3hgn - Revision history

OCA at 15:49, 1 November 2023

OCA — Wed, 01 Nov 2023 15:49:04 GMT

←Older revision		Revision as of 15:49, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3hgn' size='340' side='right'caption='[[3hgn]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='3hgn' size='340' side='right'caption='[[3hgn]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hgn]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HGN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3HGN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hgn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HGN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene>, <scene name='pdbligand=FRW:4-[[(2S)-3-METHYL-1-OXO-1-[(2S)-2-[[(3S)-1,1,1-TRIFLUORO-4-METHYL-2-OXO-PENTAN-3-YL]CARBAMOYL]PYRROLIDIN-1-YL]BUTAN-2-YL]CARBAMOYL]BENZOIC+ACID'>FRW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Hybrid , Neutron Diffraction , X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hgp\|3hgp]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene>, <scene name='pdbligand=FRW:4-[[(2S)-3-METHYL-1-OXO-1-[(2S)-2-[[(3S)-1,1,1-TRIFLUORO-4-METHYL-2-OXO-PENTAN-3-YL]CARBAMOYL]PYRROLIDIN-1-YL]BUTAN-2-YL]CARBAMOYL]BENZOIC+ACID'>FRW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hgn OCA], [https://pdbe.org/3hgn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hgn RCSB], [https://www.ebi.ac.uk/pdbsum/3hgn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hgn ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3hgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hgn OCA], [~~http~~://pdbe.org/3hgn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3hgn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3hgn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3hgn ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CELA1_PIG CELA1_PIG]] Acts upon elastin.	+	[https://www.uniprot.org/uniprot/CELA1_PIG CELA1_PIG] Acts upon elastin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Pancreatic elastase]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
-	[[Category: Kinoshita, T]]	+	[[Category: Kinoshita T]]
-	[[Category: Kuroki, R]]	+	[[Category: Kuroki R]]
-	[[Category: Tada, T]]	+	[[Category: Tada T]]
-	[[Category: Tamada, T]]	+	[[Category: Tamada T]]
-	~~[[Category: Chymotrypsin family]]~~	+
-	~~[[Category: Disulfide bond]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Protease]]~~	+
-	~~[[Category: Secreted]]~~	+
-	~~[[Category: Serine protease]]~~	+
-	~~[[Category: Zymogen~~]]	+

OCA at 10:47, 16 September 2020

OCA — Wed, 16 Sep 2020 10:47:40 GMT

←Older revision		Revision as of 10:47, 16 September 2020
Line 1:		Line 1:

	==Structure of porcine pancreatic elastase complexed with a potent peptidyl inhibitor FR130180 determined by neutron crystallography==		==Structure of porcine pancreatic elastase complexed with a potent peptidyl inhibitor FR130180 determined by neutron crystallography==
-	<StructureSection load='3hgn' size='340' side='right' caption='[[3hgn]], [[Resolution\|resolution]] 1.65Å' scene=''>	+	<StructureSection load='3hgn' size='340' side='right'caption='[[3hgn]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hgn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HGN OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3HGN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hgn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HGN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3HGN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene>, <scene name='pdbligand=FRW:4-[[(2S)-3-METHYL-1-OXO-1-[(2S)-2-[[(3S)-1,1,1-TRIFLUORO-4-METHYL-2-OXO-PENTAN-3-YL]CARBAMOYL]PYRROLIDIN-1-YL]BUTAN-2-YL]CARBAMOYL]BENZOIC+ACID'>FRW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene>, <scene name='pdbligand=FRW:4-[[(2S)-3-METHYL-1-OXO-1-[(2S)-2-[[(3S)-1,1,1-TRIFLUORO-4-METHYL-2-OXO-PENTAN-3-YL]CARBAMOYL]PYRROLIDIN-1-YL]BUTAN-2-YL]CARBAMOYL]BENZOIC+ACID'>FRW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hgp\|3hgp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hgp\|3hgp]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3hgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hgn OCA], [http://pdbe.org/3hgn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hgn RCSB], [http://www.ebi.ac.uk/pdbsum/3hgn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hgn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3hgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hgn OCA], [http://pdbe.org/3hgn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hgn RCSB], [http://www.ebi.ac.uk/pdbsum/3hgn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hgn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Elastase\|Elastase]]	+	*[[Elastase 3D structures\|Elastase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Pancreatic elastase]]		[[Category: Pancreatic elastase]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]

OCA at 08:07, 12 December 2018

OCA — Wed, 12 Dec 2018 08:07:53 GMT

←Older revision		Revision as of 08:07, 12 December 2018
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hg/3hgn_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hg/3hgn_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 12:31, 5 August 2016

OCA — Fri, 05 Aug 2016 12:31:33 GMT

←Older revision		Revision as of 12:31, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of porcine pancreatic elastase complexed with a potent peptidyl inhibitor FR130180 determined by neutron crystallography==		==Structure of porcine pancreatic elastase complexed with a potent peptidyl inhibitor FR130180 determined by neutron crystallography==
	<StructureSection load='3hgn' size='340' side='right' caption='[[3hgn]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='3hgn' size='340' side='right' caption='[[3hgn]], [[Resolution\|resolution]] 1.65Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hgp\|3hgp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hgp\|3hgp]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hgn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hgn RCSB], [http://www.ebi.ac.uk/pdbsum/3hgn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hgn OCA], [http://pdbe.org/3hgn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hgn RCSB], [http://www.ebi.ac.uk/pdbsum/3hgn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hgn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~ELA1_PIG ELA1_PIG~~]] Acts upon elastin.	+	[[http://www.uniprot.org/uniprot/CELA1_PIG CELA1_PIG]] Acts upon elastin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hgn ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3hgn" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 18:52, 25 December 2014

OCA — Thu, 25 Dec 2014 18:52:27 GMT

←Older revision		Revision as of 18:52, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3hgn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HGN FirstGlance]. <br>		<table><tr><td colspan='2'>[[3hgn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HGN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene>, <scene name='pdbligand=FRW:4-[[(2S)-3-METHYL-1-OXO-1-[(2S)-2-[[(3S)-1,1,1-TRIFLUORO-4-METHYL-2-OXO-PENTAN-3-YL]CARBAMOYL]PYRROLIDIN-1-YL]BUTAN-2-YL]CARBAMOYL]BENZOIC+ACID'>FRW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene>, <scene name='pdbligand=FRW:4-[[(2S)-3-METHYL-1-OXO-1-[(2S)-2-[[(3S)-1,1,1-TRIFLUORO-4-METHYL-2-OXO-PENTAN-3-YL]CARBAMOYL]PYRROLIDIN-1-YL]BUTAN-2-YL]CARBAMOYL]BENZOIC+ACID'>FRW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hgp\|3hgp]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hgp\|3hgp]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hgn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hgn RCSB], [http://www.ebi.ac.uk/pdbsum/3hgn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hgn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hgn RCSB], [http://www.ebi.ac.uk/pdbsum/3hgn PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ELA1_PIG ELA1_PIG]] Acts upon elastin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Pancreatic elastase]]		[[Category: Pancreatic elastase]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
-	[[Category: Kinoshita, T.]]	+	[[Category: Kinoshita, T]]
-	[[Category: Kuroki, R.]]	+	[[Category: Kuroki, R]]
-	[[Category: Tada, T.]]	+	[[Category: Tada, T]]
-	[[Category: Tamada, T.]]	+	[[Category: Tamada, T]]
	[[Category: Chymotrypsin family]]		[[Category: Chymotrypsin family]]
	[[Category: Disulfide bond]]		[[Category: Disulfide bond]]

OCA at 13:20, 29 September 2014

OCA — Mon, 29 Sep 2014 13:20:17 GMT

←Older revision		Revision as of 13:20, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3hgn.~~png~~\|~~left~~\|200px]]	+	==Structure of porcine pancreatic elastase complexed with a potent peptidyl inhibitor FR130180 determined by neutron crystallography==
		+	<StructureSection load='3hgn' size='340' side='right' caption='[[3hgn]], [[Resolution\|resolution]] 1.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3hgn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HGN FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene>, <scene name='pdbligand=FRW:4-[[(2S)-3-METHYL-1-OXO-1-[(2S)-2-[[(3S)-1,1,1-TRIFLUORO-4-METHYL-2-OXO-PENTAN-3-YL]CARBAMOYL]PYRROLIDIN-1-YL]BUTAN-2-YL]CARBAMOYL]BENZOIC+ACID'>FRW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hgp\|3hgp]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hgn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hgn RCSB], [http://www.ebi.ac.uk/pdbsum/3hgn PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hg/3hgn_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	To help resolve long-standing questions regarding the catalytic activity of the serine proteases, the structure of porcine pancreatic elastase has been analyzed by high-resolution neutron and X-ray crystallography. To mimic the tetrahedral transition intermediate, a peptidic inhibitor was used. A single large crystal was used to collect room-temperature neutron data to 1.65 A resolution and X-ray data to 1.20 A resolution. Another crystal provided a low-temperature X-ray data set to 0.94 A resolution. The neutron data are to higher resolution than previously reported for a serine protease and the X-ray data are comparable with other studies. The neutron and X-ray data show that the hydrogen bond between His57 and Asp102 (chymotrypsin numbering) is 2.60 A in length and that the hydrogen-bonding hydrogen is 0.80-0.96 A from the histidine nitrogen. This is not consistent with a low-barrier hydrogen which is predicted to have the hydrogen midway between the donor and acceptor atom. The observed interaction between His57 and Asp102 is essentially a short but conventional hydrogen bond, sometimes described as a short ionic hydrogen bond. The neutron analysis also shows that the oxygen of the oxopropyl group of the inhibitor is present as an oxygen anion rather than a hydroxyl group, supporting the role of the "oxyanion hole" in stabilizing the tetrahedral intermediate in catalysis.

-	~~{{STRUCTURE_3hgn\| PDB=3hgn \| SCENE= }}~~	+	Combined High-Resolution Neutron and X-ray Analysis of Inhibited Elastase Confirms the Active-Site Oxyanion Hole but Rules against a Low-Barrier Hydrogen Bond.,Tamada T, Kinoshita T, Kurihara K, Adachi M, Ohhara T, Imai K, Kuroki R, Tada T J Am Chem Soc. 2009 Jul 15. PMID:19603802<ref>PMID:19603802</ref>

-	~~===Structure~~ of ~~porcine pancreatic elastase complexed with a potent peptidyl inhibitor FR130180 determined by neutron crystallography===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19603802}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3hgn]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Sus_scrofa Sus scrofa]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3HGN OCA].~~	+

	==See Also==		==See Also==
	*[[Elastase\|Elastase]]		*[[Elastase\|Elastase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019603802<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Pancreatic elastase]]		[[Category: Pancreatic elastase]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]

OCA at 20:12, 20 October 2012

OCA — Sat, 20 Oct 2012 20:12:19 GMT

←Older revision		Revision as of 20:12, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3hgn]] is a 1 chain structure ~~of [[Elastase]]~~ with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HGN OCA].	+	[[3hgn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HGN OCA].

	==See Also==		==See Also==

OCA at 09:43, 27 July 2012

OCA — Fri, 27 Jul 2012 09:43:52 GMT

←Older revision		Revision as of 09:43, 27 July 2012
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	[[Image:3hgn.png\|left\|200px]]		[[Image:3hgn.png\|left\|200px]]

-	<!--
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-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_3hgn\| PDB=3hgn \| SCENE= }}		{{STRUCTURE_3hgn\| PDB=3hgn \| SCENE= }}

	===Structure of porcine pancreatic elastase complexed with a potent peptidyl inhibitor FR130180 determined by neutron crystallography===		===Structure of porcine pancreatic elastase complexed with a potent peptidyl inhibitor FR130180 determined by neutron crystallography===

-
-	<!--
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	{{ABSTRACT_PUBMED_19603802}}		{{ABSTRACT_PUBMED_19603802}}

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	==See Also==		==See Also==
-	*[[Elastase]]	+	*[[Elastase\|Elastase]]

	==Reference==		==Reference==

OCA: Protected "3hgn" [edit=sysop:move=sysop]

OCA — Thu, 26 May 2011 11:40:17 GMT

Protected "3hgn" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:40, 26 May 2011

OCA at 11:40, 26 May 2011

OCA — Thu, 26 May 2011 11:40:16 GMT

←Older revision		Revision as of 11:40, 26 May 2011
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3hgn.png\|left\|200px]]		[[Image:3hgn.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	~~3HGN~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HGN OCA].	+	[[3hgn]] is a 1 chain structure of [[Elastase]] with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HGN OCA].
		+
		+	==See Also==
		+	*[[Elastase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19603802~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019603802</ref><references group="xtra"/>
	[[Category: Pancreatic elastase]]		[[Category: Pancreatic elastase]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
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	[[Category: Serine protease]]		[[Category: Serine protease]]
	[[Category: Zymogen]]		[[Category: Zymogen]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 30 13:19:10 2010''