3hjy - Revision history

OCA at 07:22, 6 September 2023

OCA — Wed, 06 Sep 2023 07:22:50 GMT

←Older revision		Revision as of 07:22, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3hjy' size='340' side='right'caption='[[3hjy]], [[Resolution\|resolution]] 3.65Å' scene=''>		<StructureSection load='3hjy' size='340' side='right'caption='[[3hjy]], [[Resolution\|resolution]] 3.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hjy]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_43587 Atcc 43587~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HJY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hjy]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HJY FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3hjw\|3hjw]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.65Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">PF1785 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=2261 ATCC 43587]), PF1141 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 ATCC 43587])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hjy OCA], [https://pdbe.org/3hjy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hjy RCSB], [https://www.ebi.ac.uk/pdbsum/3hjy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hjy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hjy OCA], [https://pdbe.org/3hjy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hjy RCSB], [https://www.ebi.ac.uk/pdbsum/3hjy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hjy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TRUB_PYRFU TRUB_PYRFU]] Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs ~~(By similarity). [[https://www.uniprot.org/uniprot/NOP10_PYRFU NOP10_PYRFU]] Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA~~ (By similarity).	+	[https://www.uniprot.org/uniprot/TRUB_PYRFU TRUB_PYRFU] Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 43587]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kahen, E]]	+	[[Category: Pyrococcus furiosus]]
-	[[Category: Li, H]]	+	[[Category: Kahen E]]
-	[[Category: Liang, B]]	+	[[Category: Li H]]
-	[[Category: Terns~~, M P~~]]	+	[[Category: Liang B]]
-	[[Category: Terns~~, R M~~]]	+	[[Category: Terns MP]]
-	[[Category: Zhou, J]]	+	[[Category: Terns RM]]
-	~~[[Category: Box h/aca]]~~	+	[[Category: Zhou J]]
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Isomerase-rna complex]]~~	+
-	~~[[Category: Post-transcriptional modification]]~~	+
-	~~[[Category: Protein-rna complex]]~~	+
-	~~[[Category: Pseudouridine synthase]]~~	+
-	~~[[Category: Pseudouridylase]]~~	+
-	~~[[Category: Pseudouridylation]]~~	+
-	~~[[Category: Ribonucleoprotein]]~~	+
-	~~[[Category: Ribonucleoprotein particle]]~~	+
-	~~[[Category: Ribosome biogenesis]]~~	+
-	~~[[Category: Rna editing]]~~	+
-	~~[[Category: Rnp]]~~	+
-	~~[[Category: Rrna processing]]~~	+
-	~~[[Category: Trna processing~~]]	+

OCA at 12:50, 23 March 2022

OCA — Wed, 23 Mar 2022 12:50:16 GMT

←Older revision		Revision as of 12:50, 23 March 2022
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	<StructureSection load='3hjy' size='340' side='right'caption='[[3hjy]], [[Resolution\|resolution]] 3.65Å' scene=''>		<StructureSection load='3hjy' size='340' side='right'caption='[[3hjy]], [[Resolution\|resolution]] 3.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hjy]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_43587 Atcc 43587]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HJY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3HJY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hjy]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_43587 Atcc 43587]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HJY FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hjw\|3hjw]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3hjw\|3hjw]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PF1785 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 ATCC 43587]), PF1141 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 ATCC 43587])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PF1785 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 ATCC 43587]), PF1141 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 ATCC 43587])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3hjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hjy OCA], [~~http~~://pdbe.org/3hjy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3hjy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3hjy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3hjy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hjy OCA], [https://pdbe.org/3hjy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hjy RCSB], [https://www.ebi.ac.uk/pdbsum/3hjy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hjy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TRUB_PYRFU TRUB_PYRFU]] Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs (By similarity). [[~~http~~://www.uniprot.org/uniprot/NOP10_PYRFU NOP10_PYRFU]] Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA (By similarity).	+	[[https://www.uniprot.org/uniprot/TRUB_PYRFU TRUB_PYRFU]] Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs (By similarity). [[https://www.uniprot.org/uniprot/NOP10_PYRFU NOP10_PYRFU]] Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	==See Also==		==See Also==
	*[[Guide-independent Pseudouridine synthase\|Guide-independent Pseudouridine synthase]]		*[[Guide-independent Pseudouridine synthase\|Guide-independent Pseudouridine synthase]]
-	*[[Pseudouridine synthase\|Pseudouridine synthase]]	+	*[[Pseudouridine synthase 3D structures\|Pseudouridine synthase 3D structures]]
-	*[[RNA-guided pseudouridine synthase\|RNA-guided pseudouridine synthase]]	+	*[[Ribosome biogenesis protein 3D structures\|Ribosome biogenesis protein 3D structures]]
-	*[[Ribosome biogenesis protein\|Ribosome biogenesis protein]]	+
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:19, 24 July 2019

OCA — Wed, 24 Jul 2019 08:19:23 GMT

←Older revision		Revision as of 08:19, 24 July 2019
Line 1:		Line 1:

	==Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA==		==Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA==
-	<StructureSection load='3hjy' size='340' side='right' caption='[[3hjy]], [[Resolution\|resolution]] 3.65Å' scene=''>	+	<StructureSection load='3hjy' size='340' side='right'caption='[[3hjy]], [[Resolution\|resolution]] 3.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3hjy]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43587 Atcc 43587]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HJY FirstGlance]. <br>		<table><tr><td colspan='2'>[[3hjy]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43587 Atcc 43587]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HJY FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hj/3hjy_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hj/3hjy_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 3hjy" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3hjy" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Guide-independent Pseudouridine synthase\|Guide-independent Pseudouridine synthase]]
		+	*[[Pseudouridine synthase\|Pseudouridine synthase]]
		+	*[[RNA-guided pseudouridine synthase\|RNA-guided pseudouridine synthase]]
		+	*[[Ribosome biogenesis protein\|Ribosome biogenesis protein]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 40:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 43587]]		[[Category: Atcc 43587]]
		+	[[Category: Large Structures]]
	[[Category: Kahen, E]]		[[Category: Kahen, E]]
	[[Category: Li, H]]		[[Category: Li, H]]

OCA at 07:39, 1 November 2017

OCA — Wed, 01 Nov 2017 07:39:43 GMT

←Older revision		Revision as of 07:39, 1 November 2017
Line 1:		Line 1:
		+
	==Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA==		==Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA==
	<StructureSection load='3hjy' size='340' side='right' caption='[[3hjy]], [[Resolution\|resolution]] 3.65Å' scene=''>		<StructureSection load='3hjy' size='340' side='right' caption='[[3hjy]], [[Resolution\|resolution]] 3.65Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hjw\|3hjw]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hjw\|3hjw]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PF1785 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 ATCC 43587]), PF1141 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 ATCC 43587])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PF1785 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 ATCC 43587]), PF1141 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 ATCC 43587])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hjy OCA], [http://pdbe.org/3hjy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hjy RCSB], [http://www.ebi.ac.uk/pdbsum/3hjy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hjy OCA], [http://pdbe.org/3hjy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hjy RCSB], [http://www.ebi.ac.uk/pdbsum/3hjy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hjy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 3hjy" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3hjy" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[TRNA pseudouridine synthase\|TRNA pseudouridine synthase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:40, 9 February 2016

OCA — Tue, 09 Feb 2016 06:40:04 GMT

←Older revision		Revision as of 06:40, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3hjy' size='340' side='right' caption='[[3hjy]], [[Resolution\|resolution]] 3.65Å' scene=''>		<StructureSection load='3hjy' size='340' side='right' caption='[[3hjy]], [[Resolution\|resolution]] 3.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hjy]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pyrococcus_furiosus Pyrococcus furiosus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HJY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hjy]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43587 Atcc 43587]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HJY FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hjw\|3hjw]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hjw\|3hjw]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PF1785 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 ~~Pyrococcus furiosus~~]), PF1141 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 ~~Pyrococcus furiosus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PF1785 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 ATCC 43587]), PF1141 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 ATCC 43587])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hjy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hjy RCSB], [http://www.ebi.ac.uk/pdbsum/3hjy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hjy OCA], [http://pdbe.org/3hjy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hjy RCSB], [http://www.ebi.ac.uk/pdbsum/3hjy PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hjy ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3hjy" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Pyrococcus furiosus~~]]	+	[[Category: Atcc 43587]]
	[[Category: Kahen, E]]		[[Category: Kahen, E]]
	[[Category: Li, H]]		[[Category: Li, H]]

OCA at 05:06, 25 December 2014

OCA — Thu, 25 Dec 2014 05:06:35 GMT

←Older revision		Revision as of 05:06, 25 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3hjy.~~png~~\|~~left~~\|200px]]	+	==Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA==
		+	<StructureSection load='3hjy' size='340' side='right' caption='[[3hjy]], [[Resolution\|resolution]] 3.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3hjy]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HJY FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hjw\|3hjw]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PF1785 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 Pyrococcus furiosus]), PF1141 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 Pyrococcus furiosus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hjy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hjy RCSB], [http://www.ebi.ac.uk/pdbsum/3hjy PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TRUB_PYRFU TRUB_PYRFU]] Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs (By similarity). [[http://www.uniprot.org/uniprot/NOP10_PYRFU NOP10_PYRFU]] Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA (By similarity).
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hj/3hjy_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Box H/ACA small nucleolar and Cajal body ribonucleoprotein particles comprise the most complex pseudouridine synthases and are essential for ribosome and spliceosome maturation. The multistep and multicomponent-mediated enzyme mechanism remains only partially understood. Here we report a crystal structure at 2.35 A of a substrate-bound functional archaeal enzyme containing three of the four proteins, Cbf5, Nop10 and L7Ae, and a box H/ACA RNA that reveals detailed information about the protein-only active site. The substrate RNA, containing 5-fluorouridine at the modification position, is fully docked and catalytically rearranged by the enzyme in a manner similar to that seen in two stand-alone pseudouridine synthases. Structural analysis provides a mechanism for plasticity in the diversity of guide RNA sequences used and identifies a substrate-anchoring loop of Cbf5 that also interacts with Gar1 in unliganded structures. Activity analyses of mutated proteins and RNAs support the structural findings and further suggest a role of the Cbf5 loop in regulation of enzyme activity.

-	~~{{STRUCTURE_3hjy\| PDB=3hjy \| SCENE= }}~~	+	Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA.,Liang B, Zhou J, Kahen E, Terns RM, Terns MP, Li H Nat Struct Mol Biol. 2009 Jul;16(7):740-6. Epub 2009 May 28. PMID:19478803<ref>PMID:19478803</ref>

-	~~===Structure~~ of ~~a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19478803}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3hjy]] is a 5 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3HJY OCA].~~	+

	==See Also==		==See Also==
	*[[TRNA pseudouridine synthase\|TRNA pseudouridine synthase]]		*[[TRNA pseudouridine synthase\|TRNA pseudouridine synthase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019478803<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Pyrococcus furiosus]]		[[Category: Pyrococcus furiosus]]
-	[[Category: Kahen, E.]]	+	[[Category: Kahen, E]]
-	[[Category: Li, H.]]	+	[[Category: Li, H]]
-	[[Category: Liang, B.]]	+	[[Category: Liang, B]]
-	[[Category: Terns, M P.]]	+	[[Category: Terns, M P]]
-	[[Category: Terns, R M.]]	+	[[Category: Terns, R M]]
-	[[Category: Zhou, J.]]	+	[[Category: Zhou, J]]
	[[Category: Box h/aca]]		[[Category: Box h/aca]]
	[[Category: Isomerase]]		[[Category: Isomerase]]

OCA at 12:59, 20 October 2012

OCA — Sat, 20 Oct 2012 12:59:53 GMT

←Older revision		Revision as of 12:59, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[3hjy]] is a 5 chain structure ~~of [[TRNA pseudouridine synthase]]~~ with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HJY OCA].	+	[[3hjy]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HJY OCA].

	==See Also==		==See Also==

OCA: Protected "3hjy" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 10:34:57 GMT

Protected "3hjy" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:34, 26 July 2012

OCA at 10:34, 26 July 2012

OCA — Thu, 26 Jul 2012 10:34:56 GMT

←Older revision		Revision as of 10:34, 26 July 2012
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-	{{Seed}}
	[[Image:3hjy.png\|left\|200px]]		[[Image:3hjy.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_3hjy\| PDB=3hjy \| SCENE= }}		{{STRUCTURE_3hjy\| PDB=3hjy \| SCENE= }}

	===Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA===		===Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA===

-
-	<!--
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	{{ABSTRACT_PUBMED_19478803}}		{{ABSTRACT_PUBMED_19478803}}

	==About this Structure==		==About this Structure==
-	~~3HJY~~ is a 5 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HJY OCA].	+	[[3hjy]] is a 5 chain structure of [[TRNA pseudouridine synthase]] with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HJY OCA].
		+
		+	==See Also==
		+	*[[TRNA pseudouridine synthase\|TRNA pseudouridine synthase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19478803~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019478803</ref><references group="xtra"/>
	[[Category: Pyrococcus furiosus]]		[[Category: Pyrococcus furiosus]]
	[[Category: Kahen, E.]]		[[Category: Kahen, E.]]
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	[[Category: Box h/aca]]		[[Category: Box h/aca]]
	[[Category: Isomerase]]		[[Category: Isomerase]]
-	[[Category: Isomerase/rna complex]]	+	[[Category: Isomerase-rna complex]]
	[[Category: Post-transcriptional modification]]		[[Category: Post-transcriptional modification]]
	[[Category: Protein-rna complex]]		[[Category: Protein-rna complex]]
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	[[Category: Rrna processing]]		[[Category: Rrna processing]]
	[[Category: Trna processing]]		[[Category: Trna processing]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 22 20:06:31 2009''

OCA at 17:00, 22 July 2009

OCA — Wed, 22 Jul 2009 17:00:57 GMT

←Older revision		Revision as of 17:00, 22 July 2009
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-	[[Image:3hjy.~~jpg~~\|left\|200px]]	+	[[Image:3hjy.png\|left\|200px]]

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-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Jun 25 09~~:03:22 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 22 20:06:31 2009''