3hke - Revision history

OCA at 15:50, 1 November 2023

OCA — Wed, 01 Nov 2023 15:50:07 GMT

←Older revision		Revision as of 15:50, 1 November 2023
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	<StructureSection load='3hke' size='340' side='right'caption='[[3hke]], [[Resolution\|resolution]] 3.60Å' scene=''>		<StructureSection load='3hke' size='340' side='right'caption='[[3hke]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hke]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~] and [https://en.wikipedia.org/wiki/~~Ovis_aries Ovis aries~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HKE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hke]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HKE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=T13:2,3,4,5,6-PENTAFLUORO-N-(3-FLUORO-4-METHOXYPHENYL)BENZENESULFONAMIDE'>T13</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.6Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1sa0\|1sa0]], [[1sa1\|1sa1]], [[3hkb\|3hkb]], [[3hkc\|3hkc]], [[3hkd\|3hkd]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=T13:2,3,4,5,6-PENTAFLUORO-N-(3-FLUORO-4-METHOXYPHENYL)BENZENESULFONAMIDE'>T13</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STMN4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hke OCA], [https://pdbe.org/3hke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hke RCSB], [https://www.ebi.ac.uk/pdbsum/3hke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hke ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hke OCA], [https://pdbe.org/3hke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hke RCSB], [https://www.ebi.ac.uk/pdbsum/3hke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hke ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~STMN4_RAT STMN4_RAT~~]~~] Exhibits microtubule~~-~~destabilizing activity~~.~~<ref>PMID~~:~~15039434</ref> <ref>PMID~~:~~12111843</ref> <ref>PMID:15014504</ref>~~	+	[https://www.uniprot.org/uniprot/D0VWZ0_SHEEP D0VWZ0_SHEEP] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).[RuleBase:RU003505][SAAS:SAAS023123_004_019801]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Ovis aries]]		[[Category: Ovis aries]]
-	[[Category: Dorleans, A]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Gigant, B]]	+	[[Category: Dorleans A]]
-	[[Category: Knossow, M]]	+	[[Category: Gigant B]]
-	[[Category: Mailliet, P]]	+	[[Category: Knossow M]]
-	[[Category: Mikol, V]]	+	[[Category: Mailliet P]]
-	[[Category: Ravelli~~, R B.G]]~~	+	[[Category: Mikol V]]
-	~~[[Category: Alpha-tubulin]]~~	+	[[Category: Ravelli RBG]]
-	~~[[Category: Beta-tubulin]]~~	+
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Colchicine domain]]~~	+
-	~~[[Category: Covalent binding]]~~	+
-	~~[[Category: Gtpase]]~~	+
-	~~[[Category: Microtubule]]~~	+
-	~~[[Category: Stathmin]]~~	+
-	~~[[Category: Tubulin~~]]	+

OCA at 12:50, 23 March 2022

OCA — Wed, 23 Mar 2022 12:50:41 GMT

←Older revision		Revision as of 12:50, 23 March 2022
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	==Tubulin-T138067: RB3 stathmin-like domain complex==		==Tubulin-T138067: RB3 stathmin-like domain complex==
-	<StructureSection load='3hke' size='340' side='right' caption='[[3hke]], [[Resolution\|resolution]] 3.60Å' scene=''>	+	<StructureSection load='3hke' size='340' side='right'caption='[[3hke]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hke]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [~~http~~://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HKE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3HKE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hke]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HKE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=T13:2,3,4,5,6-PENTAFLUORO-N-(3-FLUORO-4-METHOXYPHENYL)BENZENESULFONAMIDE'>T13</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=T13:2,3,4,5,6-PENTAFLUORO-N-(3-FLUORO-4-METHOXYPHENYL)BENZENESULFONAMIDE'>T13</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sa0\|1sa0]], [[1sa1\|1sa1]], [[3hkb\|3hkb]], [[3hkc\|3hkc]], [[3hkd\|3hkd]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1sa0\|1sa0]], [[1sa1\|1sa1]], [[3hkb\|3hkb]], [[3hkc\|3hkc]], [[3hkd\|3hkd]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STMN4 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STMN4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3hke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hke OCA], [~~http~~://pdbe.org/3hke PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3hke RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3hke PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3hke ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hke OCA], [https://pdbe.org/3hke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hke RCSB], [https://www.ebi.ac.uk/pdbsum/3hke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hke ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref>	+	[[https://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Stathmin\|Stathmin]]	+	*[[Stathmin-4 3D structures\|Stathmin-4 3D structures]]
-	*[[Tubulin\|Tubulin]]	+	*[[Tubulin 3D Structures\|Tubulin 3D Structures]]
-	*[[User:Alisa Cario\|User:Alisa Cario]]	+
	== References ==		== References ==
	<references/>		<references/>
Line 40:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Ovis aries]]		[[Category: Ovis aries]]
	[[Category: Dorleans, A]]		[[Category: Dorleans, A]]

OCA at 07:39, 12 December 2018

OCA — Wed, 12 Dec 2018 07:39:01 GMT

←Older revision		Revision as of 07:39, 12 December 2018
Line 1:		Line 1:
		+
	==Tubulin-T138067: RB3 stathmin-like domain complex==		==Tubulin-T138067: RB3 stathmin-like domain complex==
	<StructureSection load='3hke' size='340' side='right' caption='[[3hke]], [[Resolution\|resolution]] 3.60Å' scene=''>		<StructureSection load='3hke' size='340' side='right' caption='[[3hke]], [[Resolution\|resolution]] 3.60Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sa0\|1sa0]], [[1sa1\|1sa1]], [[3hkb\|3hkb]], [[3hkc\|3hkc]], [[3hkd\|3hkd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sa0\|1sa0]], [[1sa1\|1sa1]], [[3hkb\|3hkb]], [[3hkc\|3hkc]], [[3hkd\|3hkd]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STMN4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STMN4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hke OCA], [http://pdbe.org/3hke PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hke RCSB], [http://www.ebi.ac.uk/pdbsum/3hke PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hke OCA], [http://pdbe.org/3hke PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hke RCSB], [http://www.ebi.ac.uk/pdbsum/3hke PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hke ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/3hke_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/3hke_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 34:
	*[[Stathmin\|Stathmin]]		*[[Stathmin\|Stathmin]]
	*[[Tubulin\|Tubulin]]		*[[Tubulin\|Tubulin]]
		+	*[[User:Alisa Cario\|User:Alisa Cario]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:10, 8 February 2016

OCA — Mon, 08 Feb 2016 07:10:37 GMT

←Older revision		Revision as of 07:10, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3hke' size='340' side='right' caption='[[3hke]], [[Resolution\|resolution]] 3.60Å' scene=''>		<StructureSection load='3hke' size='340' side='right' caption='[[3hke]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hke]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Ovis_aries Ovis aries~~] and [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HKE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hke]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HKE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=T13:2,3,4,5,6-PENTAFLUORO-N-(3-FLUORO-4-METHOXYPHENYL)BENZENESULFONAMIDE'>T13</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=T13:2,3,4,5,6-PENTAFLUORO-N-(3-FLUORO-4-METHOXYPHENYL)BENZENESULFONAMIDE'>T13</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sa0\|1sa0]], [[1sa1\|1sa1]], [[3hkb\|3hkb]], [[3hkc\|3hkc]], [[3hkd\|3hkd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sa0\|1sa0]], [[1sa1\|1sa1]], [[3hkb\|3hkb]], [[3hkc\|3hkc]], [[3hkd\|3hkd]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STMN4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STMN4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hke OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hke RCSB], [http://www.ebi.ac.uk/pdbsum/3hke PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hke OCA], [http://pdbe.org/3hke PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hke RCSB], [http://www.ebi.ac.uk/pdbsum/3hke PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hke ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3hke" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
		+	*[[Stathmin\|Stathmin]]
	*[[Tubulin\|Tubulin]]		*[[Tubulin\|Tubulin]]
	== References ==		== References ==
Line 35:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
	[[Category: Ovis aries]]		[[Category: Ovis aries]]
-	[[Category: Rattus norvegicus]]
	[[Category: Dorleans, A]]		[[Category: Dorleans, A]]
	[[Category: Gigant, B]]		[[Category: Gigant, B]]

OCA at 21:33, 24 December 2014

OCA — Wed, 24 Dec 2014 21:33:30 GMT

←Older revision		Revision as of 21:33, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3hke]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HKE FirstGlance]. <br>		<table><tr><td colspan='2'>[[3hke]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HKE FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=T13:2,3,4,5,6-PENTAFLUORO-N-(3-FLUORO-4-METHOXYPHENYL)BENZENESULFONAMIDE'>T13</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=T13:2,3,4,5,6-PENTAFLUORO-N-(3-FLUORO-4-METHOXYPHENYL)BENZENESULFONAMIDE'>T13</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sa0\|1sa0]], [[1sa1\|1sa1]], [[3hkb\|3hkb]], [[3hkc\|3hkc]], [[3hkd\|3hkd]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sa0\|1sa0]], [[1sa1\|1sa1]], [[3hkb\|3hkb]], [[3hkc\|3hkc]], [[3hkd\|3hkd]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STMN4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STMN4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hke OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hke RCSB], [http://www.ebi.ac.uk/pdbsum/3hke PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hke OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hke RCSB], [http://www.ebi.ac.uk/pdbsum/3hke PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Ovis aries]]		[[Category: Ovis aries]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Dorleans, A.]]	+	[[Category: Dorleans, A]]
-	[[Category: Gigant, B.]]	+	[[Category: Gigant, B]]
-	[[Category: Knossow, M.]]	+	[[Category: Knossow, M]]
-	[[Category: Mailliet, P.]]	+	[[Category: Mailliet, P]]
-	[[Category: Mikol, V.]]	+	[[Category: Mikol, V]]
-	[[Category: Ravelli, R B.G.]]	+	[[Category: Ravelli, R B.G]]
	[[Category: Alpha-tubulin]]		[[Category: Alpha-tubulin]]
	[[Category: Beta-tubulin]]		[[Category: Beta-tubulin]]

OCA at 12:46, 29 September 2014

OCA — Mon, 29 Sep 2014 12:46:34 GMT

←Older revision		Revision as of 12:46, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3hke.~~png~~\|~~left~~\|200px]]	+	==Tubulin-T138067: RB3 stathmin-like domain complex==
		+	<StructureSection load='3hke' size='340' side='right' caption='[[3hke]], [[Resolution\|resolution]] 3.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3hke]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HKE FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=T13:2,3,4,5,6-PENTAFLUORO-N-(3-FLUORO-4-METHOXYPHENYL)BENZENESULFONAMIDE'>T13</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1sa0\|1sa0]], [[1sa1\|1sa1]], [[3hkb\|3hkb]], [[3hkc\|3hkc]], [[3hkd\|3hkd]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STMN4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hke OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hke RCSB], [http://www.ebi.ac.uk/pdbsum/3hke PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/3hke_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Structural changes occur in the alphabeta-tubulin heterodimer during the microtubule assembly/disassembly cycle. Their most prominent feature is a transition from a straight, microtubular structure to a curved structure. There is a broad range of small molecule compounds that disturbs the microtubule cycle, a class of which targets the colchicine-binding site and prevents microtubule assembly. This class includes compounds with very different chemical structures, and it is presently unknown whether they prevent tubulin polymerization by the same mechanism. To address this issue, we have determined the structures of tubulin complexed with a set of such ligands and show that they interfere with several of the movements of tubulin subunits structural elements upon its transition from curved to straight. We also determined the structure of tubulin unliganded at the colchicine site; this reveals that a beta-tubulin loop (termed T7) flips into this site. As with colchicine site ligands, this prevents a helix which is at the interface with alpha-tubulin from stacking onto a beta-tubulin beta sheet as in straight protofilaments. Whereas in the presence of these ligands the interference with microtubule assembly gets frozen, by flipping in and out the beta-subunit T7 loop participates in a reversible way in the resistance to straightening that opposes microtubule assembly. Our results suggest that it thereby contributes to microtubule dynamic instability.

-	~~{{STRUCTURE_3hke\| PDB=3hke \| SCENE= }}~~	+	Variations in the colchicine-binding domain provide insight into the structural switch of tubulin.,Dorleans A, Gigant B, Ravelli RB, Mailliet P, Mikol V, Knossow M Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13775-9. Epub 2009 Aug 5. PMID:19666559<ref>PMID:19666559</ref>

-	~~===Tubulin-T138067: RB3 stathmin-like domain complex===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19666559}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3hke]] is~~ a ~~5 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Ovis_aries Ovis aries] and [http://en~~.~~wikipedia.org~~/~~wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HKE OCA].~~	+

	==See Also==		==See Also==
	*[[Tubulin\|Tubulin]]		*[[Tubulin\|Tubulin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019666559<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Ovis aries]]		[[Category: Ovis aries]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]

OCA at 09:20, 20 October 2012

OCA — Sat, 20 Oct 2012 09:20:54 GMT

←Older revision		Revision as of 09:20, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3hke]] is a 5 chain structure ~~of [[Tubulin]]~~ with sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HKE OCA].	+	[[3hke]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HKE OCA].

	==See Also==		==See Also==

OCA: Protected "3hke" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 22:33:50 GMT

Protected "3hke" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:33, 25 July 2012

OCA at 22:33, 25 July 2012

OCA — Wed, 25 Jul 2012 22:33:48 GMT

←Older revision		Revision as of 22:33, 25 July 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3hke.png\|left\|200px]]
-	[[Image:3hke.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3hke", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3hke\| PDB=3hke \| SCENE= }}		{{STRUCTURE_3hke\| PDB=3hke \| SCENE= }}

	===Tubulin-T138067: RB3 stathmin-like domain complex===		===Tubulin-T138067: RB3 stathmin-like domain complex===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19666559}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19666559 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19666559}}		{{ABSTRACT_PUBMED_19666559}}

	==About this Structure==		==About this Structure==
-	~~3HKE~~ is a 5 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HKE OCA].	+	[[3hke]] is a 5 chain structure of [[Tubulin]] with sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HKE OCA].
		+
		+	==See Also==
		+	*[[Tubulin\|Tubulin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19666559~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019666559</ref><references group="xtra"/>
	[[Category: Ovis aries]]		[[Category: Ovis aries]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
Line 41:		Line 32:
	[[Category: Stathmin]]		[[Category: Stathmin]]
	[[Category: Tubulin]]		[[Category: Tubulin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Sep 3 15:38:16 2009''

OCA at 12:38, 3 September 2009

OCA — Thu, 03 Sep 2009 12:38:17 GMT

←Older revision		Revision as of 12:38, 3 September 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3hke.jpg\|left\|200px]]

-	The ~~entry 3hke~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3hke", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3hke\| PDB=3hke \| SCENE= }}

-	~~Authors~~: ~~Dorleans, A., Gigant, B., Ravelli, R.B.G., Maillet, P., Mikol, V., Knossow, M.~~	+	===Tubulin-T138067: RB3 stathmin-like domain complex===

-	Description: Tubulin-T138067: RB3 stathmin-like domain complex

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jun 10 17~~:59:30 2009''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19666559}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19666559 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19666559}}
		+
		+	==About this Structure==
		+	3HKE is a 5 chains structure of sequences from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HKE OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19666559</ref><references group="xtra"/>
		+	[[Category: Ovis aries]]
		+	[[Category: Rattus norvegicus]]
		+	[[Category: Dorleans, A.]]
		+	[[Category: Gigant, B.]]
		+	[[Category: Knossow, M.]]
		+	[[Category: Mailliet, P.]]
		+	[[Category: Mikol, V.]]
		+	[[Category: Ravelli, R B.G.]]
		+	[[Category: Alpha-tubulin]]
		+	[[Category: Beta-tubulin]]
		+	[[Category: Cell cycle]]
		+	[[Category: Colchicine domain]]
		+	[[Category: Covalent binding]]
		+	[[Category: Gtpase]]
		+	[[Category: Microtubule]]
		+	[[Category: Stathmin]]
		+	[[Category: Tubulin]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Sep 3 15:38:16 2009''