3hhk - Revision history

OCA at 09:59, 21 February 2024

OCA — Wed, 21 Feb 2024 09:59:55 GMT

←Older revision		Revision as of 09:59, 21 February 2024
Line 10:		Line 10:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/Q99AU2_9HEPC Q99AU2_9HEPC]		[https://www.uniprot.org/uniprot/Q99AU2_9HEPC Q99AU2_9HEPC]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The synthesis and optimisation of HCV NS5B polymerase inhibitors with improved potency versus the existing compound 1 is described. Substitution in the benzothiadiazine portion of the molecule, furnishing improvement in potency in the high protein Replicon assay, is highlighted, culminating in the discovery of 12h, a highly potent oxyacetamide derivative.
-
-	Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase.,Shaw AN, Tedesco R, Bambal R, Chai D, Concha NO, Darcy MG, Dhanak D, Duffy KJ, Fitch DM, Gates A, Johnston VK, Keenan RM, Lin-Goerke J, Liu N, Sarisky RT, Wiggall KJ, Zimmerman MN Bioorg Med Chem Lett. 2009 Aug 1;19(15):4350-3. Epub 2009 May 28. PMID:19515564<ref>PMID:19515564</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3hhk" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 01:19, 28 December 2023

OCA — Thu, 28 Dec 2023 01:19:09 GMT

←Older revision		Revision as of 01:19, 28 December 2023
Line 3:		Line 3:
	<StructureSection load='3hhk' size='340' side='right'caption='[[3hhk]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3hhk' size='340' side='right'caption='[[3hhk]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hhk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Hepatitis_c_virus_subtype_1b~~ Hepatitis c virus subtype 1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HHK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hhk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_C_virus_subtype_1b Hepatitis C virus subtype 1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HHK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=77Z:2-({(3R)-3-[(3S)-1-(3-METHYLBUTYL)-2,4-DIOXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL]-1,1-DIOXIDO-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZIN-7-YL}OXY)ACETAMIDE'>77Z</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=77Z:2-({(3R)-3-[(3S)-1-(3-METHYLBUTYL)-2,4-DIOXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL]-1,1-DIOXIDO-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZIN-7-YL}OXY)ACETAMIDE'>77Z</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hhk OCA], [https://pdbe.org/3hhk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hhk RCSB], [https://www.ebi.ac.uk/pdbsum/3hhk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hhk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hhk OCA], [https://pdbe.org/3hhk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hhk RCSB], [https://www.ebi.ac.uk/pdbsum/3hhk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hhk ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q99AU2_9HEPC Q99AU2_9HEPC]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Hepatitis c virus subtype 1b]]	+	[[Category: Hepatitis C virus subtype 1b]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Concha~~, N O~~]]	+	[[Category: Concha NO]]
-	[[Category: Singh, O]]	+	[[Category: Singh O]]
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Envelope protein]]~~	+
-	~~[[Category: Hcv]]~~	+
-	~~[[Category: Helicase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Inhhibitor]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Ns5b]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Polymerase]]~~	+
-	~~[[Category: Rna replication]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 12:48, 23 March 2022

OCA — Wed, 23 Mar 2022 12:48:04 GMT

←Older revision		Revision as of 12:48, 23 March 2022
Line 3:		Line 3:
	<StructureSection load='3hhk' size='340' side='right'caption='[[3hhk]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3hhk' size='340' side='right'caption='[[3hhk]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hhk]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1b Hepatitis c virus subtype 1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3HHK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hhk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1b Hepatitis c virus subtype 1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HHK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=77Z:2-({(3R)-3-[(3S)-1-(3-METHYLBUTYL)-2,4-DIOXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL]-1,1-DIOXIDO-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZIN-7-YL}OXY)ACETAMIDE'>77Z</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=77Z:2-({(3R)-3-[(3S)-1-(3-METHYLBUTYL)-2,4-DIOXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL]-1,1-DIOXIDO-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZIN-7-YL}OXY)ACETAMIDE'>77Z</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3hhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hhk OCA], [~~http~~://pdbe.org/3hhk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3hhk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3hhk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3hhk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hhk OCA], [https://pdbe.org/3hhk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hhk RCSB], [https://www.ebi.ac.uk/pdbsum/3hhk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hhk ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:06, 7 August 2019

OCA — Wed, 07 Aug 2019 07:06:25 GMT

←Older revision		Revision as of 07:06, 7 August 2019
Line 1:		Line 1:

	==HCV NS5b polymerase complex with a substituted benzothiadizine==		==HCV NS5b polymerase complex with a substituted benzothiadizine==
-	<StructureSection load='3hhk' size='340' side='right' caption='[[3hhk]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='3hhk' size='340' side='right'caption='[[3hhk]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3hhk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1b Hepatitis c virus subtype 1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HHK FirstGlance]. <br>		<table><tr><td colspan='2'>[[3hhk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1b Hepatitis c virus subtype 1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HHK FirstGlance]. <br>
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Hepatitis c virus subtype 1b]]		[[Category: Hepatitis c virus subtype 1b]]
		+	[[Category: Large Structures]]
	[[Category: Concha, N O]]		[[Category: Concha, N O]]
	[[Category: Singh, O]]		[[Category: Singh, O]]

OCA at 15:14, 4 August 2016

OCA — Thu, 04 Aug 2016 15:14:42 GMT

←Older revision		Revision as of 15:14, 4 August 2016
Line 1:		Line 1:
		+
	==HCV NS5b polymerase complex with a substituted benzothiadizine==		==HCV NS5b polymerase complex with a substituted benzothiadizine==
	<StructureSection load='3hhk' size='340' side='right' caption='[[3hhk]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3hhk' size='340' side='right' caption='[[3hhk]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[3hhk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1b Hepatitis c virus subtype 1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HHK FirstGlance]. <br>		<table><tr><td colspan='2'>[[3hhk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1b Hepatitis c virus subtype 1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HHK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=77Z:2-({(3R)-3-[(3S)-1-(3-METHYLBUTYL)-2,4-DIOXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL]-1,1-DIOXIDO-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZIN-7-YL}OXY)ACETAMIDE'>77Z</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=77Z:2-({(3R)-3-[(3S)-1-(3-METHYLBUTYL)-2,4-DIOXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL]-1,1-DIOXIDO-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZIN-7-YL}OXY)ACETAMIDE'>77Z</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hhk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hhk RCSB], [http://www.ebi.ac.uk/pdbsum/3hhk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hhk OCA], [http://pdbe.org/3hhk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hhk RCSB], [http://www.ebi.ac.uk/pdbsum/3hhk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hhk ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3hhk" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:17, 18 December 2014

OCA — Thu, 18 Dec 2014 06:17:11 GMT

←Older revision		Revision as of 06:17, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3hhk\| PDB=3hhk \| SCENE= }}~~	+	==HCV NS5b polymerase complex with a substituted benzothiadizine==
-	===HCV NS5b polymerase complex with a substituted benzothiadizine===	+	<StructureSection load='3hhk' size='340' side='right' caption='[[3hhk]], [[Resolution\|resolution]] 1.70Å' scene=''>
-	{~~{ABSTRACT_PUBMED_19515564}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3hhk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1b Hepatitis c virus subtype 1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HHK FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=77Z:2-({(3R)-3-[(3S)-1-(3-METHYLBUTYL)-2,4-DIOXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL]-1,1-DIOXIDO-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZIN-7-YL}OXY)ACETAMIDE'>77Z</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hhk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hhk RCSB], [http://www.ebi.ac.uk/pdbsum/3hhk PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The synthesis and optimisation of HCV NS5B polymerase inhibitors with improved potency versus the existing compound 1 is described. Substitution in the benzothiadiazine portion of the molecule, furnishing improvement in potency in the high protein Replicon assay, is highlighted, culminating in the discovery of 12h, a highly potent oxyacetamide derivative.

-	~~==About this Structure==~~	+	Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase.,Shaw AN, Tedesco R, Bambal R, Chai D, Concha NO, Darcy MG, Dhanak D, Duffy KJ, Fitch DM, Gates A, Johnston VK, Keenan RM, Lin-Goerke J, Liu N, Sarisky RT, Wiggall KJ, Zimmerman MN Bioorg Med Chem Lett. 2009 Aug 1;19(15):4350-3. Epub 2009 May 28. PMID:19515564<ref>PMID:19515564</ref>
-	~~[[3hhk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1b~~ Hepatitis c virus ~~subtype 1b]~~. ~~Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3HHK OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	<~~ref group="xtra">PMID:019515564<~~/~~ref~~><~~references group="xtra"~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Hepatitis c virus subtype 1b]]		[[Category: Hepatitis c virus subtype 1b]]
-	[[Category: Concha, N O.]]	+	[[Category: Concha, N O]]
-	[[Category: Singh, O.]]	+	[[Category: Singh, O]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Envelope protein]]		[[Category: Envelope protein]]

OCA: Protected "3hhk" [edit=sysop:move=sysop]

OCA — Wed, 13 Mar 2013 10:52:56 GMT

Protected "3hhk" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:52, 13 March 2013

OCA at 10:52, 13 March 2013

OCA — Wed, 13 Mar 2013 10:52:54 GMT

←Older revision		Revision as of 10:52, 13 March 2013
Line 1:		Line 1:
-	{{Seed}}
-	[[Image:3hhk.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3hhk", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3hhk\| PDB=3hhk \| SCENE= }}		{{STRUCTURE_3hhk\| PDB=3hhk \| SCENE= }}
-
	===HCV NS5b polymerase complex with a substituted benzothiadizine===		===HCV NS5b polymerase complex with a substituted benzothiadizine===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19515564}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19515564 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19515564}}		{{ABSTRACT_PUBMED_19515564}}

	==About this Structure==		==About this Structure==
-	~~3HHK~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1b Hepatitis c virus subtype 1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHK OCA].	+	[[3hhk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1b Hepatitis c virus subtype 1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHK OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19515564~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019515564</ref><references group="xtra"/>
	[[Category: Hepatitis c virus subtype 1b]]		[[Category: Hepatitis c virus subtype 1b]]
	[[Category: Concha, N O.]]		[[Category: Concha, N O.]]
Line 32:		Line 16:
	[[Category: Helicase]]		[[Category: Helicase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
-	[[Category: Hydrolase/hydrolase inhibitor complex]]	+	[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Inhhibitor]]		[[Category: Inhhibitor]]
	[[Category: Membrane]]		[[Category: Membrane]]
Line 40:		Line 24:
	[[Category: Rna replication]]		[[Category: Rna replication]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 9 09:26:33 2009''

OCA at 06:26, 9 September 2009

OCA — Wed, 09 Sep 2009 06:26:35 GMT

←Older revision		Revision as of 06:26, 9 September 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3hhk.jpg\|left\|200px]]

-	The ~~entry 3hhk~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3hhk", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3hhk\| PDB=3hhk \| SCENE= }}

-	~~Authors: Concha, N.O., Singh, O.~~	+	===HCV NS5b polymerase complex with a substituted benzothiadizine===

-	Description: HCV NS5b polymerase complex with a substituted benzothiadizine

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~May 27 14~~:41:12 2009''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19515564}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19515564 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19515564}}
		+
		+	==About this Structure==
		+	3HHK is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1b Hepatitis c virus subtype 1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHK OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19515564</ref><references group="xtra"/>
		+	[[Category: Hepatitis c virus subtype 1b]]
		+	[[Category: Concha, N O.]]
		+	[[Category: Singh, O.]]
		+	[[Category: Atp-binding]]
		+	[[Category: Envelope protein]]
		+	[[Category: Hcv]]
		+	[[Category: Helicase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase/hydrolase inhibitor complex]]
		+	[[Category: Inhhibitor]]
		+	[[Category: Membrane]]
		+	[[Category: Ns5b]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Polymerase]]
		+	[[Category: Rna replication]]
		+	[[Category: Transmembrane]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 9 09:26:33 2009''

OCA: New page: '''Unreleased structure''' The entry 3hhk is ON HOLD Authors: Concha, N.O., Singh, O. Description: HCV NS5b polymerase complex with a substituted benzothiadizine ''Page seeded by [htt...

OCA — Wed, 27 May 2009 11:41:12 GMT

New page: '''Unreleased structure''' The entry 3hhk is ON HOLD Authors: Concha, N.O., Singh, O. Description: HCV NS5b polymerase complex with a substituted benzothiadizine ''Page seeded by [htt...

New page

'''Unreleased structure'''

The entry 3hhk is ON HOLD

Authors: Concha, N.O., Singh, O.

Description: HCV NS5b polymerase complex with a substituted benzothiadizine

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 27 14:41:12 2009''