3hme - Revision history

OCA at 15:50, 1 November 2023

OCA — Wed, 01 Nov 2023 15:50:40 GMT

←Older revision		Revision as of 15:50, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3hme' size='340' side='right'caption='[[3hme]], [[Resolution\|resolution]] 2.23Å' scene=''>		<StructureSection load='3hme' size='340' side='right'caption='[[3hme]], [[Resolution\|resolution]] 2.23Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hme]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HME FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hme]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HME FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3hmf\|3hmf]], [[3hmh\|3hmh]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.23Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">BRD9, UNQ3040/PRO9856 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hme OCA], [https://pdbe.org/3hme PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hme RCSB], [https://www.ebi.ac.uk/pdbsum/3hme PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hme ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hme OCA], [https://pdbe.org/3hme PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hme RCSB], [https://www.ebi.ac.uk/pdbsum/3hme PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hme ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BRD9_HUMAN BRD9_HUMAN]] May play a role in chromatin remodeling and regulation of transcription.	+	[https://www.uniprot.org/uniprot/BRD9_HUMAN BRD9_HUMAN] May play a role in chromatin remodeling and regulation of transcription.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	[[Category: Chaikuad, A]]	+	[[Category: Chaikuad A]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Edwards A]]
-	[[Category: Edwards, A]]	+	[[Category: Eswaran J]]
-	[[Category: Eswaran, J]]	+	[[Category: Filippakopoulos P]]
-	[[Category: Filippakopoulos, P]]	+	[[Category: Keates T]]
-	[[Category: Keates, T]]	+	[[Category: Knapp S]]
-	[[Category: Knapp, S]]	+	[[Category: Picaud S]]
-	[[Category: Picaud, S]]	+	[[Category: Roos A]]
-	[[Category: Roos, A]]	+	[[Category: Weigelt J]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Von Delft F]]
-	[[Category: Weigelt, J]]	+
-	[[Category: ~~Brd9]]~~	+
-	~~[[Category: Bromodomain]]~~	+
-	~~[[Category: Bromodomain containing 9 isoform 1]]~~	+
-	~~[[Category: Lavs3040]]~~	+
-	~~[[Category: Pro9856]]~~	+
-	~~[[Category: Rhabdomyosarcoma antigen mu-rms-40 8]]~~	+
-	~~[[Category: Sarcoma antigen ny-sar-29]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 12:52, 23 March 2022

OCA — Wed, 23 Mar 2022 12:52:16 GMT

←Older revision		Revision as of 12:52, 23 March 2022
Line 1:		Line 1:

	==Crystal structure of human bromodomain containing 9 isoform 1 (BRD9)==		==Crystal structure of human bromodomain containing 9 isoform 1 (BRD9)==
-	<StructureSection load='3hme' size='340' side='right' caption='[[3hme]], [[Resolution\|resolution]] 2.23Å' scene=''>	+	<StructureSection load='3hme' size='340' side='right'caption='[[3hme]], [[Resolution\|resolution]] 2.23Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hme]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HME OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3HME FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hme]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HME FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hmf\|3hmf]], [[3hmh\|3hmh]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3hmf\|3hmf]], [[3hmh\|3hmh]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD9, UNQ3040/PRO9856 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD9, UNQ3040/PRO9856 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3hme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hme OCA], [~~http~~://pdbe.org/3hme PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3hme RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3hme PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3hme ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hme OCA], [https://pdbe.org/3hme PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hme RCSB], [https://www.ebi.ac.uk/pdbsum/3hme PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hme ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BRD9_HUMAN BRD9_HUMAN]] May play a role in chromatin remodeling and regulation of transcription.	+	[[https://www.uniprot.org/uniprot/BRD9_HUMAN BRD9_HUMAN]] May play a role in chromatin remodeling and regulation of transcription.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Bromodomain-containing protein\|Bromodomain-containing protein]]	+	*[[Bromodomain-containing protein 3D structures\|Bromodomain-containing protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 08:18, 12 December 2018

OCA — Wed, 12 Dec 2018 08:18:05 GMT

←Older revision		Revision as of 08:18, 12 December 2018
Line 1:		Line 1:
		+
	==Crystal structure of human bromodomain containing 9 isoform 1 (BRD9)==		==Crystal structure of human bromodomain containing 9 isoform 1 (BRD9)==
	<StructureSection load='3hme' size='340' side='right' caption='[[3hme]], [[Resolution\|resolution]] 2.23Å' scene=''>		<StructureSection load='3hme' size='340' side='right' caption='[[3hme]], [[Resolution\|resolution]] 2.23Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hmf\|3hmf]], [[3hmh\|3hmh]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hmf\|3hmf]], [[3hmh\|3hmh]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD9, UNQ3040/PRO9856 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD9, UNQ3040/PRO9856 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hme OCA], [http://pdbe.org/3hme PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hme RCSB], [http://www.ebi.ac.uk/pdbsum/3hme PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hme OCA], [http://pdbe.org/3hme PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hme RCSB], [http://www.ebi.ac.uk/pdbsum/3hme PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hme ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hm/3hme_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hm/3hme_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 3hme" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3hme" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Bromodomain-containing protein\|Bromodomain-containing protein]]
	== References ==		== References ==
	<references/>		<references/>
Line 44:		Line 48:
	[[Category: Picaud, S]]		[[Category: Picaud, S]]
	[[Category: Roos, A]]		[[Category: Roos, A]]
		+	[[Category: Structural genomic]]
	[[Category: Weigelt, J]]		[[Category: Weigelt, J]]
	[[Category: Brd9]]		[[Category: Brd9]]
Line 54:		Line 59:
	[[Category: Sgc]]		[[Category: Sgc]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
-	[[Category: Structural genomic]]

OCA at 05:24, 10 February 2016

OCA — Wed, 10 Feb 2016 05:24:25 GMT

←Older revision		Revision as of 05:24, 10 February 2016
Line 2:		Line 2:
	<StructureSection load='3hme' size='340' side='right' caption='[[3hme]], [[Resolution\|resolution]] 2.23Å' scene=''>		<StructureSection load='3hme' size='340' side='right' caption='[[3hme]], [[Resolution\|resolution]] 2.23Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hme]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HME OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HME FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hme]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HME OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HME FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hmf\|3hmf]], [[3hmh\|3hmh]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hmf\|3hmf]], [[3hmh\|3hmh]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD9, UNQ3040/PRO9856 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD9, UNQ3040/PRO9856 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hme OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hme RCSB], [http://www.ebi.ac.uk/pdbsum/3hme PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hme OCA], [http://pdbe.org/3hme PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hme RCSB], [http://www.ebi.ac.uk/pdbsum/3hme PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hme ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3hme" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 12:07, 25 December 2014

OCA — Thu, 25 Dec 2014 12:07:43 GMT

←Older revision		Revision as of 12:07, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3hme]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HME OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HME FirstGlance]. <br>		<table><tr><td colspan='2'>[[3hme]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HME OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HME FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hmf\|3hmf]], [[3hmh\|3hmh]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hmf\|3hmf]], [[3hmh\|3hmh]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD9, UNQ3040/PRO9856 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD9, UNQ3040/PRO9856 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hme OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hme RCSB], [http://www.ebi.ac.uk/pdbsum/3hme PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hme OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hme RCSB], [http://www.ebi.ac.uk/pdbsum/3hme PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BRD9_HUMAN BRD9_HUMAN]] May play a role in chromatin remodeling and regulation of transcription.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 23:		Line 25:
	Histone recognition and large-scale structural analysis of the human bromodomain family.,Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Muller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S Cell. 2012 Mar 30;149(1):214-31. PMID:22464331<ref>PMID:22464331</ref>		Histone recognition and large-scale structural analysis of the human bromodomain family.,Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Muller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S Cell. 2012 Mar 30;149(1):214-31. PMID:22464331<ref>PMID:22464331</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Bountra, C.]]	+	[[Category: Bountra, C]]
-	[[Category: Chaikuad, A.]]	+	[[Category: Chaikuad, A]]
-	[[Category: Delft, F von.]]	+	[[Category: Delft, F von]]
-	[[Category: Edwards, A.]]	+	[[Category: Edwards, A]]
-	[[Category: Eswaran, J.]]	+	[[Category: Eswaran, J]]
-	[[Category: Filippakopoulos, P.]]	+	[[Category: Filippakopoulos, P]]
-	[[Category: Keates, T.]]	+	[[Category: Keates, T]]
-	[[Category: Knapp, S.]]	+	[[Category: Knapp, S]]
-	[[Category: Picaud, S.]]	+	[[Category: Picaud, S]]
-	[[Category: Roos, A.]]	+	[[Category: Roos, A]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
	[[Category: Brd9]]		[[Category: Brd9]]
	[[Category: Bromodomain]]		[[Category: Bromodomain]]
Line 52:		Line 54:
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
-	[[Category: Structural genomics consortium]]

OCA at 09:48, 21 May 2014

OCA — Wed, 21 May 2014 09:48:32 GMT

←Older revision		Revision as of 09:48, 21 May 2014
Line 1:		Line 1:
-	[[~~Image:~~3hme.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of human bromodomain containing 9 isoform 1 (BRD9)==
		+	<StructureSection load='3hme' size='340' side='right' caption='[[3hme]], [[Resolution\|resolution]] 2.23Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3hme]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HME OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HME FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hmf\|3hmf]], [[3hmh\|3hmh]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD9, UNQ3040/PRO9856 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hme OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hme RCSB], [http://www.ebi.ac.uk/pdbsum/3hme PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hm/3hme_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bromodomains (BRDs) are protein interaction modules that specifically recognize epsilon-N-lysine acetylation motifs, a key event in the reading process of epigenetic marks. The 61 BRDs in the human genome cluster into eight families based on structure/sequence similarity. Here, we present 29 high-resolution crystal structures, covering all BRD families. Comprehensive crossfamily structural analysis identifies conserved and family-specific structural features that are necessary for specific acetylation-dependent substrate recognition. Screening of more than 30 representative BRDs against systematic histone-peptide arrays identifies new BRD substrates and reveals a strong influence of flanking posttranslational modifications, such as acetylation and phosphorylation, suggesting that BRDs recognize combinations of marks rather than singly acetylated sequences. We further uncovered a structural mechanism for the simultaneous binding and recognition of diverse diacetyl-containing peptides by BRD4. These data provide a foundation for structure-based drug design of specific inhibitors for this emerging target family.

-	<!--	+	Histone recognition and large-scale structural analysis of the human bromodomain family.,Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Muller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S Cell. 2012 Mar 30;149(1):214-31. PMID:22464331<ref>PMID:22464331</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3hme"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3hme\| PDB=3hme \| SCENE= }}~~	+

-	~~===Crystal structure~~ of ~~human bromodomain containing 9 isoform 1 (BRD9)===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22464331}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22464331 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22464331}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3hme]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HME OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022464331<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]

OCA: Protected "3hme" [edit=sysop:move=sysop]

OCA — Wed, 11 Apr 2012 06:06:54 GMT

Protected "3hme" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:06, 11 April 2012

OCA at 06:06, 11 April 2012

OCA — Wed, 11 Apr 2012 06:06:52 GMT

←Older revision		Revision as of 06:06, 11 April 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3hme.png\|left\|200px]]
-	[[Image:3hme.~~jpg~~\|left\|200px]]	+

	<!--		<!--
Line 12:		Line 11:
	===Crystal structure of human bromodomain containing 9 isoform 1 (BRD9)===		===Crystal structure of human bromodomain containing 9 isoform 1 (BRD9)===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22464331}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22464331 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22464331}}

	==About this Structure==		==About this Structure==
-	~~3HME~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HME OCA].	+	[[3hme]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HME OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022464331</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]
Line 28:		Line 36:
	[[Category: Roos, A.]]		[[Category: Roos, A.]]
	[[Category: Weigelt, J.]]		[[Category: Weigelt, J.]]
-	[[Category: Alternative splicing]]
	[[Category: Brd9]]		[[Category: Brd9]]
	[[Category: Bromodomain]]		[[Category: Bromodomain]]
	[[Category: Bromodomain containing 9 isoform 1]]		[[Category: Bromodomain containing 9 isoform 1]]
	[[Category: Lavs3040]]		[[Category: Lavs3040]]
-	[[Category: Polymorphism]]
	[[Category: Pro9856]]		[[Category: Pro9856]]
	[[Category: Rhabdomyosarcoma antigen mu-rms-40 8]]		[[Category: Rhabdomyosarcoma antigen mu-rms-40 8]]
Line 41:		Line 47:
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Structural genomics consortium]]		[[Category: Structural genomics consortium]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 25 11:25:46 2009''

OCA at 08:25, 25 June 2009

OCA — Thu, 25 Jun 2009 08:25:48 GMT

←Older revision		Revision as of 08:25, 25 June 2009
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3hme.jpg\|left\|200px]]

-	The ~~entry 3hme~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3hme", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3hme\| PDB=3hme \| SCENE= }}

-	~~Authors: Filippakopoulos, P., Eswaran, J., Keates, T., Roos, A., Chaikuad, A., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Bountra, C., Knapp, S.~~	+	===Crystal structure of human bromodomain containing 9 isoform 1 (BRD9)===

-	Description: Crystal structure of human bromodomain containing 9 isoform 1 (BRD9)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed~~ Jun ~~10 17~~:59:54 2009''	+	==About this Structure==
		+	3HME is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HME OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Arrowsmith, C H.]]
		+	[[Category: Bountra, C.]]
		+	[[Category: Chaikuad, A.]]
		+	[[Category: Delft, F von.]]
		+	[[Category: Edwards, A.]]
		+	[[Category: Eswaran, J.]]
		+	[[Category: Filippakopoulos, P.]]
		+	[[Category: Keates, T.]]
		+	[[Category: Knapp, S.]]
		+	[[Category: Picaud, S.]]
		+	[[Category: Roos, A.]]
		+	[[Category: Weigelt, J.]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Brd9]]
		+	[[Category: Bromodomain]]
		+	[[Category: Bromodomain containing 9 isoform 1]]
		+	[[Category: Lavs3040]]
		+	[[Category: Polymorphism]]
		+	[[Category: Pro9856]]
		+	[[Category: Rhabdomyosarcoma antigen mu-rms-40 8]]
		+	[[Category: Sarcoma antigen ny-sar-29]]
		+	[[Category: Sgc]]
		+	[[Category: Signaling protein]]
		+	[[Category: Structural genomic]]
		+	[[Category: Structural genomics consortium]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 25 11:25:46 2009''

OCA: New page: '''Unreleased structure''' The entry 3hme is ON HOLD Authors: Filippakopoulos, P., Eswaran, J., Keates, T., Roos, A., Chaikuad, A., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt...

OCA — Wed, 10 Jun 2009 14:59:54 GMT

New page: '''Unreleased structure''' The entry 3hme is ON HOLD Authors: Filippakopoulos, P., Eswaran, J., Keates, T., Roos, A., Chaikuad, A., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt...

New page

'''Unreleased structure'''

The entry 3hme is ON HOLD

Authors: Filippakopoulos, P., Eswaran, J., Keates, T., Roos, A., Chaikuad, A., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Bountra, C., Knapp, S.

Description: Crystal structure of human bromodomain containing 9 isoform 1 (BRD9)

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 10 17:59:54 2009''