3hgk - Revision history

OCA at 15:48, 1 November 2023

OCA — Wed, 01 Nov 2023 15:48:56 GMT

←Older revision		Revision as of 15:48, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3hgk' size='340' side='right'caption='[[3hgk]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='3hgk' size='340' side='right'caption='[[3hgk]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hgk]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"pseudomonas_tomato"_(okabe_1933)_alstatt_1944 "pseudomonas~~ tomato~~" (okabe 1933) alstatt 1944~~] and [https://en.wikipedia.org/wiki/~~Currant_tomato Currant tomato~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HGK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HGK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hgk]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_syringae_pv._tomato Pseudomonas syringae pv. tomato] and [https://en.wikipedia.org/wiki/Solanum_pimpinellifolium Solanum pimpinellifolium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HGK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HGK FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=SEP:PHOSPHOSERINE'>SEP</scene~~>, ~~<scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[3hgl\|3hgl]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td><td class="sblockDat">Pto ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4084 Currant tomato]), hopAB2, avrPtoB, PSPTO_3087 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=323 "Pseudomonas tomato" (Okabe 1933) Alstatt 1944])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hgk OCA], [https://pdbe.org/3hgk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hgk RCSB], [https://www.ebi.ac.uk/pdbsum/3hgk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hgk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hgk OCA], [https://pdbe.org/3hgk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hgk RCSB], [https://www.ebi.ac.uk/pdbsum/3hgk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hgk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~HPAB2_PSESM HPAB2_PSESM~~]] Effector protein involved in gene-for-gene resistance in tomato plants. It is recognized by the host Pto resistance protein and elicits Pto and Prf-dependent hypersensitive response (HR) and programmed cell death (PCD), resulting in host immunity. In susceptible plants, acts as a virulence factor by suppressing PCD and HR-based plant immunity. This function requires its E3 ubiquitin ligase activity probably by recruiting E2 enzymes and transferring ubiquitin molecules to cellular proteins involved in regulation of PCD and targeting them for degradation. Also, induces expression of host genes involved in ethylene biosynthesis and signaling, in particular ACO1 and ACO2, encoding the ethylene-forming enzyme ACC oxidase.<ref>PMID:12062102</ref> <ref>PMID:12505984</ref> <ref>PMID:16167902</ref> <ref>PMID:16477026</ref> <ref>PMID:16373536</ref>	+	[https://www.uniprot.org/uniprot/Q40234_SOLPI Q40234_SOLPI]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Currant tomato]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Chai, J~~]]	+	[[Category: Pseudomonas syringae pv. tomato]]
-	[[Category: ~~Dong, J~~]]	+	[[Category: Solanum pimpinellifolium]]
-	[[Category: ~~Fan, F~~]]	+	[[Category: Chai J]]
-	[[Category: ~~Gu, L~~]]	+	[[Category: Dong J]]
-	[[Category: ~~Atp-binding~~]]	+	[[Category: Fan F]]
-	[[Category: ~~Five helice]]~~	+	[[Category: Gu L]]
-	~~[[Category: Hypersensitive response elicitation]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Pto p+1 loop]]~~	+
-	~~[[Category: Secreted]]~~	+
-	~~[[Category: Serine/threonine-protein kinase]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Ubl conjugation]]~~	+
-	~~[[Category: Ubl conjugation pathway]]~~	+
-	~~[[Category: Virulence~~]]	+

OCA at 07:44, 10 November 2021

OCA — Wed, 10 Nov 2021 07:44:10 GMT

←Older revision		Revision as of 07:44, 10 November 2021
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	==crystal structure of effect protein AvrptoB complexed with kinase Pto==		==crystal structure of effect protein AvrptoB complexed with kinase Pto==
-	<StructureSection load='3hgk' size='340' side='right' caption='[[3hgk]], [[Resolution\|resolution]] 3.30Å' scene=''>	+	<StructureSection load='3hgk' size='340' side='right'caption='[[3hgk]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hgk]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"pseudomonas_tomato"_(okabe_1933)_alstatt_1944 "pseudomonas tomato" (okabe 1933) alstatt 1944] and [~~http~~://en.wikipedia.org/wiki/Currant_tomato Currant tomato]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HGK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3HGK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hgk]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/"pseudomonas_tomato"_(okabe_1933)_alstatt_1944 "pseudomonas tomato" (okabe 1933) alstatt 1944] and [https://en.wikipedia.org/wiki/Currant_tomato Currant tomato]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HGK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HGK FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hgl\|3hgl]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3hgl\|3hgl]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pto ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4084 Currant tomato]), hopAB2, avrPtoB, PSPTO_3087 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=323 "Pseudomonas tomato" (Okabe 1933) Alstatt 1944])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pto ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4084 Currant tomato]), hopAB2, avrPtoB, PSPTO_3087 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=323 "Pseudomonas tomato" (Okabe 1933) Alstatt 1944])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3hgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hgk OCA], [~~http~~://pdbe.org/3hgk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3hgk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3hgk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3hgk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hgk OCA], [https://pdbe.org/3hgk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hgk RCSB], [https://www.ebi.ac.uk/pdbsum/3hgk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hgk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HPAB2_PSESM HPAB2_PSESM]] Effector protein involved in gene-for-gene resistance in tomato plants. It is recognized by the host Pto resistance protein and elicits Pto and Prf-dependent hypersensitive response (HR) and programmed cell death (PCD), resulting in host immunity. In susceptible plants, acts as a virulence factor by suppressing PCD and HR-based plant immunity. This function requires its E3 ubiquitin ligase activity probably by recruiting E2 enzymes and transferring ubiquitin molecules to cellular proteins involved in regulation of PCD and targeting them for degradation. Also, induces expression of host genes involved in ethylene biosynthesis and signaling, in particular ACO1 and ACO2, encoding the ethylene-forming enzyme ACC oxidase.<ref>PMID:12062102</ref> <ref>PMID:12505984</ref> <ref>PMID:16167902</ref> <ref>PMID:16477026</ref> <ref>PMID:16373536</ref>	+	[[https://www.uniprot.org/uniprot/HPAB2_PSESM HPAB2_PSESM]] Effector protein involved in gene-for-gene resistance in tomato plants. It is recognized by the host Pto resistance protein and elicits Pto and Prf-dependent hypersensitive response (HR) and programmed cell death (PCD), resulting in host immunity. In susceptible plants, acts as a virulence factor by suppressing PCD and HR-based plant immunity. This function requires its E3 ubiquitin ligase activity probably by recruiting E2 enzymes and transferring ubiquitin molecules to cellular proteins involved in regulation of PCD and targeting them for degradation. Also, induces expression of host genes involved in ethylene biosynthesis and signaling, in particular ACO1 and ACO2, encoding the ethylene-forming enzyme ACC oxidase.<ref>PMID:12062102</ref> <ref>PMID:12505984</ref> <ref>PMID:16167902</ref> <ref>PMID:16477026</ref> <ref>PMID:16373536</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Avirulence protein\|Avirulence protein]]	+	*[[Avirulence protein 3D structures\|Avirulence protein 3D structures]]
-	*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]	+	*[[Serine/threonine protein kinase 3D structures\|Serine/threonine protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Currant tomato]]		[[Category: Currant tomato]]
		+	[[Category: Large Structures]]
	[[Category: Chai, J]]		[[Category: Chai, J]]
	[[Category: Dong, J]]		[[Category: Dong, J]]

OCA at 08:13, 12 December 2018

OCA — Wed, 12 Dec 2018 08:13:52 GMT

←Older revision		Revision as of 08:13, 12 December 2018
Line 3:		Line 3:
	<StructureSection load='3hgk' size='340' side='right' caption='[[3hgk]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='3hgk' size='340' side='right' caption='[[3hgk]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hgk]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Currant_tomato Currant~~ tomato] and [http://en.wikipedia.org/wiki/~~Pseub Pseub~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HGK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hgk]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"pseudomonas_tomato"_(okabe_1933)_alstatt_1944 "pseudomonas tomato" (okabe 1933) alstatt 1944] and [http://en.wikipedia.org/wiki/Currant_tomato Currant tomato]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HGK FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hgl\|3hgl]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hgl\|3hgl]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pto ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4084 Currant tomato]), hopAB2, avrPtoB, PSPTO_3087 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=323 ~~PSEUB~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pto ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4084 Currant tomato]), hopAB2, avrPtoB, PSPTO_3087 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=323 "Pseudomonas tomato" (Okabe 1933) Alstatt 1944])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hgk OCA], [http://pdbe.org/3hgk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hgk RCSB], [http://www.ebi.ac.uk/pdbsum/3hgk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hgk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hgk OCA], [http://pdbe.org/3hgk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hgk RCSB], [http://www.ebi.ac.uk/pdbsum/3hgk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hgk ProSAT]</span></td></tr>
	</table>		</table>
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hg/3hgk_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hg/3hgk_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 39:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Currant tomato]]		[[Category: Currant tomato]]
-	[[Category: Pseub]]
	[[Category: Chai, J]]		[[Category: Chai, J]]
	[[Category: Dong, J]]		[[Category: Dong, J]]
Line 54:		Line 53:
	[[Category: Serine/threonine-protein kinase]]		[[Category: Serine/threonine-protein kinase]]
	[[Category: Transferase]]		[[Category: Transferase]]
		+	[[Category: Ubl conjugation]]
	[[Category: Ubl conjugation pathway]]		[[Category: Ubl conjugation pathway]]
	[[Category: Virulence]]		[[Category: Virulence]]

OCA at 19:12, 5 August 2016

OCA — Fri, 05 Aug 2016 19:12:20 GMT

←Older revision		Revision as of 19:12, 5 August 2016
Line 1:		Line 1:
		+
	==crystal structure of effect protein AvrptoB complexed with kinase Pto==		==crystal structure of effect protein AvrptoB complexed with kinase Pto==
	<StructureSection load='3hgk' size='340' side='right' caption='[[3hgk]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='3hgk' size='340' side='right' caption='[[3hgk]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hgk]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pseudomonas_syringae_pv._tomato Pseudomonas syringae pv.~~ tomato] and [http://en.wikipedia.org/wiki/~~Solanum_pimpinellifolium Solanum pimpinellifolium~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HGK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hgk]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Currant_tomato Currant tomato] and [http://en.wikipedia.org/wiki/Pseub Pseub]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HGK FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hgl\|3hgl]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hgl\|3hgl]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pto ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4084 ~~Solanum pimpinellifolium~~]), hopAB2, avrPtoB, PSPTO_3087 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=323 ~~Pseudomonas syringae pv. tomato~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pto ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4084 Currant tomato]), hopAB2, avrPtoB, PSPTO_3087 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=323 PSEUB])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hgk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hgk RCSB], [http://www.ebi.ac.uk/pdbsum/3hgk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hgk OCA], [http://pdbe.org/3hgk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hgk RCSB], [http://www.ebi.ac.uk/pdbsum/3hgk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hgk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hgk ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3hgk" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Pseudomonas syringae pv.~~ tomato]]	+	[[Category: Currant tomato]]
-	[[Category: ~~Solanum pimpinellifolium~~]]	+	[[Category: Pseub]]
	[[Category: Chai, J]]		[[Category: Chai, J]]
	[[Category: Dong, J]]		[[Category: Dong, J]]

OCA at 21:13, 25 December 2014

OCA — Thu, 25 Dec 2014 21:13:59 GMT

←Older revision		Revision as of 21:13, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hgk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hgk RCSB], [http://www.ebi.ac.uk/pdbsum/3hgk PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hgk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hgk RCSB], [http://www.ebi.ac.uk/pdbsum/3hgk PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HPAB2_PSESM HPAB2_PSESM]] Effector protein involved in gene-for-gene resistance in tomato plants. It is recognized by the host Pto resistance protein and elicits Pto and Prf-dependent hypersensitive response (HR) and programmed cell death (PCD), resulting in host immunity. In susceptible plants, acts as a virulence factor by suppressing PCD and HR-based plant immunity. This function requires its E3 ubiquitin ligase activity probably by recruiting E2 enzymes and transferring ubiquitin molecules to cellular proteins involved in regulation of PCD and targeting them for degradation. Also, induces expression of host genes involved in ethylene biosynthesis and signaling, in particular ACO1 and ACO2, encoding the ethylene-forming enzyme ACC oxidase.<ref>PMID:12062102</ref> <ref>PMID:12505984</ref> <ref>PMID:16167902</ref> <ref>PMID:16477026</ref> <ref>PMID:16373536</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:26, 18 December 2014

OCA — Thu, 18 Dec 2014 06:26:59 GMT

←Older revision		Revision as of 06:26, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3hgk\| PDB=3hgk \| SCENE= }}~~	+	==crystal structure of effect protein AvrptoB complexed with kinase Pto==
-	===crystal structure of effect protein AvrptoB complexed with kinase Pto===	+	<StructureSection load='3hgk' size='340' side='right' caption='[[3hgk]], [[Resolution\|resolution]] 3.30Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19509331}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3hgk]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_syringae_pv._tomato Pseudomonas syringae pv. tomato] and [http://en.wikipedia.org/wiki/Solanum_pimpinellifolium Solanum pimpinellifolium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HGK FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hgl\|3hgl]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Pto ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4084 Solanum pimpinellifolium]), hopAB2, avrPtoB, PSPTO_3087 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=323 Pseudomonas syringae pv. tomato])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hgk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hgk RCSB], [http://www.ebi.ac.uk/pdbsum/3hgk PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hg/3hgk_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Resistance to bacterial speck disease in tomato (Solanum lycopersicum) is activated upon recognition by the host Pto kinase of either one of two sequence-unrelated effector proteins, AvrPto or AvrPtoB, from Pseudomonas syringae pv tomato (Pst). Pto induces Pst immunity by acting in concert with the Prf protein. The recently reported structure of the AvrPto-Pto complex revealed that interaction of AvrPto with Pto appears to relieve an inhibitory effect of Pto, allowing Pto to activate Prf. Here, we present the crystal structure of the Pto binding domain of AvrPtoB (residues 121 to 205) at a resolution of 1.9A and of the AvrPtoB(121-205)-Pto complex at a resolution of 3.3 A. AvrPtoB(121-205) exhibits a tertiary fold that is completely different from that of AvrPto, and its conformation remains largely unchanged upon binding to Pto. In common with AvrPto-Pto, the AvrPtoB-Pto complex relies on two interfaces. One of these interfaces is similar in both complexes, although the primary amino acid sequences from the two effector proteins are very different. Amino acid substitutions in Pto at the other interface disrupt the interaction of AvrPtoB-Pto but not that of AvrPto-Pto. Interestingly, substitutions in Pto affecting this unique interface also cause Pto to induce Prf-dependent host cell death independently of either effector protein.

-	~~==About this Structure==~~	+	Crystal structure of the complex between Pseudomonas effector AvrPtoB and the tomato Pto kinase reveals both a shared and a unique interface compared with AvrPto-Pto.,Dong J, Xiao F, Fan F, Gu L, Cang H, Martin GB, Chai J Plant Cell. 2009 Jun;21(6):1846-59. Epub 2009 Jun 9. PMID:19509331<ref>PMID:19509331</ref>
-	~~[[3hgk]] is~~ a ~~8 chain structure~~ with ~~sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Pseudomonas_syringae_pv._tomato Pseudomonas syringae pv. tomato] and [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Solanum_pimpinellifolium Solanum pimpinellifolium]. Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=3HGK OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Avirulence protein\|Avirulence protein]]		*[[Avirulence protein\|Avirulence protein]]
	*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]		*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019509331<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Pseudomonas syringae pv. tomato]]		[[Category: Pseudomonas syringae pv. tomato]]
	[[Category: Solanum pimpinellifolium]]		[[Category: Solanum pimpinellifolium]]
-	[[Category: Chai, J.]]	+	[[Category: Chai, J]]
-	[[Category: Dong, J.]]	+	[[Category: Dong, J]]
-	[[Category: Fan, F.]]	+	[[Category: Fan, F]]
-	[[Category: Gu, L.]]	+	[[Category: Gu, L]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Five helice]]		[[Category: Five helice]]

OCA at 09:30, 11 March 2013

OCA — Mon, 11 Mar 2013 09:30:44 GMT

←Older revision		Revision as of 09:30, 11 March 2013
Line 1:		Line 1:
-	[[Image:3hgk.png\|left\|200px]]
-
	{{STRUCTURE_3hgk\| PDB=3hgk \| SCENE= }}		{{STRUCTURE_3hgk\| PDB=3hgk \| SCENE= }}
-
	===crystal structure of effect protein AvrptoB complexed with kinase Pto===		===crystal structure of effect protein AvrptoB complexed with kinase Pto===
-
	{{ABSTRACT_PUBMED_19509331}}		{{ABSTRACT_PUBMED_19509331}}

OCA at 21:43, 20 October 2012

OCA — Sat, 20 Oct 2012 21:43:54 GMT

←Older revision		Revision as of 21:43, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3hgk]] is a 8 chain structure ~~of [[Serine/threonine protein kinase]]~~ with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_syringae_pv._tomato Pseudomonas syringae pv. tomato] and [http://en.wikipedia.org/wiki/Solanum_pimpinellifolium Solanum pimpinellifolium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HGK OCA].	+	[[3hgk]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_syringae_pv._tomato Pseudomonas syringae pv. tomato] and [http://en.wikipedia.org/wiki/Solanum_pimpinellifolium Solanum pimpinellifolium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HGK OCA].

	==See Also==		==See Also==
		+	*[[Avirulence protein\|Avirulence protein]]
	*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]		*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]

OCA: Protected "3hgk" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 14:06:45 GMT

Protected "3hgk" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:06, 27 July 2012

OCA at 14:06, 27 July 2012

OCA — Fri, 27 Jul 2012 14:06:43 GMT

←Older revision		Revision as of 14:06, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3hgk.png\|left\|200px]]		[[Image:3hgk.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3hgk", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3hgk\| PDB=3hgk \| SCENE= }}		{{STRUCTURE_3hgk\| PDB=3hgk \| SCENE= }}

	===crystal structure of effect protein AvrptoB complexed with kinase Pto===		===crystal structure of effect protein AvrptoB complexed with kinase Pto===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19509331}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19509331 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19509331}}		{{ABSTRACT_PUBMED_19509331}}

	==About this Structure==		==About this Structure==
-	~~3HGK~~ is a 8 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Pseudomonas_syringae_pv._tomato Pseudomonas syringae pv. tomato] and [http://en.wikipedia.org/wiki/Solanum_pimpinellifolium Solanum pimpinellifolium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HGK OCA].	+	[[3hgk]] is a 8 chain structure of [[Serine/threonine protein kinase]] with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_syringae_pv._tomato Pseudomonas syringae pv. tomato] and [http://en.wikipedia.org/wiki/Solanum_pimpinellifolium Solanum pimpinellifolium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HGK OCA].
		+
		+	==See Also==
		+	*[[Serine/threonine protein kinase\|Serine/threonine protein kinase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19509331~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019509331</ref><references group="xtra"/>
	[[Category: Pseudomonas syringae pv. tomato]]		[[Category: Pseudomonas syringae pv. tomato]]
	[[Category: Solanum pimpinellifolium]]		[[Category: Solanum pimpinellifolium]]
Line 40:		Line 31:
	[[Category: Serine/threonine-protein kinase]]		[[Category: Serine/threonine-protein kinase]]
	[[Category: Transferase]]		[[Category: Transferase]]
-	[[Category: Ubl conjugation]]
	[[Category: Ubl conjugation pathway]]		[[Category: Ubl conjugation pathway]]
	[[Category: Virulence]]		[[Category: Virulence]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 19 13:59:28 2009''