evaluation of Modifications to~~ the ~~Central Ring System~~.~~===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19539468}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3hc8]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HC8 OCA].~~	+

	==See Also==		==See Also==
	*[[Phosphodiesterase\|Phosphodiesterase]]		*[[Phosphodiesterase\|Phosphodiesterase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019539468<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Cubbage, J W.]]		[[Category: Cubbage, J W.]]

OCA at 16:24, 20 October 2012

OCA — Sat, 20 Oct 2012 16:24:16 GMT

←Older revision		Revision as of 16:24, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3hc8]] is a 1 chain structure ~~of [[Phosphodiesterase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HC8 OCA].	+	[[3hc8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HC8 OCA].

	==See Also==		==See Also==

OCA: Protected "3hc8" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 21:34:32 GMT

Protected "3hc8" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:34, 26 July 2012